Flavanone

Overview IFRA Request a quote

  • Identifiers

    CAS number
    487-26-3

    Molecular formula
    C15H12O2

    SMILES
    C1C(OC2=CC=CC=C2C1=O)C3=CC=CC=C3

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 67.67%
    Coumarinic 56.37%
    Herbal 53.51%
    Spicy 50.54%
    Floral 41.32%
    Hay 40.94%
    Phenolic 40.61%
    Coconut 38.44%
    Balsamic 37.19%
    Aromatic 35.93%

     

    Flavor
    Bitter 74.86%
    Herbal 51.33%
    Sweet 49.9%
    Balsam 40.3%
    Tonka 39.4%
    Coconut 27.44%
    Tobacco 24.87%
    Anise 24.39%
    Coumarin 23.98%
    Almond 23.53%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    3.2

    pKa est.
    7.66 (neutral)

    Molecular weight
    224.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    384°C

    Flash point

    • 168.25 ˚C est.

  • Synonyms

    • FLAVANONE
    • 487-26-3
    • 2,3-Dihydroflavone
    • 4-Flavanone
    • 2-Phenyl-4-chromanone
    • 2,3-Dihydro-2-phenyl-4H-1-benzopyran-4-one
    • 4H-1-Benzopyran-4-one, 2,3-dihydro-2-phenyl-
    • NSC-50393
    • WX22P730FB
    • DTXSID9022318
    • 2-phenyl-2,3-dihydrochromen-4-one
    • CHEBI:5070
    • (+-)-flavanone
    • RefChem:140598
    • GlyTouCan:G01395YK
    • DTXCID302318
    • G01395YK
    • 207-654-8
    • 2-Phenylchroman-4-one
    • Flavanone-d5
    • MFCD00006841
    • 2,3-Dihydro-2-phenyl-4H-benzopyran-4-one
    • 2-Phenylchromanone
    • 2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
    • 2-Phenyl-2,3-dihydro-4H-chromen-4-one
    • Propafenone EP Impurity H
    • Flavonoid
    • MLS002667384
    • CHEMBL274318
    • NSC50393
    • (2RS)-2-Phenyl-2,3-dihydro-4H-1-benzopyran-4-one
    • SMR001306759
    • 2-Phenyl-chroman-4-one
    • EINECS 207-654-8
    • NSC 50393
    • BRN 0183227
    • UNII-WX22P730FB
    • Propafenone IMpurity H (EP/BP/USP)
    • flavan-4-one
    • Propafenone Hydrochloride Imp. H (EP); Propafenone Imp. H (EP); (2RS)-2-Phenyl-2,3-dihydro-4H-1-benzopyran-4-one; Propafenone Hydrochloride Impurity H; Propafenone Impurity H
    • Flavanone, 98%
    • (+/-)-flavanone
    • 2-phenyl-2
    • DL-FLAVANONE
    • Spectrum_000081
    • SpecPlus_000724
    • Spectrum2_000205
    • Spectrum3_000174
    • Spectrum4_001646
    • Spectrum5_000491
    • Flavone, 2,3-dihydro-
    • (2R)-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one
    • Oprea1_401736
    • SCHEMBL19745
    • BSPBio_001667
    • GTPL408
    • KBioGR_002111
    • KBioSS_000501
    • SPECTRUM200343
    • 5-17-10-00480 (Beilstein Handbook Reference)
    • MLS002207195
    • DivK1c_006820
    • SPBio_000189
    • MEGxp0_001684
    • orb1310525
    • FLAVANONE, (+/-)-
    • SCHEMBL15201568
    • SCHEMBL29470801
    • ACon1_002246
    • KBio1_001764
    • KBio2_000501
    • KBio2_003069
    • KBio2_005637
    • KBio3_001167
    • ZONYXWQDUYMKFB-UHFFFAOYSA-
    • BB_NC-02811
    • HY-N7128
    • WFA19691
    • BBL027613
    • BDBM50051358
    • CCG-21177
    • EBC-04233
    • s3679
    • SBB042502
    • STL373060
    • AKOS000120276
    • AKOS016040110
    • FF23297
    • NCGC00095802-01
    • NCGC00095802-02
    • NCGC00095802-03
    • NCGC00095802-05
    • AS-48159
    • DA-53215
    • NCI60_004213
    • ST098942
    • SY049235
    • 2-Phenyl-2,3-dihydro-4H-chromen-4-one #
    • CS-0030762
    • EU-0012871
    • F0255
    • NS00007587
    • 4H-1-Benzopyran-4-one,3-dihydro-2-phenyl-
    • EN300-17915
    • 2-Phenyl-2,3-dihydro-4H-1-benzopyran-4-one
    • C00766
    • F19539
    • F358200
    • L000786
    • SR-01000500943
    • F4C11F5A-DFFA-4E0E-BCC9-2FD60204B2DD
    • SR-01000500943-1
    • BRD-A07824748-001-02-6
    • BRD-A07824748-001-03-4
    • Q27077305
    • Z57085783
    • PROPAFENONE HYDROCHLORIDE IMPURITY H [EP IMPURITY]
    • InChI=1/C15H12O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-9,15H,10H2
    • 487-26-3

  • Applications

    Flavanone (CAS 487-26-3) is used primarily as an organic synthesis intermediate and building block for flavonoid-related compounds. In pharmaceutical research, it serves as a precursor for various flavonoid derivatives and related medicinal chemistries. In agrochemical development, it is evaluated as a starting material for the synthesis of flavonoid-like intermediates aimed at crop protection research. In the fine chemicals sector, it supports pilot-scale synthesis and downstream transformations as a versatile starting point for further chemical elaboration. In fragrance and flavor chemistry contexts, it may be explored as a precursor for aroma compound synthesis. Use is typically subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 14.08
    methanol 19.7
    isopropanol 10.41
    water 0.2
    ethyl acetate 89.71
    n-propanol 14.02
    acetone 91.41
    n-butanol 15.3
    acetonitrile 102.56
    DMF 181.1
    toluene 58.91
    isobutanol 12.19
    1,4-dioxane 282.44
    methyl acetate 112.99
    THF 214.3
    2-butanone 97.95
    n-pentanol 18.4
    sec-butanol 10.83
    n-hexane 1.64
    ethylene glycol 12.14
    NMP 123.46
    cyclohexane 5.04
    DMSO 191.9
    n-butyl acetate 75.39
    n-octanol 15.19
    chloroform 400.74
    n-propyl acetate 80.7
    acetic acid 63.62
    dichloromethane 429.98
    cyclohexanone 155.4
    propylene glycol 9.54
    isopropyl acetate 54.1
    DMAc 234.71
    2-ethoxyethanol 56.49
    isopentanol 20.84
    n-heptane 3.5
    ethyl formate 72.84
    1,2-dichloroethane 309.51
    n-hexanol 22.06
    2-methoxyethanol 75.2
    isobutyl acetate 55.85
    tetrachloromethane 18.37
    n-pentyl acetate 40.16
    transcutol 569.43
    n-heptanol 14.52
    ethylbenzene 37.49
    MIBK 51.91
    2-propoxyethanol 70.49
    tert-butanol 21.47
    MTBE 29.45
    2-butoxyethanol 44.25
    propionic acid 42.12
    o-xylene 36.76
    formic acid 22.13
    diethyl ether 44.17
    m-xylene 34.9
    p-xylene 46.12
    chlorobenzene 119.46
    dimethyl carbonate 79.39
    n-octane 1.9
    formamide 65.35
    cyclopentanone 171.91
    2-pentanone 62.56
    anisole 110.97
    cyclopentyl methyl ether 61.06
    gamma-butyrolactone 225.29
    1-methoxy-2-propanol 50.37
    pyridine 228.59
    3-pentanone 70.92
    furfural 248.44
    n-dodecane 2.76
    diethylene glycol 72.3
    diisopropyl ether 16.0
    tert-amyl alcohol 17.54
    acetylacetone 144.18
    n-hexadecane 3.31
    acetophenone 108.01
    methyl propionate 80.13
    isopentyl acetate 71.8
    trichloroethylene 560.65
    n-nonanol 17.05
    cyclohexanol 26.31
    benzyl alcohol 62.86
    2-ethylhexanol 23.88
    isooctanol 16.22
    dipropyl ether 39.26
    1,2-dichlorobenzene 117.69
    ethyl lactate 42.53
    propylene carbonate 126.35
    n-methylformamide 67.44
    2-pentanol 10.75
    n-pentane 1.12
    1-propoxy-2-propanol 48.3
    1-methoxy-2-propyl acetate 93.84
    2-(2-methoxypropoxy) propanol 85.71
    mesitylene 23.38
    ε-caprolactone 126.25
    p-cymene 25.23
    epichlorohydrin 325.48
    1,1,1-trichloroethane 133.8
    2-aminoethanol 16.09
    morpholine-4-carbaldehyde 210.62
    sulfolane 212.22
    2,2,4-trimethylpentane 2.2
    2-methyltetrahydrofuran 86.69
    n-hexyl acetate 59.7
    isooctane 1.91
    2-(2-butoxyethoxy)ethanol 107.35
    sec-butyl acetate 54.84
    tert-butyl acetate 58.32
    decalin 6.44
    glycerin 27.12
    diglyme 274.05
    acrylic acid 54.68
    isopropyl myristate 32.14
    n-butyric acid 52.79
    acetyl acetate 94.83
    di(2-ethylhexyl) phthalate 33.65
    ethyl propionate 74.67
    nitromethane 223.97
    1,2-diethoxyethane 138.14
    benzonitrile 114.94
    trioctyl phosphate 20.52
    1-bromopropane 63.37
    gamma-valerolactone 235.4
    n-decanol 14.73
    triethyl phosphate 47.08
    4-methyl-2-pentanol 13.31
    propionitrile 69.86
    vinylene carbonate 154.56
    1,1,2-trichlorotrifluoroethane 155.09
    DMS 105.96
    cumene 25.85
    2-octanol 9.82
    2-hexanone 70.83
    octyl acetate 35.31
    limonene 29.21
    1,2-dimethoxyethane 178.43
    ethyl orthosilicate 41.77
    tributyl phosphate 31.92
    diacetone alcohol 64.18
    N,N-dimethylaniline 61.57
    acrylonitrile 131.0
    aniline 67.2
    1,3-propanediol 26.58
    bromobenzene 134.83
    dibromomethane 202.33
    1,1,2,2-tetrachloroethane 337.4
    2-methyl-cyclohexyl acetate 61.32
    tetrabutyl urea 42.47
    diisobutyl methanol 19.78
    2-phenylethanol 56.06
    styrene 54.65
    dioctyl adipate 56.62
    dimethyl sulfate 114.34
    ethyl butyrate 71.55
    methyl lactate 46.84
    butyl lactate 39.2
    diethyl carbonate 64.86
    propanediol butyl ether 38.84
    triethyl orthoformate 56.14
    p-tert-butyltoluene 21.98
    methyl 4-tert-butylbenzoate 72.24
    morpholine 174.14
    tert-butylamine 12.76
    n-dodecanol 13.28
    dimethoxymethane 127.56
    ethylene carbonate 118.99
    cyrene 81.65
    2-ethoxyethyl acetate 86.37
    2-ethylhexyl acetate 58.73
    1,2,4-trichlorobenzene 132.75
    4-methylpyridine 140.83
    dibutyl ether 40.25
    2,6-dimethyl-4-heptanol 19.78
    DEF 96.88
    dimethyl isosorbide 149.59
    tetrachloroethylene 185.31
    eugenol 73.17
    triacetin 103.98
    span 80 52.68
    1,4-butanediol 13.83
    1,1-dichloroethane 138.63
    2-methyl-1-pentanol 24.6
    methyl formate 80.74
    2-methyl-1-butanol 16.57
    n-decane 3.78
    butyronitrile 52.14
    3,7-dimethyl-1-octanol 23.5
    1-chlorooctane 17.8
    1-chlorotetradecane 10.19
    n-nonane 3.03
    undecane 3.15
    tert-butylcyclohexane 5.16
    cyclooctane 2.36
    cyclopentanol 25.32
    tetrahydropyran 111.85
    tert-amyl methyl ether 25.63
    2,5,8-trioxanonane 184.92
    1-hexene 10.29
    2-isopropoxyethanol 46.35
    2,2,2-trifluoroethanol 39.73
    methyl butyrate 93.56

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction