Arginine

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  • Identifiers

    CAS number
    74-79-3

    Molecular formula
    C6H14N4O2

    SMILES
    C(C[C@@H](C(=O)O)N)CN=C(N)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 66.09%
    Fishy 42.03%
    Savory 34.29%
    Meaty 30.49%
    Cooling 24.27%
    Cheesy 21.49%
    Ripe 18.95%
    Cooked 18.81%
    Sweet 17.46%
    Animal 16.87%

     

    Flavor
    Odorless 53.47%
    Mild 31.91%
    Bitter 31.82%
    Bland 28.17%
    Faint 23.88%
    Roasted 21.98%
    Cooked 21.73%
    Sweet-like 20.98%
    Nitrile 20.44%
    Yeast 20.43%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -4.2

    pKa est.
    6.9 (neutral)

    Molecular weight
    174.2 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    387°C

    Melting point expt.

    • 244 dec °C
    • 244 °C
    • 222 °C

    Flash point

    • 175.66 ˚C est.

    Solubility expt.

    • 182000 mg/L (at 25 °C)
    • Insoluble in ethyl ether; slightly soluble in ethanol
    • In water, 1.82X10+5 mg/l @ 25 °C
    • 182 mg/mL at 25 °C
    • Soluble in water; Insoluble in ether
    • Slightly soluble (in ethanol)

  • Synonyms

    • L-arginine
    • arginine
    • 74-79-3
    • L-(+)-Arginine
    • L-Arg
    • (S)-2-Amino-5-guanidinopentanoic acid
    • H-Arg-OH
    • L(+)-Arginine
    • Arginina
    • (L)-Arginine
    • Arginine (VAN)
    • ARGININE, L-
    • L-Arginin
    • Argininum
    • Argininum [INN-Latin]
    • Arginina [INN-Spanish]
    • L-Ornithine, N5-(aminoiminomethyl)-
    • arg
    • CHEBI:16467
    • L-alpha-Amino-delta-guanidinovaleric acid
    • (S)-2-Amino-5-guanidinovaleric acid
    • 1-Amino-4-guanidovaleric acid
    • CCRIS 3609
    • (S)-2-Amino-5-((aminoiminomethyl)amino)pentanoic acid
    • NSC 206269
    • (2S)-2-amino-5-(diaminomethylideneamino)pentanoic acid
    • 2-amino-5-guanidinovaleric acid
    • HSDB 1429
    • AI3-24165
    • (2S)-2-amino-5-carbamimidamidopentanoic acid
    • MFCD00002635
    • BRN 1725413
    • 94ZLA3W45F
    • (2S)-2-amino-5-guanidinopentanoic acid
    • DTXSID6041056
    • (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid
    • L-Norvaline, 5-((aminoiminomethyl)amino)-
    • L-Arginine (JP17)
    • ARGININE [HSDB]
    • ARGININE [II]
    • ARGININE [INN]
    • ARGININE [MI]
    • ARGININE [VANDF]
    • ARGININE [MART.]
    • L-ARGININE [FCC]
    • L-ARGININE [JAN]
    • (2S)-2-amino-5-(carbamimidamido)pentanoic acid
    • ARGININE [WHO-DD]
    • L-ARGININE [FHFI]
    • NSC-206269
    • 2-amino-5-guanidinovalerate
    • CHEMBL1485
    • L-ARGININE [USP-RS]
    • ARGININE [EP IMPURITY]
    • ARGININE [EP MONOGRAPH]
    • ARGININE [USP MONOGRAPH]
    • DTXCID4021056
    • Pentanoic acid, 2-amino-5-((aminoiminomethyl)amino)-, (S)-
    • N5-(aminoiminomethyl)-L-Ornithine
    • l arginine
    • L-alpha-Amino-delta-guanidinovalerate
    • C6H14N4O2
    • 5-[(aminoiminomethyl)amino]-L-Norvaline
    • L-Isomer arginine
    • ARGININE (II)
    • L-Norvaline, 5-[(aminoiminomethyl)amino]-
    • Arginine, L isomer
    • Arginine, L-isomer
    • ARGININE (MART.)
    • LYSINE ACETATE IMPURITY F [EP IMPURITY]
    • arginin
    • L-ARGININE (USP-RS)
    • (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate
    • 4455-52-1
    • (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoate
    • ARGININE (EP IMPURITY)
    • ARGININE (EP MONOGRAPH)
    • (S)-2-amino-5-[(aminoiminomethyl)amino]-Pentanoic acid
    • ARGININE (USP MONOGRAPH)
    • (2S)-2-amino-5-[(diaminomethylidene)amino]pentanoic acid
    • Pentanoic acid, 2-amino-5-[(aminoiminomethyl)amino]-, (S)-
    • Arginine [USAN:INN]
    • CAS-74-79-3
    • 5-((Aminoiminomethyl)amino)-L-Norvaline
    • NSC203450
    • LYSINE ACETATE IMPURITY F (EP IMPURITY)
    • (S)-(+)-arginine
    • Arginine [USP:INN]
    • (S)-2-amino-5-((aminoiminomethyl)amino)-Pentanoate
    • (S)-2-Amino-5-((aminoiminomethyl)amino)pentanoate
    • EINECS 200-811-1
    • 2-AMINO-5-GUANIDINO-PENTANOIC ACID
    • (S)-2-amino-5-((aminoiminomethyl)amino)-Pentanoic acid
    • (2S)-2-amino-5-((diaminomethylidene)amino)pentanoic acid
    • UNII-94ZLA3W45F
    • LArginine
    • NSC206269
    • (l)arginine
    • L-Arginine High
    • 3h-l-arginine
    • L-Arginine, labeled with tritium
    • 1laf
    • Arginine, L
    • L-a-Amino-d-guanidinovaleric acid
    • NCGC00015064-02
    • (S)-Arginine
    • L(+)Arginine
    • L(+) arginine
    • 2-amino-5-(carbamimidamido)pentanoic acid
    • H-Arg
    • L-(+) arginine
    • L-Arginine (9CI)
    • L-Arginine 7401
    • Arginine (USP/INN)
    • Tocris-0663
    • L-Arginine (Standard)
    • (2S)-2-amino-5-guanidino-pentanoic acid
    • ARGININE [INCI]
    • GND
    • Lopac-A-5006
    • Arginine, L- (8CI)
    • L-Arginine High 7402
    • bmse000029
    • bmse000899
    • bmse000919
    • Epitope ID:140084
    • L-Arginine (H-Arg-OH)
    • EC 200-811-1

  • Applications

    L-Arginine (CAS 74-79-3) is a semi-essential amino acid widely employed in pharmaceuticals, nutraceuticals, animal feed and cosmetics; in medicine it serves as a precursor of nitric oxide, promoting vasodilation and thus being formulated in tablets, injections or oral powders for hypertension, angina, erectile dysfunction, peripheral vascular disease and accelerated wound healing; in sports nutrition it is blended into protein powders, energy bars and pre-workout drinks to stimulate growth-hormone release, enhance muscle blood flow and delay fatigue; in the food industry the compound works as a mild umami flavour enhancer and pH buffer, while in aquaculture and poultry feed it supports growth performance, strengthens immunity and improves feed conversion ratios; additionally, L-Arginine is an important intermediate for the synthesis of polyamines, creatine, L-citrulline and other high-value bio-derivatives that are used in cell culture media, biochemical research and advanced material development.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.03
    methanol 0.14
    isopropanol 0.02
    water 67.99
    ethyl acetate 0.05
    n-propanol 0.02
    acetone 0.02
    n-butanol 0.02
    acetonitrile 0.02
    DMF 0.68
    toluene 0.07
    isobutanol 0.02
    1,4-dioxane 0.04
    methyl acetate 0.03
    THF 0.09
    2-butanone 0.03
    n-pentanol 0.02
    sec-butanol 0.02
    n-hexane 0.05
    ethylene glycol 0.92
    NMP 7.44
    cyclohexane 0.03
    DMSO 4.09
    n-butyl acetate 0.05
    n-octanol 0.02
    chloroform 0.05
    n-propyl acetate 0.03
    acetic acid 1.28
    dichloromethane 0.06
    cyclohexanone 0.19
    propylene glycol 0.48
    isopropyl acetate 0.05
    DMAc 2.23
    2-ethoxyethanol 0.21
    isopentanol 0.03
    n-heptane 0.05
    ethyl formate 0.09
    1,2-dichloroethane 0.04
    n-hexanol 0.06
    2-methoxyethanol 0.39
    isobutyl acetate 0.02
    tetrachloromethane 0.07
    n-pentyl acetate 0.04
    transcutol 0.45
    n-heptanol 0.06
    ethylbenzene 0.06
    MIBK 0.05
    2-propoxyethanol 0.35
    tert-butanol 0.04
    MTBE 0.02
    2-butoxyethanol 0.23
    propionic acid 0.26
    o-xylene 0.18
    formic acid 17.5
    diethyl ether 0.02
    m-xylene 0.13
    p-xylene 0.09
    chlorobenzene 0.03
    dimethyl carbonate 0.16
    n-octane 0.02
    formamide 4.19
    cyclopentanone 0.23
    2-pentanone 0.04
    anisole 0.04
    cyclopentyl methyl ether 0.17
    gamma-butyrolactone 0.55
    1-methoxy-2-propanol 0.3
    pyridine 0.1
    3-pentanone 0.07
    furfural 1.65
    n-dodecane 0.01
    diethylene glycol 1.46
    diisopropyl ether 0.02
    tert-amyl alcohol 0.07
    acetylacetone 0.14
    n-hexadecane 0.01
    acetophenone 0.14
    methyl propionate 0.1
    isopentyl acetate 0.07
    trichloroethylene 0.1
    n-nonanol 0.03
    cyclohexanol 0.09
    benzyl alcohol 0.1
    2-ethylhexanol 0.06
    isooctanol 0.05
    dipropyl ether 0.06
    1,2-dichlorobenzene 0.07
    ethyl lactate 0.23
    propylene carbonate 0.45
    n-methylformamide 0.43
    2-pentanol 0.02
    n-pentane 0.02
    1-propoxy-2-propanol 0.24
    1-methoxy-2-propyl acetate 0.2
    2-(2-methoxypropoxy) propanol 0.5
    mesitylene 0.13
    ε-caprolactone 0.28
    p-cymene 0.1
    epichlorohydrin 0.12
    1,1,1-trichloroethane 0.04
    2-aminoethanol 0.45
    morpholine-4-carbaldehyde 1.79
    sulfolane 4.93
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.07
    n-hexyl acetate 0.04
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 0.37
    sec-butyl acetate 0.03
    tert-butyl acetate 0.08
    decalin 0.03
    glycerin 4.98
    diglyme 0.5
    acrylic acid 0.79
    isopropyl myristate 0.02
    n-butyric acid 0.24
    acetyl acetate 0.09
    di(2-ethylhexyl) phthalate 0.13
    ethyl propionate 0.06
    nitromethane 0.56
    1,2-diethoxyethane 0.04
    benzonitrile 0.07
    trioctyl phosphate 0.08
    1-bromopropane 0.02
    gamma-valerolactone 0.73
    n-decanol 0.02
    triethyl phosphate 0.16
    4-methyl-2-pentanol 0.04
    propionitrile 0.02
    vinylene carbonate 0.41
    1,1,2-trichlorotrifluoroethane 2.4
    DMS 0.12
    cumene 0.07
    2-octanol 0.03
    2-hexanone 0.03
    octyl acetate 0.03
    limonene 0.11
    1,2-dimethoxyethane 0.17
    ethyl orthosilicate 0.15
    tributyl phosphate 0.09
    diacetone alcohol 0.33
    N,N-dimethylaniline 0.15
    acrylonitrile 0.06
    aniline 0.13
    1,3-propanediol 0.22
    bromobenzene 0.03
    dibromomethane 0.04
    1,1,2,2-tetrachloroethane 0.12
    2-methyl-cyclohexyl acetate 0.11
    tetrabutyl urea 0.16
    diisobutyl methanol 0.07
    2-phenylethanol 0.13
    styrene 0.04
    dioctyl adipate 0.05
    dimethyl sulfate 1.08
    ethyl butyrate 0.07
    methyl lactate 0.77
    butyl lactate 0.21
    diethyl carbonate 0.06
    propanediol butyl ether 0.35
    triethyl orthoformate 0.12
    p-tert-butyltoluene 0.1
    methyl 4-tert-butylbenzoate 0.44
    morpholine 0.06
    tert-butylamine 0.02
    n-dodecanol 0.02
    dimethoxymethane 0.16
    ethylene carbonate 0.22
    cyrene 1.66
    2-ethoxyethyl acetate 0.07
    2-ethylhexyl acetate 0.06
    1,2,4-trichlorobenzene 0.09
    4-methylpyridine 0.11
    dibutyl ether 0.02
    2,6-dimethyl-4-heptanol 0.07
    DEF 0.23
    dimethyl isosorbide 1.16
    tetrachloroethylene 0.19
    eugenol 0.52
    triacetin 0.16
    span 80 0.45
    1,4-butanediol 0.14
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.03
    methyl formate 0.36
    2-methyl-1-butanol 0.03
    n-decane 0.01
    butyronitrile 0.02
    3,7-dimethyl-1-octanol 0.03
    1-chlorooctane 0.01
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.02
    cyclooctane 0.03
    cyclopentanol 0.11
    tetrahydropyran 0.03
    tert-amyl methyl ether 0.05
    2,5,8-trioxanonane 0.7
    1-hexene 0.04
    2-isopropoxyethanol 0.11
    2,2,2-trifluoroethanol 2.07
    methyl butyrate 0.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction