Furosemide [USAN:USP:INN:BAN:JAN]

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  • Identifiers

    CAS number
    54-31-9

    Molecular formula
    C12H11ClN2O5S

    SMILES
    C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 79.66%
    Savory 28.86%
    Cooked 27.22%
    Meaty 26.19%
    Roasted 22.95%
    Grape 19.64%
    Bitter 17.94%
    Burnt 16.11%
    Milky 15.77%
    Sulfurous 15.46%

     

    Flavor
    Bitter 73.57%
    Odorless 45.96%
    Mild 27.67%
    Bland 25.34%
    Taco 20.57%
    Nitrile 20.56%
    Roasted peanuts 20.53%
    Very mild 20.41%
    Bread crust 20.32%
    Yeast 19.88%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    2.0

    pKa est.
    6.42 (neutral)

    Molecular weight
    330.74 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    691°C

    Melting point expt.

    • 403 °F (decomposes) (NTP, 1992)
    • 220 undefined
    • 206 °C
    • 295 °C

    Flash point

    • 272.36 ˚C est.

    Solubility expt.

    • >49.6 [ug/mL] (The mean of the results at pH 7.4)
    • less than 1 mg/mL at 73 °F (NTP, 1992)
    • 73.1 mg/L (at 30 °C)
    • The sodium salt can be recrystallized from water; the solubility of the salt in water at room temperature is 6%. /Furosemide sodium salt/
    • In water, 73.1 mg/L at 30 °C
    • Slightly soluble in water
    • Slightly soluble in chloroform, ether. Soluble in acetone, methanol, DMF, aqueous solutions above pH 8.0. Less soluble in ethanol.
    • Soluble in methanol, acetone, dilute NaOH
    • Freely soluble in alkali hydroxide
    • 0.0731 mg/mL at 30 °C

  • Synonyms

    • furosemide
    • 54-31-9
    • Frusemide
    • Lasix
    • Furanthril
    • Furosemid
    • Errolon
    • Fusid
    • Aisemide
    • Beronald
    • Desdemin
    • Frusemin
    • Fuluvamide
    • Furanthryl
    • Fursemide
    • Lowpstron
    • Prefemin
    • Rosemide
    • Salix
    • Eutensin
    • Frusetic
    • Furantril
    • Fursemid
    • Logirene
    • Macasirool
    • Marsemide
    • Promedes
    • Trofurit
    • Frusid
    • Fulsix
    • Furesis
    • Katlex
    • Lasilix
    • Mirfat
    • Oedemex
    • Radonna
    • Seguril
    • Transit
    • Lasex
    • Lazix
    • Urex
    • Furanturil
    • Urosemide
    • Aluzine
    • Dryptal
    • Frusemid
    • Frusenex
    • Impugan
    • Profemin
    • Uremide
    • Disal
    • Diural
    • Laxur
    • Uresix
    • Urian
    • Yidoli
    • Apo-Frusemide
    • Anfuramaide
    • Arasemide
    • Bioretic
    • Disemide
    • Diurapid
    • Diurolasa
    • Diusemide
    • Fluidrol
    • Frusedan
    • Furobeta
    • Furodiurol
    • Furodrix
    • Furorese
    • Furosedon
    • Furosemidum
    • Furosemix
    • Furoside
    • Furosifar
    • Furovite
    • Fursemida
    • Hissuflux
    • Jenafusid
    • Lasiletten
    • Lowpston
    • Moilarorin
    • Novosemide
    • Protargen
    • Radisemide
    • Selectofur
    • Sigasalur
    • Spirofur
    • Synephron
    • Zafimida
    • Aldalix
    • Aquarid
    • Aquasin
    • Cetasix
    • Dirine
    • Discoid
    • Diurin
    • Diusil
    • Diuzol
    • Dranex
    • Edemid
    • Edenol
    • Farsix
    • Franyl
    • Frumex
    • Frumide
    • Frusema
    • Furetic
    • Furfan
    • Furmid
    • Furocot
    • Furomen
    • Furomex
    • Furosan
    • Furose
    • Furosix
    • Furoter
    • Fursol
    • Hydrex
    • Kofuzon
    • Kolkin
    • Kutrix
    • Lasemid
    • Liside
    • Luscek
    • Nelsix
    • Nicorol
    • Odemase

  • Applications

    Furosemide, CAS 54-31-9, is primarily used as an active pharmaceutical ingredient (API) in prescribed diuretic formulations; it also serves as a reference standard in analytical method development and quality control for pharmaceutical LC/HPLC methods; in addition, it is employed in veterinary medicine to prepare diuretic formulations for animals; in pharmaceutical R&D, it functions as a research tool to evaluate renal excretion mechanisms and related pharmacology; and as an educational standard, it is used as reference material for training in analytical techniques and quantitative assessment of samples.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 5.97
    methanol 17.25
    isopropanol 2.65
    water 0.09
    ethyl acetate 2.15
    n-propanol 3.85
    acetone 13.32
    n-butanol 2.01
    acetonitrile 3.18
    DMF 305.66
    toluene 0.1
    isobutanol 1.25
    1,4-dioxane 7.95
    methyl acetate 4.94
    THF 29.77
    2-butanone 12.76
    n-pentanol 0.96
    sec-butanol 2.44
    n-hexane 0.02
    ethylene glycol 13.76
    NMP 197.73
    cyclohexane 0.04
    DMSO 174.15
    n-butyl acetate 2.18
    n-octanol 0.62
    chloroform 0.13
    n-propyl acetate 2.07
    acetic acid 12.06
    dichloromethane 0.23
    cyclohexanone 10.46
    propylene glycol 22.69
    isopropyl acetate 1.56
    DMAc 280.22
    2-ethoxyethanol 28.66
    isopentanol 1.11
    n-heptane 0.05
    ethyl formate 4.46
    1,2-dichloroethane 0.35
    n-hexanol 0.93
    2-methoxyethanol 96.25
    isobutyl acetate 0.65
    tetrachloromethane 0.03
    n-pentyl acetate 1.5
    transcutol 31.63
    n-heptanol 1.01
    ethylbenzene 0.07
    MIBK 1.97
    2-propoxyethanol 25.63
    tert-butanol 1.71
    MTBE 0.81
    2-butoxyethanol 9.97
    propionic acid 6.8
    o-xylene 0.14
    formic acid 28.22
    diethyl ether 1.08
    m-xylene 0.09
    p-xylene 0.14
    chlorobenzene 0.11
    dimethyl carbonate 7.8
    n-octane 0.02
    formamide 68.21
    cyclopentanone 32.65
    2-pentanone 5.22
    anisole 1.24
    cyclopentyl methyl ether 2.2
    gamma-butyrolactone 35.16
    1-methoxy-2-propanol 52.79
    pyridine 4.56
    3-pentanone 4.06
    furfural 28.82
    n-dodecane 0.02
    diethylene glycol 35.42
    diisopropyl ether 0.17
    tert-amyl alcohol 1.88
    acetylacetone 9.84
    n-hexadecane 0.02
    acetophenone 2.94
    methyl propionate 5.83
    isopentyl acetate 1.62
    trichloroethylene 0.71
    n-nonanol 0.69
    cyclohexanol 1.16
    benzyl alcohol 1.84
    2-ethylhexanol 0.53
    isooctanol 0.71
    dipropyl ether 1.47
    1,2-dichlorobenzene 0.17
    ethyl lactate 7.12
    propylene carbonate 8.61
    n-methylformamide 69.77
    2-pentanol 0.85
    n-pentane 0.02
    1-propoxy-2-propanol 13.12
    1-methoxy-2-propyl acetate 8.82
    2-(2-methoxypropoxy) propanol 13.21
    mesitylene 0.08
    ε-caprolactone 9.52
    p-cymene 0.16
    epichlorohydrin 11.67
    1,1,1-trichloroethane 0.1
    2-aminoethanol 19.44
    morpholine-4-carbaldehyde 108.49
    sulfolane 82.69
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 4.55
    n-hexyl acetate 1.54
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 13.9
    sec-butyl acetate 0.95
    tert-butyl acetate 2.04
    decalin 0.02
    glycerin 66.69
    diglyme 32.0
    acrylic acid 10.21
    isopropyl myristate 0.68
    n-butyric acid 5.15
    acetyl acetate 1.55
    di(2-ethylhexyl) phthalate 1.78
    ethyl propionate 2.2
    nitromethane 43.65
    1,2-diethoxyethane 3.27
    benzonitrile 1.14
    trioctyl phosphate 1.11
    1-bromopropane 0.12
    gamma-valerolactone 76.73
    n-decanol 0.51
    triethyl phosphate 1.9
    4-methyl-2-pentanol 0.38
    propionitrile 1.86
    vinylene carbonate 6.91
    1,1,2-trichlorotrifluoroethane 27.26
    DMS 3.09
    cumene 0.06
    2-octanol 0.54
    2-hexanone 2.49
    octyl acetate 1.1
    limonene 0.3
    1,2-dimethoxyethane 36.83
    ethyl orthosilicate 1.48
    tributyl phosphate 1.24
    diacetone alcohol 10.33
    N,N-dimethylaniline 1.22
    acrylonitrile 5.01
    aniline 0.76
    1,3-propanediol 19.92
    bromobenzene 0.06
    dibromomethane 0.1
    1,1,2,2-tetrachloroethane 0.75
    2-methyl-cyclohexyl acetate 2.01
    tetrabutyl urea 3.47
    diisobutyl methanol 0.37
    2-phenylethanol 1.99
    styrene 0.09
    dioctyl adipate 2.18
    dimethyl sulfate 24.87
    ethyl butyrate 2.73
    methyl lactate 23.79
    butyl lactate 5.0
    diethyl carbonate 1.86
    propanediol butyl ether 10.4
    triethyl orthoformate 2.67
    p-tert-butyltoluene 0.17
    methyl 4-tert-butylbenzoate 5.86
    morpholine 18.8
    tert-butylamine 0.36
    n-dodecanol 0.37
    dimethoxymethane 49.12
    ethylene carbonate 4.24
    cyrene 26.81
    2-ethoxyethyl acetate 3.93
    2-ethylhexyl acetate 1.19
    1,2,4-trichlorobenzene 0.37
    4-methylpyridine 2.26
    dibutyl ether 0.65
    2,6-dimethyl-4-heptanol 0.37
    DEF 16.55
    dimethyl isosorbide 22.2
    tetrachloroethylene 0.44
    eugenol 8.12
    triacetin 5.52
    span 80 7.15
    1,4-butanediol 5.47
    1,1-dichloroethane 0.11
    2-methyl-1-pentanol 0.62
    methyl formate 33.28
    2-methyl-1-butanol 1.17
    n-decane 0.03
    butyronitrile 1.34
    3,7-dimethyl-1-octanol 0.48
    1-chlorooctane 0.12
    1-chlorotetradecane 0.06
    n-nonane 0.03
    undecane 0.02
    tert-butylcyclohexane 0.01
    cyclooctane 0.02
    cyclopentanol 3.33
    tetrahydropyran 2.43
    tert-amyl methyl ether 1.12
    2,5,8-trioxanonane 24.13
    1-hexene 0.08
    2-isopropoxyethanol 8.51
    2,2,2-trifluoroethanol 5.31
    methyl butyrate 4.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction