Aspartic Acid

Overview IFRA Request a quote

  • Identifiers

    CAS number
    56-84-8

    Molecular formula
    C4H7NO4

    SMILES
    C([C@@H](C(=O)O)N)C(=O)O

  • Odor profile

    Fragrance
    Odorless 80.33%
    Savory 28.68%
    Sour 25.13%
    Meaty 22.22%
    Cooked 18.58%
    Sulfurous 17.86%
    Milky 17.31%
    Sharp 16.56%
    Caramellic 16.26%
    Buttery 16.06%

     

    Flavor
    Odorless 76.23%
    Mild 34.67%
    Sour 32.95%
    Very mild 31.96%
    Bland 26.22%
    Yeast 25.02%
    Faint 23.24%
    Acidic 22.85%
    Sweet-like 21.57%
    Caramellic 20.46%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -2.8

    pKa est.
    5.48 (weak acid)

    Molecular weight
    133.1 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    331°C

    Melting point expt.

    • 270 °C
    • 270-271 °C

    Flash point

    • 191.25 ˚C est.

    Solubility expt.

    • 5390 mg/L (at 25 °C)
    • 1 g in 222.2 ml water at 20 °C; 1 g in 149.9 ml water at 30 °C; more sol in salt soln; sol in acids, alkalies
    • Insoluble in ethanol, ethyl ether, benzene; soluble in dilute HCl, pyridine
    • In water, 5,360 mg/L at 25 °C
    • 5.39 mg/mL
    • Solubility in water, g/100ml: 0.45
    • Slightly soluble in water; Insoluble in ether
    • Insoluble (in ethanol)

  • Synonyms

    • L-aspartic acid
    • aspartic acid
    • 56-84-8
    • H-Asp-OH
    • L-aspartate
    • (2S)-2-aminobutanedioic acid
    • Asparagic acid
    • aspartate
    • Aspatofort
    • L-Asparagic acid
    • L-Aminosuccinic acid
    • Asparaginic acid
    • L-Asparaginic acid
    • (S)-2-Aminosuccinic acid
    • (S)-Aspartic acid
    • Aspartic acid, L-
    • (2S)-Aspartic acid
    • (S)-Aminobutanedioic acid
    • L-Aspartinsaeure
    • L-Asparaginsaeure
    • L-Asparaginsyra
    • Acidum asparticum
    • L-(+)-Aspartic acid
    • L-2-Aminobutanedioic acid
    • Aspartate, L-
    • Asparaginsaeure
    • L-Asp
    • Acido aspartico
    • 2-aminosuccinic acid
    • Acide aspartique
    • Aminosuccinic acid
    • Butanedioic acid, amino-, (S)-
    • Asparaginsaeure [German]
    • (+)-Aspartic acid
    • (L)-ASPARTIC ACID
    • Aspartic acid (VAN)
    • Asparagic acid (VAN)
    • (S)-(+)-Aminosuccinic acid
    • Asparaginic acid (VAN)
    • Acide aspartique [INN-French]
    • Acido aspartico [INN-Spanish]
    • HSDB 1430
    • Deamidated asparagine
    • NSC 3973
    • AI3-04461
    • FEMA No. 3565
    • CCRIS 6181
    • Acidum asparticum [INN-Latin]
    • CHEBI:17053
    • BRN 1723530
    • UNII-30KYC7MIAI
    • 30KYC7MIAI
    • L( )-Aminobernsteinsaeure
    • L(+)-Aminobernsteinsaeure
    • asp
    • EINECS 200-291-6
    • MFCD00002616
    • (S)-2-aminobutanedioic acid
    • Beta-L-Aspartic Acid
    • FEMA NO. 3656
    • 6899-03-2
    • (S)-(+)-Aspartic acid
    • CHEMBL274323
    • DTXSID7022621
    • EC 200-291-6
    • (S)-Aspartate
    • (+)-Aspartate
    • ASPARTIC ACID (II)
    • ASPARTIC ACID [II]
    • L-Aspartic acid-13C4
    • 1-Amino-1,2-carboxyethane
    • asparaginsaure
    • (S)-Aminobutanedioate
    • ASPARTIC ACID (MART.)
    • ASPARTIC ACID [MART.]
    • ASPARTIC ACID (USP-RS)
    • ASPARTIC ACID [USP-RS]
    • NSC3973
    • ASPARTIC ACID (EP IMPURITY)
    • ASPARTIC ACID [EP IMPURITY]
    • l aspartic acid
    • ASPARTIC ACID (EP MONOGRAPH)
    • ASPARTIC ACID [EP MONOGRAPH]
    • ASPARTIC ACID (USP MONOGRAPH)
    • ASPARTIC ACID [USP MONOGRAPH]
    • ALANINE IMPURITY A (EP IMPURITY)
    • ALANINE IMPURITY A [EP IMPURITY]
    • Aspartic Acid [USAN:INN]
    • LYSINE ACETATE IMPURITY A (EP IMPURITY)
    • LYSINE ACETATE IMPURITY A [EP IMPURITY]
    • 39162-75-9
    • CHEBI:22660
    • Aminosuccinate
    • Asparagate
    • Asparatate
    • NSC-3973
    • aspartic acid,l
    • l-aspartic-acid
    • L-Asparagate
    • L-Aminosuccinate
    • Aspartic acid [USAN:USP:INN]
    • aspartate magnesium
    • (L)-Aspartate
    • 55443-54-4
    • alpha-Aminosuccinate
    • (2S)-Aspartate
    • L-(+)-Aspartate
    • [3H]-L-aspartate
    • L-[14C]aspartate
    • L-Aspartic acid, 2
    • [3H]L-aspartic acid
    • (R)-2-aminosuccinate
    • (S)-2-aminosuccinate
    • Tocris-0214
    • [3h]-l-asp
    • (S)-amino-Butanedioate
    • alpha-Aminosuccinic acid
    • (S)-Aminosuccinic Acid
    • (S)-(+)-Aspartate
    • [3H]-L-aspartic acid
    • butanedioic acid, amino-
    • L-Aspartic acid (9CI)
    • 2-Amino-3-methylsuccinate
    • Biomol-NT_000168
    • bmse000031
    • bmse000875
    • Aspartic acid (USP/INN)
    • ASPARTIC ACID [MI]

  • Applications

    Aspartic Acid (CAS 56-84-8) is a versatile building block and functional additive used across multiple industries: as an intermediate in pharmaceutical and peptide synthesis; as an amino acid-based nutrient for fermentation and cell-culture media; as a plant nutrient in agriculture (amino acid fertilizer or foliar supplement); in cosmetics and personal care as a buffering agent and formulation aid to stabilize pH and product stability; and as the monomer for poly(aspartic acid) and derivatives, which are used as biodegradable dispersants and scale inhibitors in water treatment and related polymer applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.0
    methanol 1.77
    isopropanol 0.58
    water 7.65
    ethyl acetate 0.51
    n-propanol 0.62
    acetone 6.27
    n-butanol 0.47
    acetonitrile 0.83
    DMF 29.16
    toluene 0.26
    isobutanol 0.37
    1,4-dioxane 9.92
    methyl acetate 0.71
    THF 5.1
    2-butanone 1.08
    n-pentanol 0.4
    sec-butanol 0.48
    n-hexane 0.2
    ethylene glycol 10.81
    NMP 19.63
    cyclohexane 0.17
    DMSO 26.89
    n-butyl acetate 0.44
    n-octanol 0.45
    chloroform 0.21
    n-propyl acetate 0.38
    acetic acid 3.45
    dichloromethane 0.39
    cyclohexanone 2.03
    propylene glycol 4.04
    isopropyl acetate 0.46
    DMAc 22.3
    2-ethoxyethanol 6.13
    isopentanol 0.57
    n-heptane 0.29
    ethyl formate 2.29
    1,2-dichloroethane 0.49
    n-hexanol 0.7
    2-methoxyethanol 13.67
    isobutyl acetate 0.15
    tetrachloromethane 0.3
    n-pentyl acetate 0.35
    transcutol 3.36
    n-heptanol 0.7
    ethylbenzene 0.31
    MIBK 0.86
    2-propoxyethanol 4.59
    tert-butanol 1.83
    MTBE 0.72
    2-butoxyethanol 2.9
    propionic acid 1.0
    o-xylene 0.59
    formic acid 21.11
    diethyl ether 0.62
    m-xylene 0.4
    p-xylene 0.4
    chlorobenzene 0.12
    dimethyl carbonate 1.54
    n-octane 0.13
    formamide 15.36
    cyclopentanone 3.47
    2-pentanone 1.08
    anisole 0.87
    cyclopentyl methyl ether 1.61
    gamma-butyrolactone 4.19
    1-methoxy-2-propanol 5.9
    pyridine 1.02
    3-pentanone 0.83
    furfural 8.19
    n-dodecane 0.07
    diethylene glycol 11.87
    diisopropyl ether 0.29
    tert-amyl alcohol 1.45
    acetylacetone 2.96
    n-hexadecane 0.08
    acetophenone 1.09
    methyl propionate 0.85
    isopentyl acetate 0.41
    trichloroethylene 0.53
    n-nonanol 0.47
    cyclohexanol 0.75
    benzyl alcohol 0.93
    2-ethylhexanol 0.56
    isooctanol 0.52
    dipropyl ether 0.78
    1,2-dichlorobenzene 0.22
    ethyl lactate 1.28
    propylene carbonate 1.9
    n-methylformamide 8.97
    2-pentanol 0.38
    n-pentane 0.1
    1-propoxy-2-propanol 2.45
    1-methoxy-2-propyl acetate 1.29
    2-(2-methoxypropoxy) propanol 3.35
    mesitylene 0.42
    ε-caprolactone 1.84
    p-cymene 0.37
    epichlorohydrin 2.52
    1,1,1-trichloroethane 0.26
    2-aminoethanol 6.15
    morpholine-4-carbaldehyde 21.67
    sulfolane 13.07
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 1.72
    n-hexyl acetate 0.44
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 3.55
    sec-butyl acetate 0.23
    tert-butyl acetate 0.85
    decalin 0.14
    glycerin 18.3
    diglyme 8.32
    acrylic acid 1.75
    isopropyl myristate 0.26
    n-butyric acid 0.94
    acetyl acetate 0.59
    di(2-ethylhexyl) phthalate 0.57
    ethyl propionate 0.5
    nitromethane 7.36
    1,2-diethoxyethane 0.83
    benzonitrile 0.45
    trioctyl phosphate 0.48
    1-bromopropane 0.15
    gamma-valerolactone 10.41
    n-decanol 0.4
    triethyl phosphate 0.83
    4-methyl-2-pentanol 0.41
    propionitrile 0.33
    vinylene carbonate 1.56
    1,1,2-trichlorotrifluoroethane 6.66
    DMS 0.58
    cumene 0.32
    2-octanol 0.38
    2-hexanone 0.57
    octyl acetate 0.37
    limonene 0.44
    1,2-dimethoxyethane 11.78
    ethyl orthosilicate 0.77
    tributyl phosphate 0.42
    diacetone alcohol 3.43
    N,N-dimethylaniline 1.52
    acrylonitrile 0.68
    aniline 0.52
    1,3-propanediol 4.61
    bromobenzene 0.1
    dibromomethane 0.22
    1,1,2,2-tetrachloroethane 0.68
    2-methyl-cyclohexyl acetate 0.58
    tetrabutyl urea 1.22
    diisobutyl methanol 0.56
    2-phenylethanol 0.97
    styrene 0.23
    dioctyl adipate 0.42
    dimethyl sulfate 6.02
    ethyl butyrate 0.58
    methyl lactate 3.14
    butyl lactate 0.92
    diethyl carbonate 0.44
    propanediol butyl ether 2.46
    triethyl orthoformate 0.76
    p-tert-butyltoluene 0.39
    methyl 4-tert-butylbenzoate 1.97
    morpholine 6.16
    tert-butylamine 0.73
    n-dodecanol 0.34
    dimethoxymethane 9.76
    ethylene carbonate 1.19
    cyrene 6.22
    2-ethoxyethyl acetate 0.6
    2-ethylhexyl acetate 0.31
    1,2,4-trichlorobenzene 0.25
    4-methylpyridine 1.08
    dibutyl ether 0.33
    2,6-dimethyl-4-heptanol 0.56
    DEF 4.12
    dimethyl isosorbide 5.85
    tetrachloroethylene 0.76
    eugenol 2.58
    triacetin 0.78
    span 80 2.08
    1,4-butanediol 2.33
    1,1-dichloroethane 0.18
    2-methyl-1-pentanol 0.44
    methyl formate 9.84
    2-methyl-1-butanol 0.46
    n-decane 0.1
    butyronitrile 0.35
    3,7-dimethyl-1-octanol 0.38
    1-chlorooctane 0.17
    1-chlorotetradecane 0.1
    n-nonane 0.11
    undecane 0.08
    tert-butylcyclohexane 0.11
    cyclooctane 0.13
    cyclopentanol 1.17
    tetrahydropyran 1.19
    tert-amyl methyl ether 0.86
    2,5,8-trioxanonane 7.24
    1-hexene 0.23
    2-isopropoxyethanol 2.6
    2,2,2-trifluoroethanol 4.75
    methyl butyrate 0.9

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction