Ferrous Gluconate

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  • Identifiers

    CAS number
    299-29-6

    Molecular formula
    C12H22FeO14

    SMILES
    C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.C([C@H]([C@H]([C@@H]([C@H](C(=O)[O-])O)O)O)O)O.[Fe+2]

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 72.18%
    Sweet 48.12%
    Caramellic 26.01%
    Buttery 21.5%
    Milky 17.36%
    Clean 17.28%
    Savory 16.84%
    Bitter 15.85%
    Alcoholic 15.73%
    Sharp 14.68%

     

    Flavor
    Odorless 71.97%
    Sweet 33.74%
    Sweet-like 30.88%
    Very mild 30.55%
    Bland 24.22%
    Mild 21.49%
    Very slight 20.22%
    Yeast 19.74%
    Caramellic 19.02%
    Acetoin 18.45%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    1.43 (strong acid)

    Molecular weight
    446.14 g/mol

    Melting point expt.

    • The melting point for D-gluconic acid, ferrous salt dihydrate (98%) is 188 °C, decomposes. The specific optical rotation is +6.7 deg at 25 °C (c=1, H2O). /Dihydrate/

    Flash point

    • 228.83 ˚C est.

    Solubility expt.

    • Soluble with slight heating in water. Practically insoluble in ethanol
    • Soluble in glycerin
    • SOLUBILITY INCR BY ADDN OF CITRIC ACID OR CITRATE ION
    • 1 gram dissolves in about 10 ml of water with slight heating and in 1.3 ml of water at 100 °C. It forms supersaturated solutions which are stable for a period of time.

  • Synonyms

    • FERROUS GLUCONATE
    • Iron(II) Gluconate
    • Ferroglyconicum
    • Glucoferron
    • Biofergate
    • Cerevon
    • Feravol
    • Ferlucon
    • Ferronicum
    • Ferrose
    • Glucomax
    • Gluferate
    • Nionate
    • Entron
    • Fenton
    • Ferox
    • Irox
    • Ferro-agepha
    • Ferrum polon
    • Gluco-ferrum
    • Ray-gluciron
    • Fergon preparations
    • Iron-II gluconate
    • Fergon
    • Ferrin 55
    • 299-29-6
    • Iron gluconate
    • Gluconic acid iron salt
    • Ferrous gluconate anhydrous
    • Iron(II) gluconate, anhydrous
    • 781E2AXH0K
    • Iron(2+) gluconate (1:2)
    • D-gluconic acid, iron(2+) salt (2:1)
    • Gluconic acid, iron(2+) salt (2:1), D-
    • ferrous-gluconate
    • INS NO.579
    • DTXSID4040478
    • INS-579
    • E-579
    • Loesferron
    • Sideromal
    • RefChem:5828
    • Iron (as ferrous gluconate)
    • DTXCID301839091
    • 206-076-3
    • U1B11I423Z
    • Ferrousgluconate
    • 18829-42-0
    • iron(2+);(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
    • Apo-Ferrous Gluconate
    • Flourish
    • Iromon (gador)
    • Irox (gador)
    • Ferrous gluconate [USAN]
    • UNII-781E2AXH0K
    • HSDB 461
    • Iron digluconate
    • Iron, bis(D-gluconato-O1,O2)-
    • EINECS 206-076-3
    • Ferrous gluconate CRS
    • bis(2,3,4,5,6-pentahydroxyhexanoic acid) iron
    • EC 206-076-3
    • SCHEMBL35424
    • Iron, bis(D-gluconato-&kappa
    • FERROUS GLUCONATE [MI]
    • FERROUS GLUCONATE [HSDB]
    • VRIVJOXICYMTAG-IYEMJOQQSA-L
    • Iron(II) (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
    • EBC-27119
    • AKOS015901488
    • DB14488
    • Gluconic acid, iron(2+) salt (2:1)
    • Iron, bis(D-gluconato-kappaO1,kappaO2)-
    • DB-187514
    • Q421291
    • 299-29-6

  • Applications

    Ferrous gluconate, CAS 299-29-6, is primarily used as an iron source for dietary supplements and for food fortification, and it serves as an iron-containing ingredient in pharmaceuticals. In agriculture, it is used as a chelated iron source to improve iron uptake by crops. In cleaning and detergent formulations, it can act as a chelating agent to stabilize metals and minimize metal deposition in hard water. Additional industrial applications may be considered where a soluble iron source is required.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.11
    methanol 40.94
    isopropanol 2.81
    water 1208.44
    ethyl acetate 0.9
    n-propanol 3.53
    acetone 3.72
    n-butanol 1.65
    acetonitrile 0.94
    DMF 145.44
    toluene 0.29
    isobutanol 1.55
    1,4-dioxane 4.15
    methyl acetate 0.96
    THF 3.76
    2-butanone 1.46
    n-pentanol 0.66
    sec-butanol 2.23
    n-hexane 0.07
    ethylene glycol 250.97
    NMP 142.13
    cyclohexane 0.54
    DMSO 701.99
    n-butyl acetate 0.47
    n-octanol 0.65
    chloroform 0.07
    n-propyl acetate 0.31
    acetic acid 22.2
    dichloromethane 0.18
    cyclohexanone 2.5
    propylene glycol 72.85
    isopropyl acetate 0.62
    DMAc 73.62
    2-ethoxyethanol 16.13
    isopentanol 1.2
    n-heptane 0.4
    ethyl formate 1.26
    1,2-dichloroethane 0.39
    n-hexanol 1.38
    2-methoxyethanol 72.59
    isobutyl acetate 0.08
    tetrachloromethane 0.15
    n-pentyl acetate 0.32
    transcutol 13.34
    n-heptanol 1.09
    ethylbenzene 0.16
    MIBK 0.94
    2-propoxyethanol 10.44
    tert-butanol 4.66
    MTBE 0.8
    2-butoxyethanol 4.42
    propionic acid 7.46
    o-xylene 0.7
    formic acid 404.26
    diethyl ether 0.75
    m-xylene 0.46
    p-xylene 0.15
    chlorobenzene 0.07
    dimethyl carbonate 4.25
    n-octane 0.13
    formamide 311.53
    cyclopentanone 4.13
    2-pentanone 1.56
    anisole 0.46
    cyclopentyl methyl ether 2.72
    gamma-butyrolactone 6.45
    1-methoxy-2-propanol 30.47
    pyridine 1.19
    3-pentanone 1.45
    furfural 7.69
    n-dodecane 0.07
    diethylene glycol 49.83
    diisopropyl ether 0.39
    tert-amyl alcohol 3.79
    acetylacetone 4.08
    n-hexadecane 0.07
    acetophenone 0.83
    methyl propionate 2.68
    isopentyl acetate 0.34
    trichloroethylene 0.34
    n-nonanol 0.61
    cyclohexanol 2.93
    benzyl alcohol 1.14
    2-ethylhexanol 0.72
    isooctanol 0.67
    dipropyl ether 0.98
    1,2-dichlorobenzene 0.12
    ethyl lactate 2.4
    propylene carbonate 1.75
    n-methylformamide 58.1
    2-pentanol 1.32
    n-pentane 0.17
    1-propoxy-2-propanol 6.06
    1-methoxy-2-propyl acetate 2.29
    2-(2-methoxypropoxy) propanol 4.38
    mesitylene 0.49
    ε-caprolactone 2.63
    p-cymene 0.38
    epichlorohydrin 1.94
    1,1,1-trichloroethane 0.09
    2-aminoethanol 99.1
    morpholine-4-carbaldehyde 67.42
    sulfolane 60.31
    2,2,4-trimethylpentane 0.12
    2-methyltetrahydrofuran 1.81
    n-hexyl acetate 0.41
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 5.82
    sec-butyl acetate 0.19
    tert-butyl acetate 1.13
    decalin 0.12
    glycerin 297.71
    diglyme 12.18
    acrylic acid 15.25
    isopropyl myristate 0.2
    n-butyric acid 2.89
    acetyl acetate 0.82
    di(2-ethylhexyl) phthalate 0.34
    ethyl propionate 0.54
    nitromethane 20.57
    1,2-diethoxyethane 0.87
    benzonitrile 0.22
    trioctyl phosphate 0.4
    1-bromopropane 0.11
    gamma-valerolactone 12.22
    n-decanol 0.48
    triethyl phosphate 0.78
    4-methyl-2-pentanol 0.73
    propionitrile 0.44
    vinylene carbonate 1.35
    1,1,2-trichlorotrifluoroethane 17.2
    DMS 0.93
    cumene 0.15
    2-octanol 0.52
    2-hexanone 0.35
    octyl acetate 0.31
    limonene 0.7
    1,2-dimethoxyethane 6.74
    ethyl orthosilicate 0.66
    tributyl phosphate 0.31
    diacetone alcohol 8.52
    N,N-dimethylaniline 1.0
    acrylonitrile 1.13
    aniline 1.07
    1,3-propanediol 44.97
    bromobenzene 0.05
    dibromomethane 0.11
    1,1,2,2-tetrachloroethane 0.5
    2-methyl-cyclohexyl acetate 0.46
    tetrabutyl urea 0.91
    diisobutyl methanol 0.64
    2-phenylethanol 1.11
    styrene 0.12
    dioctyl adipate 0.37
    dimethyl sulfate 22.21
    ethyl butyrate 0.58
    methyl lactate 18.02
    butyl lactate 1.19
    diethyl carbonate 0.36
    propanediol butyl ether 5.97
    triethyl orthoformate 0.72
    p-tert-butyltoluene 0.45
    methyl 4-tert-butylbenzoate 2.03
    morpholine 8.1
    tert-butylamine 1.51
    n-dodecanol 0.38
    dimethoxymethane 20.21
    ethylene carbonate 1.03
    cyrene 12.22
    2-ethoxyethyl acetate 0.7
    2-ethylhexyl acetate 0.26
    1,2,4-trichlorobenzene 0.17
    4-methylpyridine 0.79
    dibutyl ether 0.26
    2,6-dimethyl-4-heptanol 0.64
    DEF 9.24
    dimethyl isosorbide 6.43
    tetrachloroethylene 0.73
    eugenol 2.17
    triacetin 1.06
    span 80 3.77
    1,4-butanediol 12.22
    1,1-dichloroethane 0.08
    2-methyl-1-pentanol 0.5
    methyl formate 21.33
    2-methyl-1-butanol 1.41
    n-decane 0.11
    butyronitrile 0.26
    3,7-dimethyl-1-octanol 0.41
    1-chlorooctane 0.15
    1-chlorotetradecane 0.08
    n-nonane 0.11
    undecane 0.08
    tert-butylcyclohexane 0.06
    cyclooctane 0.38
    cyclopentanol 4.18
    tetrahydropyran 1.16
    tert-amyl methyl ether 1.24
    2,5,8-trioxanonane 10.11
    1-hexene 0.08
    2-isopropoxyethanol 4.76
    2,2,2-trifluoroethanol 24.9
    methyl butyrate 0.67

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction