Ethyl Nitrite

Overview IFRA Request a quote

  • Identifiers

    CAS number
    109-95-5

    Molecular formula
    C2H5NO2

    SMILES
    CCON=O

    Safety labels

    Flammable
    Flammable

    Compressed Gas
    Compressed Gas

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fruity 92.76%
    Ethereal 79.42%
    Sweet 67.23%
    Rummy 58.67%
    Winey 46.16%
    Fermented 41.62%
    Sharp 37.54%
    Pungent 36.03%
    Pineapple 35.56%
    Green 34.38%

     

    Flavor
    Pungent 45.23%
    Ethereal 39.03%
    Green 33.79%
    Bitter 33.49%
    Fruity 32.51%
    Sharp 25.64%
    Rum 25.59%
    Musty 24.08%
    Vegetable 22.77%
    Fatty 22.44%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.4

    pKa est.
    8.28 (weak base)

    Molecular weight
    75.07 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -58 °F (USCG, 1999)
    • FP: -58 °F= -50 °C= 233 deg K

    Boiling point

    • 63 °F at 760 mmHg (USCG, 1999)
    • 17 °C

    Flash point

    • -28.2 ˚C est.
    • -31 °F (USCG, 1999)
    • -31 °F (-35 °C) (CLOSED CUP)

    Solubility expt.

    • Slightly soluble in water; decomposes in water; miscible with alcohol, ether

  • Synonyms

    • ETHYL NITRITE
    • 109-95-5
    • Hyponitrous ether
    • Nitrosyl ethoxide
    • Nitrous ethyl ether
    • Nitrous ether
    • Nitrous acid, ethyl ester
    • Ethyl-nitrite-
    • FEMA No. 2446
    • Ethylester kyseliny dusite
    • HSDB 416
    • nitrous acid ethyl ester
    • EINECS 203-722-6
    • UNII-8C7CJ279RV
    • BRN 1699562
    • 8C7CJ279RV
    • DTXSID9046574
    • AI3-25307
    • DTXCID7026574
    • NCGC00166242-01
    • ETHYL NITRITE (MART.)
    • ETHYL NITRITE [MART.]
    • Ethylester kyseliny dusite [Czech]
    • UN1194
    • Ethylnitrite
    • ETHYL NITRITE [MI]
    • ETHYL NITRITE [FHFI]
    • ETHYL NITRITE [HSDB]
    • CHEMBL1551365
    • FEMA 2446
    • CHEBI:173313
    • Tox21_112368
    • CAS-109-95-5
    • DB-230463
    • E0152
    • NS00020727
    • A802116
    • Q3342209
    • 203-722-6

  • Applications

    Ethyl Nitrite (CAS 109-95-5) is primarily used as an alkyl nitrite intermediate and reagent for nitrosation in organic synthesis, enabling the preparation of nitrite esters and nitroso compounds. It is also considered a common source of nitric oxide for research applications, thus used in laboratories and drug development as a nitroso precursor. In the chemical industry, it can serve as a precursor or building block for other nitroso-containing compounds and participate in polymer chemistry processes at the experimental level. Additionally, Ethyl Nitrite may be used as a reagent in research and development, providing NO for mechanistic studies and related reactions.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 158.78
    methanol 231.04
    isopropanol 108.06
    water 10.77
    ethyl acetate 390.99
    n-propanol 112.94
    acetone 702.92
    n-butanol 106.55
    acetonitrile 838.42
    DMF 1113.89
    toluene 134.71
    isobutanol 90.12
    1,4-dioxane 409.43
    methyl acetate 556.2
    THF 333.77
    2-butanone 429.26
    n-pentanol 102.94
    sec-butanol 107.08
    n-hexane 22.49
    ethylene glycol 100.22
    NMP 1472.4
    cyclohexane 33.86
    DMSO 1303.53
    n-butyl acetate 207.57
    n-octanol 77.78
    chloroform 727.92
    n-propyl acetate 240.81
    acetic acid 1505.29
    dichloromethane 997.19
    cyclohexanone 610.86
    propylene glycol 86.05
    isopropyl acetate 184.17
    DMAc 941.28
    2-ethoxyethanol 243.74
    isopentanol 91.72
    n-heptane 11.05
    ethyl formate 353.82
    1,2-dichloroethane 626.36
    n-hexanol 68.9
    2-methoxyethanol 372.23
    isobutyl acetate 96.62
    tetrachloromethane 61.16
    n-pentyl acetate 156.27
    transcutol 926.09
    n-heptanol 40.67
    ethylbenzene 106.79
    MIBK 137.11
    2-propoxyethanol 177.69
    tert-butanol 137.65
    MTBE 127.58
    2-butoxyethanol 107.2
    propionic acid 433.45
    o-xylene 131.01
    formic acid 571.69
    diethyl ether 141.79
    m-xylene 96.63
    p-xylene 158.4
    chlorobenzene 465.48
    dimethyl carbonate 219.15
    n-octane 7.5
    formamide 781.61
    cyclopentanone 598.76
    2-pentanone 278.19
    anisole 294.73
    cyclopentyl methyl ether 168.12
    gamma-butyrolactone 981.38
    1-methoxy-2-propanol 247.5
    pyridine 686.8
    3-pentanone 280.95
    furfural 1404.55
    n-dodecane 8.71
    diethylene glycol 201.61
    diisopropyl ether 44.59
    tert-amyl alcohol 132.78
    acetylacetone 567.55
    n-hexadecane 10.1
    acetophenone 416.98
    methyl propionate 361.84
    isopentyl acetate 143.96
    trichloroethylene 1510.75
    n-nonanol 69.6
    cyclohexanol 145.17
    benzyl alcohol 234.6
    2-ethylhexanol 51.98
    isooctanol 33.32
    dipropyl ether 63.97
    1,2-dichlorobenzene 535.12
    ethyl lactate 141.55
    propylene carbonate 528.28
    n-methylformamide 618.5
    2-pentanol 81.46
    n-pentane 17.15
    1-propoxy-2-propanol 124.23
    1-methoxy-2-propyl acetate 223.17
    2-(2-methoxypropoxy) propanol 208.89
    mesitylene 65.46
    ε-caprolactone 599.6
    p-cymene 52.45
    epichlorohydrin 763.02
    1,1,1-trichloroethane 395.67
    2-aminoethanol 124.65
    morpholine-4-carbaldehyde 1174.03
    sulfolane 1320.89
    2,2,4-trimethylpentane 12.3
    2-methyltetrahydrofuran 281.07
    n-hexyl acetate 270.06
    isooctane 7.21
    2-(2-butoxyethoxy)ethanol 275.92
    sec-butyl acetate 130.95
    tert-butyl acetate 181.99
    decalin 23.88
    glycerin 170.68
    diglyme 455.09
    acrylic acid 683.55
    isopropyl myristate 86.2
    n-butyric acid 353.94
    acetyl acetate 444.44
    di(2-ethylhexyl) phthalate 106.79
    ethyl propionate 242.53
    nitromethane 2845.7
    1,2-diethoxyethane 238.22
    benzonitrile 529.64
    trioctyl phosphate 65.21
    1-bromopropane 223.62
    gamma-valerolactone 1075.08
    n-decanol 52.68
    triethyl phosphate 92.68
    4-methyl-2-pentanol 47.4
    propionitrile 294.48
    vinylene carbonate 694.63
    1,1,2-trichlorotrifluoroethane 747.46
    DMS 370.78
    cumene 69.58
    2-octanol 42.08
    2-hexanone 222.62
    octyl acetate 120.95
    limonene 69.73
    1,2-dimethoxyethane 432.84
    ethyl orthosilicate 69.32
    tributyl phosphate 107.51
    diacetone alcohol 224.41
    N,N-dimethylaniline 193.17
    acrylonitrile 665.53
    aniline 224.67
    1,3-propanediol 169.23
    bromobenzene 458.08
    dibromomethane 523.59
    1,1,2,2-tetrachloroethane 851.66
    2-methyl-cyclohexyl acetate 122.78
    tetrabutyl urea 152.77
    diisobutyl methanol 34.89
    2-phenylethanol 156.34
    styrene 174.95
    dioctyl adipate 162.21
    dimethyl sulfate 508.82
    ethyl butyrate 161.35
    methyl lactate 227.51
    butyl lactate 140.92
    diethyl carbonate 126.9
    propanediol butyl ether 171.88
    triethyl orthoformate 93.95
    p-tert-butyltoluene 46.09
    methyl 4-tert-butylbenzoate 203.15
    morpholine 437.73
    tert-butylamine 75.7
    n-dodecanol 42.0
    dimethoxymethane 295.19
    ethylene carbonate 439.45
    cyrene 232.22
    2-ethoxyethyl acetate 272.98
    2-ethylhexyl acetate 113.06
    1,2,4-trichlorobenzene 614.26
    4-methylpyridine 688.64
    dibutyl ether 107.11
    2,6-dimethyl-4-heptanol 34.89
    DEF 518.03
    dimethyl isosorbide 328.86
    tetrachloroethylene 537.28
    eugenol 230.75
    triacetin 367.4
    span 80 198.04
    1,4-butanediol 92.68
    1,1-dichloroethane 436.57
    2-methyl-1-pentanol 99.57
    methyl formate 558.45
    2-methyl-1-butanol 95.41
    n-decane 13.29
    butyronitrile 248.09
    3,7-dimethyl-1-octanol 77.83
    1-chlorooctane 60.91
    1-chlorotetradecane 26.86
    n-nonane 12.54
    undecane 10.33
    tert-butylcyclohexane 18.09
    cyclooctane 12.18
    cyclopentanol 162.81
    tetrahydropyran 243.06
    tert-amyl methyl ether 118.47
    2,5,8-trioxanonane 353.72
    1-hexene 74.01
    2-isopropoxyethanol 143.46
    2,2,2-trifluoroethanol 482.0
    methyl butyrate 333.22

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction