gamma-Cyclodextrin

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  • Identifiers

    CAS number
    17465-86-0

    Molecular formula
    C48H80O40

    SMILES
    C([C@@H]1[C@@H]2[C@@H]([C@H]([C@H](O1)O[C@@H]3[C@H](O[C@@H]([C@@H]([C@H]3O)O)O[C@@H]4[C@H](O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]5[C@H](O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]6[C@H](O[C@@H]([C@@H]([C@H]6O)O)O[C@@H]7[C@H](O[C@@H]([C@@H]([C@H]7O)O)O[C@@H]8[C@H](O[C@@H]([C@@H]([C@H]8O)O)O[C@@H]9[C@H](O[C@H](O2)[C@@H]([C@H]9O)O)CO)CO)CO)CO)CO)CO)CO)O)O)O

  • Odor profile

    Fragrance
    Odorless 80.41%
    Sweet 26.9%
    Alcoholic 21.3%
    Caramellic 17.16%
    Clean 15.46%
    Savory 15.25%
    Cooling 14.86%
    Milky 14.1%
    Fishy 13.96%
    Bitter 13.34%

     

    Flavor
    Sweet 75.26%
    Odorless 48.39%
    Bitter 45.59%
    Sweet-like 31.05%
    Fatty 27.48%
    Cauliflower 22.69%
    Very slight 21.41%
    Alkaline 20.85%
    Soup 20.39%
    Naphthalic 20.1%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    -17.2

    pKa est.
    86.94 (strong base)

    Molecular weight
    1297.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Very fast

    Boiling point est.
    3841°C

    Flash point

    • 689.89 ˚C est.

  • Synonyms

    • gamma-Cyclodextrin
    • 17465-86-0
    • Cyclooctaamylose
    • gamma cyclodextrin
    • Cyclomaltooctaose
    • Ringdex C
    • Cyclooctapentylose
    • .gamma.-Cyclodextrin
    • gamma-Dextrin
    • gamma-CD
    • g-cyclodextrin
    • UNII-KZJ0BYZ5VA
    • Gamma cyclodextrin [NF]
    • Cavamax w8
    • Cyclodextrin, gamma-
    • DTXSID5047033
    • KZJ0BYZ5VA
    • Ins no.458
    • EINECS 241-482-4
    • MFCD00009595
    • Ins-458
    • GAMMA CYCLODEXTRIN [II]
    • DTXCID3027033
    • GAMMA-CYCLODEXTRIN [FCC]
    • CHEBI:495056
    • EC 241-482-4
    • .GAMMA.-CYCLODEXTRIN [MI]
    • GAMMA CYCLODEXTRIN [MART.]
    • GAMMA CYCLODEXTRIN [USP-RS]
    • ALFADEX IMPURITY B [EP IMPURITY]
    • Schardinger gamma-Dextrin
    • E-458
    • GAMMA CYCLODEXTRIN (II)
    • CYCLOOCTAKIS-(1->4)-(.ALPHA.-D-GLUCOPYRANOSYL)
    • GAMMA CYCLODEXTRIN (MART.)
    • GAMMA CYCLODEXTRIN (USP-RS)
    • ALFADEX IMPURITY B (EP IMPURITY)
    • gammaDextrin
    • gammaCD
    • Gammacyclodextrin
    • cyclomalto-octaose
    • gamma -Cyclodextrin
    • Cyclooctakis-(1->4)-(a-D-glucopyranose)
    • Schardinger ?-Dextrin
    • Dexy Pearl gamma100
    • Schardinger gammaDextrin
    • 1p2g
    • SCHEMBL8768
    • gamma-Cyclodextrin, >=98%
    • CHEMBL3182126
    • BDBM36126
    • 5,10,15,20,25,30,35,40-octakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo(36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36)hexapentacontane-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecol
    • 5,10,15,20,25,30,35,40-octakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36]hexapentacontane-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecol
    • Tox21_302303
    • AKOS037643646
    • CS-W020780
    • HY-W040040
    • NCGC00256143-01
    • AS-19609
    • CAS-17465-86-0
    • F15410
    • gamma-Cyclodextrin, purum, >=98.0% (HPLC)
    • CYCLOOCTAKIS-(1->4)-(ALPHA-D-GLUCOPYRANOSYL)
    • Q27225754
    • Gamma Cyclodextrin, United States Pharmacopeia (USP) Reference Standard
    • gamma-Cyclodextrin, powder, BioReagent, suitable for cell culture, >=98%
    • Cyclomaltooctaose, Cyclooctaamylose, Schardinger gamma-Dextrin, gamma-Cyclodextrin
    • gamma-Cyclodextrin, produced by Wacker Chemie AG, Burghausen, Germany, >=90.0% cyclodextrin basis (HPLC)
    • gamma-Cyclodextrin, produced by Wacker Chemie AG, Burghausen, Germany, >=98% (on dry basis)
    • gamma-Cyclodextrin, Produced by Wacker Chemie AG, Burghausen, Germany, Life Science, 98.0-102.0% cyclodextrin basis

  • Applications

    gamma-Cyclodextrin (CAS 17465-86-0) is widely used as an inclusion complexing agent to improve solubility and stabilize hydrophobic compounds. In perfumery and cosmetics, it encapsulates fragrances for controlled release and reduced volatility. In food and flavor applications, it serves as a carrier for aroma compounds and helps stabilize formulations. In pharmaceuticals, it functions as an excipient and solubility enhancer to aid drug delivery. In household products and cleaners, it enables odor masking and controlled release of active ingredients. In coatings, inks and polymer formulations, it modifies release behavior and formulation compatibility. In agriculture, it is evaluated as a carrier for agrochemicals to improve solubility and formulation performance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 9.25
    methanol 30.29
    isopropanol 2.66
    water 13.77
    ethyl acetate 2.74
    n-propanol 4.07
    acetone 3.51
    n-butanol 2.42
    acetonitrile 1.71
    DMF 51.7
    toluene 1.02
    isobutanol 1.4
    1,4-dioxane 8.42
    methyl acetate 2.74
    THF 16.41
    2-butanone 3.03
    n-pentanol 1.37
    sec-butanol 1.68
    n-hexane 0.09
    ethylene glycol 18.22
    NMP 69.09
    cyclohexane 0.25
    DMSO 64.22
    n-butyl acetate 1.65
    n-octanol 1.57
    chloroform 1.61
    n-propyl acetate 1.18
    acetic acid 29.07
    dichloromethane 2.16
    cyclohexanone 5.54
    propylene glycol 12.62
    isopropyl acetate 1.46
    DMAc 38.93
    2-ethoxyethanol 13.61
    isopentanol 0.99
    n-heptane 0.27
    ethyl formate 4.5
    1,2-dichloroethane 1.3
    n-hexanol 1.28
    2-methoxyethanol 35.38
    isobutyl acetate 0.46
    tetrachloromethane 0.51
    n-pentyl acetate 2.59
    transcutol 22.64
    n-heptanol 2.06
    ethylbenzene 0.33
    MIBK 0.9
    2-propoxyethanol 12.55
    tert-butanol 1.11
    MTBE 0.65
    2-butoxyethanol 11.32
    propionic acid 7.73
    o-xylene 0.72
    formic acid 94.42
    diethyl ether 1.75
    m-xylene 0.59
    p-xylene 0.3
    chlorobenzene 0.51
    dimethyl carbonate 7.29
    n-octane 0.16
    formamide 78.15
    cyclopentanone 10.74
    2-pentanone 2.67
    anisole 0.85
    cyclopentyl methyl ether 4.64
    gamma-butyrolactone 19.44
    1-methoxy-2-propanol 19.75
    pyridine 6.78
    3-pentanone 2.11
    furfural 21.1
    n-dodecane 0.08
    diethylene glycol 20.59
    diisopropyl ether 0.32
    tert-amyl alcohol 1.08
    acetylacetone 4.43
    n-hexadecane 0.09
    acetophenone 1.73
    methyl propionate 4.96
    isopentyl acetate 0.95
    trichloroethylene 2.63
    n-nonanol 1.54
    cyclohexanol 2.19
    benzyl alcohol 2.16
    2-ethylhexanol 0.66
    isooctanol 1.04
    dipropyl ether 1.66
    1,2-dichlorobenzene 0.48
    ethyl lactate 3.14
    propylene carbonate 7.15
    n-methylformamide 29.7
    2-pentanol 1.15
    n-pentane 0.16
    1-propoxy-2-propanol 7.69
    1-methoxy-2-propyl acetate 5.34
    2-(2-methoxypropoxy) propanol 5.07
    mesitylene 0.31
    ε-caprolactone 7.92
    p-cymene 0.39
    epichlorohydrin 8.94
    1,1,1-trichloroethane 0.43
    2-aminoethanol 16.54
    morpholine-4-carbaldehyde 56.83
    sulfolane 42.92
    2,2,4-trimethylpentane 0.05
    2-methyltetrahydrofuran 4.47
    n-hexyl acetate 2.11
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 9.77
    sec-butyl acetate 0.64
    tert-butyl acetate 1.14
    decalin 0.07
    glycerin 37.51
    diglyme 17.84
    acrylic acid 15.0
    isopropyl myristate 0.62
    n-butyric acid 6.43
    acetyl acetate 2.28
    di(2-ethylhexyl) phthalate 1.04
    ethyl propionate 1.32
    nitromethane 26.2
    1,2-diethoxyethane 3.76
    benzonitrile 1.15
    trioctyl phosphate 1.01
    1-bromopropane 0.62
    gamma-valerolactone 33.41
    n-decanol 0.98
    triethyl phosphate 1.19
    4-methyl-2-pentanol 0.43
    propionitrile 1.21
    vinylene carbonate 8.27
    1,1,2-trichlorotrifluoroethane 24.16
    DMS 2.92
    cumene 0.19
    2-octanol 1.05
    2-hexanone 0.98
    octyl acetate 1.28
    limonene 0.59
    1,2-dimethoxyethane 9.23
    ethyl orthosilicate 1.04
    tributyl phosphate 0.85
    diacetone alcohol 3.71
    N,N-dimethylaniline 0.98
    acrylonitrile 2.86
    aniline 2.39
    1,3-propanediol 13.63
    bromobenzene 0.37
    dibromomethane 1.15
    1,1,2,2-tetrachloroethane 2.0
    2-methyl-cyclohexyl acetate 0.96
    tetrabutyl urea 1.71
    diisobutyl methanol 0.36
    2-phenylethanol 1.76
    styrene 0.36
    dioctyl adipate 1.35
    dimethyl sulfate 18.73
    ethyl butyrate 1.44
    methyl lactate 14.18
    butyl lactate 4.51
    diethyl carbonate 1.01
    propanediol butyl ether 11.07
    triethyl orthoformate 1.73
    p-tert-butyltoluene 0.39
    methyl 4-tert-butylbenzoate 3.43
    morpholine 14.97
    tert-butylamine 0.45
    n-dodecanol 0.62
    dimethoxymethane 19.77
    ethylene carbonate 5.23
    cyrene 10.11
    2-ethoxyethyl acetate 5.75
    2-ethylhexyl acetate 0.85
    1,2,4-trichlorobenzene 0.72
    4-methylpyridine 3.41
    dibutyl ether 1.0
    2,6-dimethyl-4-heptanol 0.36
    DEF 8.3
    dimethyl isosorbide 10.05
    tetrachloroethylene 2.12
    eugenol 3.78
    triacetin 4.54
    span 80 6.35
    1,4-butanediol 5.0
    1,1-dichloroethane 0.61
    2-methyl-1-pentanol 0.63
    methyl formate 20.99
    2-methyl-1-butanol 1.21
    n-decane 0.18
    butyronitrile 1.1
    3,7-dimethyl-1-octanol 0.62
    1-chlorooctane 0.47
    1-chlorotetradecane 0.16
    n-nonane 0.17
    undecane 0.12
    tert-butylcyclohexane 0.04
    cyclooctane 0.16
    cyclopentanol 3.85
    tetrahydropyran 3.73
    tert-amyl methyl ether 0.94
    2,5,8-trioxanonane 11.4
    1-hexene 0.24
    2-isopropoxyethanol 4.65
    2,2,2-trifluoroethanol 19.62
    methyl butyrate 1.79

    Scent© AI

1 4

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IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction