Artesunate

Overview IFRA Request a quote

  • Identifiers

    CAS number
    88495-63-0

    Molecular formula
    C19H28O8

    SMILES
    C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)OC(=O)CCC(=O)O)C

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 56.46%
    Roasted 23.62%
    Lactonic 22.4%
    Milky 22.35%
    Buttery 20.71%
    Cooling 20.19%
    Savory 19.75%
    Nutty 19.45%
    Mint 18.78%
    Creamy 17.84%

     

    Flavor
    Bitter 53.11%
    Fatty 32.55%
    Odorless 27.11%
    Sweet-like 23.72%
    Bland 22.31%
    Fruity 21.88%
    Cedarleaf 21.42%
    Bouillon 20.73%
    Cauliflower 20.68%
    Ripe apricot 20.63%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.5

    pKa est.
    5.62 (weak acid)

    Molecular weight
    384.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    379°C

    Melting point expt.

    • 131-135

    Flash point

    • 183.37 ˚C est.

  • Synonyms

    • Artesunate
    • Artesunic acid
    • 88495-63-0
    • Arsumax
    • Plasmotrin
    • Qinghaozhi
    • Saphnate
    • Artesunato
    • Artesunatum
    • Dihydroqinghasu hemsuccinate
    • Zysunate
    • WR 256283
    • Dihydroqinghaosu hemisuccinate
    • CHEBI:63918
    • LJPC-0118
    • Dihydroartemisinine-12alpha-succinate
    • 60W3249T9M
    • NSC-712571
    • Butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester
    • DTXSID3042681
    • 4-oxo-4-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]butanoic acid
    • Butanedioic acid, mono((3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester
    • 4-oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10-yl]oxy}butanoic acid
    • 4-oxo-4-(((1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo(10.3.1.04,13.08,13)hexadecan-10-yl)oxy)butanoic acid
    • 4-oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano(4,3-j)(1,2)benzodioxepin-10-yl)oxy)butanoic acid
    • butanedioic acid, 1-((3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester
    • alpha-artesunic acid
    • RefChem:54307
    • Dihydroartemisinin, Succinyl
    • P01BE03
    • DTXCID601508461
    • SM804
    • Dihydroartemisinine 12 alpha succinate
    • 4-oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano(4,3-j)-1,2-benzodioxepin-10-yl)oxy)butanoic acid
    • 618-170-5
    • Butanedioic acid, mono((5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester
    • Arinate
    • .alpha.-artesunic acid
    • Succinyl dihydroartemisinin
    • Arsuamoon
    • Plasmotrim
    • Asumax
    • Gsunate Forte
    • Artesunata
    • Cosinate
    • Artesunate [USAN]
    • MFCD00866204
    • (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol, hydrogen succinate
    • Artesunate [INN]
    • WR-256283
    • Armax 200
    • Artesunatum [INN-Latin]
    • Artesunato [INN-Spanish]
    • Artsuna
    • Nuartez
    • Artesunate [USAN:INN:BAN]
    • C19H28O8
    • UNII-60W3249T9M
    • HSDB 7458
    • Quinghaosu reduced succinate ester
    • 4-oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl)oxy)butanoic acid
    • D95
    • Artesunate (Standard)
    • ARTESUNATE [MI]
    • ARTESUNATE [HSDB]
    • ARTESUNATE [VANDF]
    • ARTESUNATE [MART.]
    • ARTESUNATE [USP-RS]
    • ARTESUNATE [WHO-DD]
    • ARTESUNATE [WHO-IP]
    • MLS006011590
    • CHEMBL361497
    • GTPL9956
    • orb1310621
    • ARTESUNATE [ORANGE BOOK]
    • SCHEMBL14552891
    • HY-N0193R
    • ARTESUNATUM [WHO-IP LATIN]
    • HY-N0193
    • STR09744
    • BDBM50248021
    • EBC-17081
    • AKOS037515734
    • CS-8151
    • DB09274
    • FA17994
    • NCGC00164600-10
    • NCGC00164600-15
    • SMR002499399
    • NS00099352
    • DIHYDROARTEMISININE-12.ALPHA.-SUCCINATE
    • EN300-6482026
    • Q707939
    • BRD-K54634444-001-05-9
    • WR-256283;ART;Armax 200;SM-804;HSDB-7458
    • 3R,5AS,6R,8AS,9R,10S,12R,12AR)-3,6,9-TRIMETHYLDECAHYDRO-3,12-EPOXY-12H-PYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-YL HYDROGEN BUTANEDIOATE
    • 4-OXO-4-(3R,5AS,6R,8AS,9R,10S,12R,12AR)-3,6,9-TRIMETHYLDECAHYDRO-3,12-EPOXYPYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-YL HYDROGEN BUTANEDIOATE
    • 4-oxo-4-{[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0?,(1)(3).0?,(1)(3)]hexadecan-10-yl]oxy}butanoic acid
    • 4-oxo-4-{[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.0^{4,13}.0^{8,13}]hexadecan-10-yl]oxy}butanoic acid
    • 4-Oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-12H-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10-yl]oxy}butanoic acid
    • Butanedioic acid mono(3R,5?S,6R,8?S,9R,10S,12R,12?R)-decahydro-3,6 ,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester
    • BUTANEDIOIC ACID, MONO(DECAHYDRO-3,6,9-TRIMETHYL-3,12-EPOXY-12H-PYRANO(4,3-J)-1,2-BENZODIOXEPIN-10-YL) ESTER, (3R-(3.ALPHA.,5A.BETA.,6.BETA.,8A.BETA.,9.ALPHA.,10.BETA.,12.BETA.,12AR*))-
    • 88495-63-0

  • Applications

    Artesunate is a semi-synthetic artemisinin derivative primarily used in pharmaceuticals as the active ingredient in artemisinin-based formulations, typically in parenteral and oral presentations to enable rapid onset of action. In addition to its role as an API in antimalarial products, it is also employed as a lead compound or intermediate in the synthesis of other artemisinin derivatives and related drug candidates. In research and development, artesunate supports pharmacokinetic studies, analytical method development, and quality-control benchmarks for artemisinin-derived formulations. In the chemical industry, it can serve as an intermediate in synthetic sequences related to the artemisinin system and is used as a reference material for related production processes.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 80.23
    methanol 63.65
    isopropanol 48.12
    water 0.52
    ethyl acetate 106.36
    n-propanol 87.75
    acetone 131.07
    n-butanol 66.04
    acetonitrile 27.56
    DMF 150.81
    toluene 27.1
    isobutanol 53.18
    1,4-dioxane 181.55
    methyl acetate 101.46
    THF 285.26
    2-butanone 171.42
    n-pentanol 77.6
    sec-butanol 51.92
    n-hexane 0.36
    ethylene glycol 12.3
    NMP 200.49
    cyclohexane 1.18
    DMSO 348.35
    n-butyl acetate 58.32
    n-octanol 15.53
    chloroform 129.6
    n-propyl acetate 71.42
    acetic acid 153.16
    dichloromethane 112.64
    cyclohexanone 209.54
    propylene glycol 11.29
    isopropyl acetate 57.29
    DMAc 233.28
    2-ethoxyethanol 147.29
    isopentanol 49.21
    n-heptane 0.21
    ethyl formate 85.01
    1,2-dichloroethane 75.81
    n-hexanol 34.47
    2-methoxyethanol 147.71
    isobutyl acetate 43.0
    tetrachloromethane 10.05
    n-pentyl acetate 36.94
    transcutol 115.81
    n-heptanol 19.71
    ethylbenzene 12.75
    MIBK 49.77
    2-propoxyethanol 113.14
    tert-butanol 27.93
    MTBE 15.74
    2-butoxyethanol 64.61
    propionic acid 86.63
    o-xylene 15.82
    formic acid 82.55
    diethyl ether 33.24
    m-xylene 13.86
    p-xylene 19.34
    chlorobenzene 40.28
    dimethyl carbonate 43.93
    n-octane 0.25
    formamide 101.39
    cyclopentanone 228.14
    2-pentanone 102.14
    anisole 37.45
    cyclopentyl methyl ether 47.09
    gamma-butyrolactone 258.71
    1-methoxy-2-propanol 87.4
    pyridine 153.72
    3-pentanone 77.3
    furfural 186.98
    n-dodecane 0.47
    diethylene glycol 87.69
    diisopropyl ether 6.22
    tert-amyl alcohol 28.77
    acetylacetone 104.27
    n-hexadecane 0.57
    acetophenone 65.74
    methyl propionate 86.69
    isopentyl acetate 50.37
    trichloroethylene 143.03
    n-nonanol 17.11
    cyclohexanol 47.73
    benzyl alcohol 71.95
    2-ethylhexanol 16.9
    isooctanol 16.77
    dipropyl ether 9.81
    1,2-dichlorobenzene 34.42
    ethyl lactate 40.16
    propylene carbonate 117.78
    n-methylformamide 98.11
    2-pentanol 25.55
    n-pentane 0.37
    1-propoxy-2-propanol 53.44
    1-methoxy-2-propyl acetate 68.53
    2-(2-methoxypropoxy) propanol 55.2
    mesitylene 7.7
    ε-caprolactone 184.26
    p-cymene 8.17
    epichlorohydrin 226.46
    1,1,1-trichloroethane 41.52
    2-aminoethanol 32.8
    morpholine-4-carbaldehyde 206.64
    sulfolane 241.59
    2,2,4-trimethylpentane 0.44
    2-methyltetrahydrofuran 126.53
    n-hexyl acetate 42.12
    isooctane 0.31
    2-(2-butoxyethoxy)ethanol 70.11
    sec-butyl acetate 45.17
    tert-butyl acetate 41.33
    decalin 1.27
    glycerin 28.86
    diglyme 106.09
    acrylic acid 77.67
    isopropyl myristate 18.77
    n-butyric acid 117.09
    acetyl acetate 68.53
    di(2-ethylhexyl) phthalate 30.35
    ethyl propionate 55.68
    nitromethane 168.37
    1,2-diethoxyethane 44.05
    benzonitrile 64.73
    trioctyl phosphate 22.01
    1-bromopropane 30.7
    gamma-valerolactone 340.71
    n-decanol 12.66
    triethyl phosphate 27.37
    4-methyl-2-pentanol 14.8
    propionitrile 39.62
    vinylene carbonate 117.06
    1,1,2-trichlorotrifluoroethane 122.57
    DMS 47.09
    cumene 8.66
    2-octanol 11.89
    2-hexanone 83.48
    octyl acetate 26.08
    limonene 9.57
    1,2-dimethoxyethane 152.41
    ethyl orthosilicate 23.64
    tributyl phosphate 25.15
    diacetone alcohol 57.57
    N,N-dimethylaniline 22.81
    acrylonitrile 55.49
    aniline 53.0
    1,3-propanediol 70.88
    bromobenzene 33.26
    dibromomethane 67.87
    1,1,2,2-tetrachloroethane 100.41
    2-methyl-cyclohexyl acetate 40.3
    tetrabutyl urea 34.35
    diisobutyl methanol 8.06
    2-phenylethanol 54.8
    styrene 15.89
    dioctyl adipate 34.08
    dimethyl sulfate 75.26
    ethyl butyrate 42.36
    methyl lactate 45.99
    butyl lactate 36.17
    diethyl carbonate 31.54
    propanediol butyl ether 43.58
    triethyl orthoformate 29.04
    p-tert-butyltoluene 6.48
    methyl 4-tert-butylbenzoate 47.61
    morpholine 185.74
    tert-butylamine 8.48
    n-dodecanol 9.21
    dimethoxymethane 103.47
    ethylene carbonate 110.28
    cyrene 90.45
    2-ethoxyethyl acetate 60.54
    2-ethylhexyl acetate 40.89
    1,2,4-trichlorobenzene 49.94
    4-methylpyridine 122.88
    dibutyl ether 11.68
    2,6-dimethyl-4-heptanol 8.06
    DEF 96.88
    dimethyl isosorbide 86.33
    tetrachloroethylene 62.02
    eugenol 49.7
    triacetin 50.77
    span 80 43.5
    1,4-butanediol 46.07
    1,1-dichloroethane 53.74
    2-methyl-1-pentanol 58.38
    methyl formate 82.41
    2-methyl-1-butanol 52.11
    n-decane 0.68
    butyronitrile 44.54
    3,7-dimethyl-1-octanol 15.38
    1-chlorooctane 5.4
    1-chlorotetradecane 2.8
    n-nonane 0.46
    undecane 0.55
    tert-butylcyclohexane 0.76
    cyclooctane 0.39
    cyclopentanol 65.44
    tetrahydropyran 118.91
    tert-amyl methyl ether 17.18
    2,5,8-trioxanonane 83.66
    1-hexene 4.34
    2-isopropoxyethanol 86.88
    2,2,2-trifluoroethanol 59.44
    methyl butyrate 80.29

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction