Ginsenoside Rg1

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  • Identifiers

    CAS number
    22427-39-0

    Molecular formula
    C42H72O14

    SMILES
    CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C)O)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 47.77%
    Odorless 45.57%
    Sweet 37.56%
    Spicy 33.18%
    Mint 32.31%
    Cooling 30.08%
    Balsamic 29.78%
    Amber 28.36%
    Sandalwood 25.41%
    Dry 25.32%

     

    Flavor
    Bitter 47.71%
    Sweet 33.33%
    Odorless 27.96%
    Fatty 25.9%
    Herbal 25.34%
    Sweet-like 24.87%
    Minty 22.15%
    Pine 22.14%
    Cedarleaf 22.1%
    Mentholic 21.61%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    4.38 (weak acid)

    Molecular weight
    801.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    1824°C

    Flash point

    • 238.32 ˚C est.

  • Synonyms

    • Ginsenoside RG1
    • 22427-39-0
    • Sanchinoside C1
    • Panaxoside A
    • Ginsenoside A2
    • Panaxoside Rg1
    • Sanchinoside Rg1
    • (3beta,6alpha,12beta)-3,12-Dihydroxydammar-24-ene-6,20-diyl bis-beta-D-Glucopyranoside
    • DTXSID70945111
    • PJ788634QY
    • CHEBI:67987
    • (6)-beta-D-Glucopyranosyl-(20)-beta-D-glucopyranosyl-20S-protopanaxatriol
    • (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-[(2S)-6-methyl-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhept-5-en-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
    • (3beta,6alpha,12beta)-3,12-Dihydroxydammar-24-ene-6,20-diylbis(beta-D-glucopyranoside)
    • beta-D-Glucopyranoside, (3beta,6alpha,12beta)-3,12-dihydroxy dammar-24-ene-6,20-diylbis-
    • beta-D-Glucopyranoside, (3beta,6alpha,12beta)-3,12-dihydroxydammar-24-ene-6,20-diyl bis-
    • (2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((2S)-6-methyl-2-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyhept-5-en-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-6-yl)oxy)-6-(hydroxymethyl)oxane-3,4,5-triol
    • RefChem:37717
    • DTXCID701373437
    • 244-989-9
    • ginsenoside-Rg(1)
    • sanchinoside C(1)
    • MFCD00210293
    • GinsenosideRG1
    • (20S)-ginsenoside Rg1
    • ginsenoside-Rg1
    • Ginsenoside g1
    • Panaxoside A;Panaxoside Rg1
    • CHEMBL501637
    • UNII-PJ788634QY
    • Ginsenoside Rg1?
    • RG1
    • EINECS 244-989-9
    • Ginsenoside Rg1 CRS
    • Ginsenoside Rg1 RS
    • BIDD:ER0075
    • orb1305031
    • SCHEMBL19875635
    • GINSENOSIDE RG1 [USP-RS]
    • GINSENOSIDE RG1 [WHO-DD]
    • HMS3885M12
    • (2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-[(1S)-1,5-dimethyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-hex-4-enyl]-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • EX-A6784
    • HY-N0045
    • MSK40042
    • Ginsenoside Rg1, analytical standard
    • s3923
    • AKOS037514672
    • CCG-270492
    • CS-3832
    • DB06750
    • EBC-615478
    • OG09289
    • NCGC00483065-01
    • (2S,3R,4S,5S,6R)-2-{[(2S)-2-[(1S,3aR,3bR,5S,5aR,7S,9aR,9bR,11R,11aR)-7,11-dihydroxy-3a,3b,6,6,9a-pentamethyl-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
    • BS-16671
    • SY068756
    • G0533
    • NS00073634
    • C08946
    • 427G390
    • Q2276594
    • Ginsenoside Rg1, primary pharmaceutical reference standard
    • Ginsenoside Rg1, United States Pharmacopeia (USP) Reference Standard
    • (3?,6?,12?)-3,12-Dihydroxydammar-24-ene-6,20-diylbis-?-D-glucopyranoside
    • (6)-.BETA.-D-GLUCOPYRANOSYL-(20)-.BETA.-D-GLUCOPYRANOSYL-20S- PROTOPANAXATRIOL
    • (3.BETA.,6.ALPHA.,12.BETA.)-3,12-DIHYDROXYDAMMAR-24-ENE-6,20- DIYLBIS(.BETA.-D-GLUCOPYRANOSIDE)
    • (3beta,alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl beta-D-glucopyranoside
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-3,12- DIHYDROXY DAMMAR-24-ENE-6,20-DIYLBIS-
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-3,12-DIHYDROXYDAMMAR-24-ENE-6,20-DIYL BIS-
    • 6alpha-(beta-D-Glucopyranosyloxy)-3beta,12beta-dihydroxydammar-24-en-20-yl beta-D-glucopyranoside
    • GINSENOSIDE RG1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]
    • 22427-39-0

  • Applications

    Ginsenoside Rg1 (CAS 22427-39-0) is a dammarane-type saponin isolated from ginseng, with real-world applications across cosmetic and personal care (as an active ingredient in skin and hair care products), pharmaceuticals (studied as a bioactive component in herbal or conventional formulations), and nutraceuticals/dietary supplements (evaluated as a functional ingredient). It is also considered for food processing or formulation stabilization in certain product systems, and is viewed as a natural bioactive ingredient with reported activities, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.28
    methanol 36.77
    isopropanol 2.11
    water 0.15
    ethyl acetate 4.8
    n-propanol 4.22
    acetone 10.5
    n-butanol 1.84
    acetonitrile 2.66
    DMF 55.37
    toluene 1.4
    isobutanol 1.63
    1,4-dioxane 19.48
    methyl acetate 5.28
    THF 43.87
    2-butanone 6.19
    n-pentanol 1.58
    sec-butanol 1.29
    n-hexane 0.07
    ethylene glycol 7.43
    NMP 63.38
    cyclohexane 0.14
    DMSO 82.28
    n-butyl acetate 2.33
    n-octanol 1.73
    chloroform 8.97
    n-propyl acetate 2.28
    acetic acid 49.57
    dichloromethane 7.87
    cyclohexanone 9.92
    propylene glycol 6.52
    isopropyl acetate 2.87
    DMAc 48.74
    2-ethoxyethanol 17.0
    isopentanol 1.07
    n-heptane 0.11
    ethyl formate 5.55
    1,2-dichloroethane 4.1
    n-hexanol 1.57
    2-methoxyethanol 37.58
    isobutyl acetate 1.31
    tetrachloromethane 1.28
    n-pentyl acetate 4.01
    transcutol 25.55
    n-heptanol 2.18
    ethylbenzene 0.56
    MIBK 2.43
    2-propoxyethanol 19.34
    tert-butanol 1.6
    MTBE 1.38
    2-butoxyethanol 13.01
    propionic acid 7.55
    o-xylene 0.86
    formic acid 42.47
    diethyl ether 2.44
    m-xylene 0.95
    p-xylene 0.66
    chlorobenzene 1.68
    dimethyl carbonate 9.62
    n-octane 0.07
    formamide 32.04
    cyclopentanone 22.74
    2-pentanone 4.39
    anisole 2.57
    cyclopentyl methyl ether 6.25
    gamma-butyrolactone 29.95
    1-methoxy-2-propanol 18.6
    pyridine 10.91
    3-pentanone 3.58
    furfural 27.78
    n-dodecane 0.04
    diethylene glycol 21.24
    diisopropyl ether 0.49
    tert-amyl alcohol 1.23
    acetylacetone 12.07
    n-hexadecane 0.05
    acetophenone 3.91
    methyl propionate 6.84
    isopentyl acetate 2.06
    trichloroethylene 11.99
    n-nonanol 1.79
    cyclohexanol 1.5
    benzyl alcohol 3.64
    2-ethylhexanol 0.76
    isooctanol 1.41
    dipropyl ether 1.67
    1,2-dichlorobenzene 1.7
    ethyl lactate 3.64
    propylene carbonate 9.95
    n-methylformamide 27.72
    2-pentanol 0.78
    n-pentane 0.09
    1-propoxy-2-propanol 8.27
    1-methoxy-2-propyl acetate 8.33
    2-(2-methoxypropoxy) propanol 7.74
    mesitylene 0.49
    ε-caprolactone 11.06
    p-cymene 0.52
    epichlorohydrin 26.41
    1,1,1-trichloroethane 2.34
    2-aminoethanol 11.22
    morpholine-4-carbaldehyde 61.53
    sulfolane 60.97
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 7.56
    n-hexyl acetate 4.0
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 12.15
    sec-butyl acetate 1.3
    tert-butyl acetate 3.05
    decalin 0.07
    glycerin 18.98
    diglyme 23.58
    acrylic acid 14.01
    isopropyl myristate 0.9
    n-butyric acid 7.34
    acetyl acetate 6.26
    di(2-ethylhexyl) phthalate 1.99
    ethyl propionate 2.23
    nitromethane 51.05
    1,2-diethoxyethane 4.89
    benzonitrile 2.23
    trioctyl phosphate 1.36
    1-bromopropane 1.15
    gamma-valerolactone 60.78
    n-decanol 0.96
    triethyl phosphate 1.53
    4-methyl-2-pentanol 0.57
    propionitrile 1.81
    vinylene carbonate 11.74
    1,1,2-trichlorotrifluoroethane 39.99
    DMS 4.92
    cumene 0.39
    2-octanol 1.03
    2-hexanone 2.37
    octyl acetate 1.77
    limonene 0.73
    1,2-dimethoxyethane 16.95
    ethyl orthosilicate 1.41
    tributyl phosphate 1.13
    diacetone alcohol 6.75
    N,N-dimethylaniline 2.07
    acrylonitrile 4.3
    aniline 2.5
    1,3-propanediol 10.46
    bromobenzene 1.46
    dibromomethane 3.71
    1,1,2,2-tetrachloroethane 7.95
    2-methyl-cyclohexyl acetate 2.13
    tetrabutyl urea 2.03
    diisobutyl methanol 0.45
    2-phenylethanol 3.75
    styrene 0.67
    dioctyl adipate 2.15
    dimethyl sulfate 21.54
    ethyl butyrate 2.01
    methyl lactate 12.14
    butyl lactate 4.96
    diethyl carbonate 1.32
    propanediol butyl ether 11.82
    triethyl orthoformate 2.11
    p-tert-butyltoluene 0.52
    methyl 4-tert-butylbenzoate 6.76
    morpholine 21.63
    tert-butylamine 0.47
    n-dodecanol 0.52
    dimethoxymethane 33.46
    ethylene carbonate 7.62
    cyrene 15.36
    2-ethoxyethyl acetate 10.24
    2-ethylhexyl acetate 1.55
    1,2,4-trichlorobenzene 2.77
    4-methylpyridine 5.2
    dibutyl ether 0.88
    2,6-dimethyl-4-heptanol 0.45
    DEF 8.67
    dimethyl isosorbide 15.1
    tetrachloroethylene 6.68
    eugenol 6.84
    triacetin 8.61
    span 80 7.72
    1,4-butanediol 4.0
    1,1-dichloroethane 2.2
    2-methyl-1-pentanol 0.95
    methyl formate 23.17
    2-methyl-1-butanol 1.14
    n-decane 0.1
    butyronitrile 1.29
    3,7-dimethyl-1-octanol 0.93
    1-chlorooctane 0.53
    1-chlorotetradecane 0.15
    n-nonane 0.08
    undecane 0.06
    tert-butylcyclohexane 0.05
    cyclooctane 0.07
    cyclopentanol 3.27
    tetrahydropyran 5.97
    tert-amyl methyl ether 1.28
    2,5,8-trioxanonane 14.07
    1-hexene 0.26
    2-isopropoxyethanol 7.0
    2,2,2-trifluoroethanol 17.87
    methyl butyrate 2.97

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction