Ginsenoside Re

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  • Identifiers

    CAS number
    52286-59-6

    Molecular formula
    C48H82O18

    SMILES
    C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@@H]([C@H](O[C@H]2O[C@H]3C[C@@]4([C@H](C[C@H]([C@H]5[C@]4(CC[C@@H]5[C@](C)(CCC=C(C)C)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)O)[C@@]7([C@@H]3C([C@H](CC7)O)(C)C)C)C)CO)O)O)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 53.04%
    Woody 40.02%
    Sweet 35.53%
    Spicy 29.47%
    Mint 28.09%
    Cooling 27.82%
    Balsamic 24.37%
    Amber 23.31%
    Dry 21.98%
    Warm 21.71%

     

    Flavor
    Bitter 48.05%
    Sweet 35.59%
    Odorless 30.66%
    Fatty 29.46%
    Sweet-like 26.3%
    Cedarleaf 21.92%
    Mentholic 21.64%
    Bland 21.1%
    Herbal 20.91%
    Patchouli 20.9%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    3.67 (weak acid)

    Molecular weight
    947.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    2807°C

    Flash point

    • 206.69 ˚C est.

  • Synonyms

    • Ginsenoside Re
    • 52286-59-6
    • Ginsenoside B2
    • Panaxoside RE
    • ginsenoside-Re
    • Sanchinoside Re
    • NSC 308877
    • NSC-308877
    • 46F3R0BL3I
    • DTXSID801317298
    • CHEBI:77148
    • RefChem:37695
    • DTXCID201747118
    • (2S,3R,4R,5R,6S)-2-((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-17-((1S)-1,5-dimethyl-1-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl)oxy-hex-4-enyl)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl)oxy-6-methyl-tetrahydropyran-3,4,5-triol
    • (2S,3R,4R,5R,6S)-2-((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((2S)-6-methyl-2-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyhept-5-en-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)oxan-3-yl)oxy-6-methyloxane-3,4,5-triol
    • Chikusetsusaponin IVc
    • MFCD00133369
    • CHEMBL510095
    • b-D-Glucopyranoside,(3b,6a,12b)-20-(b-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-
    • GinsenosideRe
    • UNII-46F3R0BL3I
    • panaxsaponin Re
    • EINECS 257-814-6
    • Ginsenoside B2; Panaxoside Re; Sanchinoside Re
    • (20S)-ginsenoside Re
    • 20(S)-ginsenoside Re
    • Ginsenoside Re (Standard)
    • SCHEMBL669738
    • HY-N0044R
    • WLZ4722
    • GLXC-13358
    • (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
    • EX-A6794
    • HY-N0044
    • MSK40093
    • BDBM50378779
    • s3811
    • AKOS025310861
    • CCG-270589
    • CS-3838
    • DB14815
    • EBC-618394
    • OG09285
    • NCGC00483098-01
    • 2-O-(6-Deoxy-alpha-L-mannopyranosyl)-(3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl-beta-D-glucopyranoside
    • AC-33946
    • SY076028
    • G0551
    • C08944
    • 286G596
    • Q27105064
    • (2S,3R,4S,5S,6R)-2-{[(2S)-2-[(1S,3aR,3bR,5S,5aR,7S,9aR,9bR,11R,11aR)-5-{[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-{[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}oxan-2-yl]oxy}-7,11-dihydroxy-3a,3b,6,6,9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
    • (3b,6a,12b)-20-(b-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranoside
    • (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-20-(.BETA.-D-GLUCOPYRANOSYLOXY)-3,12-DIHYDROXYDAMMAR-24-EN-6-YL 2-O-(6-DEOXY-.ALPHA.-L-MANNOPYRANOSYL)-
    • 20-(beta-D-Glucopyranosyloxy)-3beta,12beta-dihydroxydammar-24-en-6alpha-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
    • GINSENOSIDE RE (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]
    • 52286-59-6

  • Applications

    Ginsenoside Re (CAS 52286-59-6) is a dammarane-type triterpenoid saponin isolated from Panax ginseng. In industry, it is commonly used as a quality-control marker and analytical reference for ginseng extracts and ginseng-based nutraceuticals and cosmetics. It is often evaluated as a natural cosmetic ingredient/component derived from ginseng, with potential surfactant-like and emulsifying properties in formulation studies, and as a skin-conditioning constituent in topical products. In pharmaceutical and biochemical research, Re serves as a research reagent and a starting point for the synthesis or SAR exploration of ginsenoside derivatives. It is also used as an analytical standard in LC-MS/HPLC methods for ginseng quality assessment and, where allowed, may be present in standardized ginseng extracts used in nutraceuticals subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.27
    methanol 35.39
    isopropanol 1.27
    water 0.17
    ethyl acetate 4.06
    n-propanol 2.72
    acetone 7.41
    n-butanol 1.18
    acetonitrile 2.45
    DMF 61.38
    toluene 0.97
    isobutanol 1.04
    1,4-dioxane 15.21
    methyl acetate 4.87
    THF 29.73
    2-butanone 4.7
    n-pentanol 1.03
    sec-butanol 0.89
    n-hexane 0.04
    ethylene glycol 7.56
    NMP 69.37
    cyclohexane 0.08
    DMSO 81.18
    n-butyl acetate 1.82
    n-octanol 1.28
    chloroform 8.6
    n-propyl acetate 1.86
    acetic acid 52.23
    dichloromethane 8.04
    cyclohexanone 7.36
    propylene glycol 6.34
    isopropyl acetate 2.27
    DMAc 51.34
    2-ethoxyethanol 14.7
    isopentanol 0.71
    n-heptane 0.07
    ethyl formate 5.04
    1,2-dichloroethane 3.51
    n-hexanol 1.03
    2-methoxyethanol 35.06
    isobutyl acetate 1.02
    tetrachloromethane 1.02
    n-pentyl acetate 3.28
    transcutol 22.61
    n-heptanol 1.66
    ethylbenzene 0.39
    MIBK 1.71
    2-propoxyethanol 15.92
    tert-butanol 0.95
    MTBE 0.92
    2-butoxyethanol 11.18
    propionic acid 7.03
    o-xylene 0.64
    formic acid 56.1
    diethyl ether 1.57
    m-xylene 0.66
    p-xylene 0.46
    chlorobenzene 1.34
    dimethyl carbonate 10.08
    n-octane 0.04
    formamide 38.5
    cyclopentanone 17.15
    2-pentanone 3.21
    anisole 2.19
    cyclopentyl methyl ether 4.53
    gamma-butyrolactone 27.43
    1-methoxy-2-propanol 15.94
    pyridine 9.17
    3-pentanone 2.77
    furfural 30.88
    n-dodecane 0.03
    diethylene glycol 20.04
    diisopropyl ether 0.31
    tert-amyl alcohol 0.84
    acetylacetone 10.63
    n-hexadecane 0.03
    acetophenone 3.53
    methyl propionate 6.14
    isopentyl acetate 1.61
    trichloroethylene 12.0
    n-nonanol 1.33
    cyclohexanol 1.01
    benzyl alcohol 3.08
    2-ethylhexanol 0.55
    isooctanol 1.04
    dipropyl ether 1.21
    1,2-dichlorobenzene 1.55
    ethyl lactate 3.58
    propylene carbonate 10.23
    n-methylformamide 29.83
    2-pentanol 0.52
    n-pentane 0.05
    1-propoxy-2-propanol 6.84
    1-methoxy-2-propyl acetate 7.22
    2-(2-methoxypropoxy) propanol 7.33
    mesitylene 0.35
    ε-caprolactone 9.1
    p-cymene 0.39
    epichlorohydrin 23.71
    1,1,1-trichloroethane 1.96
    2-aminoethanol 10.16
    morpholine-4-carbaldehyde 66.09
    sulfolane 63.87
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 5.2
    n-hexyl acetate 3.31
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 10.62
    sec-butyl acetate 1.05
    tert-butyl acetate 2.39
    decalin 0.05
    glycerin 21.83
    diglyme 22.58
    acrylic acid 15.1
    isopropyl myristate 0.71
    n-butyric acid 6.33
    acetyl acetate 5.93
    di(2-ethylhexyl) phthalate 1.78
    ethyl propionate 1.92
    nitromethane 63.17
    1,2-diethoxyethane 3.66
    benzonitrile 2.06
    trioctyl phosphate 1.15
    1-bromopropane 0.81
    gamma-valerolactone 57.91
    n-decanol 0.71
    triethyl phosphate 1.43
    4-methyl-2-pentanol 0.38
    propionitrile 1.47
    vinylene carbonate 12.98
    1,1,2-trichlorotrifluoroethane 46.62
    DMS 4.65
    cumene 0.27
    2-octanol 0.74
    2-hexanone 1.74
    octyl acetate 1.46
    limonene 0.51
    1,2-dimethoxyethane 15.14
    ethyl orthosilicate 1.26
    tributyl phosphate 0.97
    diacetone alcohol 5.75
    N,N-dimethylaniline 1.82
    acrylonitrile 4.04
    aniline 1.96
    1,3-propanediol 8.39
    bromobenzene 1.16
    dibromomethane 3.11
    1,1,2,2-tetrachloroethane 7.65
    2-methyl-cyclohexyl acetate 1.75
    tetrabutyl urea 1.72
    diisobutyl methanol 0.31
    2-phenylethanol 3.01
    styrene 0.49
    dioctyl adipate 1.91
    dimethyl sulfate 25.03
    ethyl butyrate 1.68
    methyl lactate 13.12
    butyl lactate 4.39
    diethyl carbonate 1.23
    propanediol butyl ether 10.33
    triethyl orthoformate 1.88
    p-tert-butyltoluene 0.39
    methyl 4-tert-butylbenzoate 6.24
    morpholine 16.81
    tert-butylamine 0.27
    n-dodecanol 0.39
    dimethoxymethane 30.22
    ethylene carbonate 7.58
    cyrene 15.84
    2-ethoxyethyl acetate 9.03
    2-ethylhexyl acetate 1.22
    1,2,4-trichlorobenzene 2.67
    4-methylpyridine 4.44
    dibutyl ether 0.63
    2,6-dimethyl-4-heptanol 0.31
    DEF 7.95
    dimethyl isosorbide 14.22
    tetrachloroethylene 6.23
    eugenol 6.57
    triacetin 8.51
    span 80 6.95
    1,4-butanediol 3.2
    1,1-dichloroethane 1.77
    2-methyl-1-pentanol 0.65
    methyl formate 25.94
    2-methyl-1-butanol 0.78
    n-decane 0.07
    butyronitrile 1.02
    3,7-dimethyl-1-octanol 0.67
    1-chlorooctane 0.38
    1-chlorotetradecane 0.1
    n-nonane 0.06
    undecane 0.04
    tert-butylcyclohexane 0.03
    cyclooctane 0.04
    cyclopentanol 2.19
    tetrahydropyran 3.92
    tert-amyl methyl ether 0.94
    2,5,8-trioxanonane 13.48
    1-hexene 0.14
    2-isopropoxyethanol 5.69
    2,2,2-trifluoroethanol 20.35
    methyl butyrate 2.53

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction