Fluopicolide

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  • Identifiers

    CAS number
    239110-15-7

    Molecular formula
    C14H8Cl3F3N2O

    SMILES
    C1=CC(=C(C(=C1)Cl)C(=O)NCC2=C(C=C(C=N2)C(F)(F)F)Cl)Cl

    Safety labels

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 55.4%
    Savory 24.9%
    Grape 24.68%
    Cooling 23.74%
    Animal 23.01%
    Fruity 19.92%
    Bitter 19.71%
    Milky 19.57%
    Cooked 19.49%
    Meaty 19.07%

     

    Flavor
    Bitter 72.67%
    Odorless 45.32%
    Bland 26.4%
    Mild 23.95%
    Sweet-like 20.19%
    Nitrile 19.68%
    Scallion 18.71%
    Very strong 18.68%
    Indole 18.45%
    Bread crust 18.3%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    4.4

    pKa est.
    4.9 (weak acid)

    Molecular weight
    383.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    462°C

    Melting point expt.

    • 149 °C

    Flash point

    • 166.91 ˚C est.

    Solubility expt.

    • In water, 2.80 mg/L at 20 °C
    • Solvent solubility (g/L at 20 °C): n-hexane 0.20; ethanol 19.2; toluene 20.5; ethyl acetate 37.7; acetone 74.7; dichloromethane 126; dimethyl sulfoxide 183

  • Synonyms

    • Fluopicolide
    • 239110-15-7
    • Fluopicolide [ISO]
    • 2,6-Dichloro-N-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)benzamide
    • UNII-6TRO75M67P
    • 6TRO75M67P
    • DTXSID7034624
    • HSDB 7886
    • 2,6-dichloro-N-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl]benzamide
    • FLUOPICOLIDE [MI]
    • AE C638206
    • DTXCID5014624
    • CHEBI:81764
    • 2,6-Dichloro-N-[3-chloro-5-(trifluoromethyl)-2-pyridylmethyl]benzamide
    • Fluopicolide 100 microg/mL in Acetonitrile
    • 2,6-dichloro-N-(3-chloro-5-(trifluoromethyl)-2-pyridylmethyl)benzamide
    • 2,6-dichloro-N-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}benzamide
    • 2,6-dichloro-N-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)methyl)benzamide
    • SCHEMBL21950
    • CHEMBL3560526
    • Tox21_303793
    • USEPA/OPP Pesticide Code: 027412
    • NCGC00357081-01
    • CAS-239110-15-7
    • CS-0539926
    • NS00004383
    • C18464
    • Fluopicolide, PESTANAL(R), analytical standard
    • Q13636695
    • Benzamide, 2,6-dichloro-N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl]methyl]-

  • Applications

    Fluopicolide (CAS 239110-15-7) is a fungicide used in agriculture to control oomycete diseases such as Phytophthora and Pythium on crops including vegetables (e.g., tomatoes, cucumbers, lettuce), fruits (grapes, strawberries), potatoes, and ornamental plants. It is applied in both field and greenhouse settings as a foliar spray or soil treatment, and is commonly formulated in products used in tank mixes with other fungicides (often with propamocarb) to broaden spectrum and manage resistance. Fluopicolide is also used in nurseries and in protected cultivation of ornamentals and high-value crops, and as part of integrated disease management programs for oomycete control.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 21.46
    methanol 24.62
    isopropanol 11.14
    water 0.0
    ethyl acetate 56.14
    n-propanol 19.86
    acetone 53.7
    n-butanol 16.04
    acetonitrile 18.8
    DMF 83.02
    toluene 26.25
    isobutanol 12.16
    1,4-dioxane 53.68
    methyl acetate 49.85
    THF 167.35
    2-butanone 68.23
    n-pentanol 15.73
    sec-butanol 18.17
    n-hexane 0.54
    ethylene glycol 3.11
    NMP 100.07
    cyclohexane 0.45
    DMSO 50.18
    n-butyl acetate 36.19
    n-octanol 7.23
    chloroform 50.96
    n-propyl acetate 40.14
    acetic acid 21.54
    dichloromethane 67.87
    cyclohexanone 63.19
    propylene glycol 5.07
    isopropyl acetate 38.19
    DMAc 133.13
    2-ethoxyethanol 51.54
    isopentanol 14.37
    n-heptane 1.24
    ethyl formate 25.82
    1,2-dichloroethane 34.54
    n-hexanol 16.07
    2-methoxyethanol 69.96
    isobutyl acetate 15.05
    tetrachloromethane 2.07
    n-pentyl acetate 28.88
    transcutol 104.71
    n-heptanol 11.07
    ethylbenzene 12.25
    MIBK 28.86
    2-propoxyethanol 63.83
    tert-butanol 12.32
    MTBE 24.82
    2-butoxyethanol 33.77
    propionic acid 16.5
    o-xylene 16.03
    formic acid 11.0
    diethyl ether 34.13
    m-xylene 15.05
    p-xylene 11.59
    chlorobenzene 11.09
    dimethyl carbonate 33.68
    n-octane 0.54
    formamide 29.05
    cyclopentanone 89.34
    2-pentanone 53.57
    anisole 42.62
    cyclopentyl methyl ether 48.41
    gamma-butyrolactone 93.24
    1-methoxy-2-propanol 53.35
    pyridine 58.97
    3-pentanone 45.43
    furfural 76.19
    n-dodecane 0.57
    diethylene glycol 37.24
    diisopropyl ether 8.27
    tert-amyl alcohol 19.86
    acetylacetone 74.33
    n-hexadecane 0.65
    acetophenone 42.96
    methyl propionate 56.36
    isopentyl acetate 26.08
    trichloroethylene 82.55
    n-nonanol 8.39
    cyclohexanol 13.93
    benzyl alcohol 26.39
    2-ethylhexanol 12.09
    isooctanol 9.25
    dipropyl ether 25.59
    1,2-dichlorobenzene 12.87
    ethyl lactate 24.95
    propylene carbonate 37.28
    n-methylformamide 38.44
    2-pentanol 13.35
    n-pentane 0.76
    1-propoxy-2-propanol 44.61
    1-methoxy-2-propyl acetate 62.89
    2-(2-methoxypropoxy) propanol 43.17
    mesitylene 6.83
    ε-caprolactone 61.28
    p-cymene 9.49
    epichlorohydrin 116.89
    1,1,1-trichloroethane 19.91
    2-aminoethanol 10.12
    morpholine-4-carbaldehyde 100.03
    sulfolane 77.87
    2,2,4-trimethylpentane 0.82
    2-methyltetrahydrofuran 71.7
    n-hexyl acetate 27.28
    isooctane 0.47
    2-(2-butoxyethoxy)ethanol 47.76
    sec-butyl acetate 27.35
    tert-butyl acetate 41.18
    decalin 0.67
    glycerin 9.81
    diglyme 94.98
    acrylic acid 15.83
    isopropyl myristate 13.42
    n-butyric acid 24.27
    acetyl acetate 31.78
    di(2-ethylhexyl) phthalate 15.3
    ethyl propionate 40.87
    nitromethane 72.07
    1,2-diethoxyethane 47.94
    benzonitrile 22.97
    trioctyl phosphate 9.32
    1-bromopropane 20.86
    gamma-valerolactone 121.78
    n-decanol 6.82
    triethyl phosphate 15.92
    4-methyl-2-pentanol 9.01
    propionitrile 21.51
    vinylene carbonate 32.91
    1,1,2-trichlorotrifluoroethane 61.77
    DMS 33.55
    cumene 7.09
    2-octanol 7.99
    2-hexanone 41.39
    octyl acetate 17.56
    limonene 11.9
    1,2-dimethoxyethane 99.56
    ethyl orthosilicate 15.46
    tributyl phosphate 10.94
    diacetone alcohol 45.43
    N,N-dimethylaniline 28.51
    acrylonitrile 31.5
    aniline 25.79
    1,3-propanediol 15.61
    bromobenzene 12.11
    dibromomethane 36.33
    1,1,2,2-tetrachloroethane 50.56
    2-methyl-cyclohexyl acetate 25.87
    tetrabutyl urea 22.52
    diisobutyl methanol 8.05
    2-phenylethanol 30.92
    styrene 13.78
    dioctyl adipate 22.75
    dimethyl sulfate 43.11
    ethyl butyrate 36.4
    methyl lactate 33.74
    butyl lactate 25.37
    diethyl carbonate 21.18
    propanediol butyl ether 22.09
    triethyl orthoformate 25.56
    p-tert-butyltoluene 8.85
    methyl 4-tert-butylbenzoate 41.68
    morpholine 69.83
    tert-butylamine 6.68
    n-dodecanol 5.26
    dimethoxymethane 105.21
    ethylene carbonate 25.65
    cyrene 50.57
    2-ethoxyethyl acetate 54.66
    2-ethylhexyl acetate 21.55
    1,2,4-trichlorobenzene 19.25
    4-methylpyridine 54.38
    dibutyl ether 12.79
    2,6-dimethyl-4-heptanol 8.05
    DEF 67.36
    dimethyl isosorbide 85.3
    tetrachloroethylene 27.26
    eugenol 41.61
    triacetin 37.77
    span 80 29.97
    1,4-butanediol 7.0
    1,1-dichloroethane 25.06
    2-methyl-1-pentanol 16.39
    methyl formate 33.93
    2-methyl-1-butanol 16.69
    n-decane 0.85
    butyronitrile 19.18
    3,7-dimethyl-1-octanol 8.37
    1-chlorooctane 4.46
    1-chlorotetradecane 2.13
    n-nonane 0.67
    undecane 0.69
    tert-butylcyclohexane 0.74
    cyclooctane 0.25
    cyclopentanol 17.8
    tetrahydropyran 38.54
    tert-amyl methyl ether 30.02
    2,5,8-trioxanonane 71.54
    1-hexene 5.2
    2-isopropoxyethanol 33.52
    2,2,2-trifluoroethanol 8.44
    methyl butyrate 46.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction