Ganoderenic Acid D

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  • Identifiers

    CAS number
    100665-43-8

    Molecular formula
    C30H40O7

    SMILES
    CC(CC(=O)/C=C(\C)/[C@H]1CC(=O)[C@@]2([C@@]1(CC(=O)C3=C2[C@H](C[C@@H]4[C@@]3(CCC(=O)C4(C)C)C)O)C)C)C(=O)O

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  • Odor profile

    Fragrance
    Woody 61.64%
    Dry 32.33%
    Odorless 30.67%
    Cedar 30.23%
    Tobacco 28.54%
    Mint 27.42%
    Amber 24.98%
    Camphoreous 24.44%
    Spicy 24.02%
    Sweet 23.11%

     

    Flavor
    Bitter 80.98%
    Odorless 24.16%
    Cedarleaf 21.42%
    Bland 20.64%
    Ripe apricot 20.14%
    Sweet-like 20.05%
    Parsley 19.98%
    Leaves 19.98%
    Heather 19.86%
    Broom 19.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    4.08 (weak acid)

    Molecular weight
    512.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Boiling point est.
    310°C

    Flash point

    • 289.04 ˚C est.

  • Synonyms

    • Ganoderenic Acid D
    • 100665-43-8
    • WYD6MYH3HY
    • DTXSID201316109
    • (E)-6-((5R,7S,10S,13R,14R,17R)-7-hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-1,2,5,6,7,12,16,17-octahydrocyclopenta(a)phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
    • (E)-6-[(5R,7S,10S,13R,14R,17R)-7-hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-1,2,5,6,7,12,16,17-octahydrocyclopenta[a]phenanthren-17-yl]-2-methyl-4-oxohept-5-enoic acid
    • RefChem:1085718
    • DTXCID001745978
    • (Z)-6-((5R,7S,10S,13R,14R,17R)-7-hydroxy-4,4,10,13,14-pentamethyl-3,11,15-trioxo-1,2,5,6,7,12,16,17-octahydrocyclopenta(a)phenanthren-17-yl)-2-methyl-4-oxohept-5-enoic acid
    • CHEMBL1922179
    • (E)-6-((5R,7S,10S,13R,14R,17R)-7-Hydroxy-4,4,10,13,14-Pentamethyl-3,11,15-Trioxo-2,3,4,5,6,7,10,11,12,13,14,15,16,17-Tetradecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)-2-Methyl-4-Oxohept-5-Enoic Acid
    • BDBM50359045
    • 100665-43-8

  • Applications

    Ganoderenic Acid D (CAS 100665-43-8) is a lanostane-type triterpenoid isolated from Ganoderma lucidum. In practical terms, it is mainly considered for cosmetics/personal care as a potential bioactive ingredient; in pharmaceutical research as a natural product lead compound and for SAR studies; in nutraceutical development as a functional ingredient under evaluation; and as a chemical intermediate for the synthesis of related ganoderic acid derivatives and as an analytical reference material in natural products research.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 20.96
    methanol 32.37
    isopropanol 11.66
    water 0.03
    ethyl acetate 3.98
    n-propanol 17.21
    acetone 19.27
    n-butanol 7.89
    acetonitrile 6.43
    DMF 101.5
    toluene 1.39
    isobutanol 6.72
    1,4-dioxane 34.48
    methyl acetate 7.74
    THF 78.38
    2-butanone 13.09
    n-pentanol 5.36
    sec-butanol 4.52
    n-hexane 0.07
    ethylene glycol 6.02
    NMP 54.55
    cyclohexane 0.09
    DMSO 80.53
    n-butyl acetate 2.83
    n-octanol 1.19
    chloroform 19.49
    n-propyl acetate 3.26
    acetic acid 22.61
    dichloromethane 12.36
    cyclohexanone 17.46
    propylene glycol 7.86
    isopropyl acetate 2.5
    DMAc 60.61
    2-ethoxyethanol 25.52
    isopentanol 3.53
    n-heptane 0.03
    ethyl formate 5.38
    1,2-dichloroethane 6.42
    n-hexanol 3.47
    2-methoxyethanol 53.52
    isobutyl acetate 2.0
    tetrachloromethane 1.54
    n-pentyl acetate 3.03
    transcutol 13.75
    n-heptanol 2.2
    ethylbenzene 0.72
    MIBK 3.04
    2-propoxyethanol 30.82
    tert-butanol 5.42
    MTBE 1.75
    2-butoxyethanol 12.77
    propionic acid 8.41
    o-xylene 0.7
    formic acid 15.18
    diethyl ether 3.65
    m-xylene 0.65
    p-xylene 1.03
    chlorobenzene 2.25
    dimethyl carbonate 7.1
    n-octane 0.02
    formamide 21.78
    cyclopentanone 38.74
    2-pentanone 6.5
    anisole 3.34
    cyclopentyl methyl ether 6.13
    gamma-butyrolactone 35.59
    1-methoxy-2-propanol 29.5
    pyridine 20.9
    3-pentanone 4.59
    furfural 23.01
    n-dodecane 0.02
    diethylene glycol 25.3
    diisopropyl ether 0.37
    tert-amyl alcohol 2.83
    acetylacetone 8.08
    n-hexadecane 0.02
    acetophenone 4.29
    methyl propionate 6.91
    isopentyl acetate 2.39
    trichloroethylene 15.93
    n-nonanol 1.28
    cyclohexanol 2.7
    benzyl alcohol 6.32
    2-ethylhexanol 0.93
    isooctanol 1.35
    dipropyl ether 1.38
    1,2-dichlorobenzene 1.93
    ethyl lactate 3.55
    propylene carbonate 8.32
    n-methylformamide 39.24
    2-pentanol 1.85
    n-pentane 0.06
    1-propoxy-2-propanol 11.46
    1-methoxy-2-propyl acetate 6.18
    2-(2-methoxypropoxy) propanol 5.99
    mesitylene 0.31
    ε-caprolactone 12.72
    p-cymene 0.3
    epichlorohydrin 39.51
    1,1,1-trichloroethane 3.63
    2-aminoethanol 15.16
    morpholine-4-carbaldehyde 63.83
    sulfolane 44.75
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 13.5
    n-hexyl acetate 3.09
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 8.65
    sec-butyl acetate 1.53
    tert-butyl acetate 2.32
    decalin 0.05
    glycerin 14.6
    diglyme 17.57
    acrylic acid 9.98
    isopropyl myristate 0.66
    n-butyric acid 8.14
    acetyl acetate 3.09
    di(2-ethylhexyl) phthalate 2.1
    ethyl propionate 2.76
    nitromethane 35.96
    1,2-diethoxyethane 3.57
    benzonitrile 4.28
    trioctyl phosphate 1.14
    1-bromopropane 2.35
    gamma-valerolactone 69.84
    n-decanol 0.66
    triethyl phosphate 1.33
    4-methyl-2-pentanol 0.93
    propionitrile 5.95
    vinylene carbonate 10.03
    1,1,2-trichlorotrifluoroethane 28.0
    DMS 4.01
    cumene 0.43
    2-octanol 0.91
    2-hexanone 5.12
    octyl acetate 1.21
    limonene 0.36
    1,2-dimethoxyethane 30.42
    ethyl orthosilicate 1.2
    tributyl phosphate 1.05
    diacetone alcohol 6.27
    N,N-dimethylaniline 2.28
    acrylonitrile 9.67
    aniline 4.19
    1,3-propanediol 22.73
    bromobenzene 1.75
    dibromomethane 6.28
    1,1,2,2-tetrachloroethane 12.69
    2-methyl-cyclohexyl acetate 2.18
    tetrabutyl urea 2.09
    diisobutyl methanol 0.41
    2-phenylethanol 5.47
    styrene 0.9
    dioctyl adipate 1.76
    dimethyl sulfate 13.1
    ethyl butyrate 1.84
    methyl lactate 8.56
    butyl lactate 4.16
    diethyl carbonate 1.38
    propanediol butyl ether 8.57
    triethyl orthoformate 1.83
    p-tert-butyltoluene 0.27
    methyl 4-tert-butylbenzoate 4.26
    morpholine 48.71
    tert-butylamine 1.2
    n-dodecanol 0.34
    dimethoxymethane 43.53
    ethylene carbonate 7.6
    cyrene 12.78
    2-ethoxyethyl acetate 6.63
    2-ethylhexyl acetate 1.68
    1,2,4-trichlorobenzene 3.24
    4-methylpyridine 11.47
    dibutyl ether 0.68
    2,6-dimethyl-4-heptanol 0.41
    DEF 9.45
    dimethyl isosorbide 10.9
    tetrachloroethylene 7.59
    eugenol 5.82
    triacetin 4.13
    span 80 5.18
    1,4-butanediol 8.5
    1,1-dichloroethane 5.14
    2-methyl-1-pentanol 2.66
    methyl formate 20.81
    2-methyl-1-butanol 3.52
    n-decane 0.04
    butyronitrile 4.58
    3,7-dimethyl-1-octanol 0.73
    1-chlorooctane 0.3
    1-chlorotetradecane 0.07
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.04
    cyclooctane 0.02
    cyclopentanol 8.04
    tetrahydropyran 12.91
    tert-amyl methyl ether 1.29
    2,5,8-trioxanonane 9.86
    1-hexene 0.47
    2-isopropoxyethanol 10.04
    2,2,2-trifluoroethanol 8.02
    methyl butyrate 3.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction