Galantamine Hydrobromide

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  • Identifiers

    CAS number
    1953-04-4

    Molecular formula
    C17H22BrNO3

    SMILES
    CN1CC[C@@]23C=C[C@@H](C[C@@H]2OC4=C(C=CC(=C34)C1)OC)O.Br

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 37.28%
    Vanilla 32.0%
    Sweet 31.4%
    Animal 25.07%
    Spicy 24.57%
    Phenolic 22.66%
    Smoky 19.98%
    Roasted 18.56%
    Creamy 18.31%
    Savory 17.42%

     

    Flavor
    Bitter 90.34%
    Cedarleaf 21.2%
    Sweet-like 21.05%
    Parsley 19.67%
    Cereal 19.67%
    Alkaline 19.35%
    Bland 19.35%
    Lovage 19.35%
    Naphthalic 19.23%
    Ripe apricot 19.06%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    6.53 (neutral)

    Molecular weight
    368.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    535°C

    Flash point

    • 182.08 ˚C est.

  • Synonyms

    • Galanthamine hydrobromide
    • Galantamine hydrobromide
    • 1953-04-4
    • Nivaline
    • Nivalin
    • Lycoremine hydrobromide
    • Jilkon hydrobromide
    • Tamilin
    • (-)-Galantamine Hydrobromide
    • MJ4PTD2VVW
    • Razadyne ER
    • 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide (1:1), (4aS,6R,8aS)-
    • 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide (1:1), (4aS,6R,8aS)-
    • RefChem:56717
    • DTXCID001473878
    • Benzofuro(4,3,2-efg)(2)benzazocin-6-ol, 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-, hydrobromide
    • 217-780-5
    • DTXSID4052768
    • Razadyne
    • MFCD00067672
    • 193146-85-9
    • Galanthamine (hydrobromide)
    • (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol Hydrobromide
    • Jilcon hydrobromide
    • Galanthamine HBr
    • (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;hydrobromide
    • 5N4SA4KQX9
    • (+/-)-Galantamine hydrobromide
    • (+/-)-Galanthamine hydrobromide
    • Galantamine hydrobromide (racemic)
    • Galantamine hydrobromide, (+/-)-
    • (4aS,6R,8aS)-3-Methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol hydrobromide
    • Galanthamine-O-methyl-d3 Hydrobromide
    • Reminyl (TN)
    • rac Galanthamine Hydrobromide
    • (1S,12S,14R)-9-Methoxy-4-methyl-11-oxa-4-azoniatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;bromide
    • (4aS,6R,8aS)-3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-ol hydrobromide
    • 1953-04-4 (HBr); 1953-04-4 (free base).
    • (1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.0^{1,12}.0^{6,17}]heptadeca-6(17),7,9,15-tetraen-14-ol hydrobromide
    • 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol hydrobromide
    • 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide (1:1), (4aR,6S,8aR)-rel-
    • SMR000449267
    • Galanthamine hydrobromide from Lycoris sp.
    • SR-01000597844
    • Nivaline (pharmaceutical)
    • anti-Alzheimer
    • SR-05000001783
    • Nivalin;Razadyne
    • Galantamine hydrobromide [USAN]
    • Razadyne (TN)
    • Prestwick_236
    • EINECS 217-780-5
    • galanthamine bromide
    • UNII-MJ4PTD2VVW
    • UNII-5N4SA4KQX9
    • Galantamine hydrobromide CRS
    • 1953-04-4 unlabeled
    • CHEMBL1555
    • Galanthamine-d3 Hydrobromide
    • MLS000758283
    • MLS001401401
    • SCHEMBL177993
    • SPECTRUM1501202
    • Galantamine racemic mixture CRS
    • SCHEMBL29519916
    • HY-A0009R
    • MSK10278X
    • CHEBI:180473
    • GLXC-03041
    • HMS1569F18
    • HMS1921P21
    • HY-A0009
    • Galantamine hydrobromide (JAN/USP)
    • AC-469
    • CCG-38829
    • EBC-13578
    • GALANTAMINE HYDROBROMIDE [MI]
    • Galantamine hydrobromide [USAN:USP]
    • s1339
    • GALANTAMINE HYDROBROMIDE [JAN]
    • AKOS007930166
    • AKOS015960209
    • CS-0378
    • FD10095
    • FH15701
    • GALANTAMINE HYDROBROMIDE [HSDB]
    • Galanthamine (hydrobromide) (Standard)
    • NC00061
    • GALANTAMINE HYDROBROMIDE [MART.]
    • GALANTAMINE HYDROBROMIDE [VANDF]
    • GALANTAMINE HYDROBROMIDE [USP-RS]
    • GALANTAMINE HYDROBROMIDE [WHO-DD]
    • AS-12155
    • Galantamine Hydrobromide Impurity Standard
    • GP-37267
    • G0293
    • NS00081782
    • GALANTAMINE HYDROBROMIDE [ORANGE BOOK]
    • Galantamine natural for system suitability CRS
    • D02173
    • EN300-123969
    • GALANTAMINE HYDROBROMIDE [EP MONOGRAPH]
    • GALANTAMINE HYDROBROMIDE [USP MONOGRAPH]
    • GALANTAMINE HYDROBROMIDE RACEMIC [USP-RS]
    • Galantamine synthetic for system suitability CRS
    • 953G044
    • R-113675
    • SR-01000597844-1
    • SR-01000597844-5
    • SR-05000001783-3
    • Q47495772
    • Z1557400300
    • Galanthamine hydrobromide from Lycoris sp., >=94% (TLC)
    • (4aS,6R,8aS)-3-Methoxy-11-methyl-5,6,9,10,11,12-hexahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6-olhydrobromide
    • (4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-d3-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol Hydrobromide
    • 6H-BENZOFURO(3A,3,2-EF)(2)BENZAZEPIN-6-OL, 4A,5,9,10,11,12-HEXAHYDRO-3-METHOXY-11-METHYL-, HYDROBROMIDE, (4A.ALPHA.,6.BETA.,8AR*)-
    • 6H-Benzofuro(3a,3,2-ef)(2)benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide, (4aalpha,6beta,8ar*)-
    • 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide, (4aR,6S,8aR)-rel- (9CI); 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide, (4aa,6ss,8aR*)-; (+/-)-Galantamine hydrobromide; (+/-)-Galanthamine hydrobromide; rac-Galantamine Hydrobromide
    • 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-, hydrobromide, (4aS,6R,8aS)-
    • 1953-04-4

  • Applications

    Galantamine Hydrobromide, CAS 1953-04-4, is primarily used as an active pharmaceutical ingredient (API) in prescription medications for Alzheimer's disease, owing to its activity as a cholinesterase inhibitor. In pharmaceutical development, it is supplied for formulation and process development and scale-up; in medicinal chemistry and pharmacology research it is used to study cholinergic systems and enzyme inhibition; in analytical laboratories it can serve as a reference material for assay development and quality control. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 45.3
    methanol 95.71
    isopropanol 23.11
    water 5.15
    ethyl acetate 35.57
    n-propanol 39.51
    acetone 44.35
    n-butanol 39.22
    acetonitrile 26.7
    DMF 151.45
    toluene 12.56
    isobutanol 30.72
    1,4-dioxane 73.62
    methyl acetate 39.83
    THF 75.86
    2-butanone 43.15
    n-pentanol 33.69
    sec-butanol 17.14
    n-hexane 0.5
    ethylene glycol 74.67
    NMP 121.43
    cyclohexane 2.38
    DMSO 176.95
    n-butyl acetate 37.77
    n-octanol 16.83
    chloroform 202.1
    n-propyl acetate 40.26
    acetic acid 142.7
    dichloromethane 165.19
    cyclohexanone 90.95
    propylene glycol 33.43
    isopropyl acetate 25.67
    DMAc 130.25
    2-ethoxyethanol 99.23
    isopentanol 36.02
    n-heptane 0.99
    ethyl formate 71.23
    1,2-dichloroethane 85.24
    n-hexanol 34.28
    2-methoxyethanol 137.5
    isobutyl acetate 36.91
    tetrachloromethane 25.08
    n-pentyl acetate 33.85
    transcutol 111.36
    n-heptanol 26.44
    ethylbenzene 9.13
    MIBK 27.53
    2-propoxyethanol 96.2
    tert-butanol 21.87
    MTBE 8.54
    2-butoxyethanol 69.41
    propionic acid 55.26
    o-xylene 12.96
    formic acid 166.63
    diethyl ether 11.8
    m-xylene 12.49
    p-xylene 14.07
    chlorobenzene 39.86
    dimethyl carbonate 46.44
    n-octane 0.86
    formamide 152.84
    cyclopentanone 96.67
    2-pentanone 33.83
    anisole 25.08
    cyclopentyl methyl ether 28.38
    gamma-butyrolactone 122.98
    1-methoxy-2-propanol 74.82
    pyridine 73.49
    3-pentanone 27.28
    furfural 160.15
    n-dodecane 1.12
    diethylene glycol 138.67
    diisopropyl ether 5.01
    tert-amyl alcohol 16.54
    acetylacetone 49.91
    n-hexadecane 1.27
    acetophenone 47.19
    methyl propionate 39.23
    isopentyl acetate 37.82
    trichloroethylene 182.59
    n-nonanol 17.69
    cyclohexanol 36.28
    benzyl alcohol 54.1
    2-ethylhexanol 22.39
    isooctanol 23.17
    dipropyl ether 11.39
    1,2-dichlorobenzene 45.36
    ethyl lactate 48.02
    propylene carbonate 87.79
    n-methylformamide 107.36
    2-pentanol 15.73
    n-pentane 0.75
    1-propoxy-2-propanol 50.83
    1-methoxy-2-propyl acetate 51.14
    2-(2-methoxypropoxy) propanol 50.91
    mesitylene 8.64
    ε-caprolactone 84.57
    p-cymene 12.22
    epichlorohydrin 130.63
    1,1,1-trichloroethane 50.23
    2-aminoethanol 67.35
    morpholine-4-carbaldehyde 145.74
    sulfolane 152.23
    2,2,4-trimethylpentane 0.85
    2-methyltetrahydrofuran 40.97
    n-hexyl acetate 32.39
    isooctane 0.77
    2-(2-butoxyethoxy)ethanol 66.17
    sec-butyl acetate 24.93
    tert-butyl acetate 24.12
    decalin 1.97
    glycerin 103.32
    diglyme 108.44
    acrylic acid 79.3
    isopropyl myristate 15.41
    n-butyric acid 74.96
    acetyl acetate 41.74
    di(2-ethylhexyl) phthalate 30.43
    ethyl propionate 29.97
    nitromethane 134.34
    1,2-diethoxyethane 29.9
    benzonitrile 58.93
    trioctyl phosphate 23.23
    1-bromopropane 23.2
    gamma-valerolactone 153.03
    n-decanol 14.09
    triethyl phosphate 26.57
    4-methyl-2-pentanol 15.79
    propionitrile 30.23
    vinylene carbonate 108.13
    1,1,2-trichlorotrifluoroethane 178.8
    DMS 40.5
    cumene 9.24
    2-octanol 13.47
    2-hexanone 34.47
    octyl acetate 21.83
    limonene 13.59
    1,2-dimethoxyethane 89.06
    ethyl orthosilicate 24.13
    tributyl phosphate 24.24
    diacetone alcohol 41.66
    N,N-dimethylaniline 22.52
    acrylonitrile 53.27
    aniline 36.26
    1,3-propanediol 82.89
    bromobenzene 34.52
    dibromomethane 82.96
    1,1,2,2-tetrachloroethane 134.68
    2-methyl-cyclohexyl acetate 35.56
    tetrabutyl urea 31.09
    diisobutyl methanol 11.76
    2-phenylethanol 52.15
    styrene 10.22
    dioctyl adipate 29.47
    dimethyl sulfate 78.88
    ethyl butyrate 31.08
    methyl lactate 58.76
    butyl lactate 43.12
    diethyl carbonate 29.11
    propanediol butyl ether 54.04
    triethyl orthoformate 27.62
    p-tert-butyltoluene 10.46
    methyl 4-tert-butylbenzoate 43.85
    morpholine 83.41
    tert-butylamine 9.11
    n-dodecanol 11.02
    dimethoxymethane 84.84
    ethylene carbonate 88.78
    cyrene 79.23
    2-ethoxyethyl acetate 50.71
    2-ethylhexyl acetate 31.16
    1,2,4-trichlorobenzene 59.13
    4-methylpyridine 55.48
    dibutyl ether 10.25
    2,6-dimethyl-4-heptanol 11.76
    DEF 54.19
    dimethyl isosorbide 75.68
    tetrachloroethylene 99.8
    eugenol 54.96
    triacetin 43.57
    span 80 42.94
    1,4-butanediol 55.31
    1,1-dichloroethane 51.22
    2-methyl-1-pentanol 32.71
    methyl formate 104.28
    2-methyl-1-butanol 32.41
    n-decane 1.58
    butyronitrile 32.98
    3,7-dimethyl-1-octanol 17.04
    1-chlorooctane 7.76
    1-chlorotetradecane 4.26
    n-nonane 1.18
    undecane 1.29
    tert-butylcyclohexane 1.41
    cyclooctane 1.03
    cyclopentanol 36.97
    tetrahydropyran 39.73
    tert-amyl methyl ether 9.74
    2,5,8-trioxanonane 83.12
    1-hexene 2.85
    2-isopropoxyethanol 60.03
    2,2,2-trifluoroethanol 95.64
    methyl butyrate 46.13

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction