FD&C Red 4

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  • Identifiers

    CAS number
    4548-53-2

    Molecular formula
    C18H14N2Na2O7S2

    SMILES
    CC1=CC(=C(C=C1N=NC2=C(C3=CC=CC=C3C(=C2)S(=O)(=O)[O-])O)S(=O)(=O)[O-])C.[Na+].[Na+]

    Safety labels

  • Odor profile

    Fragrance
    Odorless 78.5%
    Cooked 21.47%
    Bitter 19.88%
    Savory 19.76%
    Roasted 16.94%
    Burnt 16.83%
    Grape 14.25%
    Meaty 13.87%
    Milky 13.77%
    Clean 13.33%

     

    Flavor
    Bitter 90.01%
    Odorless 32.73%
    Bland 20.56%
    Nitrile 20.36%
    Very strong 18.53%
    Taco 18.46%
    Bread crust 18.43%
    Indole 18.22%
    Roasted peanuts 18.02%
    Sweet-like 17.7%

     

    Odor impact est.
    Odorless

  • Properties

    pKa est.
    3.52 (weak acid)

    Molecular weight
    480.4 g/mol

    Flash point

    • 300.6 ˚C est.

  • Synonyms

    • FD&C Red 4
    • DTXSID2021234
    • DTXCID001234
    • RefChem:200921
    • Ponceau SX
    • 4548-53-2
    • Food red 1
    • C.I. Food Red 1
    • Crimson 4R
    • FD&C Red No. 4
    • FD & C Red no. 4
    • C.I. Food Red 1, disodium salt
    • CI 14700
    • FD and C Red No. 4
    • X3W0AM1JLX
    • C.I. 14700
    • MFCD00046402
    • 1-Naphthalenesulfonic acid, 3-((2,4-dimethyl-5-sulfophenyl)azo)-4-hydroxy-, disodium salt
    • 3-((2,4-Dimethyl-5-sulfophenyl)azo)-4-hydroxy-1-naphthalenesulfonic acid, disodium salt
    • disodium;3-[(2,4-dimethyl-5-sulfonatophenyl)diazenyl]-4-hydroxynaphthalene-1-sulfonate
    • Red 4
    • Ponceau SX Lake
    • 4R purple
    • Maple Ponceau SX
    • 1-Naphthalenesulfonic acid, 4-hydroxy-3-((6-sulfo-2,4-xylyl)azo)-, disodium salt
    • Disodium 3-((2,4-dimethyl-5-sulphonatophenyl)azo)-4-hydroxynaphthalene-1-sulphonate
    • Purple 4R
    • Hexacol Ponceau SX
    • Red shade #24
    • Certicol Ponceau SXS
    • Usacert Red No. 4
    • Dye FD & C Red No. 4
    • Red No. 1
    • Red No. 4
    • Edicol Supra Ponceau SX
    • Red Lake 89865N
    • 1-Naphthalenesulfonic acid, 3-(2-(2,4-dimethyl-5-sulfophenyl)diazenyl)-4-hydroxy-, sodium salt (1:2)
    • Dye FD and C Red No. 4
    • 1306 Red
    • D&C RED NO. 4
    • CCRIS 3188
    • 12101 Red
    • Cerven potravinarska 1 [Czech]
    • Usacert FD & C Red No. 4
    • Cerven potravinarska 1
    • EINECS 224-909-9
    • UNII-X3W0AM1JLX
    • FD&C Red No. 4 - Aluminium Lake
    • Disodium 2-(5-sulfo-2,4-xylylazo)-1-naphthol-4-sulfonate
    • Ponceau SX, AldrichCPR
    • PONCEAU SX [MI]
    • 2-(6-Sulfo-2,4-xylylazo)-1-naphthol-4-sulfonic acid, disodium salt
    • 2-(6-Sulpho-2,4-xylylazo)-1-naphthol-4-sulphonic acid, disodium salt
    • PONCEAU SX [IARC]
    • 4-Hydroxy-3-((5-sulfo-2,4-xylyl)azo)-1-naphthalenesulfonic acid, disodium salt
    • Disodium 3-((2,4-dimethyl-5-sulfophenyl)azo)-4-hydroxy-1-naphthalenesulfonate
    • FDC RED NO. 4
    • 3-((2,4-Dimethyl-5-sulphophenyl)azo)-4-hydroxy-1-naphthalenesulphonic acid, disodium salt
    • 4-Hydroxy-3-((5-sulpho-2,4-xylyl)azo)-1-naphthalenesulphonic acid, disodium salt
    • SCHEMBL110710
    • SCHEMBL110711
    • SCHEMBL341298
    • AKA504
    • Ponceau SX, analytical standard
    • CHEMBL3185981
    • SCHEMBL29382053
    • MSK2450
    • GRRDBTDTMCTWQZ-ZAWKPCBGSA-L
    • FD&C RED NO. 4 [II]
    • Tox21_302855
    • 3-((2,4-Dimethyl-5-sulfophenyl)azo)-4-hydroxy-1-naphthalenesulfon- ic acid, disodium salt
    • disodium 3-[(E)-(2,4-dimethyl-5-sulfonatophenyl)diazenyl]-4-hydroxynaphthalene-1-sulfonate
    • NCGC00256380-01
    • SY075727
    • CAS-4548-53-2
    • DB-051307
    • fd&c red no. 4 (c.i. 14700 (Na))
    • NS00083588
    • P0588
    • D91976
    • Q27293524
    • 3-((2,4-DIMETHYL-5-SULFOPHENYL)AZO)-4-HYDROXY-1-NAPHTHALENESULFO
    • Disodium 3-[(2,4-dimethyl-5-sulfonatophenyl)diazenyl]-4-hydroxynaphthalene-1-sulfonate
    • DISODIUM 3-[(E)-2-(2,4-DIMETHYL-5-SULFONATOPHENYL)DIAZEN-1-YL]-4-HYDROXYNAPHTHALENE-1-SULFONATE
    • 4548-53-2

  • Applications

    FD&C Red 4 (CAS 4548-53-2) is a synthetic colorant used primarily as a color additive in cosmetics and personal care products; it is also employed as a dye in coatings, inks, and plastics to impart red hues to packaging, components, and molded parts; in industrial manufacturing it can serve as a pigment in polymer formulations and as a labeling color for cleaning and household products; it is sometimes used as a colorant in pharmaceutical dosage forms, subject to regulatory controls; overall, use is governed by local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.52
    methanol 0.83
    isopropanol 0.27
    water 0.0
    ethyl acetate 0.88
    n-propanol 0.44
    acetone 1.62
    n-butanol 0.23
    acetonitrile 0.87
    DMF 31.33
    toluene 0.2
    isobutanol 0.19
    1,4-dioxane 6.27
    methyl acetate 2.04
    THF 11.61
    2-butanone 2.52
    n-pentanol 0.17
    sec-butanol 0.33
    n-hexane 0.0
    ethylene glycol 0.68
    NMP 29.62
    cyclohexane 0.01
    DMSO 9.27
    n-butyl acetate 0.83
    n-octanol 0.17
    chloroform 1.15
    n-propyl acetate 0.82
    acetic acid 1.92
    dichloromethane 1.56
    cyclohexanone 2.84
    propylene glycol 0.92
    isopropyl acetate 0.62
    DMAc 29.76
    2-ethoxyethanol 3.03
    isopentanol 0.15
    n-heptane 0.01
    ethyl formate 0.78
    1,2-dichloroethane 0.94
    n-hexanol 0.18
    2-methoxyethanol 8.52
    isobutyl acetate 0.33
    tetrachloromethane 0.04
    n-pentyl acetate 0.8
    transcutol 7.36
    n-heptanol 0.25
    ethylbenzene 0.08
    MIBK 0.51
    2-propoxyethanol 4.55
    tert-butanol 0.25
    MTBE 0.34
    2-butoxyethanol 2.25
    propionic acid 1.32
    o-xylene 0.15
    formic acid 2.03
    diethyl ether 0.42
    m-xylene 0.12
    p-xylene 0.12
    chlorobenzene 0.27
    dimethyl carbonate 2.5
    n-octane 0.01
    formamide 5.44
    cyclopentanone 8.29
    2-pentanone 0.97
    anisole 0.92
    cyclopentyl methyl ether 1.06
    gamma-butyrolactone 10.26
    1-methoxy-2-propanol 5.34
    pyridine 5.09
    3-pentanone 1.06
    furfural 10.07
    n-dodecane 0.01
    diethylene glycol 4.17
    diisopropyl ether 0.08
    tert-amyl alcohol 0.32
    acetylacetone 2.81
    n-hexadecane 0.01
    acetophenone 1.29
    methyl propionate 1.85
    isopentyl acetate 0.63
    trichloroethylene 3.49
    n-nonanol 0.22
    cyclohexanol 0.26
    benzyl alcohol 0.76
    2-ethylhexanol 0.14
    isooctanol 0.18
    dipropyl ether 0.54
    1,2-dichlorobenzene 0.36
    ethyl lactate 1.15
    propylene carbonate 2.03
    n-methylformamide 6.19
    2-pentanol 0.14
    n-pentane 0.01
    1-propoxy-2-propanol 2.77
    1-methoxy-2-propyl acetate 2.84
    2-(2-methoxypropoxy) propanol 2.91
    mesitylene 0.06
    ε-caprolactone 2.97
    p-cymene 0.11
    epichlorohydrin 10.5
    1,1,1-trichloroethane 0.27
    2-aminoethanol 1.0
    morpholine-4-carbaldehyde 33.94
    sulfolane 16.49
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 2.19
    n-hexyl acetate 0.67
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 3.3
    sec-butyl acetate 0.45
    tert-butyl acetate 0.81
    decalin 0.01
    glycerin 3.35
    diglyme 8.76
    acrylic acid 2.33
    isopropyl myristate 0.32
    n-butyric acid 0.77
    acetyl acetate 0.8
    di(2-ethylhexyl) phthalate 0.59
    ethyl propionate 0.81
    nitromethane 9.24
    1,2-diethoxyethane 1.78
    benzonitrile 0.72
    trioctyl phosphate 0.31
    1-bromopropane 0.19
    gamma-valerolactone 22.38
    n-decanol 0.16
    triethyl phosphate 0.61
    4-methyl-2-pentanol 0.08
    propionitrile 0.71
    vinylene carbonate 2.28
    1,1,2-trichlorotrifluoroethane 10.09
    DMS 2.04
    cumene 0.05
    2-octanol 0.14
    2-hexanone 0.79
    octyl acetate 0.47
    limonene 0.15
    1,2-dimethoxyethane 6.91
    ethyl orthosilicate 0.51
    tributyl phosphate 0.38
    diacetone alcohol 2.0
    N,N-dimethylaniline 0.62
    acrylonitrile 2.12
    aniline 0.63
    1,3-propanediol 1.21
    bromobenzene 0.23
    dibromomethane 0.47
    1,1,2,2-tetrachloroethane 2.32
    2-methyl-cyclohexyl acetate 0.72
    tetrabutyl urea 0.99
    diisobutyl methanol 0.12
    2-phenylethanol 0.83
    styrene 0.13
    dioctyl adipate 0.89
    dimethyl sulfate 5.74
    ethyl butyrate 0.82
    methyl lactate 3.06
    butyl lactate 1.18
    diethyl carbonate 0.62
    propanediol butyl ether 1.7
    triethyl orthoformate 0.94
    p-tert-butyltoluene 0.11
    methyl 4-tert-butylbenzoate 2.11
    morpholine 8.18
    tert-butylamine 0.08
    n-dodecanol 0.12
    dimethoxymethane 8.99
    ethylene carbonate 1.26
    cyrene 5.31
    2-ethoxyethyl acetate 2.47
    2-ethylhexyl acetate 0.51
    1,2,4-trichlorobenzene 0.82
    4-methylpyridine 2.0
    dibutyl ether 0.3
    2,6-dimethyl-4-heptanol 0.12
    DEF 3.21
    dimethyl isosorbide 7.81
    tetrachloroethylene 0.96
    eugenol 2.67
    triacetin 2.34
    span 80 2.0
    1,4-butanediol 0.35
    1,1-dichloroethane 0.38
    2-methyl-1-pentanol 0.14
    methyl formate 4.64
    2-methyl-1-butanol 0.18
    n-decane 0.01
    butyronitrile 0.35
    3,7-dimethyl-1-octanol 0.16
    1-chlorooctane 0.08
    1-chlorotetradecane 0.04
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.68
    tetrahydropyran 1.31
    tert-amyl methyl ether 0.37
    2,5,8-trioxanonane 6.51
    1-hexene 0.03
    2-isopropoxyethanol 1.42
    2,2,2-trifluoroethanol 0.9
    methyl butyrate 1.12

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction