Ginsenoside Rf

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  • Identifiers

    CAS number
    52286-58-5

    Molecular formula
    C42H72O14

    SMILES
    CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)O)C)O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Woody 46.9%
    Odorless 45.75%
    Sweet 40.71%
    Mint 34.17%
    Spicy 32.61%
    Cooling 32.0%
    Balsamic 31.37%
    Amber 27.71%
    Sandalwood 25.43%
    Dry 24.68%

     

    Flavor
    Bitter 46.31%
    Sweet 37.02%
    Odorless 29.02%
    Herbal 27.69%
    Fatty 27.41%
    Sweet-like 25.05%
    Minty 23.96%
    Pine 22.7%
    Balsam 21.92%
    Cedarleaf 21.9%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.7

    pKa est.
    4.74 (weak acid)

    Molecular weight
    801.0 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    1834°C

    Flash point

    • 235.79 ˚C est.

  • Synonyms

    • Ginsenoside Rf
    • 52286-58-5
    • JOS8BON5YW
    • (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
    • CHEBI:67986
    • DTXSID90904205
    • (2S,3R,4S,5S,6R)-2-((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-((1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl)oxy-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • (2S,3R,4S,5S,6R)-2-((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-((2S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl)oxy-6-(hydroxymethyl)oxane-3,4,5-triol
    • (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-2-[[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-17-[(1S)-1-hydroxy-1,5-dimethyl-hex-4-enyl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-6-yl]oxy]-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]oxy-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • RefChem:37706
    • DTXCID101333354
    • beta-D-Glucopyranoside, (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl 2-O-beta-D-glucopyranosyl-
    • 634-870-3
    • Panaxoside RF
    • GinsenosideRf
    • ginsenoside-rf
    • MFCD00210509
    • GINSENOSIDE- RF
    • UNII-JOS8BON5YW
    • CHEMBL1773987
    • ss-D-Glucopyranoside, (3ss,6a,12ss)-3,12,20-trihydroxydammar-24-en-6-yl 2-O-ss-D-glucopyranosyl-; Dammarane, ss-D-glucopyranoside deriv.; (3ss,6a,12ss)-3,12,20-Trihydroxydammar-24-en-6-yl 2-O-ss-D-glucopyranosyl-ss-D-glucopyranoside; Ginsenoside Rf; Panaxoside Rf
    • 20(S)-ginsenoside Rf
    • Ginsenoside Rf (Standard)
    • orb1300211
    • SCHEMBL22607970
    • HY-N0601R
    • WLZ4721
    • Ginsenoside Rf, analytical standard
    • HY-N0601
    • MSK40274
    • AKOS027251120
    • CS-3841
    • EBC-615933
    • OG09284
    • (2S,3R,4S,5S,6R)-2-{[(2R,3R,4S,5S,6R)-2-{[(1S,3aR,3bR,5S,5aR,7S,9aR,9bR,11R,11aR)-7,11-dihydroxy-1-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-3a,3b,6,6,9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-5-yl]oxy}-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
    • (3b,6a,12b)-3,12,20-Trihydroxydammar-24-en-6-yl-2-O-(b-D-glucopyranosyl)-b-D-glucopyranoside
    • AS-56543
    • DA-63765
    • C08945
    • 286G585
    • Q27104950
    • Ginsenoside Rf, primary pharmaceutical reference standard
    • (2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-Dihydroxy-17-((S)-2-hydroxy-6-methylhept-5-en-2-yl)-4,4,8,10,14-pentamethylhexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol
    • (beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-3,12,20-TRIHYDROXYDAMMAR-24-EN-6-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-
    • 3beta,12beta,20-Trihydroxydammar-24-en-6alpha-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
    • GINSENOSIDE RF (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]
    • 52286-58-5

  • Applications

    Ginsenoside Rf (CAS 52286-58-5) is a dammarane-type saponin from Panax ginseng and is mainly used as a research-active constituent in natural product and pharmacology studies. It is commonly employed as an analytical reference compound for quality control and standardization of Panax ginseng extracts and related nutraceuticals. In addition, Rf is studied for potential cosmetic applications as part of botanical skin-care formulations where ginsenosides are explored for bioactivity in cosmetic science. It may also appear in dietary supplements and functional foods as part of standardized ginseng extracts, with use limited by formulation considerations and local regulations. Overall, its applications span pharmaceutical research, cosmetic science, extract standardization, and nutraceutical development.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.61
    methanol 16.62
    isopropanol 0.4
    water 0.09
    ethyl acetate 1.1
    n-propanol 0.78
    acetone 3.64
    n-butanol 0.3
    acetonitrile 1.03
    DMF 29.07
    toluene 0.34
    isobutanol 0.29
    1,4-dioxane 6.3
    methyl acetate 1.54
    THF 11.07
    2-butanone 1.61
    n-pentanol 0.34
    sec-butanol 0.23
    n-hexane 0.02
    ethylene glycol 3.07
    NMP 26.68
    cyclohexane 0.03
    DMSO 39.3
    n-butyl acetate 0.59
    n-octanol 0.53
    chloroform 2.38
    n-propyl acetate 0.71
    acetic acid 16.16
    dichloromethane 2.42
    cyclohexanone 2.31
    propylene glycol 1.89
    isopropyl acetate 0.69
    DMAc 21.74
    2-ethoxyethanol 5.76
    isopentanol 0.19
    n-heptane 0.03
    ethyl formate 1.46
    1,2-dichloroethane 1.11
    n-hexanol 0.3
    2-methoxyethanol 11.61
    isobutyl acetate 0.43
    tetrachloromethane 0.29
    n-pentyl acetate 1.26
    transcutol 10.29
    n-heptanol 0.64
    ethylbenzene 0.18
    MIBK 0.64
    2-propoxyethanol 5.82
    tert-butanol 0.3
    MTBE 0.29
    2-butoxyethanol 4.67
    propionic acid 1.8
    o-xylene 0.24
    formic acid 23.91
    diethyl ether 0.52
    m-xylene 0.26
    p-xylene 0.23
    chlorobenzene 0.48
    dimethyl carbonate 3.51
    n-octane 0.02
    formamide 15.93
    cyclopentanone 6.11
    2-pentanone 1.07
    anisole 0.95
    cyclopentyl methyl ether 1.4
    gamma-butyrolactone 8.75
    1-methoxy-2-propanol 4.87
    pyridine 3.33
    3-pentanone 0.99
    furfural 11.69
    n-dodecane 0.01
    diethylene glycol 8.15
    diisopropyl ether 0.11
    tert-amyl alcohol 0.23
    acetylacetone 4.36
    n-hexadecane 0.02
    acetophenone 1.58
    methyl propionate 1.86
    isopentyl acetate 0.53
    trichloroethylene 3.8
    n-nonanol 0.55
    cyclohexanol 0.25
    benzyl alcohol 1.19
    2-ethylhexanol 0.18
    isooctanol 0.41
    dipropyl ether 0.51
    1,2-dichlorobenzene 0.55
    ethyl lactate 1.34
    propylene carbonate 2.69
    n-methylformamide 11.69
    2-pentanol 0.13
    n-pentane 0.02
    1-propoxy-2-propanol 2.54
    1-methoxy-2-propyl acetate 2.65
    2-(2-methoxypropoxy) propanol 3.4
    mesitylene 0.14
    ε-caprolactone 2.48
    p-cymene 0.16
    epichlorohydrin 7.91
    1,1,1-trichloroethane 0.55
    2-aminoethanol 3.41
    morpholine-4-carbaldehyde 25.98
    sulfolane 23.26
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.45
    n-hexyl acetate 1.25
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 5.01
    sec-butyl acetate 0.36
    tert-butyl acetate 0.82
    decalin 0.02
    glycerin 7.49
    diglyme 10.31
    acrylic acid 4.37
    isopropyl myristate 0.31
    n-butyric acid 1.26
    acetyl acetate 1.77
    di(2-ethylhexyl) phthalate 0.79
    ethyl propionate 0.64
    nitromethane 24.36
    1,2-diethoxyethane 1.67
    benzonitrile 0.83
    trioctyl phosphate 0.47
    1-bromopropane 0.24
    gamma-valerolactone 20.9
    n-decanol 0.31
    triethyl phosphate 0.5
    4-methyl-2-pentanol 0.11
    propionitrile 0.54
    vinylene carbonate 3.75
    1,1,2-trichlorotrifluoroethane 15.91
    DMS 1.78
    cumene 0.13
    2-octanol 0.3
    2-hexanone 0.74
    octyl acetate 0.6
    limonene 0.19
    1,2-dimethoxyethane 6.69
    ethyl orthosilicate 0.44
    tributyl phosphate 0.38
    diacetone alcohol 1.97
    N,N-dimethylaniline 0.87
    acrylonitrile 1.56
    aniline 0.61
    1,3-propanediol 2.24
    bromobenzene 0.44
    dibromomethane 0.92
    1,1,2,2-tetrachloroethane 2.3
    2-methyl-cyclohexyl acetate 0.67
    tetrabutyl urea 0.79
    diisobutyl methanol 0.12
    2-phenylethanol 1.16
    styrene 0.21
    dioctyl adipate 0.82
    dimethyl sulfate 9.18
    ethyl butyrate 0.58
    methyl lactate 3.9
    butyl lactate 1.73
    diethyl carbonate 0.4
    propanediol butyl ether 4.74
    triethyl orthoformate 0.68
    p-tert-butyltoluene 0.16
    methyl 4-tert-butylbenzoate 2.86
    morpholine 5.54
    tert-butylamine 0.09
    n-dodecanol 0.17
    dimethoxymethane 13.01
    ethylene carbonate 2.0
    cyrene 7.64
    2-ethoxyethyl acetate 3.6
    2-ethylhexyl acetate 0.41
    1,2,4-trichlorobenzene 0.87
    4-methylpyridine 1.56
    dibutyl ether 0.28
    2,6-dimethyl-4-heptanol 0.12
    DEF 2.42
    dimethyl isosorbide 6.87
    tetrachloroethylene 2.02
    eugenol 3.18
    triacetin 3.42
    span 80 3.02
    1,4-butanediol 1.22
    1,1-dichloroethane 0.52
    2-methyl-1-pentanol 0.21
    methyl formate 10.89
    2-methyl-1-butanol 0.19
    n-decane 0.03
    butyronitrile 0.33
    3,7-dimethyl-1-octanol 0.27
    1-chlorooctane 0.16
    1-chlorotetradecane 0.05
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.02
    cyclopentanol 0.56
    tetrahydropyran 1.15
    tert-amyl methyl ether 0.28
    2,5,8-trioxanonane 6.54
    1-hexene 0.06
    2-isopropoxyethanol 2.43
    2,2,2-trifluoroethanol 6.2
    methyl butyrate 0.85

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction