Ascorbyl Palmitate

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  • Identifiers

    CAS number
    137-66-6

    Molecular formula
    C22H38O7

    SMILES
    CCCCCCCCCCCCCCCC(=O)OC[C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fatty 46.71%
    Odorless 44.92%
    Waxy 42.73%
    Oily 31.17%
    Lactonic 27.32%
    Milky 26.87%
    Buttery 26.01%
    Creamy 24.02%
    Peach 23.45%
    Dairy 22.93%

     

    Flavor
    Waxy 38.9%
    Bland 37.74%
    Fatty 34.59%
    Odorless 33.44%
    Mild 33.25%
    Oily 32.04%
    Faint 24.29%
    Slightly waxy 22.68%
    Bay oil 22.03%
    Creamy 21.55%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.3

    pKa est.
    5.51 (weak acid)

    Molecular weight
    414.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    636°C

    Melting point expt.

    • Between 107 °C and 117 °C
    • 112 °C

    Flash point

    • 216.89 ˚C est.

    Solubility expt.

    • Soluble in alcohol, animal oil, and vegetable oil; slightly soluble in water

  • Synonyms

    • ASCORBYL PALMITATE
    • 137-66-6
    • L-Ascorbyl 6-palmitate
    • L-Ascorbic acid 6-palmitate
    • Ascorbyl monopalmitate
    • Ascorbic palmitate
    • L-Ascorbic acid, 6-hexadecanoate
    • 6-O-Palmitoyl-L-ascorbic acid
    • L-Ascorbyl palmitate
    • Cetyl ascorbate
    • (S)-2-((R)-3,4-Dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl palmitate
    • Ascorboyl palmitate
    • Ascorbylpalmitic acid
    • Ascorbyl 6-palmitate
    • 6-O-Palmitoyl ascorbate
    • Ins no.304
    • Ascorbyl palmitate [NF]
    • Ascorbyl palmitate (VAN)
    • Ins-304
    • QN83US2B0N
    • Ondascora
    • Quicifal
    • 6-O-Palmitoylascorbic acid
    • Ascorbyl 6-hexadecanoate, L-
    • CCRIS 3930
    • HSDB 418
    • Ascorbic acid palmitate (ester)
    • DTXSID3041611
    • L-Ascorbic acid 6-hexadecanoate
    • Ascorbyl palmitate (NF)
    • EINECS 205-305-4
    • MFCD00005377
    • 1-Ascorbyl palmitate
    • NSC 402451
    • NSC-402451
    • BRN 0096552
    • Ascorbic acid palmitate
    • L-Ascorbyl monopalmitate
    • 6-Palmitoylascorbic acid
    • ASCORBYL PALMITATE [II]
    • ASCORBYL PALMITATE [FCC]
    • DTXCID1021611
    • E-304
    • ASCORBYL PALMITATE [HSDB]
    • ASCORBYL PALMITATE [VANDF]
    • 6-Palmitoyl-L-ascorbic acid
    • ASCORBYL PALMITATE [MART.]
    • 5-18-05-00031 (Beilstein Handbook Reference)
    • ASCORBYL PALMITATE [USP-RS]
    • ASCORBYL PALMITATE [WHO-DD]
    • ASCORBYL PALMITATE [EP MONOGRAPH]
    • E304
    • Ascorbic acid 6-palmitate
    • Palmitic acid, ester with ascorbic acid
    • L-Ascorbic acid, 6-palmitate
    • ASCORBYL PALMITATE (II)
    • ASCORBYL PALMITATE (MART.)
    • ASCORBYL PALMITATE (USP-RS)
    • C22H38O7
    • [(2S)-2-[(2R)-3,4-dihydroxy-5-oxo-2H-furan-2-yl]-2-hydroxyethyl] hexadecanoate
    • ASCORBYL PALMITATE (EP MONOGRAPH)
    • CAS-137-66-6
    • Ascorbyl palmitate, USAN
    • UNII-QN83US2B0N
    • LAscorbyl palmitate
    • NCGC00161605-01
    • 1Ascorbyl palmitate
    • Ascorbyl 6palmitate
    • Ascorbyl palmitate; (2S)-2-[(2R)-3,4-Dihydroxy-5-oxo-2,5-dihydrofuran-2-yl]-2-hydroxyethyl hexadecanoate
    • L-Ascorbyl 6-pal
    • LAscorbyl 6palmitate
    • Grindox 562
    • 6OPalmitoyl ascorbate
    • LAscorbyl monopalmitate
    • 6Palmitoylascorbic acid
    • 6MonopalmitoylLascorbate
    • 6OPalmitoylascorbic acid
    • 6PalmitoylLascorbic acid
    • Palmitoyl Lascorbic acid
    • LAscorbic acid 6palmitate
    • Palmitoyl-L-ascorbic acid
    • 6HexadecanoylLascorbic acid
    • Ascorbyl 6hexadecanoate, L
    • SCHEMBL15363
    • Ascorbyl palmitate (Standard)
    • LAscorbic acid, 6hexadecanoate
    • CHEMBL220190
    • SCHEMBL17817668
    • HY-B0987R
    • ASCORBYL PALMITATE [INCI]
    • CHEBI:140768
    • HY-B0987
    • Tox21_113637
    • Tox21_301926
    • BDBM50451094
    • s2532
    • AKOS015895292
    • CCG-207947
    • CS-4478
    • FA30308
    • NCGC00255543-01
    • AS-12990
    • A0540
    • NS00005460
    • SW220267-1
    • D02412
    • D88276
    • Q424521
    • 6-O-Palmitoyl-L-ascorbic acid, BioXtra, >=99.0% (RT)
    • Ascorbic acid 6-palmitate, meets USP testing specifications
    • 6-O-Palmitoyl-L-ascorbic acid, analytical reference material
    • 6-O-Palmitoyl-L-ascorbic acid, Vetec(TM) reagent grade, 95%
    • Ascorbyl palmitate, European Pharmacopoeia (EP) Reference Standard
    • Ascorbyl palmitate, United States Pharmacopeia (USP) Reference Standard
    • Ascorbyl Palmitate, Pharmaceutical Secondary Standard; Certified Reference Material

  • Applications

    Ascorbyl Palmitate (CAS 137-66-6) is the fat-soluble ester of ascorbic acid with palmitic acid and functions as an antioxidant. In cosmetics and personal care, it acts as a lipophilic antioxidant and can contribute to skin conditioning in formulations. In the food processing industry, it is used as a lipid-soluble antioxidant to prevent lipid oxidation and extend shelf life of processed foods, oils and fats. In pharmaceutical and dietary supplement formulations, it is used as a lipophilic vitamin C derivative to stabilize fat-containing systems and deliver vitamin C activity. In industrial manufacturing, polymers and coatings, it is studied or used as an antioxidant additive to improve oxidative stability of polymer materials and coatings.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 42.1
    methanol 96.78
    isopropanol 33.61
    water 3.01
    ethyl acetate 57.71
    n-propanol 38.64
    acetone 140.05
    n-butanol 26.11
    acetonitrile 35.59
    DMF 278.33
    toluene 11.3
    isobutanol 25.26
    1,4-dioxane 75.72
    methyl acetate 65.86
    THF 208.98
    2-butanone 79.71
    n-pentanol 27.28
    sec-butanol 32.71
    n-hexane 1.38
    ethylene glycol 16.22
    NMP 342.3
    cyclohexane 3.58
    DMSO 686.54
    n-butyl acetate 27.57
    n-octanol 20.41
    chloroform 63.44
    n-propyl acetate 43.86
    acetic acid 158.82
    dichloromethane 81.51
    cyclohexanone 136.35
    propylene glycol 29.05
    isopropyl acetate 47.71
    DMAc 459.67
    2-ethoxyethanol 105.16
    isopentanol 24.31
    n-heptane 1.24
    ethyl formate 41.6
    1,2-dichloroethane 71.39
    n-hexanol 14.7
    2-methoxyethanol 132.08
    isobutyl acetate 25.42
    tetrachloromethane 16.73
    n-pentyl acetate 53.03
    transcutol 219.48
    n-heptanol 21.47
    ethylbenzene 9.56
    MIBK 37.82
    2-propoxyethanol 60.83
    tert-butanol 49.53
    MTBE 35.2
    2-butoxyethanol 76.06
    propionic acid 76.45
    o-xylene 14.95
    formic acid 88.94
    diethyl ether 22.37
    m-xylene 10.5
    p-xylene 13.1
    chlorobenzene 17.75
    dimethyl carbonate 52.57
    n-octane 1.43
    formamide 185.43
    cyclopentanone 189.86
    2-pentanone 57.77
    anisole 25.34
    cyclopentyl methyl ether 59.16
    gamma-butyrolactone 226.44
    1-methoxy-2-propanol 100.73
    pyridine 61.73
    3-pentanone 51.61
    furfural 136.1
    n-dodecane 1.08
    diethylene glycol 50.96
    diisopropyl ether 9.52
    tert-amyl alcohol 46.06
    acetylacetone 130.59
    n-hexadecane 1.24
    acetophenone 47.33
    methyl propionate 65.62
    isopentyl acetate 29.83
    trichloroethylene 124.09
    n-nonanol 20.25
    cyclohexanol 39.4
    benzyl alcohol 33.54
    2-ethylhexanol 10.84
    isooctanol 19.46
    dipropyl ether 12.77
    1,2-dichlorobenzene 23.28
    ethyl lactate 41.9
    propylene carbonate 101.33
    n-methylformamide 123.93
    2-pentanol 19.2
    n-pentane 1.18
    1-propoxy-2-propanol 44.49
    1-methoxy-2-propyl acetate 52.82
    2-(2-methoxypropoxy) propanol 59.5
    mesitylene 7.65
    ε-caprolactone 127.5
    p-cymene 7.19
    epichlorohydrin 163.69
    1,1,1-trichloroethane 59.82
    2-aminoethanol 39.52
    morpholine-4-carbaldehyde 203.14
    sulfolane 434.44
    2,2,4-trimethylpentane 1.79
    2-methyltetrahydrofuran 88.94
    n-hexyl acetate 53.14
    isooctane 0.84
    2-(2-butoxyethoxy)ethanol 80.11
    sec-butyl acetate 31.58
    tert-butyl acetate 60.16
    decalin 2.63
    glycerin 56.29
    diglyme 171.93
    acrylic acid 71.79
    isopropyl myristate 15.7
    n-butyric acid 85.26
    acetyl acetate 56.28
    di(2-ethylhexyl) phthalate 22.09
    ethyl propionate 40.39
    nitromethane 267.31
    1,2-diethoxyethane 52.1
    benzonitrile 27.62
    trioctyl phosphate 18.0
    1-bromopropane 20.63
    gamma-valerolactone 247.01
    n-decanol 13.25
    triethyl phosphate 22.62
    4-methyl-2-pentanol 13.16
    propionitrile 25.54
    vinylene carbonate 77.73
    1,1,2-trichlorotrifluoroethane 182.13
    DMS 52.8
    cumene 8.26
    2-octanol 17.31
    2-hexanone 42.49
    octyl acetate 24.85
    limonene 10.75
    1,2-dimethoxyethane 113.89
    ethyl orthosilicate 22.35
    tributyl phosphate 20.95
    diacetone alcohol 96.71
    N,N-dimethylaniline 24.3
    acrylonitrile 39.32
    aniline 27.02
    1,3-propanediol 53.22
    bromobenzene 16.1
    dibromomethane 42.55
    1,1,2,2-tetrachloroethane 124.9
    2-methyl-cyclohexyl acetate 29.12
    tetrabutyl urea 31.66
    diisobutyl methanol 7.83
    2-phenylethanol 24.09
    styrene 10.0
    dioctyl adipate 32.04
    dimethyl sulfate 142.12
    ethyl butyrate 25.5
    methyl lactate 67.27
    butyl lactate 57.64
    diethyl carbonate 19.03
    propanediol butyl ether 64.92
    triethyl orthoformate 24.97
    p-tert-butyltoluene 7.33
    methyl 4-tert-butylbenzoate 67.74
    morpholine 112.92
    tert-butylamine 19.56
    n-dodecanol 8.97
    dimethoxymethane 114.88
    ethylene carbonate 69.92
    cyrene 82.18
    2-ethoxyethyl acetate 82.7
    2-ethylhexyl acetate 22.09
    1,2,4-trichlorobenzene 35.8
    4-methylpyridine 46.64
    dibutyl ether 17.09
    2,6-dimethyl-4-heptanol 7.83
    DEF 102.71
    dimethyl isosorbide 98.21
    tetrachloroethylene 82.18
    eugenol 57.09
    triacetin 86.77
    span 80 48.53
    1,4-butanediol 30.45
    1,1-dichloroethane 46.98
    2-methyl-1-pentanol 26.24
    methyl formate 87.54
    2-methyl-1-butanol 26.97
    n-decane 2.17
    butyronitrile 21.75
    3,7-dimethyl-1-octanol 16.06
    1-chlorooctane 11.07
    1-chlorotetradecane 3.83
    n-nonane 1.88
    undecane 1.47
    tert-butylcyclohexane 1.99
    cyclooctane 1.51
    cyclopentanol 60.39
    tetrahydropyran 60.59
    tert-amyl methyl ether 33.55
    2,5,8-trioxanonane 104.9
    1-hexene 5.48
    2-isopropoxyethanol 65.87
    2,2,2-trifluoroethanol 98.72
    methyl butyrate 58.43

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction