Ethyl vanillin glucoside

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  • Identifiers

    CAS number
    122397-96-0

    Molecular formula
    C15H20O8

    SMILES
    CCOC1=C(C=CC(=C1)C=O)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O

  • Odor profile

    Fragrance
    Odorless 57.68%
    Vanilla 53.48%
    Sweet 38.57%
    Milky 30.38%
    Creamy 29.44%
    Caramellic 27.71%
    Spicy 21.0%
    Dairy 20.89%
    Savory 19.07%
    Balsamic 18.81%

     

    Flavor
    Bitter 75.31%
    Sweet 32.19%
    Odorless 29.4%
    Vanilla 28.27%
    Bland 26.98%
    Sweet-like 26.47%
    Very mild 21.32%
    Eugenol 21.08%
    Naphthalic 20.87%
    Parsley 20.54%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.2

    pKa est.
    6.7 (neutral)

    Molecular weight
    328.31 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1231°C

    Flash point

    • 229.56 ˚C est.

    Solubility expt.

    • slightly soluble in water; insoluble in fats, oils
    • slightly soluble (in ethanol)

  • Synonyms

    • 122397-96-0
    • Ethyl vanillin beta-D-glucopyranoside
    • Ethyl vanillin glucoside
    • Glucoethylvanillin
    • ETHYLVANILLINBETA-D-GLUCOPYRANOSIDE
    • 24XJ91ONU1
    • UNII-24XJ91ONU1
    • Glucoethyl Vanillin
    • 2-Ethoxy-4-formylphenyl beta-D-glucopyranoside
    • EC 602-769-3
    • 3-Ethoxy-4-(beta-D-glucopyranosyloxy)benzaldehyde
    • Benzaldehyde, 3-ethoxy-4-(beta-D-glucopyranosyloxy)-
    • 3-ethoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybenzaldehyde
    • FEMA NO. 3801
    • DTXSID50153590
    • ETHYL VANILLIN .BETA.-D-GLUCOPYRANOSIDE
    • ETHYL VANILLIN .BETA.-D-GLUCOPYRANOSIDE [FHFI]
    • BENZALDEHYDE, 3-ETHOXY-4-(.BETA.-D-GLUCOPYRANOSYLOXY)-
    • SCHEMBL2949239
    • DTXCID6076081
    • SWESETWDPGZBCR-UXXRCYHCSA-N
    • AC-32346
    • XG182086
    • 4-(-D-Glucopyranosyloxy)-3-Ethoxybenzaldehyde
    • Q27253884
    • 2-ETHOXY-4-FORMYLPHENYL .BETA.-D-GLUCOPYRANOSIDE
    • 3-Ethoxy-4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)benzaldehyde

  • Applications

    Ethyl vanillin glucoside (CAS 122397-96-0) is used primarily as a fragrance and flavor-related material; in perfumery it can act as a vanilla-like aroma source or as a pro-fragrance that releases ethyl vanillin upon enzymatic or hydrolytic transformation, offering potential for controlled release in formulations. In the flavor sector it may be used as a vanilla flavor precursor or aroma modifier, particularly in processes that benefit from glycosidic stabilization or gradual aroma release. In cosmetics and personal care, it serves as a fragrance ingredient contributing vanilla notes to creams, lotions, and hair-care products. In household products, it can function as a fragrance additive in cleaners and detergents, delivering a vanilla note with extended release potential. In industrial manufacturing, it can serve as an intermediate for the synthesis of aroma or flavor compounds or as a glycoside-building block for fragrance inventories, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 25.41
    methanol 68.87
    isopropanol 9.81
    water 32.72
    ethyl acetate 8.38
    n-propanol 12.47
    acetone 25.15
    n-butanol 12.95
    acetonitrile 11.27
    DMF 153.87
    toluene 2.61
    isobutanol 4.51
    1,4-dioxane 22.8
    methyl acetate 8.3
    THF 38.87
    2-butanone 9.13
    n-pentanol 4.55
    sec-butanol 6.91
    n-hexane 0.2
    ethylene glycol 112.65
    NMP 114.03
    cyclohexane 1.56
    DMSO 840.67
    n-butyl acetate 2.54
    n-octanol 4.32
    chloroform 2.47
    n-propyl acetate 3.35
    acetic acid 196.56
    dichloromethane 4.2
    cyclohexanone 20.52
    propylene glycol 54.05
    isopropyl acetate 4.54
    DMAc 176.05
    2-ethoxyethanol 56.07
    isopentanol 7.02
    n-heptane 0.7
    ethyl formate 11.77
    1,2-dichloroethane 5.68
    n-hexanol 4.27
    2-methoxyethanol 157.85
    isobutyl acetate 1.48
    tetrachloromethane 0.71
    n-pentyl acetate 3.36
    transcutol 89.24
    n-heptanol 5.11
    ethylbenzene 1.22
    MIBK 4.79
    2-propoxyethanol 27.65
    tert-butanol 10.69
    MTBE 2.93
    2-butoxyethanol 18.12
    propionic acid 27.27
    o-xylene 2.6
    formic acid 436.7
    diethyl ether 4.42
    m-xylene 2.06
    p-xylene 1.3
    chlorobenzene 1.47
    dimethyl carbonate 20.1
    n-octane 0.49
    formamide 454.41
    cyclopentanone 30.34
    2-pentanone 8.49
    anisole 4.13
    cyclopentyl methyl ether 10.78
    gamma-butyrolactone 47.99
    1-methoxy-2-propanol 66.21
    pyridine 14.41
    3-pentanone 7.04
    furfural 47.42
    n-dodecane 0.37
    diethylene glycol 75.56
    diisopropyl ether 1.31
    tert-amyl alcohol 7.94
    acetylacetone 26.16
    n-hexadecane 0.4
    acetophenone 8.01
    methyl propionate 12.45
    isopentyl acetate 2.6
    trichloroethylene 8.71
    n-nonanol 4.46
    cyclohexanol 13.69
    benzyl alcohol 10.35
    2-ethylhexanol 2.58
    isooctanol 3.83
    dipropyl ether 3.89
    1,2-dichlorobenzene 1.8
    ethyl lactate 12.6
    propylene carbonate 18.44
    n-methylformamide 89.74
    2-pentanol 5.68
    n-pentane 0.38
    1-propoxy-2-propanol 15.94
    1-methoxy-2-propyl acetate 10.53
    2-(2-methoxypropoxy) propanol 23.0
    mesitylene 1.42
    ε-caprolactone 20.3
    p-cymene 1.39
    epichlorohydrin 27.97
    1,1,1-trichloroethane 1.61
    2-aminoethanol 78.25
    morpholine-4-carbaldehyde 95.0
    sulfolane 143.44
    2,2,4-trimethylpentane 0.23
    2-methyltetrahydrofuran 11.61
    n-hexyl acetate 4.7
    isooctane 0.13
    2-(2-butoxyethoxy)ethanol 30.18
    sec-butyl acetate 2.0
    tert-butyl acetate 5.66
    decalin 0.37
    glycerin 160.6
    diglyme 53.18
    acrylic acid 51.93
    isopropyl myristate 2.56
    n-butyric acid 24.96
    acetyl acetate 10.68
    di(2-ethylhexyl) phthalate 4.93
    ethyl propionate 3.8
    nitromethane 182.45
    1,2-diethoxyethane 9.39
    benzonitrile 4.79
    trioctyl phosphate 4.04
    1-bromopropane 1.62
    gamma-valerolactone 63.23
    n-decanol 3.59
    triethyl phosphate 4.82
    4-methyl-2-pentanol 2.94
    propionitrile 4.92
    vinylene carbonate 18.2
    1,1,2-trichlorotrifluoroethane 74.51
    DMS 8.46
    cumene 0.89
    2-octanol 2.9
    2-hexanone 3.28
    octyl acetate 3.83
    limonene 2.28
    1,2-dimethoxyethane 37.65
    ethyl orthosilicate 4.19
    tributyl phosphate 3.96
    diacetone alcohol 21.73
    N,N-dimethylaniline 4.7
    acrylonitrile 11.58
    aniline 7.94
    1,3-propanediol 82.5
    bromobenzene 1.12
    dibromomethane 2.06
    1,1,2,2-tetrachloroethane 8.02
    2-methyl-cyclohexyl acetate 4.5
    tetrabutyl urea 7.51
    diisobutyl methanol 2.21
    2-phenylethanol 7.05
    styrene 1.3
    dioctyl adipate 6.29
    dimethyl sulfate 56.47
    ethyl butyrate 3.71
    methyl lactate 41.36
    butyl lactate 7.8
    diethyl carbonate 3.89
    propanediol butyl ether 21.85
    triethyl orthoformate 4.82
    p-tert-butyltoluene 1.37
    methyl 4-tert-butylbenzoate 13.04
    morpholine 36.66
    tert-butylamine 3.24
    n-dodecanol 2.89
    dimethoxymethane 55.07
    ethylene carbonate 14.35
    cyrene 34.96
    2-ethoxyethyl acetate 8.11
    2-ethylhexyl acetate 1.88
    1,2,4-trichlorobenzene 3.1
    4-methylpyridine 7.7
    dibutyl ether 2.82
    2,6-dimethyl-4-heptanol 2.21
    DEF 27.86
    dimethyl isosorbide 31.08
    tetrachloroethylene 6.33
    eugenol 14.14
    triacetin 13.02
    span 80 17.13
    1,4-butanediol 27.17
    1,1-dichloroethane 1.71
    2-methyl-1-pentanol 3.7
    methyl formate 62.69
    2-methyl-1-butanol 5.96
    n-decane 0.62
    butyronitrile 4.61
    3,7-dimethyl-1-octanol 3.32
    1-chlorooctane 1.43
    1-chlorotetradecane 0.76
    n-nonane 0.55
    undecane 0.46
    tert-butylcyclohexane 0.19
    cyclooctane 0.74
    cyclopentanol 14.27
    tetrahydropyran 10.65
    tert-amyl methyl ether 3.84
    2,5,8-trioxanonane 45.91
    1-hexene 0.55
    2-isopropoxyethanol 21.35
    2,2,2-trifluoroethanol 88.97
    methyl butyrate 5.61

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction