cis-2-Methylcyclohexanol

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  • Identifiers

    CAS number
    7443-70-1

    Molecular formula
    C7H14O

    SMILES
    C[C@H]1CCCC[C@H]1O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Mint 54.63%
    Solvent 52.18%
    Fermented 47.54%
    Camphoreous 43.75%
    Oily 41.83%
    Musty 39.46%
    Alcoholic 34.1%
    Ethereal 33.23%
    Herbal 32.93%
    Earthy 30.9%

     

    Flavor
    Minty 34.95%
    Camphor 30.16%
    Medicinal 24.37%
    Musty 23.03%
    Beet 21.68%
    Soil 21.37%
    Phenol 21.19%
    Cauliflower 21.16%
    Herb 21.13%
    Mentholic 20.82%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    9.26 (weak base)

    Molecular weight
    114.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    172°C

    Flash point

    • 59.39 ˚C est.

  • Synonyms

    • cis-2-Methylcyclohexanol
    • 7443-70-1
    • Cyclohexanol, 2-methyl-, cis-
    • EINECS 231-187-9
    • NSC 100902
    • RefChem:126399
    • 231-187-9
    • InChI=1/C7H14O/c1-6-4-2-3-5-7(6)8/h6-8H,2-5H2,1H
    • NDVWOBYBJYUSMF-NKWVEPMBSA-N
    • (1R,2S)-2-methylcyclohexan-1-ol
    • cis-2-Methylcyclohexan-1-ol
    • (1R,2S)-2-methylcyclohexanol
    • 19043-02-8
    • 2-Methyl-cyclohexanol
    • cyclohexanol, 2-methyl-, (1R,2S)-
    • MFCD00064169
    • SCHEMBL43021
    • SCHEMBL5405664
    • SCHEMBL6188707
    • BDBM36190
    • (+/-)-cis-2-methylcyclohexanol
    • DTXSID701032695
    • rel-(1R,2S)-2-Methylcyclohexanol
    • AKOS025295691
    • SY110514
    • CS-0343026
    • D91322
    • InChI=1/C7H14O/c1-6-4-2-3-5-7(6)8/h6-8H,2-5H2,1H3/t6-,7+/m0/s
    • 7443-70-1

  • Applications

    cis-2-Methylcyclohexanol (CAS 7443-70-1) is primarily used as an intermediate in organic synthesis, serving as a chiral building block for enantioselective routes to pharmaceutical and agrochemical compounds and as a precursor to other cyclohexane derivatives. It is frequently considered in perfumery and flavor applications as a fragrance intermediate or odor-active precursor. In coatings and inks, it can act as a processing aid or formulation component, and in plastics and polymers it provides access to cyclohexanone-type intermediates used in specialty polymers. It may also be encountered as a solvent-like component or reagent in various industrial formulations, subject to regulatory and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3197.82
    methanol 2985.86
    isopropanol 2142.24
    water 2.03
    ethyl acetate 1679.53
    n-propanol 2235.28
    acetone 1405.74
    n-butanol 2191.94
    acetonitrile 1571.55
    DMF 666.66
    toluene 309.46
    isobutanol 1282.47
    1,4-dioxane 1981.93
    methyl acetate 1100.85
    THF 3125.3
    2-butanone 1177.51
    n-pentanol 1103.88
    sec-butanol 1311.91
    n-hexane 232.62
    ethylene glycol 210.16
    NMP 413.89
    cyclohexane 237.47
    DMSO 962.67
    n-butyl acetate 1972.44
    n-octanol 402.35
    chloroform 2561.75
    n-propyl acetate 879.42
    acetic acid 1261.5
    dichloromethane 1825.0
    cyclohexanone 1181.58
    propylene glycol 311.79
    isopropyl acetate 878.0
    DMAc 320.19
    2-ethoxyethanol 939.71
    isopentanol 1489.31
    n-heptane 233.75
    ethyl formate 1035.8
    1,2-dichloroethane 1022.38
    n-hexanol 1691.64
    2-methoxyethanol 1790.33
    isobutyl acetate 476.8
    tetrachloromethane 523.68
    n-pentyl acetate 651.43
    transcutol 3082.21
    n-heptanol 561.18
    ethylbenzene 128.03
    MIBK 637.18
    2-propoxyethanol 1796.48
    tert-butanol 1910.02
    MTBE 1406.37
    2-butoxyethanol 850.26
    propionic acid 1078.06
    o-xylene 159.92
    formic acid 422.7
    diethyl ether 2030.33
    m-xylene 208.95
    p-xylene 169.2
    chlorobenzene 469.24
    dimethyl carbonate 128.16
    n-octane 67.98
    formamide 507.36
    cyclopentanone 1283.79
    2-pentanone 1246.05
    anisole 305.6
    cyclopentyl methyl ether 1035.47
    gamma-butyrolactone 1323.49
    1-methoxy-2-propanol 1180.8
    pyridine 1170.42
    3-pentanone 593.85
    furfural 958.91
    n-dodecane 39.45
    diethylene glycol 778.77
    diisopropyl ether 494.54
    tert-amyl alcohol 1035.99
    acetylacetone 712.73
    n-hexadecane 43.3
    acetophenone 228.22
    methyl propionate 721.42
    isopentyl acetate 1251.11
    trichloroethylene 1598.29
    n-nonanol 347.89
    cyclohexanol 904.24
    benzyl alcohol 270.36
    2-ethylhexanol 850.56
    isooctanol 429.42
    dipropyl ether 1236.16
    1,2-dichlorobenzene 340.51
    ethyl lactate 216.96
    propylene carbonate 742.96
    n-methylformamide 861.04
    2-pentanol 1199.74
    n-pentane 272.66
    1-propoxy-2-propanol 1465.53
    1-methoxy-2-propyl acetate 862.99
    2-(2-methoxypropoxy) propanol 423.04
    mesitylene 140.02
    ε-caprolactone 1068.63
    p-cymene 164.48
    epichlorohydrin 1500.7
    1,1,1-trichloroethane 1042.4
    2-aminoethanol 693.56
    morpholine-4-carbaldehyde 729.6
    sulfolane 781.75
    2,2,4-trimethylpentane 92.34
    2-methyltetrahydrofuran 1880.38
    n-hexyl acetate 647.2
    isooctane 117.3
    2-(2-butoxyethoxy)ethanol 819.54
    sec-butyl acetate 479.16
    tert-butyl acetate 755.14
    decalin 75.27
    glycerin 355.99
    diglyme 1307.37
    acrylic acid 598.93
    isopropyl myristate 206.74
    n-butyric acid 2272.07
    acetyl acetate 541.17
    di(2-ethylhexyl) phthalate 151.98
    ethyl propionate 527.39
    nitromethane 1514.57
    1,2-diethoxyethane 1692.51
    benzonitrile 556.23
    trioctyl phosphate 137.04
    1-bromopropane 973.19
    gamma-valerolactone 1455.04
    n-decanol 251.44
    triethyl phosphate 183.77
    4-methyl-2-pentanol 580.34
    propionitrile 1376.56
    vinylene carbonate 613.32
    1,1,2-trichlorotrifluoroethane 688.67
    DMS 255.22
    cumene 101.45
    2-octanol 320.04
    2-hexanone 810.08
    octyl acetate 253.37
    limonene 283.1
    1,2-dimethoxyethane 1488.87
    ethyl orthosilicate 217.39
    tributyl phosphate 184.33
    diacetone alcohol 634.84
    N,N-dimethylaniline 154.25
    acrylonitrile 1129.54
    aniline 518.93
    1,3-propanediol 1147.77
    bromobenzene 426.33
    dibromomethane 1364.48
    1,1,2,2-tetrachloroethane 1133.07
    2-methyl-cyclohexyl acetate 364.93
    tetrabutyl urea 179.11
    diisobutyl methanol 442.55
    2-phenylethanol 471.99
    styrene 173.6
    dioctyl adipate 224.54
    dimethyl sulfate 133.06
    ethyl butyrate 954.14
    methyl lactate 233.61
    butyl lactate 400.47
    diethyl carbonate 429.87
    propanediol butyl ether 510.39
    triethyl orthoformate 529.34
    p-tert-butyltoluene 152.44
    methyl 4-tert-butylbenzoate 226.88
    morpholine 2305.03
    tert-butylamine 1446.49
    n-dodecanol 186.47
    dimethoxymethane 757.24
    ethylene carbonate 619.51
    cyrene 206.9
    2-ethoxyethyl acetate 682.03
    2-ethylhexyl acetate 866.81
    1,2,4-trichlorobenzene 340.36
    4-methylpyridine 935.87
    dibutyl ether 719.79
    2,6-dimethyl-4-heptanol 442.55
    DEF 774.88
    dimethyl isosorbide 555.87
    tetrachloroethylene 912.66
    eugenol 249.48
    triacetin 325.26
    span 80 420.02
    1,4-butanediol 328.17
    1,1-dichloroethane 1341.87
    2-methyl-1-pentanol 761.38
    methyl formate 465.71
    2-methyl-1-butanol 1136.33
    n-decane 76.96
    butyronitrile 1888.11
    3,7-dimethyl-1-octanol 447.17
    1-chlorooctane 247.17
    1-chlorotetradecane 80.95
    n-nonane 79.32
    undecane 52.79
    tert-butylcyclohexane 85.83
    cyclooctane 79.04
    cyclopentanol 959.35
    tetrahydropyran 2248.78
    tert-amyl methyl ether 691.3
    2,5,8-trioxanonane 695.98
    1-hexene 709.5
    2-isopropoxyethanol 621.52
    2,2,2-trifluoroethanol 280.28
    methyl butyrate 771.0

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction