Butabarbital Sodium

Overview IFRA Request a quote

  • Identifiers

    CAS number
    143-81-7

    Molecular formula
    C10H15N2NaO3

    SMILES
    CCC(C)C1(C(=O)NC(=NC1=O)[O-])CC.[Na+]

    Safety labels

    Acute Toxic
    Acute Toxic

  • Odor profile

    Fragrance
    Odorless 41.19%
    Mint 35.38%
    Cooling 31.94%
    Herbal 31.91%
    Spicy 27.85%
    Woody 19.04%
    Nutty 17.16%
    Roasted 16.15%
    Camphoreous 15.85%
    Warm 15.72%

     

    Flavor
    Bitter 58.64%
    Cedarleaf 21.33%
    Odorless 20.38%
    Lovage 19.5%
    Leaves 19.22%
    Basil 19.2%
    Carrot 18.91%
    Green pepper 18.77%
    Ripe apricot 18.66%
    Parsley 18.53%

     

    Odor impact est.
    Medium

  • Properties

    pKa est.
    7.76 (neutral)

    Molecular weight
    234.23 g/mol

    Flash point

    • 113.3 ˚C est.

  • Synonyms

    • BUTABARBITAL SODIUM
    • Carrbutabarb
    • Asturidon
    • Barbitab
    • Bubartal
    • Butasaron
    • Cambrised
    • Expansatol
    • Intasedol
    • Noctinal
    • Prelital
    • Butased
    • Butazem
    • Ciprial
    • Insolat
    • Neravan
    • Quiebar
    • Butak
    • Butatal sodium
    • Bubartal TT
    • Butabarpal sodium
    • Seda-Bute
    • Butabarbitone sodium
    • Sodium butobarbitone
    • Butabarb
    • Butalan
    • Buticaps
    • Loubarb
    • Mebutal
    • Sarisol No. 1
    • Secbutabarbital sodique
    • Secbutobarbitone sodium
    • Sodium butabarbital
    • SARISOL NO. 2
    • Sarisol
    • Butisol sodium
    • DEA No. 2100
    • Secbubarbital sodium
    • EINECS 205-611-8
    • NSC 11778
    • Sodium 5-ethyl-5-sec-butylbarbiturate
    • UNII-9WTD50I918
    • 143-81-7
    • Sodium 5-ethyl-5-(1-methylpropyl)barbiturate
    • Sodium 5-sec-butyl-5-ethylbarbiturate
    • 5-sec-Butyl-5-ethylbarbituric acid sodium salt
    • Butabarbital sodium (USP)
    • Butabarbital sodium [USP]
    • Sodium 5-(sec-butyl)-5-ethylbarbiturate
    • 5-Ethyl-5-(1-methylpropyl)barbituric acid sodium salt
    • 9WTD50I918
    • 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-5-(1-methylpropyl)-, monosodium salt
    • Barbituric acid, 5-sec-butyl-5-ethyl-, sodium salt
    • Butibel
    • DTXSID70874119
    • NSC-11778
    • SECBUTABARBITAL SODIUM (MART.)
    • BUTABARBITAL SODIUM (USP MONOGRAPH)
    • Butabarb (TN)
    • Butisol sodium (TN)
    • 2,4,6(1H,3H,5H)-PYRIMIDINETRIONE, 5-ETHYL-5-(1-METHYLPROPYL)-, SODIUM SALT (1:1)
    • Secbutabarbital sodium (INN)
    • SCHEMBL122121
    • CHEBI:3229
    • DTXCID601012252
    • NS00079446
    • D00699
    • Q27273326
    • sodium;5-butan-2-yl-5-ethyl-4,6-dioxo-1H-pyrimidin-2-olate
    • 205-611-8

  • Applications

    Butabarbital Sodium (CAS 143-81-7) is a barbiturate used in pharmaceutical formulations as a sedative and hypnotic. In practice it is employed for short-term treatment of insomnia and for preoperative sedation in select clinical settings; it may appear in oral dosage forms or solutions as part of legacy sedative regimens. Use is strictly controlled and subject to local regulations and formulation limits, and it may also be encountered in pharmacological research and development contexts as a reference compound or in formulation studies.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 20.22
    methanol 30.62
    isopropanol 11.01
    water 0.35
    ethyl acetate 35.01
    n-propanol 15.25
    acetone 55.4
    n-butanol 13.41
    acetonitrile 23.25
    DMF 149.35
    toluene 22.48
    isobutanol 10.29
    1,4-dioxane 38.04
    methyl acetate 37.52
    THF 170.99
    2-butanone 58.11
    n-pentanol 8.98
    sec-butanol 11.88
    n-hexane 0.59
    ethylene glycol 14.26
    NMP 404.85
    cyclohexane 0.99
    DMSO 368.68
    n-butyl acetate 23.99
    n-octanol 2.5
    chloroform 106.91
    n-propyl acetate 15.11
    acetic acid 51.24
    dichloromethane 146.01
    cyclohexanone 100.3
    propylene glycol 16.05
    isopropyl acetate 20.12
    DMAc 132.24
    2-ethoxyethanol 30.29
    isopentanol 12.32
    n-heptane 0.33
    ethyl formate 26.76
    1,2-dichloroethane 99.58
    n-hexanol 11.34
    2-methoxyethanol 73.39
    isobutyl acetate 7.99
    tetrachloromethane 11.81
    n-pentyl acetate 13.81
    transcutol 59.86
    n-heptanol 4.67
    ethylbenzene 8.98
    MIBK 22.64
    2-propoxyethanol 47.27
    tert-butanol 13.02
    MTBE 8.8
    2-butoxyethanol 19.8
    propionic acid 34.09
    o-xylene 14.01
    formic acid 45.64
    diethyl ether 11.26
    m-xylene 14.34
    p-xylene 10.3
    chlorobenzene 48.37
    dimethyl carbonate 33.61
    n-octane 0.11
    formamide 77.51
    cyclopentanone 196.95
    2-pentanone 43.97
    anisole 23.88
    cyclopentyl methyl ether 43.12
    gamma-butyrolactone 230.99
    1-methoxy-2-propanol 51.7
    pyridine 85.04
    3-pentanone 33.92
    furfural 215.64
    n-dodecane 0.08
    diethylene glycol 51.1
    diisopropyl ether 2.88
    tert-amyl alcohol 14.72
    acetylacetone 67.38
    n-hexadecane 0.1
    acetophenone 37.97
    methyl propionate 46.4
    isopentyl acetate 21.48
    trichloroethylene 270.48
    n-nonanol 2.48
    cyclohexanol 16.23
    benzyl alcohol 27.21
    2-ethylhexanol 6.47
    isooctanol 3.73
    dipropyl ether 5.27
    1,2-dichlorobenzene 50.23
    ethyl lactate 16.77
    propylene carbonate 90.18
    n-methylformamide 79.71
    2-pentanol 8.47
    n-pentane 0.56
    1-propoxy-2-propanol 26.73
    1-methoxy-2-propyl acetate 42.47
    2-(2-methoxypropoxy) propanol 25.09
    mesitylene 6.78
    ε-caprolactone 83.92
    p-cymene 5.46
    epichlorohydrin 265.16
    1,1,1-trichloroethane 60.39
    2-aminoethanol 20.87
    morpholine-4-carbaldehyde 157.69
    sulfolane 506.53
    2,2,4-trimethylpentane 0.51
    2-methyltetrahydrofuran 81.06
    n-hexyl acetate 14.85
    isooctane 0.32
    2-(2-butoxyethoxy)ethanol 25.21
    sec-butyl acetate 11.17
    tert-butyl acetate 24.99
    decalin 0.91
    glycerin 38.28
    diglyme 52.45
    acrylic acid 50.83
    isopropyl myristate 4.08
    n-butyric acid 36.68
    acetyl acetate 27.0
    di(2-ethylhexyl) phthalate 11.88
    ethyl propionate 19.22
    nitromethane 129.92
    1,2-diethoxyethane 10.85
    benzonitrile 31.69
    trioctyl phosphate 6.65
    1-bromopropane 24.69
    gamma-valerolactone 221.45
    n-decanol 1.7
    triethyl phosphate 13.36
    4-methyl-2-pentanol 5.64
    propionitrile 18.24
    vinylene carbonate 76.63
    1,1,2-trichlorotrifluoroethane 171.04
    DMS 33.51
    cumene 5.45
    2-octanol 2.53
    2-hexanone 20.29
    octyl acetate 6.83
    limonene 7.13
    1,2-dimethoxyethane 41.41
    ethyl orthosilicate 9.86
    tributyl phosphate 9.11
    diacetone alcohol 49.37
    N,N-dimethylaniline 16.25
    acrylonitrile 40.43
    aniline 38.71
    1,3-propanediol 28.46
    bromobenzene 48.25
    dibromomethane 72.91
    1,1,2,2-tetrachloroethane 160.45
    2-methyl-cyclohexyl acetate 18.58
    tetrabutyl urea 13.4
    diisobutyl methanol 3.55
    2-phenylethanol 28.32
    styrene 10.63
    dioctyl adipate 10.53
    dimethyl sulfate 123.98
    ethyl butyrate 16.33
    methyl lactate 42.15
    butyl lactate 18.12
    diethyl carbonate 12.34
    propanediol butyl ether 18.66
    triethyl orthoformate 10.7
    p-tert-butyltoluene 5.1
    methyl 4-tert-butylbenzoate 28.16
    morpholine 65.14
    tert-butylamine 5.27
    n-dodecanol 1.13
    dimethoxymethane 58.99
    ethylene carbonate 46.62
    cyrene 55.21
    2-ethoxyethyl acetate 28.18
    2-ethylhexyl acetate 16.31
    1,2,4-trichlorobenzene 77.05
    4-methylpyridine 80.96
    dibutyl ether 2.2
    2,6-dimethyl-4-heptanol 3.55
    DEF 54.66
    dimethyl isosorbide 80.06
    tetrachloroethylene 84.83
    eugenol 31.87
    triacetin 21.76
    span 80 19.25
    1,4-butanediol 9.84
    1,1-dichloroethane 54.47
    2-methyl-1-pentanol 10.43
    methyl formate 62.33
    2-methyl-1-butanol 12.51
    n-decane 0.14
    butyronitrile 16.52
    3,7-dimethyl-1-octanol 3.52
    1-chlorooctane 1.61
    1-chlorotetradecane 0.55
    n-nonane 0.12
    undecane 0.1
    tert-butylcyclohexane 0.7
    cyclooctane 0.38
    cyclopentanol 29.21
    tetrahydropyran 33.86
    tert-amyl methyl ether 11.35
    2,5,8-trioxanonane 36.59
    1-hexene 3.06
    2-isopropoxyethanol 16.69
    2,2,2-trifluoroethanol 37.79
    methyl butyrate 24.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction