Ginsenoside Rb1

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  • Identifiers

    CAS number
    41753-43-9

    Molecular formula
    C54H92O23

    SMILES
    CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(CC[C@@H]4[C@@]3(CC[C@@H](C4(C)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O)C)C)O)C)O[C@H]7[C@@H]([C@H]([C@@H]([C@H](O7)CO[C@H]8[C@@H]([C@H]([C@@H]([C@H](O8)CO)O)O)O)O)O)O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 54.32%
    Sweet 38.41%
    Woody 37.42%
    Spicy 26.78%
    Cooling 26.6%
    Mint 25.56%
    Balsamic 23.35%
    Amber 23.08%
    Dry 21.55%
    Warm 21.42%

     

    Flavor
    Bitter 46.27%
    Sweet 41.8%
    Odorless 33.86%
    Fatty 30.15%
    Sweet-like 27.5%
    Bland 22.29%
    Cedarleaf 21.3%
    Mentholic 21.28%
    Patchouli 20.76%
    Old paper 20.67%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.3

    pKa est.
    4.24 (weak acid)

    Molecular weight
    1109.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    3454°C

    Flash point

    • 218.84 ˚C est.

  • Synonyms

    • Ginsenoside rb1
    • 41753-43-9
    • Gypenoside III
    • Gynosaponin C
    • Sanchinoside E1
    • Arasaponin E1
    • Panax saponin E
    • Pseudoginsenoside D
    • ginsenoside-Rb1
    • Panaxsaponin E
    • Panaxoside Rb1
    • Notoginsenoside Rb1
    • Sanchinoside Rb1
    • 7413S0WMH6
    • GRb 1
    • CHEBI:67989
    • DTXSID401316929
    • NSC-310103
    • 3-GlcGlc-20-GlcGlc-ginsenoside
    • RefChem:37701
    • DTXCID601746750
    • 255-532-8
    • (2R,3R,4S,5S,6R)-2-(((2R,3S,4S,5R,6S)-6-((1S)-1-((3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-((2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl)oxy-tetrahydropyran-2-yl)oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-17-yl)-1,5-dimethyl-hex-4-enoxy)-3,4,5-trihydroxy-tetrahydropyran-2-yl)methoxy)-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • (2R,3R,4S,5S,6R)-2-(((2R,3S,4S,5R,6S)-6-((2S)-2-((3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-((2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxyoxan-2-yl)oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-17-yl)-6-methylhept-5-en-2-yl)oxy-3,4,5-trihydroxyoxan-2-yl)methoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
    • GinsenosideRb1
    • MFCD00133367
    • (20S)-ginsenoside Rb1
    • 20(S)-ginsenoside Rb1
    • CHEMBL501515
    • 2-O-beta-Glucopyranosyl-(3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl beta-D-glucopyranoside
    • EINECS 255-532-8
    • 2-O-beta-Glucopyranosyl-(3beta,12beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside
    • GS-Rb1
    • C54H92O23
    • UNII-7413S0WMH6
    • Ginsenoside Rb1 CRS
    • NSC 310103
    • GSRb1
    • Ginsenoside Rb1 RS
    • Ginsenoside Rb1 - 94%
    • Ginsenoside Rb1 - 98%
    • Ginsenoside Rb1 (Standard)
    • BIDD:ER0108
    • orb1304975
    • SCHEMBL29350543
    • HY-N0039R
    • GINSENOSIDE RB1 [USP-RS]
    • GINSENOSIDE RB1 [WHO-DD]
    • GLXC-19161
    • HMS3885O12
    • HMS6018L20
    • EX-A6786
    • HY-N0039
    • MSK40041
    • BDBM50317541
    • s3924
    • AKOS025311537
    • CCG-270640
    • CS-3829
    • DB06749
    • EBC-616566
    • OG09288
    • NCGC00347398-02
    • NCGC00347398-04
    • BS-32417
    • LS-71528
    • SY068870
    • XG164977
    • 13 - Ginseng supplement chemical analysis
    • C20713
    • 753G439
    • Ginsenoside Rb1, primary pharmaceutical reference standard
    • Ginsenoside Rb1, European Pharmacopoeia (EP) Reference Standard
    • (3b,12b)-20-[(6-O-b-D-Glucopyranosyl-b-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-(b-D-gluco pyranosyl)-b-D-glucopyranoside
    • (3b,12b)-20-[(6-O-b-D-Glucopyranosyl-b-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-(b-D-glucopyranosyl)-b-D-glucopyranosid e
    • (3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
    • (3beta,12beta)-20-{[6-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]oxy}-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
    • .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-20-((6-O-.BETA.-D-GLUCOPYRANOSYL-.BETA.-D-GLUCOPYRANOSYL)OXY)-12-HYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-
    • 20(S)-protopanaxadiol-3-[O-beta-D-glucopyranosyl(1->2)-beta-D-glucopyranoside]-20-[O-beta-D-glucopyranosyl(1->6)-beta-D-glucopyranoside]
    • 20-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
    • 3beta-[beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy]-20-[beta-D-glucopyranosyl-(1->2)-beta-D glucopyranosyloxy]dammar-24-en-12beta-ol
    • beta-D-Glucopyranoside, (3-beta,12-beta)-20-((6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-
    • GINSENOSIDE RB1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]
    • 41753-43-9

  • Applications

    Ginsenoside Rb1 (CAS 41753-43-9) is used in several industrial contexts as an active constituent of Panax ginseng extracts for cosmetics and personal care; in nutraceuticals and dietary supplements, Rb1 is commonly included as an ingredient in ginseng extract preparations and serves as a marker compound for standardization and quality control; in pharmaceutical research, it is studied as an active component of ginseng-based formulations; in industrial manufacturing of ginseng extracts, Rb1 is employed as a reference standard and supports analytical quantification of ginsenoside content.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.33
    methanol 14.8
    isopropanol 0.38
    water 0.16
    ethyl acetate 1.47
    n-propanol 0.68
    acetone 3.37
    n-butanol 0.28
    acetonitrile 1.34
    DMF 35.79
    toluene 0.39
    isobutanol 0.27
    1,4-dioxane 6.05
    methyl acetate 1.99
    THF 9.32
    2-butanone 1.66
    n-pentanol 0.29
    sec-butanol 0.24
    n-hexane 0.02
    ethylene glycol 3.37
    NMP 34.89
    cyclohexane 0.04
    DMSO 43.18
    n-butyl acetate 0.7
    n-octanol 0.54
    chloroform 2.59
    n-propyl acetate 0.8
    acetic acid 19.05
    dichloromethane 2.76
    cyclohexanone 2.26
    propylene glycol 2.11
    isopropyl acetate 0.88
    DMAc 29.27
    2-ethoxyethanol 5.41
    isopentanol 0.17
    n-heptane 0.04
    ethyl formate 1.7
    1,2-dichloroethane 1.21
    n-hexanol 0.28
    2-methoxyethanol 10.93
    isobutyl acetate 0.43
    tetrachloromethane 0.33
    n-pentyl acetate 1.39
    transcutol 10.97
    n-heptanol 0.62
    ethylbenzene 0.17
    MIBK 0.64
    2-propoxyethanol 5.32
    tert-butanol 0.3
    MTBE 0.33
    2-butoxyethanol 4.57
    propionic acid 2.24
    o-xylene 0.3
    formic acid 31.54
    diethyl ether 0.54
    m-xylene 0.29
    p-xylene 0.24
    chlorobenzene 0.51
    dimethyl carbonate 5.52
    n-octane 0.02
    formamide 21.11
    cyclopentanone 5.93
    2-pentanone 1.08
    anisole 0.97
    cyclopentyl methyl ether 1.52
    gamma-butyrolactone 10.49
    1-methoxy-2-propanol 5.2
    pyridine 3.62
    3-pentanone 1.11
    furfural 14.29
    n-dodecane 0.02
    diethylene glycol 8.04
    diisopropyl ether 0.13
    tert-amyl alcohol 0.25
    acetylacetone 5.02
    n-hexadecane 0.02
    acetophenone 1.72
    methyl propionate 2.54
    isopentyl acetate 0.56
    trichloroethylene 4.49
    n-nonanol 0.57
    cyclohexanol 0.26
    benzyl alcohol 1.11
    2-ethylhexanol 0.18
    isooctanol 0.39
    dipropyl ether 0.56
    1,2-dichlorobenzene 0.63
    ethyl lactate 1.67
    propylene carbonate 3.63
    n-methylformamide 13.6
    2-pentanol 0.14
    n-pentane 0.02
    1-propoxy-2-propanol 2.76
    1-methoxy-2-propyl acetate 3.21
    2-(2-methoxypropoxy) propanol 3.57
    mesitylene 0.16
    ε-caprolactone 2.62
    p-cymene 0.18
    epichlorohydrin 8.16
    1,1,1-trichloroethane 0.66
    2-aminoethanol 3.29
    morpholine-4-carbaldehyde 31.78
    sulfolane 27.97
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 1.42
    n-hexyl acetate 1.37
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 5.18
    sec-butyl acetate 0.42
    tert-butyl acetate 0.95
    decalin 0.02
    glycerin 8.34
    diglyme 11.38
    acrylic acid 5.85
    isopropyl myristate 0.34
    n-butyric acid 1.49
    acetyl acetate 2.54
    di(2-ethylhexyl) phthalate 0.8
    ethyl propionate 0.83
    nitromethane 32.74
    1,2-diethoxyethane 1.77
    benzonitrile 0.92
    trioctyl phosphate 0.51
    1-bromopropane 0.25
    gamma-valerolactone 20.98
    n-decanol 0.32
    triethyl phosphate 0.66
    4-methyl-2-pentanol 0.11
    propionitrile 0.65
    vinylene carbonate 5.16
    1,1,2-trichlorotrifluoroethane 19.36
    DMS 2.3
    cumene 0.13
    2-octanol 0.3
    2-hexanone 0.72
    octyl acetate 0.67
    limonene 0.21
    1,2-dimethoxyethane 6.42
    ethyl orthosilicate 0.57
    tributyl phosphate 0.42
    diacetone alcohol 2.22
    N,N-dimethylaniline 0.92
    acrylonitrile 2.01
    aniline 0.68
    1,3-propanediol 2.04
    bromobenzene 0.47
    dibromomethane 1.0
    1,1,2,2-tetrachloroethane 2.67
    2-methyl-cyclohexyl acetate 0.71
    tetrabutyl urea 0.89
    diisobutyl methanol 0.12
    2-phenylethanol 1.09
    styrene 0.22
    dioctyl adipate 0.89
    dimethyl sulfate 14.53
    ethyl butyrate 0.73
    methyl lactate 5.55
    butyl lactate 1.93
    diethyl carbonate 0.54
    propanediol butyl ether 4.82
    triethyl orthoformate 0.9
    p-tert-butyltoluene 0.19
    methyl 4-tert-butylbenzoate 3.23
    morpholine 5.38
    tert-butylamine 0.09
    n-dodecanol 0.18
    dimethoxymethane 14.56
    ethylene carbonate 2.65
    cyrene 8.16
    2-ethoxyethyl acetate 4.15
    2-ethylhexyl acetate 0.45
    1,2,4-trichlorobenzene 1.02
    4-methylpyridine 1.66
    dibutyl ether 0.3
    2,6-dimethyl-4-heptanol 0.12
    DEF 3.06
    dimethyl isosorbide 7.8
    tetrachloroethylene 2.24
    eugenol 3.42
    triacetin 4.38
    span 80 3.2
    1,4-butanediol 1.11
    1,1-dichloroethane 0.6
    2-methyl-1-pentanol 0.18
    methyl formate 13.16
    2-methyl-1-butanol 0.18
    n-decane 0.04
    butyronitrile 0.35
    3,7-dimethyl-1-octanol 0.26
    1-chlorooctane 0.17
    1-chlorotetradecane 0.05
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.02
    cyclopentanol 0.59
    tetrahydropyran 1.13
    tert-amyl methyl ether 0.33
    2,5,8-trioxanonane 7.28
    1-hexene 0.06
    2-isopropoxyethanol 2.28
    2,2,2-trifluoroethanol 8.98
    methyl butyrate 0.98

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction