Chloromethyl Methyl Ether

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  • Identifiers

    CAS number
    107-30-2

    Molecular formula
    C2H5ClO

    SMILES
    COCCl

    Safety labels

    Flammable
    Flammable

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Ethereal 80.29%
    Alcoholic 62.31%
    Fruity 55.21%
    Sweet 51.95%
    Fermented 46.78%
    Solvent 42.3%
    Rummy 37.63%
    Winey 37.62%
    Cognac 35.6%
    Pungent 34.44%

     

    Flavor
    Sulfurous 42.33%
    Sweet 40.96%
    Alcoholic 39.88%
    Vegetable 38.56%
    Onion 33.3%
    Musty 29.71%
    Potato 29.31%
    Coffee 26.89%
    Fishy 25.74%
    Bitter 25.55%

     

    Odor impact est.
    High

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    5.41 (weak acid)

    Molecular weight
    80.51 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra fast

    Melting point expt.

    • -154.3 °F (EPA, 1998)
    • -103.5 °C
    • -104 °C
    • -154 °F

    Boiling point

    • 138 °F at 760 mmHg (EPA, 1998)
    • 59.5 °C
    • 59.00 to 60.00 °C. @ 760.00 mm Hg
    • 59 °C
    • 138 °F

    Flash point

    • -1.75 ˚C est.
    • 32 °F (EPA, 1998)
    • 0 °C
    • 0 °C (open cup).
    • -8 °C c.c.
    • 32 °F (open cup)
    • (oc) 32 °F

    Solubility expt.

    • Reacts with water (NIOSH, 2024)
    • MISCIBLE WITH ETHANOL & ETHER & MANY OTHER ORG SOLVENTS
    • SOL IN ACETONE, CHLOROFORM, ETHYL ETHER, ETHYL ALCOHOL
    • Soluble in oxygenated solvents
    • Solubility in water: decomposes
    • Reacts

  • Synonyms

    • CHLOROMETHYL METHYL ETHER
    • 107-30-2
    • chloro(methoxy)methane
    • Methane, chloromethoxy-
    • Methoxymethyl chloride
    • Chloromethoxymethane
    • Chlorodimethyl ether
    • Methyl chloromethyl ether
    • Methoxychloromethane
    • CMME
    • Ether, chloromethyl methyl
    • Chlordimethylether
    • Dimethylchloroether
    • Ether, dimethyl chloro
    • Monochlorodimethyl ether
    • Methylchloromethyl ether
    • Monochloromethyl methyl ether
    • Ether methylique monochlore
    • alpha,alpha-Dichlorodimethyl ether
    • CH3OCH2Cl
    • MOM chloride
    • Chlormethyl methyl ether
    • RCRA waste number U046
    • CCRIS 138
    • NSC 21208
    • HSDB 908
    • Chloromethyl methyl ether (CMME)
    • Chloromethyl methyl ether (technical grade)
    • EINECS 203-480-1
    • UN1239
    • chloro-methoxymethane
    • UNII-334G5B96VG
    • BRN 0505943
    • Chloromethoxy-Methane
    • Chloromethylmethylether
    • DTXSID6020307
    • Chloromethyl methyl ether, technical grade
    • 334G5B96VG
    • Methyl chloromethyl ether, anhydrous
    • NSC-21208
    • DTXCID40307
    • CHEBI:82271
    • 4-01-00-03046 (Beilstein Handbook Reference)
    • Chloromethyl Methyl Ether (>85%)
    • NSC21208
    • NSC93873
    • CHLOROMETHYL METHYL ETHER [MI]
    • UN 1239
    • CHLOROMETHYL METHYL ETHER [HSDB]
    • Methyl chloromethyl ether, anhydrous(dot)
    • WLN: G1O1
    • Chlordimethylether [Czech]
    • .alpha.,.alpha.-Dichlorodimethyl ether
    • CAS-107-30-2
    • methoxymethylchloride
    • MOM-Cl
    • CHLOROMETHYL METHYL ETHER, (ANHYDROUS)
    • CHLOROMETHYL METHYL ETHER, [ANHYDROUS]
    • Ether methylique monochlore [French]
    • RCRA waste no. U046
    • chlorodimethylether
    • MOMCl
    • Dimethylchloro ether
    • chloromethoxy methane
    • MFCD00000885
    • methoxy methylchloride
    • chloro-methoxy-methane
    • chloromethyl methyl methoxychloromethane
    • chloromethymethyl ether
    • methane, chloromethoxy
    • methoxy methyl chloride
    • chloromethyl methylether
    • chloromethyl-methylether
    • chloromethylmethyl ether
    • methyloxymethyl chloride
    • chloro (methoxy)methane
    • chloro(methoxy) methane
    • ClCH2OCH3
    • chloro(methyloxy)methane
    • methyl choromethyl ether
    • (chloromethyl)methylether
    • chloromethyl-methyl ether
    • chloromethyl-methyl-ether
    • chloromethylm ethyl ether
    • chloro (methoxy) methane
    • (chloromethyl)methyl ether
    • chloromethyl (methyl)ether
    • DIMETHYL-CHLOROETHER
    • Methyl chloromethyl ether [UN1239] [Poison]
    • (chloromethyl) methyl ether
    • 1-Chloro-1-methoxy-methane
    • ETHER DIMETHYL CHLORO
    • alpha,alphaDichlorodimethyl ether
    • CHEMBL3185256
    • CHLORODIMETHYLETHER (CZECH)
    • BCP08223
    • Tox21_201575
    • Tox21_302939
    • NSC-93873
    • AKOS000121040
    • GS-5886
    • Chloromethyl methyl ether (ACGIH:OSHA)
    • NCGC00249073-01
    • NCGC00256384-01
    • NCGC00259124-01
    • Chloromethyl Methyl Ether, > 90per cent
    • METHYLCHLOROMETHYL ETHER, ANHYDROUS
    • DB-002671
    • NS00020923
    • C19160
    • Methyl chloromethyl ether [UN1239] [Poison]
    • METHYLCHLOROMETHYL ETHER, ANHYDROUS (DOT)
    • Q158539
    • F8881-7077
    • 203-480-1

  • Applications

    Chloromethyl methyl ether (CAS 107-30-2) is primarily used as a chloromethylating agent in chemical synthesis, enabling the introduction of chloromethyl groups into substrates such as phenols and other arenes to afford chloromethylated intermediates. In industry, it typically serves as a building block for chloromethylated derivatives used in polymers and plastics, coatings and adhesives, electronics and other advanced materials, and industrial manufacturing of specialty chemicals. Due to its toxicity and handling risks, its use is tightly controlled and subject to local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 938.15
    methanol 1116.36
    isopropanol 649.33
    water 115.4
    ethyl acetate 281.98
    n-propanol 566.19
    acetone 744.95
    n-butanol 453.59
    acetonitrile 604.45
    DMF 1286.75
    toluene 74.36
    isobutanol 360.24
    1,4-dioxane 603.35
    methyl acetate 428.8
    THF 633.22
    2-butanone 404.35
    n-pentanol 202.01
    sec-butanol 441.06
    n-hexane 16.91
    ethylene glycol 532.4
    NMP 793.84
    cyclohexane 58.92
    DMSO 1068.47
    n-butyl acetate 164.94
    n-octanol 89.99
    chloroform 789.8
    n-propyl acetate 150.58
    acetic acid 2313.61
    dichloromethane 641.9
    cyclohexanone 411.6
    propylene glycol 448.46
    isopropyl acetate 138.74
    DMAc 790.82
    2-ethoxyethanol 473.58
    isopentanol 264.61
    n-heptane 35.48
    ethyl formate 271.88
    1,2-dichloroethane 361.49
    n-hexanol 185.93
    2-methoxyethanol 1000.94
    isobutyl acetate 85.82
    tetrachloromethane 237.11
    n-pentyl acetate 93.41
    transcutol 735.87
    n-heptanol 103.21
    ethylbenzene 34.6
    MIBK 124.51
    2-propoxyethanol 364.58
    tert-butanol 654.43
    MTBE 231.06
    2-butoxyethanol 239.66
    propionic acid 651.17
    o-xylene 75.05
    formic acid 1228.25
    diethyl ether 240.07
    m-xylene 56.45
    p-xylene 59.74
    chlorobenzene 139.16
    dimethyl carbonate 122.14
    n-octane 10.14
    formamide 1246.36
    cyclopentanone 514.25
    2-pentanone 273.15
    anisole 140.29
    cyclopentyl methyl ether 272.06
    gamma-butyrolactone 544.0
    1-methoxy-2-propanol 576.05
    pyridine 479.4
    3-pentanone 215.38
    furfural 595.35
    n-dodecane 7.4
    diethylene glycol 401.48
    diisopropyl ether 53.87
    tert-amyl alcohol 432.08
    acetylacetone 292.98
    n-hexadecane 8.14
    acetophenone 150.36
    methyl propionate 270.34
    isopentyl acetate 126.32
    trichloroethylene 836.69
    n-nonanol 78.41
    cyclohexanol 408.49
    benzyl alcohol 169.3
    2-ethylhexanol 110.38
    isooctanol 78.96
    dipropyl ether 143.42
    1,2-dichlorobenzene 136.46
    ethyl lactate 117.31
    propylene carbonate 261.92
    n-methylformamide 786.99
    2-pentanol 267.33
    n-pentane 34.84
    1-propoxy-2-propanol 278.73
    1-methoxy-2-propyl acetate 172.92
    2-(2-methoxypropoxy) propanol 189.97
    mesitylene 39.44
    ε-caprolactone 323.19
    p-cymene 52.31
    epichlorohydrin 533.16
    1,1,1-trichloroethane 434.6
    2-aminoethanol 710.59
    morpholine-4-carbaldehyde 753.72
    sulfolane 612.72
    2,2,4-trimethylpentane 19.42
    2-methyltetrahydrofuran 435.95
    n-hexyl acetate 118.67
    isooctane 12.25
    2-(2-butoxyethoxy)ethanol 243.01
    sec-butyl acetate 86.69
    tert-butyl acetate 150.68
    decalin 15.52
    glycerin 615.71
    diglyme 501.41
    acrylic acid 748.79
    isopropyl myristate 47.93
    n-butyric acid 597.03
    acetyl acetate 205.07
    di(2-ethylhexyl) phthalate 58.15
    ethyl propionate 120.59
    nitromethane 1657.12
    1,2-diethoxyethane 181.05
    benzonitrile 184.33
    trioctyl phosphate 41.88
    1-bromopropane 188.94
    gamma-valerolactone 607.08
    n-decanol 55.92
    triethyl phosphate 75.91
    4-methyl-2-pentanol 100.9
    propionitrile 323.78
    vinylene carbonate 263.59
    1,1,2-trichlorotrifluoroethane 833.55
    DMS 104.12
    cumene 32.63
    2-octanol 61.86
    2-hexanone 140.58
    octyl acetate 68.42
    limonene 94.88
    1,2-dimethoxyethane 474.36
    ethyl orthosilicate 75.99
    tributyl phosphate 50.29
    diacetone alcohol 289.18
    N,N-dimethylaniline 111.32
    acrylonitrile 490.95
    aniline 250.28
    1,3-propanediol 707.14
    bromobenzene 109.1
    dibromomethane 404.34
    1,1,2,2-tetrachloroethane 602.04
    2-methyl-cyclohexyl acetate 104.49
    tetrabutyl urea 75.41
    diisobutyl methanol 68.23
    2-phenylethanol 143.5
    styrene 50.57
    dioctyl adipate 86.28
    dimethyl sulfate 224.69
    ethyl butyrate 140.59
    methyl lactate 212.14
    butyl lactate 101.24
    diethyl carbonate 92.1
    propanediol butyl ether 209.06
    triethyl orthoformate 101.98
    p-tert-butyltoluene 53.83
    methyl 4-tert-butylbenzoate 152.01
    morpholine 831.43
    tert-butylamine 340.37
    n-dodecanol 43.08
    dimethoxymethane 406.72
    ethylene carbonate 195.02
    cyrene 185.1
    2-ethoxyethyl acetate 139.79
    2-ethylhexyl acetate 97.57
    1,2,4-trichlorobenzene 196.14
    4-methylpyridine 326.91
    dibutyl ether 76.49
    2,6-dimethyl-4-heptanol 68.23
    DEF 426.89
    dimethyl isosorbide 251.69
    tetrachloroethylene 537.33
    eugenol 154.38
    triacetin 157.87
    span 80 185.02
    1,4-butanediol 243.26
    1,1-dichloroethane 398.21
    2-methyl-1-pentanol 146.17
    methyl formate 504.59
    2-methyl-1-butanol 289.59
    n-decane 12.43
    butyronitrile 272.59
    3,7-dimethyl-1-octanol 83.46
    1-chlorooctane 46.44
    1-chlorotetradecane 18.59
    n-nonane 12.36
    undecane 9.03
    tert-butylcyclohexane 16.19
    cyclooctane 16.11
    cyclopentanol 500.02
    tetrahydropyran 442.55
    tert-amyl methyl ether 177.8
    2,5,8-trioxanonane 327.45
    1-hexene 53.66
    2-isopropoxyethanol 268.85
    2,2,2-trifluoroethanol 836.9
    methyl butyrate 182.91

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction