Ascorbyl retinoate

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  • Identifiers

    CAS number
    119207-20-4

    Molecular formula
    C26H34O7

    SMILES
    CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C/C(=O)OC[C@@H]([C@@H]2C(=C(C(=O)O2)O)O)O)/C)/C

    Safety labels

  • Odor profile

    Fragrance
    Sweet 39.58%
    Fruity 38.2%
    Woody 37.15%
    Floral 28.83%
    Spicy 27.04%
    Tropical 25.45%
    Balsamic 25.43%
    Citrus 24.46%
    Fresh 24.23%
    Odorless 24.01%

     

    Flavor
    Bitter 50.22%
    Odorless 24.72%
    Heather 20.1%
    Oriental 19.87%
    Broom 19.86%
    Genet 19.56%
    Basil 19.36%
    Cedarleaf 19.23%
    Lovage 19.21%
    Parsley 18.89%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    5.4

    pKa est.
    5.86 (weak acid)

    Molecular weight
    458.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    930°C

    Flash point

    • 244.02 ˚C est.

  • Synonyms

    • Ascorbyl retinoate
    • Retinyl-L-ascorbic acid
    • Retinoic acid, 6-ester with L-ascorbic acid
    • 915WW480O7
    • 119207-20-4
    • Ascorbyl retinoate [INCI]
    • UNII-915WW480O7
    • Q27271370
    • 119207-20-4

  • Applications

    Ascorbyl retinoate (CAS 119207-20-4) is commonly used in cosmetics and personal care as a skin-active ingredient that combines vitamin C and retinoid functionalities, providing antioxidant protection and potential formulation benefits in topical products. It is also used as a stabilizer for vitamin C–retinoid systems, helping improve formulation stability and shelf life. In industrial manufacturing, it serves as an intermediate for the synthesis of vitamin C/retinoid derivatives and related cosmetic actives. In pharmaceutical and research contexts, it is evaluated as a synthetic building block or lead intermediate for the development of vitamin C and retinoid–based compounds. Overall, applications focus on cosmetic actives, formulation stabilization, and chemical synthesis pathways for related derivatives; usage is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.21
    methanol 32.53
    isopropanol 4.33
    water 0.04
    ethyl acetate 3.64
    n-propanol 9.33
    acetone 19.33
    n-butanol 5.33
    acetonitrile 2.42
    DMF 45.76
    toluene 1.76
    isobutanol 3.23
    1,4-dioxane 18.5
    methyl acetate 5.16
    THF 74.87
    2-butanone 12.29
    n-pentanol 6.7
    sec-butanol 4.93
    n-hexane 0.13
    ethylene glycol 1.57
    NMP 31.92
    cyclohexane 0.16
    DMSO 67.06
    n-butyl acetate 1.31
    n-octanol 3.46
    chloroform 5.89
    n-propyl acetate 2.61
    acetic acid 19.0
    dichloromethane 5.79
    cyclohexanone 11.71
    propylene glycol 4.76
    isopropyl acetate 2.53
    DMAc 66.51
    2-ethoxyethanol 33.36
    isopentanol 3.3
    n-heptane 0.13
    ethyl formate 3.37
    1,2-dichloroethane 3.66
    n-hexanol 2.73
    2-methoxyethanol 43.05
    isobutyl acetate 1.65
    tetrachloromethane 0.63
    n-pentyl acetate 3.91
    transcutol 45.88
    n-heptanol 3.94
    ethylbenzene 1.07
    MIBK 4.17
    2-propoxyethanol 19.95
    tert-butanol 4.38
    MTBE 3.65
    2-butoxyethanol 16.65
    propionic acid 4.95
    o-xylene 1.14
    formic acid 11.82
    diethyl ether 3.78
    m-xylene 1.26
    p-xylene 1.23
    chlorobenzene 1.37
    dimethyl carbonate 3.94
    n-octane 0.12
    formamide 16.7
    cyclopentanone 22.84
    2-pentanone 7.99
    anisole 4.98
    cyclopentyl methyl ether 6.93
    gamma-butyrolactone 16.65
    1-methoxy-2-propanol 25.86
    pyridine 10.48
    3-pentanone 5.43
    furfural 12.32
    n-dodecane 0.08
    diethylene glycol 10.98
    diisopropyl ether 0.68
    tert-amyl alcohol 5.2
    acetylacetone 12.45
    n-hexadecane 0.09
    acetophenone 5.42
    methyl propionate 5.5
    isopentyl acetate 1.68
    trichloroethylene 9.17
    n-nonanol 3.7
    cyclohexanol 2.78
    benzyl alcohol 6.08
    2-ethylhexanol 1.23
    isooctanol 2.82
    dipropyl ether 2.0
    1,2-dichlorobenzene 1.28
    ethyl lactate 2.95
    propylene carbonate 3.67
    n-methylformamide 16.04
    2-pentanol 2.27
    n-pentane 0.11
    1-propoxy-2-propanol 8.65
    1-methoxy-2-propyl acetate 4.31
    2-(2-methoxypropoxy) propanol 11.84
    mesitylene 0.64
    ε-caprolactone 8.94
    p-cymene 0.55
    epichlorohydrin 24.04
    1,1,1-trichloroethane 1.83
    2-aminoethanol 6.8
    morpholine-4-carbaldehyde 32.92
    sulfolane 29.32
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 12.72
    n-hexyl acetate 4.84
    isooctane 0.05
    2-(2-butoxyethoxy)ethanol 18.58
    sec-butyl acetate 1.73
    tert-butyl acetate 4.03
    decalin 0.11
    glycerin 8.3
    diglyme 31.91
    acrylic acid 5.75
    isopropyl myristate 1.38
    n-butyric acid 5.67
    acetyl acetate 2.68
    di(2-ethylhexyl) phthalate 2.62
    ethyl propionate 2.22
    nitromethane 24.94
    1,2-diethoxyethane 7.4
    benzonitrile 2.19
    trioctyl phosphate 1.67
    1-bromopropane 1.59
    gamma-valerolactone 42.12
    n-decanol 2.13
    triethyl phosphate 1.15
    4-methyl-2-pentanol 1.37
    propionitrile 2.14
    vinylene carbonate 3.77
    1,1,2-trichlorotrifluoroethane 17.82
    DMS 2.83
    cumene 0.74
    2-octanol 2.12
    2-hexanone 5.62
    octyl acetate 2.51
    limonene 0.75
    1,2-dimethoxyethane 30.8
    ethyl orthosilicate 1.34
    tributyl phosphate 1.39
    diacetone alcohol 10.51
    N,N-dimethylaniline 3.76
    acrylonitrile 3.35
    aniline 3.18
    1,3-propanediol 10.62
    bromobenzene 1.15
    dibromomethane 2.93
    1,1,2,2-tetrachloroethane 6.93
    2-methyl-cyclohexyl acetate 2.29
    tetrabutyl urea 3.03
    diisobutyl methanol 0.7
    2-phenylethanol 4.03
    styrene 1.14
    dioctyl adipate 3.09
    dimethyl sulfate 7.33
    ethyl butyrate 1.43
    methyl lactate 5.57
    butyl lactate 4.59
    diethyl carbonate 0.8
    propanediol butyl ether 12.44
    triethyl orthoformate 1.76
    p-tert-butyltoluene 0.6
    methyl 4-tert-butylbenzoate 7.16
    morpholine 27.01
    tert-butylamine 1.29
    n-dodecanol 1.21
    dimethoxymethane 32.86
    ethylene carbonate 2.72
    cyrene 16.03
    2-ethoxyethyl acetate 7.84
    2-ethylhexyl acetate 1.16
    1,2,4-trichlorobenzene 2.11
    4-methylpyridine 5.81
    dibutyl ether 2.01
    2,6-dimethyl-4-heptanol 0.7
    DEF 9.64
    dimethyl isosorbide 15.58
    tetrachloroethylene 4.53
    eugenol 8.67
    triacetin 6.26
    span 80 9.14
    1,4-butanediol 5.58
    1,1-dichloroethane 1.98
    2-methyl-1-pentanol 4.68
    methyl formate 11.11
    2-methyl-1-butanol 3.68
    n-decane 0.18
    butyronitrile 1.99
    3,7-dimethyl-1-octanol 2.07
    1-chlorooctane 0.96
    1-chlorotetradecane 0.27
    n-nonane 0.15
    undecane 0.11
    tert-butylcyclohexane 0.1
    cyclooctane 0.08
    cyclopentanol 4.7
    tetrahydropyran 9.82
    tert-amyl methyl ether 3.41
    2,5,8-trioxanonane 20.99
    1-hexene 0.68
    2-isopropoxyethanol 15.23
    2,2,2-trifluoroethanol 3.57
    methyl butyrate 3.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction