Floxuridine

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  • Identifiers

    CAS number
    50-91-9

    Molecular formula
    C9H11FN2O5

    SMILES
    C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O

    Safety labels

    Acute Toxic
    Acute Toxic

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 84.08%
    Bitter 21.21%
    Savory 18.3%
    Burnt 17.62%
    Caramellic 15.3%
    Cooked 15.1%
    Milky 15.04%
    Roasted 14.54%
    Popcorn 14.06%
    Nutty 12.64%

     

    Flavor
    Bitter 84.61%
    Odorless 38.76%
    Bland 23.62%
    Sweet-like 22.27%
    Cedarleaf 19.35%
    Nitrile 19.08%
    Bread crust 19.03%
    Taco 18.74%
    Very mild 18.74%
    Mild 18.72%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.2

    pKa est.
    6.79 (neutral)

    Molecular weight
    246.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1013°C

    Melting point expt.

    • 302 to 304 °F (NTP, 1992)
    • 150.5 °C
    • 150-151 °C

    Flash point

    • 241.71 ˚C est.

    Solubility expt.

    • 11900 mg/L
    • 1 g in about 4.5 ml isopropanol, about 7.5 ml methanol, about 12 ml alcohol, about 27 ml acetone; insol in chloroform, ether, and benzene
    • 4.08e+01 g/L

  • Synonyms

    • floxuridine
    • 50-91-9
    • 5-Fluorodeoxyuridine
    • 2'-Deoxy-5-fluorouridine
    • Fluorodeoxyuridine
    • FUDR
    • 5-Fluoro-2'-deoxyuridine
    • Floxuridin
    • FdUrd
    • Deoxyfluorouridine
    • Fluoruridine deoxyribose
    • 5FdU
    • Floxiridina
    • Floxuridinum
    • 5-Fluoro-2-desoxyuridine
    • 5 Fluorodeoxyuridine
    • FDUR
    • beta-5-Fluoro-2'-deoxyuridine
    • 5-Fluorouracil 2'-deoxyriboside
    • 5-fluoro-1-((2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1h,3h)-dione
    • 5-Fluoro-2-deoxyuridine
    • Floxuridinum [INN-Latin]
    • Uridine, 2'-deoxy-5-fluoro-
    • 5-FdUrd
    • 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil
    • Floxiridina [INN-Spanish]
    • 5-Fluorouracil deoxyriboside
    • NSC-27640
    • 1beta-D-2'-Deoxyribofuranosyl-5-flurouracil
    • 1-beta-D-2'-Deoxyribofuranosyl-5-flurouracil
    • 5-FUDR
    • floxidine
    • floxuridina
    • CHEBI:60761
    • HSDB 3227
    • EINECS 200-072-5
    • MFCD00006530
    • Uridine, 2'-deoxy-5-fluoro
    • UNII-039LU44I5M
    • BRN 0090221
    • 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione
    • DTXSID3023057
    • AI3-50691
    • 039LU44I5M
    • CHEMBL917
    • Floxuridine [USAN:USP:INN]
    • MLS000069439
    • Uridine, 2'-deoxy-5'-fluoro-
    • DTXCID603057
    • 5-Fluoro-2'-deoxy-beta-uridine
    • NSC 27640
    • 5-24-06-00291 (Beilstein Handbook Reference)
    • NSC27640
    • Ro 5-0360
    • FdU
    • (+)-5-fluoro-2'-deoxyuridine
    • NCGC00023722-05
    • SMR000059051
    • 5-Fluor-1-(beta-2'-deoxyribofuranosyl)pyrimidin-2,4(1H,3H)-dion
    • Floxuridinum (INN-Latin)
    • Floxiridina (INN-Spanish)
    • FLOXURIDINE (MART.)
    • FLOXURIDINE [MART.]
    • FLOXURIDINE (USP-RS)
    • FLOXURIDINE [USP-RS]
    • Floxuridine (USAN:USP:INN)
    • FLOXURIDINE (USP IMPURITY)
    • FLOXURIDINE [USP IMPURITY]
    • FLOXURIDINE (USP MONOGRAPH)
    • FLOXURIDINE [USP MONOGRAPH]
    • CAS-50-91-9
    • 5-Fluoro-1-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidine-2,4-dione
    • (+)-5-fluorodeoxyuridine
    • FUDR (TN)
    • 5-floxuridine
    • 5-Fluoro-dUrd
    • Floxuridine (Fludara)
    • Fluorouridine Deoxyribose
    • Floxuridine (USP/INN)
    • FLOXURIDINE [MI]
    • 2-Deoxy-5-fluorouridine
    • Opera_ID_1559
    • FLOXURIDINE [INN]
    • 2-deoxy-5'-fluorouridine
    • FLOXURIDINE [HSDB]
    • FLOXURIDINE [USAN]
    • Epitope ID:138108
    • 5-Fluor-1-(beta-2'-deoxyribofuranosyl)pyrimidin-2,4(1H,3H)-dion [Czech]
    • 5-Fluorouridine Deoxyribose
    • FLOXURIDINE [VANDF]
    • SCHEMBL4424
    • 2''-deoxy-5-fluorouridine
    • 2'-deoxy-5-fluoro uridine
    • 5-fluoro-2''-deoxyuridine
    • FLOXURIDINE [WHO-DD]
    • 5-Fluoro-2 inverted exclamation marka-deoxyuridine
    • MLS002695934
    • MLS006011768
    • 5-fluoro-2''-Deoxy-uridine
    • 2'-deoxy-5-fluoro-d-uridine
    • GTPL4801
    • FLOXURIDINE [ORANGE BOOK]
    • L01BC09
    • HMS2090I12
    • HMS2230N22
    • HMS3715A11
    • 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione
    • BCP02871
    • HY-B0097
    • Tox21_110892
    • BBL033765
    • BDBM50340678
    • s1299
    • STK801909
    • AKOS005622662
    • Tox21_110892_1
    • BCP9000691
    • CCG-220965
    • CS-1827
    • DB00322
    • ND02921
    • PS-7520
    • 5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
    • SRI-9246-15
    • SRI-9246_18
    • NCGC00023722-03
    • NCGC00023722-06
    • NCGC00023722-08

  • Applications

    Floxuridine (CAS 50-91-9) is used in pharmaceuticals as an active ingredient in chemotherapy regimens and in hepatic arterial infusion for liver metastases. It is also employed in medicinal chemistry and biomedical research as a nucleoside analog, serving as a lead compound or intermediate for synthesizing related nucleoside analogs and as a laboratory tool to study DNA/RNA synthesis and enzyme inhibition in cell-based assays. In nucleoside synthesis workflows, floxuridine can act as a starting material or intermediate for other nucleoside derivatives, supporting drug development and pharmaceutical chemistry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.05
    methanol 14.04
    isopropanol 2.55
    water 27.93
    ethyl acetate 0.55
    n-propanol 2.56
    acetone 2.62
    n-butanol 2.32
    acetonitrile 2.24
    DMF 98.68
    toluene 0.16
    isobutanol 1.38
    1,4-dioxane 1.39
    methyl acetate 1.2
    THF 4.23
    2-butanone 2.08
    n-pentanol 1.17
    sec-butanol 1.82
    n-hexane 0.05
    ethylene glycol 15.24
    NMP 142.37
    cyclohexane 0.08
    DMSO 314.75
    n-butyl acetate 1.13
    n-octanol 0.51
    chloroform 0.18
    n-propyl acetate 0.79
    acetic acid 19.75
    dichloromethane 0.38
    cyclohexanone 4.94
    propylene glycol 11.78
    isopropyl acetate 0.48
    DMAc 96.61
    2-ethoxyethanol 14.87
    isopentanol 2.02
    n-heptane 0.13
    ethyl formate 2.24
    1,2-dichloroethane 0.45
    n-hexanol 1.2
    2-methoxyethanol 35.73
    isobutyl acetate 0.29
    tetrachloromethane 0.11
    n-pentyl acetate 0.61
    transcutol 16.0
    n-heptanol 0.9
    ethylbenzene 0.14
    MIBK 1.14
    2-propoxyethanol 9.63
    tert-butanol 2.51
    MTBE 0.38
    2-butoxyethanol 5.27
    propionic acid 5.05
    o-xylene 0.3
    formic acid 104.9
    diethyl ether 0.48
    m-xylene 0.23
    p-xylene 0.22
    chlorobenzene 0.09
    dimethyl carbonate 2.11
    n-octane 0.04
    formamide 143.71
    cyclopentanone 6.84
    2-pentanone 1.53
    anisole 0.51
    cyclopentyl methyl ether 1.33
    gamma-butyrolactone 11.49
    1-methoxy-2-propanol 16.04
    pyridine 2.03
    3-pentanone 1.13
    furfural 14.24
    n-dodecane 0.03
    diethylene glycol 20.88
    diisopropyl ether 0.17
    tert-amyl alcohol 2.18
    acetylacetone 2.44
    n-hexadecane 0.03
    acetophenone 1.54
    methyl propionate 1.6
    isopentyl acetate 1.09
    trichloroethylene 0.62
    n-nonanol 0.54
    cyclohexanol 1.8
    benzyl alcohol 1.47
    2-ethylhexanol 0.76
    isooctanol 0.66
    dipropyl ether 0.86
    1,2-dichlorobenzene 0.16
    ethyl lactate 3.72
    propylene carbonate 4.18
    n-methylformamide 44.2
    2-pentanol 1.12
    n-pentane 0.06
    1-propoxy-2-propanol 5.82
    1-methoxy-2-propyl acetate 2.86
    2-(2-methoxypropoxy) propanol 7.01
    mesitylene 0.21
    ε-caprolactone 4.99
    p-cymene 0.36
    epichlorohydrin 4.28
    1,1,1-trichloroethane 0.17
    2-aminoethanol 15.66
    morpholine-4-carbaldehyde 43.36
    sulfolane 53.61
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 1.57
    n-hexyl acetate 0.68
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 7.32
    sec-butyl acetate 0.41
    tert-butyl acetate 0.85
    decalin 0.04
    glycerin 35.32
    diglyme 13.28
    acrylic acid 9.17
    isopropyl myristate 0.34
    n-butyric acid 3.58
    acetyl acetate 0.57
    di(2-ethylhexyl) phthalate 0.98
    ethyl propionate 0.81
    nitromethane 28.01
    1,2-diethoxyethane 1.22
    benzonitrile 0.96
    trioctyl phosphate 0.73
    1-bromopropane 0.21
    gamma-valerolactone 20.98
    n-decanol 0.41
    triethyl phosphate 1.52
    4-methyl-2-pentanol 0.68
    propionitrile 1.36
    vinylene carbonate 3.42
    1,1,2-trichlorotrifluoroethane 17.02
    DMS 1.18
    cumene 0.15
    2-octanol 0.42
    2-hexanone 0.98
    octyl acetate 0.52
    limonene 0.47
    1,2-dimethoxyethane 10.19
    ethyl orthosilicate 1.15
    tributyl phosphate 0.89
    diacetone alcohol 5.82
    N,N-dimethylaniline 0.87
    acrylonitrile 2.94
    aniline 0.78
    1,3-propanediol 14.55
    bromobenzene 0.06
    dibromomethane 0.23
    1,1,2,2-tetrachloroethane 0.67
    2-methyl-cyclohexyl acetate 1.28
    tetrabutyl urea 2.19
    diisobutyl methanol 0.55
    2-phenylethanol 1.44
    styrene 0.11
    dioctyl adipate 0.93
    dimethyl sulfate 10.06
    ethyl butyrate 1.38
    methyl lactate 8.72
    butyl lactate 2.63
    diethyl carbonate 1.13
    propanediol butyl ether 5.82
    triethyl orthoformate 1.46
    p-tert-butyltoluene 0.32
    methyl 4-tert-butylbenzoate 2.72
    morpholine 4.57
    tert-butylamine 0.73
    n-dodecanol 0.3
    dimethoxymethane 8.82
    ethylene carbonate 2.24
    cyrene 14.8
    2-ethoxyethyl acetate 1.25
    2-ethylhexyl acetate 0.77
    1,2,4-trichlorobenzene 0.29
    4-methylpyridine 1.56
    dibutyl ether 0.37
    2,6-dimethyl-4-heptanol 0.55
    DEF 7.9
    dimethyl isosorbide 10.26
    tetrachloroethylene 0.5
    eugenol 3.73
    triacetin 1.94
    span 80 3.98
    1,4-butanediol 6.15
    1,1-dichloroethane 0.16
    2-methyl-1-pentanol 0.96
    methyl formate 15.82
    2-methyl-1-butanol 1.68
    n-decane 0.05
    butyronitrile 1.19
    3,7-dimethyl-1-octanol 0.52
    1-chlorooctane 0.12
    1-chlorotetradecane 0.06
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.03
    cyclooctane 0.04
    cyclopentanol 2.47
    tetrahydropyran 0.85
    tert-amyl methyl ether 0.61
    2,5,8-trioxanonane 10.72
    1-hexene 0.13
    2-isopropoxyethanol 4.75
    2,2,2-trifluoroethanol 13.96
    methyl butyrate 1.69

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction