Diisopropylamine

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  • Identifiers

    CAS number
    108-18-9

    Molecular formula
    C6H15N

    SMILES
    CC(C)NC(C)C

    Safety labels

    Flammable
    Flammable

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fishy 62.67%
    Cheesy 51.12%
    Ripe 40.28%
    Meaty 26.54%
    Roasted 23.96%
    Savory 22.25%
    Sulfurous 22.18%
    Odorless 21.91%
    Mint 21.71%
    Animal 19.2%

     

    Flavor
    Fishy 36.19%
    Ammoniacal 30.7%
    Meaty 26.37%
    Sulfurous 25.88%
    Ammonia 24.43%
    Glue 22.8%
    Bloody 22.14%
    Yeasty 22.02%
    Skunky 20.52%
    Leathery 20.3%

     

    Odor impact est.
    High

    Odor threshold

    • Odor Threshold Low: 0.13 [mmHg]. Detection odor threshold from AIHA (mean = 0.13 ppm)
    • Odor threshold = 1.8 ppm

  • Properties

    XLogP3-AA
    1.4

    pKa est.
    9.16 (weak base)

    Molecular weight
    101.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -78 °F (NTP, 1992)
    • -61 °C
    • -78 °F
    • -141 °F

    Boiling point

    • 183 °F at 760 mmHg (NTP, 1992)
    • 84 °C @ 760 mm Hg
    • 84 °C
    • 183 °F

    Flash point

    • -4.08 ˚C est.
    • 30 °F (NTP, 1992)
    • -1 °C
    • 30 °F (-1 °C)(OPEN CUP)
    • -6 °C o.c.
    • 20 °F

    Solubility expt.

    • Slightly soluble (NTP, 1992)
    • Very soluble in acetone, benzene, ether, and ethanol.
    • In water, 1.1X10+5 mg/l @ 25 °C
    • Solubility in water, g/l: 10 (slightly soluble)
    • Miscible

  • Synonyms

    • DIISOPROPYLAMINE
    • 108-18-9
    • N,N-Diisopropylamine
    • N-(1-Methylethyl)-2-propanamine
    • 2-Propanamine, N-(1-methylethyl)-
    • N-propan-2-ylpropan-2-amine
    • bis(isopropyl)amine
    • N-isopropylpropan-2-amine
    • diisopropyl amine
    • N-Isopropyl-1-amino-2-methylethane
    • NSC 6758
    • CCRIS 6235
    • HSDB 931
    • Bis(Propan-2-Yl)Amine
    • UNII-BR9JLI40NO
    • BR9JLI40NO
    • EINECS 203-558-5
    • di-isopropylammonium
    • DTXSID9025085
    • AI3-15345
    • NSC-6758
    • MFCD00008862
    • 2-Propaneamine, N-(1-methylethyl)-
    • DTXCID905085
    • N-(propan-2-yl)propan-2-amine
    • EC 203-558-5
    • NCGC00091070-01
    • NCGC00091070-02
    • propane, 2-isopropylamino-
    • Diisopropylamin
    • CAS-108-18-9
    • UN1158
    • Diisoproylamine
    • diisoproplyamine
    • diisopropyiamine
    • diisopropylarnine
    • Diisoproyl amine
    • di-isopropylamine
    • diiso-propylamine
    • diisoproply amine
    • diisopropyl-amine
    • diisopropylamine-
    • di-i-propylamine
    • di(isopropyl)amine
    • di-iso-propylamine
    • di-isopropyl amine
    • Diiso propyl amine
    • di-iso-propyl amine
    • di-iso-propyl-amine
    • HNiPr2
    • iPr2NH
    • N,N-diisoproplyamine
    • i-Pr2NH
    • N, N-diisopropylamine
    • N,N-di-isopropylamine
    • N,N-diisopropyl amine
    • N,N-diisopropyl-amine
    • di(1-methylethyl)amine
    • Diisopropylamine, 99%
    • N,N,-di-isopropylamine
    • N,N-di-iso-propylamine
    • (iPr)2NH
    • HN(iPr)2
    • N-isopropyl-isopropylamine
    • (i-Pr)2NH
    • HN(i-Pr)2
    • NH(i-Pr)2
    • (iso-C3H7)2NH
    • Diisopropylamine, >=99%
    • N-isopropylpropane-2-amine
    • SCHEMBL2020
    • DIISOPROPYLAMINE [MI]
    • Diisopropylamine, >=99.5%
    • DIISOPROPYLAMINE [HSDB]
    • CHEMBL1450356
    • Diisopropylamine sulfate (2:1)
    • N-(1-Methylethyl)-2-propamine
    • SCHEMBL11097419
    • DIISOPROPYLAMINE [WHO-DD]
    • NSC6758
    • WLN: 1Y1&MY1&1
    • N-(1-methylethyl)propan-2-amine
    • Diisopropylamine, redistilled grade
    • N-(1-methylethyl)--2-propanamine
    • STR01875
    • Diisopropylamine, analytical standard
    • Tox21_111075
    • Tox21_200216
    • STL264227
    • AKOS000120153
    • Tox21_111075_1
    • UN 1158
    • NCGC00091070-03
    • NCGC00257770-01
    • BP-31036
    • D0925
    • NS00077148
    • Diisopropylamine, SAJ first grade, >=98.0%
    • Diisopropylamine [UN1158] [Flammable liquid]
    • Diisopropylamine, puriss. p.a., >=99.0% (GC)
    • Q420331
    • Diisopropylamine, purified by redistillation, 99.95%
    • InChI=1/C6H15N/c1-5(2)7-6(3)4/h5-7H,1-4H
    • 203-558-5

  • Applications

    Diisopropylamine (CAS 108-18-9) is a secondary amine broadly used in industrial organic synthesis as an intermediate and reagent. In practice, it is employed as a building block to prepare amide, urea, and carbamate derivatives for pharmaceuticals and agrochemicals; it also serves as a base and nucleophilic reagent in acylation and alkylation steps, and may be used as a solvent or processing aid in certain manufacturing processes; it can act as a precursor in the production of polymers, coatings, and inks, or as a component in surfactant-related chemistries. Its use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 282.66
    methanol 412.47
    isopropanol 192.97
    water 5.33
    ethyl acetate 202.27
    n-propanol 263.51
    acetone 206.48
    n-butanol 265.65
    acetonitrile 128.87
    DMF 166.04
    toluene 118.21
    isobutanol 187.33
    1,4-dioxane 306.72
    methyl acetate 213.05
    THF 584.64
    2-butanone 218.34
    n-pentanol 155.08
    sec-butanol 233.12
    n-hexane 249.11
    ethylene glycol 87.78
    NMP 443.17
    cyclohexane 298.87
    DMSO 164.39
    n-butyl acetate 326.68
    n-octanol 203.35
    chloroform 459.11
    n-propyl acetate 135.3
    acetic acid 322.75
    dichloromethane 317.36
    cyclohexanone 395.64
    propylene glycol 122.42
    isopropyl acetate 134.0
    DMAc 227.54
    2-ethoxyethanol 139.78
    isopentanol 175.88
    n-heptane 339.52
    ethyl formate 131.08
    1,2-dichloroethane 185.17
    n-hexanol 442.99
    2-methoxyethanol 251.1
    isobutyl acetate 109.36
    tetrachloromethane 199.71
    n-pentyl acetate 182.52
    transcutol 379.13
    n-heptanol 187.7
    ethylbenzene 65.86
    MIBK 99.13
    2-propoxyethanol 390.18
    tert-butanol 218.06
    MTBE 253.17
    2-butoxyethanol 201.3
    propionic acid 267.28
    o-xylene 97.59
    formic acid 118.69
    diethyl ether 276.27
    m-xylene 88.41
    p-xylene 96.87
    chlorobenzene 143.63
    dimethyl carbonate 53.49
    n-octane 92.31
    formamide 74.97
    cyclopentanone 401.26
    2-pentanone 171.19
    anisole 89.13
    cyclopentyl methyl ether 364.31
    gamma-butyrolactone 415.46
    1-methoxy-2-propanol 170.73
    pyridine 202.22
    3-pentanone 188.22
    furfural 250.82
    n-dodecane 52.34
    diethylene glycol 213.5
    diisopropyl ether 111.72
    tert-amyl alcohol 251.61
    acetylacetone 140.51
    n-hexadecane 56.63
    acetophenone 93.33
    methyl propionate 164.46
    isopentyl acetate 264.97
    trichloroethylene 300.11
    n-nonanol 171.69
    cyclohexanol 353.98
    benzyl alcohol 81.84
    2-ethylhexanol 306.56
    isooctanol 136.49
    dipropyl ether 361.67
    1,2-dichlorobenzene 130.1
    ethyl lactate 76.46
    propylene carbonate 237.54
    n-methylformamide 122.91
    2-pentanol 180.56
    n-pentane 187.1
    1-propoxy-2-propanol 347.39
    1-methoxy-2-propyl acetate 235.04
    2-(2-methoxypropoxy) propanol 158.17
    mesitylene 63.02
    ε-caprolactone 360.67
    p-cymene 112.86
    epichlorohydrin 256.42
    1,1,1-trichloroethane 256.92
    2-aminoethanol 144.03
    morpholine-4-carbaldehyde 271.08
    sulfolane 429.03
    2,2,4-trimethylpentane 94.93
    2-methyltetrahydrofuran 511.25
    n-hexyl acetate 275.75
    isooctane 52.35
    2-(2-butoxyethoxy)ethanol 198.38
    sec-butyl acetate 102.35
    tert-butyl acetate 154.29
    decalin 85.0
    glycerin 147.16
    diglyme 291.66
    acrylic acid 200.43
    isopropyl myristate 123.42
    n-butyric acid 295.13
    acetyl acetate 137.79
    di(2-ethylhexyl) phthalate 101.44
    ethyl propionate 122.58
    nitromethane 209.58
    1,2-diethoxyethane 214.94
    benzonitrile 98.8
    trioctyl phosphate 94.96
    1-bromopropane 221.23
    gamma-valerolactone 362.23
    n-decanol 126.35
    triethyl phosphate 107.75
    4-methyl-2-pentanol 90.99
    propionitrile 143.78
    vinylene carbonate 177.88
    1,1,2-trichlorotrifluoroethane 268.78
    DMS 139.45
    cumene 59.72
    2-octanol 140.9
    2-hexanone 144.07
    octyl acetate 158.17
    limonene 239.28
    1,2-dimethoxyethane 192.66
    ethyl orthosilicate 116.99
    tributyl phosphate 118.37
    diacetone alcohol 142.37
    N,N-dimethylaniline 75.96
    acrylonitrile 123.72
    aniline 139.62
    1,3-propanediol 174.29
    bromobenzene 138.04
    dibromomethane 293.05
    1,1,2,2-tetrachloroethane 295.99
    2-methyl-cyclohexyl acetate 205.51
    tetrabutyl urea 137.92
    diisobutyl methanol 142.66
    2-phenylethanol 149.89
    styrene 72.11
    dioctyl adipate 146.12
    dimethyl sulfate 82.93
    ethyl butyrate 201.25
    methyl lactate 92.38
    butyl lactate 150.9
    diethyl carbonate 116.4
    propanediol butyl ether 171.18
    triethyl orthoformate 180.41
    p-tert-butyltoluene 115.03
    methyl 4-tert-butylbenzoate 146.86
    morpholine 331.9
    tert-butylamine 184.9
    n-dodecanol 100.78
    dimethoxymethane 127.49
    ethylene carbonate 169.11
    cyrene 131.64
    2-ethoxyethyl acetate 178.17
    2-ethylhexyl acetate 264.5
    1,2,4-trichlorobenzene 162.56
    4-methylpyridine 194.38
    dibutyl ether 244.13
    2,6-dimethyl-4-heptanol 142.66
    DEF 191.76
    dimethyl isosorbide 265.68
    tetrachloroethylene 269.77
    eugenol 119.75
    triacetin 197.53
    span 80 205.91
    1,4-butanediol 79.68
    1,1-dichloroethane 210.36
    2-methyl-1-pentanol 131.44
    methyl formate 99.6
    2-methyl-1-butanol 206.63
    n-decane 93.75
    butyronitrile 152.64
    3,7-dimethyl-1-octanol 178.04
    1-chlorooctane 168.79
    1-chlorotetradecane 76.16
    n-nonane 111.02
    undecane 65.54
    tert-butylcyclohexane 92.88
    cyclooctane 115.35
    cyclopentanol 355.6
    tetrahydropyran 469.82
    tert-amyl methyl ether 241.35
    2,5,8-trioxanonane 211.9
    1-hexene 250.23
    2-isopropoxyethanol 113.0
    2,2,2-trifluoroethanol 123.09
    methyl butyrate 146.94

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction