Ethylene Glycol

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  • Identifiers

    CAS number
    107-21-1

    Molecular formula
    C2H6O2

    SMILES
    C(CO)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 66.46%
    Alcoholic 38.27%
    Ethereal 29.61%
    Sweet 27.66%
    Fishy 22.39%
    Solvent 22.27%
    Caramellic 19.94%
    Oily 18.58%
    Clean 15.88%
    Musty 15.4%

     

    Flavor
    Odorless 59.54%
    Sweet 55.09%
    Alcoholic 50.91%
    Bitter 49.89%
    Musty 34.34%
    Pungent 33.96%
    Sweet-like 26.27%
    Very slight 25.83%
    Fusel 22.55%
    Cauliflower 21.4%

     

    Odor impact est.
    Low

    Odor threshold

    • Odor Threshold Low: 159.0 [mmHg]. Odor threshold
    • Odor index: 3 at 20 °C

  • Properties

    XLogP3-AA
    -1.4

    pKa est.
    7.6 (neutral)

    Molecular weight
    62.07 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Melting point expt.

    • 9 °F (NTP, 1992)
    • PEG 400: 4-8 °C; PEG 3000: 50-56 °C; PEG 3350: 53-57 °C; PEG 4000: 53-59 °C; PEG 6000:55-61 °C; PEG 8000: 55-62 °C
    • -12.69 °C
    • 4 - 10 °C
    • -13 °C
    • 9 °F

    Boiling point

    • 387.7 °F at 760 mmHg (NTP, 1992)
    • 197.3 °C
    • 197.00 to 198.00 °C. @ 760.00 mm Hg
    • 197 °C
    • 388 °F

    Flash point

    • 99.99 ˚C est.
    • 232 °F (NTP, 1992)
    • 232 °F
    • 232 °F (111 °C) (closed cup)
    • 111.11 °C c.c., 115 °C o.c.

    Solubility expt.

    • greater than or equal to 100 mg/mL at 63.5 °F (NTP, 1992)
    • PEG 400 is miscible with water, very soluble in acetone, in alcohol and in methylene chloride, practically insoluble in fatty oils and in mineral oils; PEG 3000 and PEG 3350: very soluble in water and in methylene chloride, very slightly soluble in alcohol, practically insoluble in fatty oils and in mineral oils; PEG 4000, PEG 6000 and PEG 8000: very soluble in water and in methylene chloride, practically insoluble in alcohol and in fatty oils and in mineral oils.
    • Miscible with lower aliphatic alcohols, glycerol, acetic acid, acetone and similar ketones, aldehydes, pyridine, similar coal tar bases; slightly soluble in ether (1:200); practically insoluble in benzene, its homologs, chlorinated hydrocarbons, petroleum ether, oils
    • Miscible with water
    • Solubility in water: miscible
    • Miscible

  • Synonyms

    • ETHYLENE GLYCOL
    • Ethane-1,2-diol
    • 1,2-ethanediol
    • 107-21-1
    • glycol
    • monoethylene glycol
    • 1,2-Dihydroxyethane
    • 2-hydroxyethanol
    • Glycol alcohol
    • Ethylene alcohol
    • Macrogol
    • Fridex
    • Tescol
    • Ethylene dihydrate
    • Norkool
    • Macrogol 400 BPC
    • Dowtherm SR 1
    • Zerex
    • Ucar 17
    • Lutrol-9
    • ethanediol
    • ethyleneglycol
    • Aethylenglykol
    • Glycol, ethylene-
    • 1,2-Ethandiol
    • 1,2-ethylene glycol
    • Caswell No. 441
    • 146AR
    • MFCD00002885
    • NSC 93876
    • Athylenglykol
    • CCRIS 3744
    • ethylen glycol
    • DTXSID8020597
    • HSDB 5012
    • M.e.g.
    • NCI-C00920
    • UNII-FC72KVT52F
    • EINECS 203-473-3
    • FC72KVT52F
    • Lutrol 9
    • EPA Pesticide Chemical Code 042203
    • NANOSILVER+EG
    • PEG
    • CHEBI:30742
    • AI3-03050
    • HOCH2CH2OH
    • NSC-93876
    • LOWENOL T-163A
    • DTXCID40597
    • EC 203-473-3
    • 1,2-Ethylene Glycol (Ethylene Glycol)
    • Kollisolv PEG 300
    • ETHYLENE GLYCOL (II)
    • ETHYLENE GLYCOL [II]
    • Poly(ethylene Glycol) ~200
    • Poly(ethylene Glycol) ~400
    • Poly(ethylene Glycol) ~600
    • Poly(ethylene Glycol) ~1000
    • Poly(ethylene Glycol) ~2000
    • Poly(ethylene Glycol) ~4000
    • Poly(ethylene Glycol) ~6000
    • Poly(ethylene Glycol) ~9000
    • ETHYLENE GLYCOL (MART.)
    • ETHYLENE GLYCOL [MART.]
    • Poly(ethylene Glycol) ~20000
    • Ethylenglycol
    • Aethylenglykol [German]
    • ethylene-glycol
    • Poly(ethylene Glycol) ~30,000
    • Poly(ethylene Glycol) ~40,000
    • 2 Hydroxyethanol
    • Glycol, Ethylene
    • PEG 1000
    • CAS-107-21-1
    • GLYCEROL IMPURITY B (EP IMPURITY)
    • GLYCEROL IMPURITY B [EP IMPURITY]
    • Macrogol 400
    • Glycol, Monoethylene
    • Dowtherm 4000
    • 1,2-dihydroxy ethane
    • PEG 4000
    • WLN: Q2Q
    • ethyleneglycole
    • Macrogola
    • ehtylene glycol
    • etylene glycol
    • 2-ethanediol
    • Ilexan E
    • MEG 100
    • Solbanon (TN)
    • 1,2-ethane diol
    • 1,2-ethane-diol
    • ethane-1.2-diol
    • GXT
    • Hydroxyethyl Salicylate Imp. B (EP); Ethylene Glycol; Propan-1,2-diol; Glycerol Impurity B; Hydroxyethyl Salicylate Impurity B
    • 1,2-ethyleneglycol
    • ethan-1,2-diol
    • mono-ethylene glycol
    • Ethane-1,2-diol (Ethylene Glycol)
    • Mono Ethylene Glycol
    • 1,2-ethylene-glycol
    • Lutrol E (TN)
    • Ethylene glycol,98%
    • DuPont Zonyl FSO Fluorinated Surfactants
    • Ethylene glycol, aerosol
    • Macrogol 400 (TN)
    • Ethylene glycol 1000 microg/mL in Methanol
    • Poly(ethylene oxide);PEO
    • Macrogol 1500 (TN)
    • Macrogol 4000 (TN)
    • Polyethylene glycol 8000
    • Macrogol ointment (JP17)
    • HO-CH2-CH2-OH
    • HO(CH2)2OH
    • NCIOpen2_001979
    • NCIOpen2_002019
    • NCIOpen2_002100
    • Poly(ethylene glycol) 200
    • Poly(ethylene glycol) 400
    • Poly(ethylene glycol)3350
    • Macrogol 400 (JP17)
    • ETHYLENE GLYCOL [MI]
    • MLS002454404
    • BIDD:ER0283
    • Macrogol 1500 (JP17)
    • Macrogol 4000 (JP17)
    • ETHYLENE GLYCOL [HSDB]

  • Applications

    Ethylene Glycol (CAS 107-21-1) is widely used as a heat-transfer fluid and antifreeze in automotive and industrial cooling systems, including solar thermal and HVAC applications. It is a key building block for polyester resins and the production of polyethylene terephthalate (PET), supporting packaging, textiles, and films. It also serves as a solvent and processing aid in coatings, inks, and cleaning formulations. As a chemical intermediate, it is used in the synthesis of polyesters, polyurethanes, and related plasticizers. Additionally, ethylene glycol is employed in de-icing fluids for aircraft and other de-icing applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 150.04
    methanol 390.94
    isopropanol 57.03
    water 1141.9
    ethyl acetate 7.51
    n-propanol 87.36
    acetone 20.56
    n-butanol 57.67
    acetonitrile 25.74
    DMF 171.0
    toluene 0.69
    isobutanol 37.51
    1,4-dioxane 19.91
    methyl acetate 13.52
    THF 33.11
    2-butanone 11.94
    n-pentanol 21.0
    sec-butanol 36.8
    n-hexane 1.05
    ethylene glycol 302.28
    NMP 107.38
    cyclohexane 2.06
    DMSO 258.29
    n-butyl acetate 5.19
    n-octanol 5.77
    chloroform 9.97
    n-propyl acetate 4.88
    acetic acid 362.22
    dichloromethane 12.68
    cyclohexanone 17.49
    propylene glycol 158.57
    isopropyl acetate 3.13
    DMAc 73.58
    2-ethoxyethanol 64.92
    isopentanol 24.44
    n-heptane 1.99
    ethyl formate 30.43
    1,2-dichloroethane 8.42
    n-hexanol 13.8
    2-methoxyethanol 197.05
    isobutyl acetate 1.92
    tetrachloromethane 4.85
    n-pentyl acetate 3.74
    transcutol 51.96
    n-heptanol 8.8
    ethylbenzene 0.53
    MIBK 2.57
    2-propoxyethanol 39.06
    tert-butanol 31.43
    MTBE 4.42
    2-butoxyethanol 28.49
    propionic acid 122.94
    o-xylene 0.98
    formic acid 901.9
    diethyl ether 6.4
    m-xylene 0.6
    p-xylene 0.82
    chlorobenzene 1.58
    dimethyl carbonate 6.17
    n-octane 0.66
    formamide 627.45
    cyclopentanone 27.76
    2-pentanone 6.9
    anisole 2.06
    cyclopentyl methyl ether 7.8
    gamma-butyrolactone 49.85
    1-methoxy-2-propanol 66.98
    pyridine 14.52
    3-pentanone 5.34
    furfural 57.27
    n-dodecane 0.38
    diethylene glycol 86.87
    diisopropyl ether 1.15
    tert-amyl alcohol 24.11
    acetylacetone 6.5
    n-hexadecane 0.37
    acetophenone 3.65
    methyl propionate 10.13
    isopentyl acetate 3.18
    trichloroethylene 11.51
    n-nonanol 4.84
    cyclohexanol 26.07
    benzyl alcohol 8.84
    2-ethylhexanol 5.64
    isooctanol 5.46
    dipropyl ether 5.42
    1,2-dichlorobenzene 1.95
    ethyl lactate 10.55
    propylene carbonate 17.5
    n-methylformamide 206.5
    2-pentanol 16.77
    n-pentane 1.8
    1-propoxy-2-propanol 23.16
    1-methoxy-2-propyl acetate 5.55
    2-(2-methoxypropoxy) propanol 12.71
    mesitylene 0.54
    ε-caprolactone 20.25
    p-cymene 1.08
    epichlorohydrin 25.91
    1,1,1-trichloroethane 3.15
    2-aminoethanol 285.4
    morpholine-4-carbaldehyde 79.54
    sulfolane 77.6
    2,2,4-trimethylpentane 0.65
    2-methyltetrahydrofuran 14.93
    n-hexyl acetate 3.96
    isooctane 0.3
    2-(2-butoxyethoxy)ethanol 22.12
    sec-butyl acetate 1.87
    tert-butyl acetate 2.54
    decalin 0.48
    glycerin 274.28
    diglyme 35.4
    acrylic acid 155.1
    isopropyl myristate 1.46
    n-butyric acid 80.45
    acetyl acetate 4.99
    di(2-ethylhexyl) phthalate 3.19
    ethyl propionate 3.99
    nitromethane 167.25
    1,2-diethoxyethane 6.01
    benzonitrile 5.23
    trioctyl phosphate 3.04
    1-bromopropane 3.83
    gamma-valerolactone 51.08
    n-decanol 3.41
    triethyl phosphate 4.03
    4-methyl-2-pentanol 4.99
    propionitrile 17.45
    vinylene carbonate 19.64
    1,1,2-trichlorotrifluoroethane 79.04
    DMS 3.67
    cumene 0.57
    2-octanol 3.84
    2-hexanone 3.63
    octyl acetate 2.48
    limonene 1.94
    1,2-dimethoxyethane 32.51
    ethyl orthosilicate 3.74
    tributyl phosphate 3.22
    diacetone alcohol 10.63
    N,N-dimethylaniline 2.78
    acrylonitrile 30.69
    aniline 7.78
    1,3-propanediol 218.45
    bromobenzene 0.85
    dibromomethane 7.26
    1,1,2,2-tetrachloroethane 10.79
    2-methyl-cyclohexyl acetate 3.29
    tetrabutyl urea 5.46
    diisobutyl methanol 2.88
    2-phenylethanol 5.45
    styrene 0.77
    dioctyl adipate 3.42
    dimethyl sulfate 15.2
    ethyl butyrate 5.21
    methyl lactate 26.17
    butyl lactate 9.78
    diethyl carbonate 3.65
    propanediol butyl ether 28.88
    triethyl orthoformate 4.91
    p-tert-butyltoluene 1.03
    methyl 4-tert-butylbenzoate 5.58
    morpholine 44.65
    tert-butylamine 14.84
    n-dodecanol 2.55
    dimethoxymethane 23.75
    ethylene carbonate 14.81
    cyrene 18.01
    2-ethoxyethyl acetate 5.18
    2-ethylhexyl acetate 2.44
    1,2,4-trichlorobenzene 2.53
    4-methylpyridine 7.0
    dibutyl ether 2.81
    2,6-dimethyl-4-heptanol 2.88
    DEF 23.14
    dimethyl isosorbide 14.48
    tetrachloroethylene 14.01
    eugenol 10.22
    triacetin 5.54
    span 80 16.25
    1,4-butanediol 72.99
    1,1-dichloroethane 4.32
    2-methyl-1-pentanol 10.54
    methyl formate 86.35
    2-methyl-1-butanol 28.9
    n-decane 0.58
    butyronitrile 15.44
    3,7-dimethyl-1-octanol 3.7
    1-chlorooctane 1.27
    1-chlorotetradecane 0.58
    n-nonane 0.62
    undecane 0.45
    tert-butylcyclohexane 0.4
    cyclooctane 0.7
    cyclopentanol 46.64
    tetrahydropyran 12.4
    tert-amyl methyl ether 3.94
    2,5,8-trioxanonane 24.13
    1-hexene 2.11
    2-isopropoxyethanol 21.46
    2,2,2-trifluoroethanol 180.18
    methyl butyrate 7.76

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction