Ginsenoside Rb3

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  • Identifiers

    CAS number
    68406-26-8

    Molecular formula
    C53H90O22

    SMILES
    CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO[C@H]8[C@@H]([C@H]([C@@H](CO8)O)O)O)O)O)O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 51.88%
    Woody 40.18%
    Sweet 39.4%
    Spicy 28.55%
    Cooling 26.31%
    Mint 25.65%
    Balsamic 24.47%
    Amber 24.17%
    Dry 22.38%
    Warm 22.23%

     

    Flavor
    Bitter 46.63%
    Sweet 39.25%
    Odorless 32.3%
    Fatty 30.56%
    Sweet-like 27.15%
    Bland 22.41%
    Cedarleaf 21.39%
    Mentholic 21.23%
    Patchouli 20.78%
    Old paper 20.65%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    4.22 (weak acid)

    Molecular weight
    1079.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    3287°C

    Flash point

    • 218.63 ˚C est.

  • Synonyms

    • Ginsenoside-Rb3
    • W6V49A8FJQ
    • CHEBI:77153
    • DTXSID601317092
    • RefChem:143222
    • DTXCID901746909
    • (2S,3R,4S,5S,6R)-2-((2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-((2S)-6-methyl-2-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl)oxymethyl)oxan-2-yl)oxyhept-5-en-2-yl)-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-3-yl)oxy)oxan-3-yl)oxy-6-(hydroxymethyl)oxane-3,4,5-triol
    • 68406-26-8
    • Ginsenoside Rb3
    • Gypenoside IV
    • MFCD10566396
    • CHEMBL507688
    • GinsenosideRb3
    • C53H90O22
    • ss-D-Glucopyranoside, (3ss,12ss)-3-[(2-O-ss-D-glucopyranosyl-ss-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-ss-D-xylopyranosyl-; Dammarane, ss-D-glucopyranoside deriv.; (3ss,12ss)-3-[(2-O-ss-D-Glucopyranosyl-ss-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-20-yl 6-O-ss-D-xylopyranosyl-ss-D-glucopyranoside; Ginsenoside Rb3; Gypenoside IV
    • 20(S)-ginsenoside Rb3
    • UNII-W6V49A8FJQ
    • Ginsenoside Rb3 (Standard)
    • SCHEMBL29350590
    • HY-N0041R
    • HY-N0041
    • MSK15593
    • BDBM50317540
    • Ginsenoside Rb3, analytical standard
    • s9208
    • AKOS037514669
    • CCG-270634
    • CS-3831
    • EBC-618392
    • NCGC00485982-01
    • Q27146709
    • (3beta,12beta)-20-{[6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranosyl]oxy}-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-3-((2-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-12-HYDROXYDAMMAR-24-EN-20-YL 6-O-.BETA.-D-XYLOPYRANOSYL-
    • 12beta-Hydroxy-20-[(6-O-beta-D-xylopyranosyl-beta-D-glucopyranosyl)oxy]dammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
    • 3beta-[beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy]-20-[beta-D-xylopyranosyl-(1->2)-beta-D glucopyranosyloxy]dammar-24-en-12beta-ol
    • alpha-D-Glucopyranoside, (3-beta,12-beta)-3-((2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-20-yl 6-O-beta-D-xylopyranosyl-
    • 68406-26-8

  • Applications

    Chemical name: Ginsenoside Rb3; CAS number: 68406-26-8 is a steroidal saponin derived from ginseng. Practical applications include cosmetics and personal care as a natural ingredient in formulations; pharmaceutical research and analytics, with Rb3 used as a reference standard for quantifying ginsenosides in extracts; nutraceuticals from ginseng extracts in natural form; and formulation development for plant-based products, where it can serve as an intermediate or research component.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.55
    methanol 18.25
    isopropanol 0.44
    water 0.16
    ethyl acetate 1.63
    n-propanol 0.79
    acetone 3.6
    n-butanol 0.32
    acetonitrile 1.44
    DMF 40.55
    toluene 0.4
    isobutanol 0.31
    1,4-dioxane 6.75
    methyl acetate 2.15
    THF 10.41
    2-butanone 1.81
    n-pentanol 0.32
    sec-butanol 0.27
    n-hexane 0.02
    ethylene glycol 4.02
    NMP 38.22
    cyclohexane 0.04
    DMSO 47.08
    n-butyl acetate 0.75
    n-octanol 0.6
    chloroform 2.89
    n-propyl acetate 0.84
    acetic acid 23.42
    dichloromethane 3.02
    cyclohexanone 2.5
    propylene glycol 2.6
    isopropyl acetate 0.98
    DMAc 32.32
    2-ethoxyethanol 6.29
    isopentanol 0.2
    n-heptane 0.04
    ethyl formate 1.91
    1,2-dichloroethane 1.29
    n-hexanol 0.31
    2-methoxyethanol 13.51
    isobutyl acetate 0.46
    tetrachloromethane 0.34
    n-pentyl acetate 1.56
    transcutol 13.04
    n-heptanol 0.69
    ethylbenzene 0.18
    MIBK 0.7
    2-propoxyethanol 6.26
    tert-butanol 0.34
    MTBE 0.36
    2-butoxyethanol 5.3
    propionic acid 2.55
    o-xylene 0.3
    formic acid 37.91
    diethyl ether 0.59
    m-xylene 0.31
    p-xylene 0.24
    chlorobenzene 0.55
    dimethyl carbonate 5.99
    n-octane 0.02
    formamide 24.59
    cyclopentanone 6.52
    2-pentanone 1.19
    anisole 1.07
    cyclopentyl methyl ether 1.67
    gamma-butyrolactone 11.52
    1-methoxy-2-propanol 6.27
    pyridine 3.93
    3-pentanone 1.19
    furfural 15.87
    n-dodecane 0.02
    diethylene glycol 9.59
    diisopropyl ether 0.13
    tert-amyl alcohol 0.29
    acetylacetone 5.65
    n-hexadecane 0.02
    acetophenone 1.84
    methyl propionate 2.8
    isopentyl acetate 0.62
    trichloroethylene 4.94
    n-nonanol 0.63
    cyclohexanol 0.29
    benzyl alcohol 1.25
    2-ethylhexanol 0.19
    isooctanol 0.43
    dipropyl ether 0.59
    1,2-dichlorobenzene 0.67
    ethyl lactate 1.86
    propylene carbonate 4.14
    n-methylformamide 15.55
    2-pentanol 0.16
    n-pentane 0.02
    1-propoxy-2-propanol 3.2
    1-methoxy-2-propyl acetate 3.63
    2-(2-methoxypropoxy) propanol 4.18
    mesitylene 0.17
    ε-caprolactone 2.96
    p-cymene 0.19
    epichlorohydrin 9.15
    1,1,1-trichloroethane 0.72
    2-aminoethanol 3.99
    morpholine-4-carbaldehyde 36.21
    sulfolane 30.52
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.57
    n-hexyl acetate 1.54
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 6.02
    sec-butyl acetate 0.45
    tert-butyl acetate 1.07
    decalin 0.02
    glycerin 10.34
    diglyme 13.17
    acrylic acid 6.71
    isopropyl myristate 0.37
    n-butyric acid 1.74
    acetyl acetate 2.86
    di(2-ethylhexyl) phthalate 0.9
    ethyl propionate 0.88
    nitromethane 38.12
    1,2-diethoxyethane 1.96
    benzonitrile 1.0
    trioctyl phosphate 0.57
    1-bromopropane 0.26
    gamma-valerolactone 24.02
    n-decanol 0.35
    triethyl phosphate 0.72
    4-methyl-2-pentanol 0.12
    propionitrile 0.69
    vinylene carbonate 5.8
    1,1,2-trichlorotrifluoroethane 22.77
    DMS 2.52
    cumene 0.13
    2-octanol 0.33
    2-hexanone 0.75
    octyl acetate 0.75
    limonene 0.22
    1,2-dimethoxyethane 7.29
    ethyl orthosilicate 0.61
    tributyl phosphate 0.47
    diacetone alcohol 2.56
    N,N-dimethylaniline 0.99
    acrylonitrile 2.15
    aniline 0.76
    1,3-propanediol 2.47
    bromobenzene 0.49
    dibromomethane 1.07
    1,1,2,2-tetrachloroethane 2.91
    2-methyl-cyclohexyl acetate 0.77
    tetrabutyl urea 0.97
    diisobutyl methanol 0.13
    2-phenylethanol 1.24
    styrene 0.22
    dioctyl adipate 1.0
    dimethyl sulfate 15.7
    ethyl butyrate 0.78
    methyl lactate 6.42
    butyl lactate 2.2
    diethyl carbonate 0.58
    propanediol butyl ether 5.68
    triethyl orthoformate 0.98
    p-tert-butyltoluene 0.2
    methyl 4-tert-butylbenzoate 3.59
    morpholine 6.18
    tert-butylamine 0.1
    n-dodecanol 0.2
    dimethoxymethane 16.86
    ethylene carbonate 3.0
    cyrene 9.27
    2-ethoxyethyl acetate 4.72
    2-ethylhexyl acetate 0.48
    1,2,4-trichlorobenzene 1.1
    4-methylpyridine 1.84
    dibutyl ether 0.32
    2,6-dimethyl-4-heptanol 0.13
    DEF 3.38
    dimethyl isosorbide 8.8
    tetrachloroethylene 2.43
    eugenol 3.87
    triacetin 5.03
    span 80 3.75
    1,4-butanediol 1.28
    1,1-dichloroethane 0.65
    2-methyl-1-pentanol 0.2
    methyl formate 14.95
    2-methyl-1-butanol 0.21
    n-decane 0.04
    butyronitrile 0.39
    3,7-dimethyl-1-octanol 0.29
    1-chlorooctane 0.18
    1-chlorotetradecane 0.05
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.02
    cyclopentanol 0.67
    tetrahydropyran 1.26
    tert-amyl methyl ether 0.36
    2,5,8-trioxanonane 8.45
    1-hexene 0.06
    2-isopropoxyethanol 2.57
    2,2,2-trifluoroethanol 10.34
    methyl butyrate 1.05

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction