Ginsenoside F1

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  • Identifiers

    CAS number
    53963-43-2

    Molecular formula
    C36H62O9

    SMILES
    CC(=CCC[C@@](C)([C@H]1CC[C@@]2([C@@H]1[C@@H](C[C@H]3[C@]2(C[C@@H]([C@@H]4[C@@]3(CC[C@@H](C4(C)C)O)C)O)C)O)C)O[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 60.26%
    Sweet 42.63%
    Spicy 39.0%
    Balsamic 38.89%
    Mint 36.52%
    Amber 35.14%
    Herbal 32.1%
    Odorless 31.98%
    Sandalwood 31.79%
    Cooling 31.0%

     

    Flavor
    Bitter 41.83%
    Herbal 35.42%
    Minty 30.84%
    Sweet 29.68%
    Woody 29.3%
    Pine 29.05%
    Balsam 27.0%
    Earthy 25.38%
    Fresh 24.7%
    Camphor 22.97%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.3

    pKa est.
    5.15 (weak acid)

    Molecular weight
    638.9 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    655°C

    Flash point

    • 266.27 ˚C est.

  • Synonyms

    • Ginsenoside F1
    • 53963-43-2
    • DTXSID00968777
    • CHEBI:77150
    • ginsenoside G-F1
    • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[(2S)-6-methyl-2-[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,6,12-trihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]hept-5-en-2-yl]oxyoxane-3,4,5-triol
    • (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-((2S)-6-methyl-2-((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,6,12-trihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthren-17-yl)hept-5-en-2-yl)oxyoxane-3,4,5-triol
    • RefChem:143210
    • DTXCID901775409
    • 20(S)-ginsenoside F1
    • GINSENOSIDEF1
    • MFCD06410947
    • (20S)-ginsenoside F1
    • CHEMBL584011
    • orb1304236
    • SCHEMBL29379947
    • HY-N0598
    • Ginsenoside F1, >=98% (HPLC)
    • s9299
    • AKOS037514665
    • CCG-270314
    • CS-3842
    • EBC-616216
    • MG33284
    • (2S,3R,4S,5S,6R)-2-{[(2S)-2-[(1S,3aR,3bR,5S,5aR,7S,9aR,9bR,11R,11aR)-5,7,11-trihydroxy-3a,3b,6,6,9a-pentamethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol
    • AS-76768
    • DA-63761
    • SY068854
    • C20780
    • 963G432
    • Q27146705
    • 3beta,6alpha,12beta-Trihydroxydammar-24-en-20-yl beta-D-glucopyranoside
    • (beta,6alpha,12beta)-3,6,12-trihydroxydammar-24-en-20-yl beta-D-glucopyranoside
    • (2S,3R,4S,5S,6R)-2-[(1S)-1,5-dimethyl-1-[(3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,6,12-trihydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]hex-4-enoxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol
    • (3ss,6a,12ss)-3,6,12-Trihydroxydammar-24-en-20-yl ss-D-glucopyranoside; 20(S)-Ginsenoside F1; Panaxoside A progenin
    • 53963-43-2

  • Applications

    Ginsenoside F1 (CAS 53963-43-2) is a ginsenoside saponin that is mainly explored for applications across cosmetics and personal care, pharmaceuticals and biomedical research, and functional foods or dietary supplements; in cosmetics, it is considered a bioactive ingredient with potential to support skin care and hair care formulations; in pharmaceutical research, F1 is evaluated as a bioactive natural product lead or research reagent with potential pharmacological effects, and may be used as an analytical reference or synthetic intermediate; in the area of functional foods or dietary supplements, it may be considered as a functional ingredient derived from ginseng; and in general scientific workflows it is used as an analytical standard or intermediate for the isolation, characterization, and synthesis of ginsenosides, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.43
    methanol 30.98
    isopropanol 1.65
    water 0.08
    ethyl acetate 1.98
    n-propanol 3.52
    acetone 8.62
    n-butanol 1.46
    acetonitrile 1.39
    DMF 34.07
    toluene 0.95
    isobutanol 1.35
    1,4-dioxane 14.19
    methyl acetate 2.35
    THF 37.98
    2-butanone 3.88
    n-pentanol 1.58
    sec-butanol 0.84
    n-hexane 0.06
    ethylene glycol 3.84
    NMP 32.93
    cyclohexane 0.09
    DMSO 58.8
    n-butyl acetate 1.47
    n-octanol 1.41
    chloroform 4.05
    n-propyl acetate 1.45
    acetic acid 20.71
    dichloromethane 3.55
    cyclohexanone 6.69
    propylene glycol 3.59
    isopropyl acetate 1.39
    DMAc 26.47
    2-ethoxyethanol 12.63
    isopentanol 0.9
    n-heptane 0.08
    ethyl formate 2.79
    1,2-dichloroethane 2.16
    n-hexanol 1.43
    2-methoxyethanol 25.24
    isobutyl acetate 0.99
    tetrachloromethane 0.69
    n-pentyl acetate 2.79
    transcutol 16.51
    n-heptanol 1.97
    ethylbenzene 0.48
    MIBK 1.74
    2-propoxyethanol 15.41
    tert-butanol 1.13
    MTBE 0.91
    2-butoxyethanol 10.93
    propionic acid 3.21
    o-xylene 0.57
    formic acid 18.34
    diethyl ether 1.6
    m-xylene 0.65
    p-xylene 0.56
    chlorobenzene 1.09
    dimethyl carbonate 3.77
    n-octane 0.05
    formamide 14.94
    cyclopentanone 15.45
    2-pentanone 2.79
    anisole 1.96
    cyclopentyl methyl ether 4.04
    gamma-butyrolactone 15.36
    1-methoxy-2-propanol 11.42
    pyridine 7.39
    3-pentanone 2.11
    furfural 14.55
    n-dodecane 0.03
    diethylene glycol 14.02
    diisopropyl ether 0.31
    tert-amyl alcohol 0.77
    acetylacetone 6.62
    n-hexadecane 0.03
    acetophenone 2.76
    methyl propionate 3.05
    isopentyl acetate 1.4
    trichloroethylene 5.34
    n-nonanol 1.47
    cyclohexanol 0.95
    benzyl alcohol 2.93
    2-ethylhexanol 0.67
    isooctanol 1.29
    dipropyl ether 1.24
    1,2-dichlorobenzene 0.98
    ethyl lactate 2.0
    propylene carbonate 4.31
    n-methylformamide 15.06
    2-pentanol 0.51
    n-pentane 0.06
    1-propoxy-2-propanol 6.05
    1-methoxy-2-propyl acetate 4.62
    2-(2-methoxypropoxy) propanol 5.91
    mesitylene 0.35
    ε-caprolactone 5.9
    p-cymene 0.39
    epichlorohydrin 16.15
    1,1,1-trichloroethane 1.02
    2-aminoethanol 7.75
    morpholine-4-carbaldehyde 34.47
    sulfolane 31.42
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 4.89
    n-hexyl acetate 2.78
    isooctane 0.03
    2-(2-butoxyethoxy)ethanol 9.58
    sec-butyl acetate 0.76
    tert-butyl acetate 1.73
    decalin 0.06
    glycerin 9.51
    diglyme 17.05
    acrylic acid 5.64
    isopropyl myristate 0.64
    n-butyric acid 3.29
    acetyl acetate 2.34
    di(2-ethylhexyl) phthalate 1.63
    ethyl propionate 1.16
    nitromethane 20.64
    1,2-diethoxyethane 3.34
    benzonitrile 1.53
    trioctyl phosphate 1.09
    1-bromopropane 0.69
    gamma-valerolactone 36.07
    n-decanol 0.77
    triethyl phosphate 0.88
    4-methyl-2-pentanol 0.43
    propionitrile 1.08
    vinylene carbonate 5.25
    1,1,2-trichlorotrifluoroethane 18.01
    DMS 2.57
    cumene 0.35
    2-octanol 0.82
    2-hexanone 1.93
    octyl acetate 1.22
    limonene 0.49
    1,2-dimethoxyethane 13.08
    ethyl orthosilicate 0.89
    tributyl phosphate 0.81
    diacetone alcohol 3.97
    N,N-dimethylaniline 1.65
    acrylonitrile 2.23
    aniline 1.66
    1,3-propanediol 7.2
    bromobenzene 0.93
    dibromomethane 1.85
    1,1,2,2-tetrachloroethane 3.7
    2-methyl-cyclohexyl acetate 1.53
    tetrabutyl urea 1.57
    diisobutyl methanol 0.35
    2-phenylethanol 3.09
    styrene 0.52
    dioctyl adipate 1.52
    dimethyl sulfate 8.69
    ethyl butyrate 1.12
    methyl lactate 5.1
    butyl lactate 3.63
    diethyl carbonate 0.68
    propanediol butyl ether 9.54
    triethyl orthoformate 1.29
    p-tert-butyltoluene 0.38
    methyl 4-tert-butylbenzoate 4.77
    morpholine 15.46
    tert-butylamine 0.34
    n-dodecanol 0.4
    dimethoxymethane 22.11
    ethylene carbonate 3.52
    cyrene 10.82
    2-ethoxyethyl acetate 6.51
    2-ethylhexyl acetate 1.08
    1,2,4-trichlorobenzene 1.54
    4-methylpyridine 3.61
    dibutyl ether 0.64
    2,6-dimethyl-4-heptanol 0.35
    DEF 4.39
    dimethyl isosorbide 10.43
    tetrachloroethylene 3.4
    eugenol 5.47
    triacetin 4.61
    span 80 5.57
    1,4-butanediol 3.18
    1,1-dichloroethane 1.06
    2-methyl-1-pentanol 0.92
    methyl formate 11.22
    2-methyl-1-butanol 0.88
    n-decane 0.07
    butyronitrile 0.87
    3,7-dimethyl-1-octanol 0.78
    1-chlorooctane 0.38
    1-chlorotetradecane 0.1
    n-nonane 0.06
    undecane 0.04
    tert-butylcyclohexane 0.05
    cyclooctane 0.04
    cyclopentanol 2.1
    tetrahydropyran 4.03
    tert-amyl methyl ether 0.78
    2,5,8-trioxanonane 10.14
    1-hexene 0.23
    2-isopropoxyethanol 5.64
    2,2,2-trifluoroethanol 6.17
    methyl butyrate 1.62

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction