Ethylenediaminetetraacetic acid disodium salt

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  • Identifiers

    CAS number
    139-33-3

    Molecular formula
    C10H14N2Na2O8

    SMILES
    C(CN(CC(=O)O)CC(=O)[O-])N(CC(=O)O)CC(=O)[O-].[Na+].[Na+]

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Odorless 67.07%
    Sweet 37.22%
    Savory 26.45%
    Fishy 18.93%
    Alcoholic 18.3%
    Meaty 15.95%
    Clean 15.5%
    Cooked 14.67%
    Oily 14.61%
    Milky 14.32%

     

    Flavor
    Odorless 65.26%
    Bitter 34.9%
    Mild 34.38%
    Bland 32.75%
    Very mild 26.3%
    Yeast 22.35%
    Sweet-like 22.06%
    Faint 20.42%
    Bread crust 19.31%
    Nitrile 19.22%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    0.83 (strong acid)

    Molecular weight
    336.21 g/mol

    Melting point expt.

    • MP: 242 °C /EDTA disodium dihydrate/

    Flash point

    • 282.81 ˚C est.
    • Flash point is> 100 °C,

  • Synonyms

    • 139-33-3
    • EDTA disodium salt
    • Edetate disodium
    • Disodium edetate
    • Edetate disodium anhydrous
    • Edta disodium
    • Ethylenediaminetetraacetic acid disodium salt
    • Titriplex III
    • Disodium EDTA
    • Disodium edta, anhydrous
    • Cheladrate
    • Disodium versene
    • Endrate disodium
    • Sodium versenate
    • Disodium salt of EDTA
    • Metaquest B
    • Kiresuto B
    • Chelaplex III
    • Chelest B
    • Diso-Tate
    • Komplexon III
    • Chelaton III
    • Clewat N
    • Versene NA
    • Triplex III
    • Chelaton 3
    • Disodium versenate
    • Edathamil disodium
    • Trilon BD
    • Versene Na2
    • Zonon D
    • Dotite 2NA
    • Selekton B 2
    • Disodium sequestrene
    • Disodium tetracemate
    • Anhydrous disodium edetate
    • Mavacid ED 4
    • Versonol 120
    • Disodium ethylenediaminetetraacetate
    • Chelest 200
    • Edetate disodium, anhydrous
    • Sequestrene sodium 2
    • Edetic Acid, Disodium Salt
    • Veresene disodium salt
    • Perma Kleer Di Crystals
    • Edetic acid disodium salt
    • Glycine, N,N'-1,2-ethanediylbis[N-(carboxymethyl)-, disodium salt
    • Ethylenediaminetetraacetic acid, disodium salt
    • MFCD00070672
    • Disodium (ethylenedinitrilo)tetraacetate
    • CCRIS 3658
    • 8NLQ36F6MM
    • E.D.T.A. disodique
    • EDTA-Na2
    • Disodium dihydrogen ethylenediaminetetraacetate
    • NSC 2760
    • EDTA disodium salt (anhydrous)
    • EINECS 205-358-3
    • Disodium ethylenediamine-N,N,N',N'-tetraacetate
    • Perma kleer 50 crystals disodium salt
    • UNII-8NLQ36F6MM
    • Disodium ethylenediaminetetraacetic acid
    • Ethylene diamine tetraacetic acid, disodium salt
    • CBC 50152966
    • DR-16133
    • Ethylenediaminetetraacetate, disodium salt
    • Disodium diacid ethylenediaminetetraacetate
    • AI3-18049
    • Disodium (ethylenedinitrilo)tetraacetic acid
    • Dinatrium ethylendiamintetraacetat
    • HSDB 8013
    • Trilon B
    • Disodium dihydrogen(ethylenedinitrilo)tetraacetate
    • Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, disodium salt
    • NSC-2760
    • Endrate (TN)
    • Disodium edathamil
    • 6381-92-6
    • disodium 2-({2-[(carboxylatomethyl)(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetate
    • Tetracemate disodium
    • Na2-EDTA
    • N,N'-1,2-Ethanediylbis(N-(carboxymethyl)glycine) disodium salt
    • EC 205-358-3
    • Edta disodium salt anhydrous
    • CHEBI:64734
    • Disodium N,N'-1,2-ethanediylbis(N-(carboxymethyl)glycine)
    • ACETIC ACID, (ETHYLENEDINITRILO)TETRA-, DISODIUM SALT
    • E.D.T.A. disodique [French]
    • F 1 (VAN)
    • EDETATE DISODIUM ANHYDROUS [II]
    • ethylenediamine tetraacetic acid disodium salt
    • Dinatrium ethylendiamintetraacetat [Czech]
    • Ethylenebis(iminodiacetic acid) disodium salt
    • (Ethylenedinitrilo)-tetraacetic acid disodium salt
    • Na2EDTA
    • 0.5M Sodium EDTA
    • Disodium edetate (TN)
    • Na2.EDTA
    • CHEMBL1749
    • DTXSID9027073
    • EDETATE DISODIUM [WHO-DD]
    • disodium ethylenediamine-tetraacetate
    • AKOS016370696
    • DB14600
    • SB40706
    • 69772-70-9
    • E386
    • EDTA DISODIUM SALT ANHYDROUS [MI]
    • ethylenediaminetetracetic acid disodium salt
    • DB-042467
    • NS00078150
    • EN300-35828
    • ethylenediaminetetra-acetic acid disodium salt
    • D03945
    • P17519
    • Q4532977
    • Ethylenediaminetetraacetic acid disodium salt, (2% solution)
    • disodium 2-({2-[bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetate
    • Glycine, N,N'-1,2-ethanediylbis(N-(carboxymethyl)-, sodium salt (1:2)
    • (Ethylenedinitrilo)tetraacetic acid disodium salt, EDTA disodium salt, EDTA-Na2
    • 2-[2-(Carboxylatomethyl-(carboxymethyl)amino)ethyl-(carboxymethyl)amino]acetate disodium
    • disodium;2-[2-[carboxylatomethyl(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetate
    • DISODIUM 2-({2-[(CARBOXYLATOMETHYL)(CARBOXYMETHYL)AMINO]ETHYL(CARBOXYMETHYL)AMINO)ACETATE

  • Applications

    Ethylenediaminetetraacetic acid disodium salt (CAS 139-33-3) is widely used as a chelating and stabilizing agent across industries: in detergents and household cleaners to soften water and minimize metal-catalyzed degradation; in cosmetics and personal care to improve formulation stability by sequestering trace metals; in food processing as a sequestrant to bind metal ions and help preserve color and flavor; in pharmaceuticals as a stabilizer and excipient to control metal-related reactions; in industrial manufacturing and water treatment as a corrosion/scale inhibitor and water-softening additive for cooling systems and boilers; and in polymers and plastics processing as a stabilizer during polymerization to control trace metal impurities.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.33
    methanol 2.75
    isopropanol 0.06
    water 3.43
    ethyl acetate 0.04
    n-propanol 0.16
    acetone 0.1
    n-butanol 0.07
    acetonitrile 0.04
    DMF 22.71
    toluene 0.03
    isobutanol 0.06
    1,4-dioxane 0.02
    methyl acetate 0.08
    THF 0.16
    2-butanone 0.13
    n-pentanol 0.02
    sec-butanol 0.07
    n-hexane 0.0
    ethylene glycol 1.68
    NMP 45.73
    cyclohexane 0.0
    DMSO 32.14
    n-butyl acetate 0.05
    n-octanol 0.02
    chloroform 0.04
    n-propyl acetate 0.03
    acetic acid 1.31
    dichloromethane 0.08
    cyclohexanone 0.23
    propylene glycol 1.48
    isopropyl acetate 0.02
    DMAc 16.06
    2-ethoxyethanol 0.33
    isopentanol 0.03
    n-heptane 0.01
    ethyl formate 0.16
    1,2-dichloroethane 0.06
    n-hexanol 0.04
    2-methoxyethanol 2.46
    isobutyl acetate 0.01
    tetrachloromethane 0.01
    n-pentyl acetate 0.02
    transcutol 0.74
    n-heptanol 0.03
    ethylbenzene 0.02
    MIBK 0.04
    2-propoxyethanol 0.52
    tert-butanol 0.05
    MTBE 0.01
    2-butoxyethanol 0.2
    propionic acid 0.62
    o-xylene 0.07
    formic acid 16.42
    diethyl ether 0.02
    m-xylene 0.04
    p-xylene 0.02
    chlorobenzene 0.02
    dimethyl carbonate 0.33
    n-octane 0.0
    formamide 16.54
    cyclopentanone 0.55
    2-pentanone 0.08
    anisole 0.04
    cyclopentyl methyl ether 0.1
    gamma-butyrolactone 1.13
    1-methoxy-2-propanol 1.12
    pyridine 0.18
    3-pentanone 0.13
    furfural 2.31
    n-dodecane 0.0
    diethylene glycol 1.08
    diisopropyl ether 0.0
    tert-amyl alcohol 0.08
    acetylacetone 0.13
    n-hexadecane 0.0
    acetophenone 0.16
    methyl propionate 0.25
    isopentyl acetate 0.04
    trichloroethylene 0.15
    n-nonanol 0.02
    cyclohexanol 0.05
    benzyl alcohol 0.09
    2-ethylhexanol 0.03
    isooctanol 0.02
    dipropyl ether 0.05
    1,2-dichlorobenzene 0.03
    ethyl lactate 0.27
    propylene carbonate 0.32
    n-methylformamide 7.56
    2-pentanol 0.03
    n-pentane 0.0
    1-propoxy-2-propanol 0.39
    1-methoxy-2-propyl acetate 0.23
    2-(2-methoxypropoxy) propanol 0.46
    mesitylene 0.02
    ε-caprolactone 0.28
    p-cymene 0.03
    epichlorohydrin 0.3
    1,1,1-trichloroethane 0.02
    2-aminoethanol 2.34
    morpholine-4-carbaldehyde 5.06
    sulfolane 13.84
    2,2,4-trimethylpentane 0.0
    2-methyltetrahydrofuran 0.05
    n-hexyl acetate 0.03
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 0.29
    sec-butyl acetate 0.02
    tert-butyl acetate 0.04
    decalin 0.0
    glycerin 7.13
    diglyme 0.6
    acrylic acid 1.61
    isopropyl myristate 0.01
    n-butyric acid 0.28
    acetyl acetate 0.03
    di(2-ethylhexyl) phthalate 0.05
    ethyl propionate 0.06
    nitromethane 1.63
    1,2-diethoxyethane 0.03
    benzonitrile 0.04
    trioctyl phosphate 0.03
    1-bromopropane 0.02
    gamma-valerolactone 1.78
    n-decanol 0.01
    triethyl phosphate 0.14
    4-methyl-2-pentanol 0.01
    propionitrile 0.06
    vinylene carbonate 0.46
    1,1,2-trichlorotrifluoroethane 2.71
    DMS 0.1
    cumene 0.02
    2-octanol 0.01
    2-hexanone 0.03
    octyl acetate 0.02
    limonene 0.04
    1,2-dimethoxyethane 0.27
    ethyl orthosilicate 0.09
    tributyl phosphate 0.05
    diacetone alcohol 0.28
    N,N-dimethylaniline 0.15
    acrylonitrile 0.22
    aniline 0.11
    1,3-propanediol 0.67
    bromobenzene 0.01
    dibromomethane 0.04
    1,1,2,2-tetrachloroethane 0.13
    2-methyl-cyclohexyl acetate 0.06
    tetrabutyl urea 0.15
    diisobutyl methanol 0.02
    2-phenylethanol 0.07
    styrene 0.02
    dioctyl adipate 0.03
    dimethyl sulfate 2.93
    ethyl butyrate 0.08
    methyl lactate 1.57
    butyl lactate 0.19
    diethyl carbonate 0.05
    propanediol butyl ether 0.33
    triethyl orthoformate 0.08
    p-tert-butyltoluene 0.03
    methyl 4-tert-butylbenzoate 0.26
    morpholine 0.12
    tert-butylamine 0.02
    n-dodecanol 0.01
    dimethoxymethane 0.94
    ethylene carbonate 0.16
    cyrene 1.3
    2-ethoxyethyl acetate 0.05
    2-ethylhexyl acetate 0.03
    1,2,4-trichlorobenzene 0.05
    4-methylpyridine 0.17
    dibutyl ether 0.01
    2,6-dimethyl-4-heptanol 0.02
    DEF 0.77
    dimethyl isosorbide 0.92
    tetrachloroethylene 0.13
    eugenol 0.29
    triacetin 0.12
    span 80 0.25
    1,4-butanediol 0.13
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.02
    methyl formate 2.46
    2-methyl-1-butanol 0.06
    n-decane 0.0
    butyronitrile 0.03
    3,7-dimethyl-1-octanol 0.02
    1-chlorooctane 0.01
    1-chlorotetradecane 0.0
    n-nonane 0.0
    undecane 0.0
    tert-butylcyclohexane 0.0
    cyclooctane 0.0
    cyclopentanol 0.08
    tetrahydropyran 0.02
    tert-amyl methyl ether 0.04
    2,5,8-trioxanonane 0.5
    1-hexene 0.01
    2-isopropoxyethanol 0.08
    2,2,2-trifluoroethanol 1.07
    methyl butyrate 0.11

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction