Florasulam

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  • Identifiers

    CAS number
    145701-23-1

    Molecular formula
    C12H8F3N5O3S

    SMILES
    COC1=NC=C(C2=NC(=NN21)S(=O)(=O)NC3=C(C=CC=C3F)F)F

    Safety labels

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 77.39%
    Cooked 22.49%
    Savory 21.29%
    Bitter 19.01%
    Roasted 18.02%
    Meaty 17.53%
    Grape 16.19%
    Burnt 15.06%
    Milky 14.49%
    Cooling 13.57%

     

    Flavor
    Bitter 95.12%
    Odorless 36.67%
    Bland 24.03%
    Nitrile 18.79%
    Sweet-like 18.31%
    Bread crust 17.61%
    Very strong 17.59%
    Cedarleaf 17.48%
    Taco 17.41%
    Roasted peanuts 17.31%

     

    Odor impact est.
    Odorless

  • Properties

    XLogP3-AA
    1.6

    pKa est.
    6.46 (neutral)

    Molecular weight
    359.29 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    532°C

    Melting point expt.

    • 220-221 °C (decomposes); also reported as 193.5-230.5 °C

    Flash point

    • 176.0 ˚C est.

    Solubility expt.

    • In n-heptane 0.019X10-3; xylene 0.227; n-octanol 0.184 (all in g/L solution, 20 °C). In dichloroethane 3.75; methanol 9.81; acetone 123; ethyl acetate 15.9; acetonitrile 72.1( all in g/L solvent, 20 °C)
    • In water, 0.121 (purified, pH 5.6-5.8); 0.084 (pH 5.0); 6.36 (pH 7.0); 94.2 (pH 9) (all in g/L, 20 °C)

  • Synonyms

    • Florasulam
    • 145701-23-1
    • N-(2,6-Difluorophenyl)-8-fluoro-5-methoxy-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide
    • Primus
    • 00A64ZX8NB
    • Boxer
    • NIKOS
    • DTXSID7044340
    • [1,2,4]Triazolo[1,5-c]pyrimidine-2-sulfonamide, N-(2,6-difluorophenyl)-8-fluoro-5-methoxy-
    • DTXCID5024340
    • N-(2,6-difluorophenyl)-5-methoxy-8-fluoro-(1,2,4)-triazolo-(1,5c)-pyrimidine-2-sulfonamide
    • N-(2,6-Difluorophenyl)-8-fluoro-5-methoxy[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide
    • (1,2,4)TRIAZOLO(1,5-C)PYRIMIDINE-2-SULFONAMIDE, N-(2,6-DIFLUOROPHENYL)-8-FLUORO-5-METHOXY-
    • N-(2,6-DIFLUOROPHENYL)-8-FLUORO-5-METHOXY(1,2,4)TRIAZOLO(1,5-C)PYRIMIDINE-2-SULFONAMIDE
    • N-(2,6-difluorophenyl)-8-fluoro-5-methoxy-(1,2,4)triazolo(1,5-c)pyrimidine-2-sulfonamide
    • RefChem:140725
    • 604-488-1
    • Kantor
    • Florasulam [ISO]
    • UNII-00A64ZX8NB
    • C12H8F3N5O3S
    • HSDB 7941
    • Kantor; Primus; Primus SC
    • Florasulam 10 microg/mL in Acetonitrile
    • MFCD08273843
    • FLORASULAM [MI]
    • SCHEMBL116614
    • CHEMBL3185236
    • CHEBI:82009
    • MSK22380
    • Tox21_302433
    • AKOS015901201
    • DB15316
    • DS-6608
    • NCGC00255762-01
    • FF102367
    • DB-042799
    • CAS-145701-23-1
    • CS-0013914
    • NS00001447
    • Florasulam, PESTANAL(R), analytical standard
    • C18850
    • 701F231
    • A1-01909
    • Q22807578
    • 2',6',8-TRIFLUORO-5-METHOXY(1,2,4)TRIAZOLO(1,5-C)PYRIMIDINE-2-SULFONANILIDE
    • [1,2,4]Triazolo[1,5-c]pyrimidine-2- sulfonamide, N-(2,6-difluorophenyl)-8-fluoro-5-methoxy-
    • 145701-23-1

  • Applications

    Florasulam (CAS 145701-23-1) is a selective herbicide used in cereal crops to control broadleaf weeds; it acts as an ALS inhibitor and is typically applied post-emergence as part of crop-protection formulations or tank mixes with other herbicides to broaden the spectrum and manage resistance. Common applications include wheat, barley, and oats within integrated pest management programs, often with adjuvants to improve spray coverage and application reliability.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 10.61
    methanol 21.74
    isopropanol 3.77
    water 0.27
    ethyl acetate 15.54
    n-propanol 6.46
    acetone 26.74
    n-butanol 4.13
    acetonitrile 23.03
    DMF 105.49
    toluene 1.05
    isobutanol 3.17
    1,4-dioxane 21.21
    methyl acetate 33.09
    THF 39.16
    2-butanone 26.93
    n-pentanol 2.57
    sec-butanol 4.64
    n-hexane 0.08
    ethylene glycol 11.77
    NMP 179.21
    cyclohexane 0.2
    DMSO 134.12
    n-butyl acetate 9.89
    n-octanol 1.59
    chloroform 3.09
    n-propyl acetate 13.0
    acetic acid 37.63
    dichloromethane 7.88
    cyclohexanone 23.36
    propylene glycol 8.46
    isopropyl acetate 6.08
    DMAc 136.89
    2-ethoxyethanol 33.64
    isopentanol 2.68
    n-heptane 0.24
    ethyl formate 21.6
    1,2-dichloroethane 6.08
    n-hexanol 2.43
    2-methoxyethanol 69.24
    isobutyl acetate 3.18
    tetrachloromethane 0.27
    n-pentyl acetate 5.37
    transcutol 53.15
    n-heptanol 1.98
    ethylbenzene 0.67
    MIBK 3.64
    2-propoxyethanol 25.01
    tert-butanol 2.42
    MTBE 2.94
    2-butoxyethanol 13.58
    propionic acid 18.03
    o-xylene 0.85
    formic acid 51.01
    diethyl ether 5.15
    m-xylene 0.45
    p-xylene 0.92
    chlorobenzene 1.48
    dimethyl carbonate 19.25
    n-octane 0.08
    formamide 106.21
    cyclopentanone 43.49
    2-pentanone 11.21
    anisole 7.39
    cyclopentyl methyl ether 7.03
    gamma-butyrolactone 75.21
    1-methoxy-2-propanol 28.89
    pyridine 29.66
    3-pentanone 9.95
    furfural 87.5
    n-dodecane 0.08
    diethylene glycol 33.41
    diisopropyl ether 0.7
    tert-amyl alcohol 3.82
    acetylacetone 22.38
    n-hexadecane 0.09
    acetophenone 13.38
    methyl propionate 20.95
    isopentyl acetate 5.73
    trichloroethylene 10.46
    n-nonanol 1.66
    cyclohexanol 3.3
    benzyl alcohol 8.18
    2-ethylhexanol 1.85
    isooctanol 1.38
    dipropyl ether 4.04
    1,2-dichlorobenzene 1.68
    ethyl lactate 15.28
    propylene carbonate 28.5
    n-methylformamide 67.24
    2-pentanol 2.03
    n-pentane 0.12
    1-propoxy-2-propanol 14.28
    1-methoxy-2-propyl acetate 16.89
    2-(2-methoxypropoxy) propanol 19.78
    mesitylene 0.24
    ε-caprolactone 30.82
    p-cymene 0.83
    epichlorohydrin 47.8
    1,1,1-trichloroethane 1.22
    2-aminoethanol 14.51
    morpholine-4-carbaldehyde 119.19
    sulfolane 93.99
    2,2,4-trimethylpentane 0.06
    2-methyltetrahydrofuran 18.91
    n-hexyl acetate 5.5
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 20.86
    sec-butyl acetate 5.2
    tert-butyl acetate 4.56
    decalin 0.07
    glycerin 23.89
    diglyme 52.18
    acrylic acid 27.38
    isopropyl myristate 2.03
    n-butyric acid 12.12
    acetyl acetate 10.41
    di(2-ethylhexyl) phthalate 3.9
    ethyl propionate 11.77
    nitromethane 132.25
    1,2-diethoxyethane 9.78
    benzonitrile 9.21
    trioctyl phosphate 2.25
    1-bromopropane 2.1
    gamma-valerolactone 96.29
    n-decanol 1.28
    triethyl phosphate 6.52
    4-methyl-2-pentanol 0.9
    propionitrile 10.91
    vinylene carbonate 27.4
    1,1,2-trichlorotrifluoroethane 47.36
    DMS 13.22
    cumene 0.4
    2-octanol 1.12
    2-hexanone 8.62
    octyl acetate 3.49
    limonene 1.31
    1,2-dimethoxyethane 53.4
    ethyl orthosilicate 4.75
    tributyl phosphate 3.11
    diacetone alcohol 11.87
    N,N-dimethylaniline 4.04
    acrylonitrile 25.21
    aniline 5.08
    1,3-propanediol 15.8
    bromobenzene 0.95
    dibromomethane 3.1
    1,1,2,2-tetrachloroethane 6.98
    2-methyl-cyclohexyl acetate 7.0
    tetrabutyl urea 6.4
    diisobutyl methanol 0.8
    2-phenylethanol 6.86
    styrene 1.02
    dioctyl adipate 5.76
    dimethyl sulfate 37.68
    ethyl butyrate 10.45
    methyl lactate 26.58
    butyl lactate 8.24
    diethyl carbonate 9.24
    propanediol butyl ether 10.16
    triethyl orthoformate 8.8
    p-tert-butyltoluene 0.55
    methyl 4-tert-butylbenzoate 8.94
    morpholine 34.19
    tert-butylamine 0.88
    n-dodecanol 0.94
    dimethoxymethane 43.11
    ethylene carbonate 18.03
    cyrene 33.83
    2-ethoxyethyl acetate 15.5
    2-ethylhexyl acetate 4.86
    1,2,4-trichlorobenzene 3.55
    4-methylpyridine 16.0
    dibutyl ether 2.17
    2,6-dimethyl-4-heptanol 0.8
    DEF 27.86
    dimethyl isosorbide 33.66
    tetrachloroethylene 3.65
    eugenol 13.79
    triacetin 15.64
    span 80 10.18
    1,4-butanediol 5.84
    1,1-dichloroethane 2.28
    2-methyl-1-pentanol 2.12
    methyl formate 54.92
    2-methyl-1-butanol 3.27
    n-decane 0.13
    butyronitrile 7.01
    3,7-dimethyl-1-octanol 1.29
    1-chlorooctane 0.54
    1-chlorotetradecane 0.24
    n-nonane 0.11
    undecane 0.1
    tert-butylcyclohexane 0.04
    cyclooctane 0.07
    cyclopentanol 6.36
    tetrahydropyran 9.22
    tert-amyl methyl ether 3.54
    2,5,8-trioxanonane 36.38
    1-hexene 0.45
    2-isopropoxyethanol 14.11
    2,2,2-trifluoroethanol 18.65
    methyl butyrate 18.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction