Azadirachtin

Overview IFRA Request a quote

  • Identifiers

    CAS number
    11141-17-6

    Molecular formula
    C35H44O16

    SMILES
    C/C=C(\C)/C(=O)O[C@H]1C[C@H]([C@]2(CO[C@@H]3[C@@H]2[C@]14CO[C@@]([C@H]4[C@]([C@@H]3O)(C)[C@@]56[C@@H]7C[C@H]([C@@]5(O6)C)[C@]8(C=CO[C@H]8O7)O)(C(=O)OC)O)C(=O)OC)OC(=O)C

    Safety labels

    Irritant
    Irritant

    Environmental Hazard
    Environmental

  • Odor profile

    Fragrance
    Odorless 58.41%
    Sweet 21.23%
    Mint 20.95%
    Cooling 20.29%
    Milky 17.36%
    Roasted 17.35%
    Woody 17.14%
    Lactonic 16.78%
    Nutty 16.68%
    Fresh 16.64%

     

    Flavor
    Bitter 91.87%
    Bland 25.98%
    Sweet-like 22.81%
    Cedarleaf 21.32%
    Odorless 20.75%
    Parsley 19.56%
    Ripe apricot 19.37%
    Broom 18.94%
    Heather 18.86%
    Red fruit 18.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.6

    pKa est.
    3.14 (weak acid)

    Molecular weight
    720.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately fast

    Boiling point est.
    769°C

    Melting point expt.

    • 154-158 °C

    Flash point

    • 184.57 ˚C est.
    • Flash point > 58 °C
    • >137 °F (Closed cup)

    Solubility expt.

    • Readily soluble in ethanol, diethyl ether, acetone, and chloroform. Insoluble in hexane.
    • In water, 0.26 g/L at 25 °C

  • Synonyms

    • azadirachtin
    • 11141-17-6
    • Azadirachtin A
    • Nimbicidine
    • NeemAzal
    • bioneem
    • Nimurin
    • Ornazin
    • Azatin
    • Suneem
    • Superneem
    • Ecozin
    • Gronim
    • Oikos
    • Safer BioNEEM
    • O4U1SAF85H
    • BIOSAL
    • CHEBI:2942
    • DTXSID0037497
    • NSC-368675
    • azadyrachtin
    • 1H,7H-Naphtho(1,8-bc:4,4a-c')difuran-5,10a(8H)-dicarboxylic acid, 10-(acetyloxy)octahydro-3,5-dihydroxy-4-methyl-8-(((2E)-2-methyl-1-oxo-2-butenyl)oxy)-4-((1aR,2S,3aS,6aS,7S,7aS)-3a,6a,7,7a-tetrahydro-6a-hydroxy-7a-methyl-2,7-methanofuro(2,3-b)oxireno(e)oxepin-1a(2H)-yl)-, dimethyl ester, (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-
    • dimethyl (1S,4S,5R,6S,7S,8R,11S,12R,14S,15R)-12-acetyloxy-4,7-dihydroxy-6-[(1S,2S,6S,8S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.02,6.09,11]dodec-3-en-9-yl]-6-methyl-14-[(E)-2-methylbut-2-enoyl]oxy-3,9-dioxatetracyclo[6.6.1.01,5.011,15]pentadecane-4,11-dicarboxylate
    • dimethyl (1S,4S,5R,6S,7S,8R,11S,12R,14S,15R)-12-acetyloxy-4,7-dihydroxy-6-((1S,2S,6S,8S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo(6.3.1.02,6.09,11)dodec-3-en-9-yl)-6-methyl-14-((E)-2-methylbut-2-enoyl)oxy-3,9-dioxatetracyclo(6.6.1.01,5.011,15)pentadecane-4,11-dicarboxylate
    • RefChem:560444
    • DTXCID8017497
    • CHEBI:38473
    • 601-089-4
    • AZADIRACTIN
    • C35H44O16
    • Azadirachtin-A
    • Align
    • HSDB 7372
    • dimethyl acetoxy-dihydroxy-[hydroxy(methyl)[?]yl]-methyl-[(E)-2-methylbut-2-enoyl]oxy-[?]dicarboxylate
    • NSC 368675
    • Azadirachtin (Standard)
    • Azadirachtin 100 microg/mL in Acetonitrile
    • AZADIRACHTIN [MI]
    • UNII-O4U1SAF85H
    • SCHEMBL27784
    • CCRIS 9142
    • CHEMBL509309
    • orb1297455
    • orb3025898
    • GLXC-23432
    • MSK20401
    • BDBM50634024
    • AKOS040760284
    • EBC-615467
    • HY-126741R
    • LMPR0106100001
    • NCGC00163746-01
    • DA-50844
    • MS-31232
    • HY-126741
    • CS-0107060
    • C08748
    • Q793471
    • 176087-49-3
    • 1H,7H-Naphtho[1,8-bc:4,4a-c']difuran-5,10a(8H)-dicarboxylic acid, 10-(acetyloxy)octahydro-3,5-dihydroxy-4-methyl-8-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]oxy]-4-[(1aR,2S,3aS,6aS,7S,7aS)-3a,6a,7,7a-tetrahydro-6a-hydroxy-7a-methyl-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-, 5,10a-dimethyl ester, (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-
    • 4,11-dimethyl (1S,4S,5R,6S,7S,8R,11S,12R,14S,15R)-12-(acetyloxy)-4,7-dihydroxy-6-[(1S,2S,6S,8S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.0^{2,6}.0^{9,11}]dodec-3-en-9-yl]-6-methyl-14-{[(2E)-2-methylbut-2-enoyl]oxy}-3,9-dioxatetracyclo[6.6.1.0^{1,5}.0^{11,15}]pentadecane-4,11-dicarboxylate
    • dimethyl (1S,4S,5R,6S,7S,8R,11S,12R,14S,15R)-12-acetoxy-4,7-dihydroxy-6-[(1S,2S,6S,8S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.02,6.09,11]dodec-3-en-9-yl]-6-methyl-14-[(E)-2-methylbut-2-enoyl]oxy-3,9-dioxatetracyclo[6.6.1.01,5.011,15]pentadecane-4,11-dicarboxylate
    • Dimethyl (1S,4S,5R,6S,7S,8R,11S,12R,14S,15R)-12-acetyloxy-4,7-dihydroxy-6-[(1S,2S,6S,9R,11S)-2-hydroxy-11-methyl-5,7,10-trioxatetracyclo[6.3.1.02,6.09,11]dodec-3-en-9-yl]-6-methyl-14-[(E)-2-methylbut-2-enoyl]oxy-3,9-dioxatetracyclo[6.6.1.01,5.011,15]pentadecane-4,11-dicarboxylate
    • Dimethyl (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-10-(acetyloxy)-3,5-dihydroxy-4-[(1aR,2S,3aS,6aS,7S,7aS)-6a-hydroxy-7a-methyl-3a,6a,7,7a-tetrahydro-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H,7H-naphtho[1,8a-c:4,5-b'c']difuran-5,10a(8H)-dicarboxylate
    • dimethyl (2aR,3S,4S,4aR,5S,7aS,8S,10R,10aS,10bR)-10-acetoxy-3,5-dihydroxy-4-[(1aR,2S,3aS,6aS,7S,7aS)-6a-hydroxy-7a-methyl-3a,6a,7,7a-tetrahydro-2,7-methanofuro[2,3-b]oxireno[e]oxepin-1a(2H)-yl]-4-methyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}octahydro-1H-naphtho[1,8a-c:4,5-b'c']difuran-5,10a(8H)-dicarboxylate
    • 11141-17-6

  • Applications

    Azadirachtin (CAS 11141-17-6) is a botanical insecticide derived from Azadirachta indica (neem). It is primarily used as an active ingredient in biopesticide formulations for pest management, acting as an insect growth regulator and antifeedant. Real-world applications include crop protection in field agriculture and greenhouse/ornamental horticulture, where it helps suppress pests such as aphids, whiteflies, and thrips; use in home/garden pest control products for residential or small-scale applications; protection of stored products against insects in post-harvest storage; and integration into pest management programs (IPM) to reduce reliance on conventional synthetic insecticides. All uses are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 8.8
    methanol 55.02
    isopropanol 2.57
    water 0.43
    ethyl acetate 12.57
    n-propanol 5.63
    acetone 38.29
    n-butanol 2.59
    acetonitrile 21.83
    DMF 227.53
    toluene 2.47
    isobutanol 2.35
    1,4-dioxane 28.36
    methyl acetate 24.61
    THF 42.0
    2-butanone 18.23
    n-pentanol 2.35
    sec-butanol 1.9
    n-hexane 0.07
    ethylene glycol 18.88
    NMP 238.26
    cyclohexane 0.1
    DMSO 147.64
    n-butyl acetate 4.58
    n-octanol 1.24
    chloroform 25.41
    n-propyl acetate 7.38
    acetic acid 140.81
    dichloromethane 30.25
    cyclohexanone 22.65
    propylene glycol 13.9
    isopropyl acetate 5.09
    DMAc 142.25
    2-ethoxyethanol 27.68
    isopentanol 1.39
    n-heptane 0.07
    ethyl formate 17.92
    1,2-dichloroethane 12.06
    n-hexanol 1.52
    2-methoxyethanol 62.22
    isobutyl acetate 3.19
    tetrachloromethane 1.72
    n-pentyl acetate 4.39
    transcutol 20.61
    n-heptanol 1.53
    ethylbenzene 0.81
    MIBK 3.78
    2-propoxyethanol 25.45
    tert-butanol 1.82
    MTBE 1.48
    2-butoxyethanol 11.87
    propionic acid 25.4
    o-xylene 1.24
    formic acid 157.71
    diethyl ether 3.29
    m-xylene 1.09
    p-xylene 1.11
    chlorobenzene 4.5
    dimethyl carbonate 34.89
    n-octane 0.04
    formamide 151.81
    cyclopentanone 60.68
    2-pentanone 9.71
    anisole 4.48
    cyclopentyl methyl ether 6.88
    gamma-butyrolactone 105.0
    1-methoxy-2-propanol 28.38
    pyridine 32.77
    3-pentanone 8.86
    furfural 99.86
    n-dodecane 0.03
    diethylene glycol 36.68
    diisopropyl ether 0.46
    tert-amyl alcohol 1.56
    acetylacetone 30.96
    n-hexadecane 0.04
    acetophenone 9.5
    methyl propionate 22.65
    isopentyl acetate 2.95
    trichloroethylene 48.01
    n-nonanol 1.29
    cyclohexanol 1.87
    benzyl alcohol 6.89
    2-ethylhexanol 0.8
    isooctanol 1.03
    dipropyl ether 1.97
    1,2-dichlorobenzene 4.41
    ethyl lactate 10.19
    propylene carbonate 33.27
    n-methylformamide 119.34
    2-pentanol 0.96
    n-pentane 0.07
    1-propoxy-2-propanol 10.85
    1-methoxy-2-propyl acetate 12.18
    2-(2-methoxypropoxy) propanol 9.37
    mesitylene 0.47
    ε-caprolactone 24.87
    p-cymene 0.47
    epichlorohydrin 66.6
    1,1,1-trichloroethane 5.69
    2-aminoethanol 19.6
    morpholine-4-carbaldehyde 149.0
    sulfolane 150.6
    2,2,4-trimethylpentane 0.03
    2-methyltetrahydrofuran 10.05
    n-hexyl acetate 4.27
    isooctane 0.02
    2-(2-butoxyethoxy)ethanol 11.57
    sec-butyl acetate 3.02
    tert-butyl acetate 4.12
    decalin 0.06
    glycerin 43.89
    diglyme 25.0
    acrylic acid 56.88
    isopropyl myristate 1.08
    n-butyric acid 14.99
    acetyl acetate 16.16
    di(2-ethylhexyl) phthalate 3.07
    ethyl propionate 6.85
    nitromethane 310.91
    1,2-diethoxyethane 4.84
    benzonitrile 7.88
    trioctyl phosphate 1.77
    1-bromopropane 2.23
    gamma-valerolactone 155.72
    n-decanol 0.79
    triethyl phosphate 2.7
    4-methyl-2-pentanol 0.56
    propionitrile 8.96
    vinylene carbonate 47.21
    1,1,2-trichlorotrifluoroethane 87.03
    DMS 9.53
    cumene 0.43
    2-octanol 0.7
    2-hexanone 6.17
    octyl acetate 2.22
    limonene 0.61
    1,2-dimethoxyethane 27.88
    ethyl orthosilicate 2.02
    tributyl phosphate 1.76
    diacetone alcohol 10.32
    N,N-dimethylaniline 3.01
    acrylonitrile 28.06
    aniline 5.3
    1,3-propanediol 16.16
    bromobenzene 3.79
    dibromomethane 9.85
    1,1,2,2-tetrachloroethane 21.94
    2-methyl-cyclohexyl acetate 3.53
    tetrabutyl urea 3.16
    diisobutyl methanol 0.37
    2-phenylethanol 5.1
    styrene 1.18
    dioctyl adipate 3.31
    dimethyl sulfate 70.56
    ethyl butyrate 4.24
    methyl lactate 32.91
    butyl lactate 6.62
    diethyl carbonate 3.55
    propanediol butyl ether 11.27
    triethyl orthoformate 3.27
    p-tert-butyltoluene 0.41
    methyl 4-tert-butylbenzoate 7.39
    morpholine 31.23
    tert-butylamine 0.49
    n-dodecanol 0.48
    dimethoxymethane 67.59
    ethylene carbonate 26.7
    cyrene 32.65
    2-ethoxyethyl acetate 12.25
    2-ethylhexyl acetate 2.31
    1,2,4-trichlorobenzene 7.24
    4-methylpyridine 16.65
    dibutyl ether 0.85
    2,6-dimethyl-4-heptanol 0.37
    DEF 20.93
    dimethyl isosorbide 19.56
    tetrachloroethylene 14.53
    eugenol 9.89
    triacetin 11.59
    span 80 8.08
    1,4-butanediol 8.23
    1,1-dichloroethane 6.53
    2-methyl-1-pentanol 1.34
    methyl formate 107.75
    2-methyl-1-butanol 1.54
    n-decane 0.06
    butyronitrile 4.47
    3,7-dimethyl-1-octanol 0.76
    1-chlorooctane 0.41
    1-chlorotetradecane 0.14
    n-nonane 0.05
    undecane 0.04
    tert-butylcyclohexane 0.04
    cyclooctane 0.04
    cyclopentanol 4.76
    tetrahydropyran 7.05
    tert-amyl methyl ether 1.49
    2,5,8-trioxanonane 16.38
    1-hexene 0.34
    2-isopropoxyethanol 11.32
    2,2,2-trifluoroethanol 54.97
    methyl butyrate 9.09

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction