Arachidonic Acid

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  • Identifiers

    CAS number
    506-32-1

    Molecular formula
    C20H32O2

    SMILES
    CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Fatty 81.73%
    Oily 59.38%
    Waxy 34.98%
    Fishy 28.21%
    Fruity 27.18%
    Green 25.09%
    Dairy 21.38%
    Citrus 21.15%
    Herbal 20.61%
    Sweet 20.08%

     

    Flavor
    Faint 22.53%
    Fatty 20.49%
    Oriental 18.91%
    Pumpkin 18.09%
    Diterpene 18.04%
    Delicate 18.0%
    Slightly waxy 17.9%
    Low 17.84%
    Nitrile 17.56%
    Terpentine 17.44%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    6.3

    pKa est.
    8.11 (weak base)

    Molecular weight
    304.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • -49.5 °C

    Boiling point

    • 170 °C at 1.50E-01 mm Hg

    Flash point

    • 239.23 ˚C est.

  • Synonyms

    • arachidonic acid
    • 506-32-1
    • (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid
    • (all-Z)-5,8,11,14-Eicosatetraenoic acid
    • cis-5,8,11,14-Eicosatetraenoic acid
    • 5Z,8Z,11Z,14Z-eicosatetraenoic acid
    • 5,8,11,14-Eicosatetraenoic acid, (all-Z)-
    • all-cis-5,8,11,14-eicosatetraenoic acid
    • 27YG812J1I
    • C20:4
    • DTXSID4040420
    • CHEBI:15843
    • (5Z,8Z,11Z,14Z)-Icosatetraenoic acid
    • Arachidonate, Sodium
    • RefChem:5560
    • Fatty Acid 20:4 n-6
    • DTXCID2020420
    • All-cis-icosa-5,8,11,14-tetraenoic acid
    • 208-033-4
    • Immunocytophyte
    • MFCD00004417
    • (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic Acid
    • CHEMBL15594
    • cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic acid
    • (5Z,8Z,11Z,14Z)-5,8,11,14-Icosatetraenoic acid
    • 5Z,8Z,11Z,14Z-icosatetraenoic acid
    • FA 20:4
    • ARACHIDONIC ACID (20:4, n-6)
    • [1-14C]Arachidonic acid
    • 93444-49-6
    • 5Z,8Z,11Z,14Z-Eicosatetraenoate
    • (14C)Arachidonic acid
    • Arachidonic Acid, 99%
    • Arachidonic Acid, >97%
    • Arachidonic Acid-d8 (Major, 10mg/ml in Methyl Acetate)
    • Arachidonsaeure
    • UNII-27YG812J1I
    • arachidonic-acid
    • CCRIS 6312
    • 1adl
    • 1gnj
    • 1vyg
    • (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoic-5,6,8,9,11,12,14,15-d8 Acid; (all-Z)-5,8,11,14-Eicosatetraenoic-5,6,8,9,11,12,14,15-d8 Acid; Arachidonic Acid-5,6,8,9,11,12,14,15-2H8;
    • EINECS 208-033-4
    • ARA/Arachidonic?acid
    • AI3-09613
    • (14C)-arachidonic acid
    • Spectrum5_001910
    • Arachidonic acid - 10%
    • Arachidonic acid - 40%
    • Arachidonic acid - 98%
    • SCHEMBL16162
    • BSPBio_001539
    • MLS001361328
    • ARACHIDONIC ACID [MI]
    • AA-[d8]
    • (5Z,8Z,11Z,14Z)-5,8,11,14-Eikosatetraensaeure
    • BML3-B03
    • GTPL2391
    • orb1303125
    • orb3025908
    • SCHEMBL5887680
    • 5,8,11,14-Eicosatetraenoate
    • 6,9,12,15-arachidonic acid
    • BDBM22319
    • ARACHIDONIC ACID [MART.]
    • ARACHIDONIC ACID [WHO-DD]
    • CHEBI:137828
    • HMS1361M21
    • HMS1791M21
    • HMS1989M21
    • HMS3402M21
    • HMS3649B05
    • Arachidonic acid, >95.0% (GC)
    • 5,8,11,14-Eicosatetraenoic acid, labeled with carbon-14, (all-Z)-
    • Arachidonic acid, analytical standard
    • cis-D5,8,11,14-Eicosatetraenoate
    • LMFA01030001
    • s6185
    • AKOS015950830
    • MSK1762-1000M
    • CCG-214838
    • DB04557
    • EBC-616000
    • FA40762
    • FA76490
    • FS-5880
    • 5,8,11,14-all-cis-Eicosatetraenoate
    • all-cis-5,8,11,14-Eicosatetraenoate
    • ARACHIDONIC ACID (20:4 n-6)
    • IDI1_034009
    • cis-D5,8,11,14-Eicosatetraenoic acid
    • NCGC00094608-01
    • NCGC00094608-02
    • NCGC00094608-03
    • NCGC00094608-04
    • NCGC00094608-05
    • NCGC00094608-06
    • (all-Z)-5,8,11,14-Eicosatetraenoate
    • AC-14348
    • AC-33769
    • BP-29803
    • Eicosa-5Z,8Z,11Z,14Z-tetraenoic acid
    • FA165223
    • SMR000857374
    • ST069383
    • SY045398
    • 5,8,11,14-all-cis-Eicosatetraenoic acid
    • HY-109590
    • A0781
    • all-cis-eicosa-5,8,11,14-tetraenoic acid
    • CS-0032762
    • cis-Delta(5,8,11,14)-eicosatetraenoic acid
    • 5-cis,8-cis,11-cis,14-cis-Eicosatetraenoate
    • C00219
    • M03710
    • W15452
    • FA(20:4(5Z,8Z,11Z,14Z))
    • 5-cis,8-cis,11-cis,14-cis-Eicosatetraenoic acid
    • 506A321
    • Q407699
    • SR-01000838311
    • Q-200649
    • SR-01000838311-2
    • BRD-K03070961-001-02-8
    • BRD-K03070961-001-04-4
    • BRD-K03070961-001-08-5
    • 506-32-1

  • Applications

    Arachidonic Acid (CAS 506-32-1) is a long-chain polyunsaturated omega-6 fatty acid used as a lipid ingredient and chemical intermediate in various applications. In cosmetics and personal care, it serves as a lipid component and emollient in topical formulations. In nutrition and food processing, it is employed as a dietary supplement and fortifying ingredient in infant formula and specialty foods. In pharmaceutical and research settings, it functions as a substrate for eicosanoid biosynthesis studies and as a lipid standard in lipidomics analyses. In industrial manufacturing, it serves as a fatty acid feedstock for the synthesis of esters, surfactants, and other specialty chemicals. In analytical laboratories, it is used as a reference material for lipid analysis.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 62.28
    methanol 55.81
    isopropanol 51.75
    water 0.01
    ethyl acetate 67.14
    n-propanol 53.63
    acetone 71.29
    n-butanol 61.56
    acetonitrile 13.14
    DMF 118.95
    toluene 29.16
    isobutanol 41.18
    1,4-dioxane 102.49
    methyl acetate 39.62
    THF 391.19
    2-butanone 85.48
    n-pentanol 63.42
    sec-butanol 56.04
    n-hexane 14.85
    ethylene glycol 2.35
    NMP 191.27
    cyclohexane 21.55
    DMSO 260.82
    n-butyl acetate 98.63
    n-octanol 35.54
    chloroform 129.62
    n-propyl acetate 102.47
    acetic acid 28.11
    dichloromethane 140.3
    cyclohexanone 188.72
    propylene glycol 11.67
    isopropyl acetate 74.93
    DMAc 265.22
    2-ethoxyethanol 114.92
    isopentanol 72.95
    n-heptane 9.81
    ethyl formate 28.46
    1,2-dichloroethane 126.16
    n-hexanol 56.52
    2-methoxyethanol 106.72
    isobutyl acetate 79.38
    tetrachloromethane 23.88
    n-pentyl acetate 95.9
    transcutol 585.86
    n-heptanol 37.52
    ethylbenzene 31.36
    MIBK 106.01
    2-propoxyethanol 122.38
    tert-butanol 85.02
    MTBE 108.51
    2-butoxyethanol 99.89
    propionic acid 29.29
    o-xylene 30.26
    formic acid 6.99
    diethyl ether 78.69
    m-xylene 30.13
    p-xylene 36.4
    chlorobenzene 40.28
    dimethyl carbonate 18.0
    n-octane 4.96
    formamide 13.8
    cyclopentanone 190.07
    2-pentanone 106.21
    anisole 73.39
    cyclopentyl methyl ether 152.16
    gamma-butyrolactone 143.49
    1-methoxy-2-propanol 121.61
    pyridine 77.06
    3-pentanone 67.79
    furfural 105.65
    n-dodecane 3.38
    diethylene glycol 43.99
    diisopropyl ether 36.54
    tert-amyl alcohol 85.22
    acetylacetone 112.0
    n-hexadecane 3.91
    acetophenone 86.46
    methyl propionate 54.15
    isopentyl acetate 110.98
    trichloroethylene 173.47
    n-nonanol 38.07
    cyclohexanol 69.48
    benzyl alcohol 46.77
    2-ethylhexanol 49.54
    isooctanol 42.09
    dipropyl ether 85.14
    1,2-dichlorobenzene 49.12
    ethyl lactate 44.51
    propylene carbonate 79.62
    n-methylformamide 29.85
    2-pentanol 50.53
    n-pentane 7.51
    1-propoxy-2-propanol 123.51
    1-methoxy-2-propyl acetate 122.45
    2-(2-methoxypropoxy) propanol 109.89
    mesitylene 25.09
    ε-caprolactone 156.12
    p-cymene 25.75
    epichlorohydrin 204.2
    1,1,1-trichloroethane 91.45
    2-aminoethanol 14.86
    morpholine-4-carbaldehyde 159.19
    sulfolane 279.2
    2,2,4-trimethylpentane 10.04
    2-methyltetrahydrofuran 209.93
    n-hexyl acetate 108.12
    isooctane 7.13
    2-(2-butoxyethoxy)ethanol 157.14
    sec-butyl acetate 86.6
    tert-butyl acetate 122.41
    decalin 16.87
    glycerin 18.16
    diglyme 302.51
    acrylic acid 16.55
    isopropyl myristate 44.1
    n-butyric acid 78.46
    acetyl acetate 36.24
    di(2-ethylhexyl) phthalate 36.76
    ethyl propionate 73.42
    nitromethane 51.29
    1,2-diethoxyethane 192.96
    benzonitrile 40.21
    trioctyl phosphate 27.69
    1-bromopropane 81.41
    gamma-valerolactone 243.09
    n-decanol 26.02
    triethyl phosphate 51.26
    4-methyl-2-pentanol 42.3
    propionitrile 22.4
    vinylene carbonate 50.71
    1,1,2-trichlorotrifluoroethane 125.07
    DMS 51.25
    cumene 28.36
    2-octanol 28.84
    2-hexanone 120.74
    octyl acetate 49.03
    limonene 44.42
    1,2-dimethoxyethane 213.27
    ethyl orthosilicate 58.39
    tributyl phosphate 37.22
    diacetone alcohol 138.7
    N,N-dimethylaniline 67.81
    acrylonitrile 19.34
    aniline 36.06
    1,3-propanediol 34.71
    bromobenzene 44.69
    dibromomethane 98.33
    1,1,2,2-tetrachloroethane 193.11
    2-methyl-cyclohexyl acetate 99.12
    tetrabutyl urea 60.83
    diisobutyl methanol 38.48
    2-phenylethanol 50.72
    styrene 33.44
    dioctyl adipate 74.67
    dimethyl sulfate 46.89
    ethyl butyrate 89.89
    methyl lactate 34.07
    butyl lactate 77.19
    diethyl carbonate 46.95
    propanediol butyl ether 83.39
    triethyl orthoformate 82.92
    p-tert-butyltoluene 25.69
    methyl 4-tert-butylbenzoate 94.28
    morpholine 176.31
    tert-butylamine 53.61
    n-dodecanol 18.49
    dimethoxymethane 104.9
    ethylene carbonate 46.83
    cyrene 99.6
    2-ethoxyethyl acetate 119.83
    2-ethylhexyl acetate 88.94
    1,2,4-trichlorobenzene 61.85
    4-methylpyridine 83.18
    dibutyl ether 90.22
    2,6-dimethyl-4-heptanol 38.48
    DEF 125.27
    dimethyl isosorbide 225.8
    tetrachloroethylene 107.12
    eugenol 79.64
    triacetin 109.4
    span 80 95.9
    1,4-butanediol 14.64
    1,1-dichloroethane 85.07
    2-methyl-1-pentanol 74.23
    methyl formate 16.0
    2-methyl-1-butanol 61.64
    n-decane 6.94
    butyronitrile 40.78
    3,7-dimethyl-1-octanol 46.06
    1-chlorooctane 31.58
    1-chlorotetradecane 11.2
    n-nonane 6.45
    undecane 4.58
    tert-butylcyclohexane 14.88
    cyclooctane 7.13
    cyclopentanol 61.97
    tetrahydropyran 175.49
    tert-amyl methyl ether 100.1
    2,5,8-trioxanonane 196.85
    1-hexene 45.89
    2-isopropoxyethanol 101.36
    2,2,2-trifluoroethanol 8.49
    methyl butyrate 111.54

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction