Epifriedelanol

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  • Identifiers

    CAS number
    16844-71-6

    Molecular formula
    C30H52O

    SMILES
    C[C@H]1[C@H](CC[C@@H]2[C@@]1(CC[C@H]3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4CC(CC5)(C)C)C)C)C)C)C)O

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  • Odor profile

    Fragrance
    Woody 88.46%
    Amber 62.01%
    Dry 58.03%
    Cedar 48.92%
    Musk 47.72%
    Sandalwood 42.9%
    Sweet 39.54%
    Spicy 36.63%
    Vetiver 35.71%
    Balsamic 34.27%

     

    Flavor
    Woody 62.53%
    Sweet 60.48%
    Camphor 49.14%
    Dry 45.86%
    Earthy 45.49%
    Pine 43.7%
    Balsam 34.84%
    Earth 33.19%
    Fresh 33.16%
    Medical 30.74%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    10.1

    pKa est.
    7.14 (neutral)

    Molecular weight
    428.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    506°C

    Flash point

    • 220.3 ˚C est.

  • Synonyms

    • Epifriedelanol
    • 16844-71-6
    • RefChem:1084140
    • Friedelan-3beta-ol
    • Epifriedelinol
    • Epi-Friedelanol
    • (3S,4R,4aS,6aS,6aS,6bR,8aR,12aR,14aS,14bS)-4,4a,6a,6b,8a,11,11,14a-octamethyl-1,2,3,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-hexadecahydropicen-3-ol
    • MFCD04039822
    • Epifriendelanol
    • 24,25,26-Trinoroleanan-3-ol, 5,9,13-trimethyl-, (3beta,4beta,5beta,8alpha,9beta,10alpha,13alpha,14beta)-
    • Friedelin-3beta-ol
    • Longan triterpane A
    • epi-friedellanol
    • beta-Friedelinol
    • CHEMBL464649
    • orb1303775
    • SCHEMBL2989072
    • CHEBI:80941
    • DTXSID10937494
    • HY-N1931
    • MSK163922
    • NSC741685
    • AKOS015896828
    • EBC-617732
    • FE74290
    • NSC 741685
    • NSC-741685
    • (3S,4R,4AS,6AS,6BR,8AR,12AR,12BS,14AS,14BS)-4,4A,6B,8A,11,11,12B,14A-OCTAMETHYL-DOCOSAHYDROPICEN-3-OL
    • 24,25,26-Trinoroleanan-3-ol, 5,9,13-trimethyl-, (3beta,4beta,5beta,8alpha,9beta,10alpha,13alha,14beta)-
    • 5,9,13-Trimethyl-24,25,26-trinoroleanan-3-ol (3beta,4beta,5beta,8alpha,9beta,10alpha,13alha,14beta)-
    • AC-34019
    • DA-52942
    • MS-27600
    • CS-0018243
    • C17123
    • 844E716
    • Q27154914
    • 4,4a,6b,8a,11,11,12b,14a-Octamethyldocosahydropicen-3-ol
    • (3S,4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS)-4,4a,6b,8a,11,11,12b,14a-octamethyldocosahydropicen-3-ol
    • 16844-71-6

  • Applications

    Epifriedelanol (CAS 16844-71-6) is a natural triterpenoid alcohol that is commonly evaluated for use in cosmetics and personal care as an emollient, skin conditioning agent, and texture-enhancing component in creams and lotions. It can also function as a wax-like processing aid to adjust viscosity and handling in formulations, contributing to film formation and the feel of the skin. In industrial manufacturing, epifriedelanol may serve as an intermediate for the synthesis of other triterpenoid derivatives and specialty chemicals. In coatings, inks, and plastics, it can be used as a wax-like additive to improve gloss and processing performance of films and polymer substrates.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.01
    methanol 2.98
    isopropanol 9.38
    water 0.03
    ethyl acetate 18.36
    n-propanol 13.48
    acetone 18.29
    n-butanol 15.79
    acetonitrile 4.24
    DMF 34.49
    toluene 32.15
    isobutanol 11.7
    1,4-dioxane 47.25
    methyl acetate 11.8
    THF 104.53
    2-butanone 20.96
    n-pentanol 10.64
    sec-butanol 8.02
    n-hexane 1.85
    ethylene glycol 0.76
    NMP 36.66
    cyclohexane 2.15
    DMSO 11.6
    n-butyl acetate 24.18
    n-octanol 13.5
    chloroform 42.11
    n-propyl acetate 14.65
    acetic acid 6.01
    dichloromethane 22.89
    cyclohexanone 37.42
    propylene glycol 2.09
    isopropyl acetate 23.93
    DMAc 41.0
    2-ethoxyethanol 16.75
    isopentanol 14.73
    n-heptane 2.74
    ethyl formate 5.9
    1,2-dichloroethane 16.68
    n-hexanol 15.91
    2-methoxyethanol 18.49
    isobutyl acetate 18.73
    tetrachloromethane 9.62
    n-pentyl acetate 33.84
    transcutol 67.51
    n-heptanol 19.44
    ethylbenzene 14.3
    MIBK 25.18
    2-propoxyethanol 44.72
    tert-butanol 11.37
    MTBE 19.28
    2-butoxyethanol 43.36
    propionic acid 7.16
    o-xylene 16.95
    formic acid 1.27
    diethyl ether 23.5
    m-xylene 25.53
    p-xylene 15.61
    chlorobenzene 23.54
    dimethyl carbonate 12.54
    n-octane 1.09
    formamide 2.42
    cyclopentanone 48.94
    2-pentanone 25.98
    anisole 29.75
    cyclopentyl methyl ether 41.1
    gamma-butyrolactone 36.68
    1-methoxy-2-propanol 29.02
    pyridine 39.0
    3-pentanone 20.83
    furfural 28.97
    n-dodecane 0.48
    diethylene glycol 14.01
    diisopropyl ether 11.53
    tert-amyl alcohol 8.65
    acetylacetone 32.79
    n-hexadecane 0.62
    acetophenone 23.53
    methyl propionate 19.44
    isopentyl acetate 32.4
    trichloroethylene 39.26
    n-nonanol 15.73
    cyclohexanol 12.27
    benzyl alcohol 16.34
    2-ethylhexanol 13.54
    isooctanol 18.03
    dipropyl ether 26.57
    1,2-dichlorobenzene 22.17
    ethyl lactate 9.59
    propylene carbonate 19.58
    n-methylformamide 7.29
    2-pentanol 10.98
    n-pentane 2.12
    1-propoxy-2-propanol 41.76
    1-methoxy-2-propyl acetate 49.09
    2-(2-methoxypropoxy) propanol 32.98
    mesitylene 15.02
    ε-caprolactone 34.11
    p-cymene 14.29
    epichlorohydrin 42.87
    1,1,1-trichloroethane 22.24
    2-aminoethanol 3.38
    morpholine-4-carbaldehyde 54.73
    sulfolane 36.88
    2,2,4-trimethylpentane 1.63
    2-methyltetrahydrofuran 36.81
    n-hexyl acetate 35.77
    isooctane 1.93
    2-(2-butoxyethoxy)ethanol 44.3
    sec-butyl acetate 15.26
    tert-butyl acetate 32.68
    decalin 2.26
    glycerin 3.72
    diglyme 81.3
    acrylic acid 5.54
    isopropyl myristate 14.09
    n-butyric acid 14.57
    acetyl acetate 15.29
    di(2-ethylhexyl) phthalate 15.97
    ethyl propionate 16.01
    nitromethane 11.41
    1,2-diethoxyethane 32.9
    benzonitrile 15.41
    trioctyl phosphate 12.12
    1-bromopropane 12.9
    gamma-valerolactone 74.2
    n-decanol 9.39
    triethyl phosphate 13.47
    4-methyl-2-pentanol 10.74
    propionitrile 9.1
    vinylene carbonate 19.55
    1,1,2-trichlorotrifluoroethane 23.7
    DMS 23.14
    cumene 11.01
    2-octanol 11.66
    2-hexanone 17.5
    octyl acetate 16.23
    limonene 14.8
    1,2-dimethoxyethane 37.69
    ethyl orthosilicate 15.68
    tributyl phosphate 10.78
    diacetone alcohol 27.05
    N,N-dimethylaniline 25.21
    acrylonitrile 8.14
    aniline 21.77
    1,3-propanediol 8.05
    bromobenzene 27.29
    dibromomethane 17.19
    1,1,2,2-tetrachloroethane 31.74
    2-methyl-cyclohexyl acetate 23.25
    tetrabutyl urea 16.33
    diisobutyl methanol 12.28
    2-phenylethanol 26.36
    styrene 14.37
    dioctyl adipate 19.62
    dimethyl sulfate 18.17
    ethyl butyrate 20.83
    methyl lactate 10.35
    butyl lactate 26.43
    diethyl carbonate 12.42
    propanediol butyl ether 27.24
    triethyl orthoformate 23.47
    p-tert-butyltoluene 15.31
    methyl 4-tert-butylbenzoate 44.54
    morpholine 49.59
    tert-butylamine 8.58
    n-dodecanol 5.57
    dimethoxymethane 42.91
    ethylene carbonate 16.84
    cyrene 27.15
    2-ethoxyethyl acetate 44.92
    2-ethylhexyl acetate 27.45
    1,2,4-trichlorobenzene 28.84
    4-methylpyridine 35.72
    dibutyl ether 14.62
    2,6-dimethyl-4-heptanol 12.28
    DEF 26.13
    dimethyl isosorbide 60.91
    tetrachloroethylene 21.58
    eugenol 39.52
    triacetin 34.4
    span 80 28.42
    1,4-butanediol 3.16
    1,1-dichloroethane 17.28
    2-methyl-1-pentanol 10.13
    methyl formate 5.66
    2-methyl-1-butanol 12.56
    n-decane 1.47
    butyronitrile 10.99
    3,7-dimethyl-1-octanol 13.42
    1-chlorooctane 7.72
    1-chlorotetradecane 1.95
    n-nonane 1.25
    undecane 0.78
    tert-butylcyclohexane 2.5
    cyclooctane 1.43
    cyclopentanol 12.36
    tetrahydropyran 40.46
    tert-amyl methyl ether 15.36
    2,5,8-trioxanonane 45.84
    1-hexene 6.16
    2-isopropoxyethanol 16.65
    2,2,2-trifluoroethanol 3.74
    methyl butyrate 16.77

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction