Anileridine

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  • Identifiers

    CAS number
    144-14-9

    Molecular formula
    C22H28N2O2

    SMILES
    CCOC(=O)C1(CCN(CC1)CCC2=CC=C(C=C2)N)C3=CC=CC=C3

  • Odor profile

    Fragrance
    Floral 50.36%
    Grape 45.53%
    Sweet 41.23%
    Fruity 34.72%
    Citrus 33.03%
    Honey 32.08%
    Animal 31.25%
    Neroli 28.8%
    Orange 26.54%
    Fresh 26.0%

     

    Flavor
    Fruity 50.5%
    Floral 48.87%
    Bitter 48.47%
    Sweet 44.99%
    Rose 34.37%
    Balsam 30.53%
    Honey 26.92%
    Mild 25.5%
    Fruit 24.71%
    Waxy 23.64%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.7

    pKa est.
    6.22 (neutral)

    Molecular weight
    352.5 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    518°C

    Melting point expt.

    • 275-277
    • 83 °C

    Flash point

    • 221.96 ˚C est.

    Solubility expt.

    • ODORLESS; PH (1 IN 20 SOLN) BETWEEN 2.5 & 3; PRACTICALLY INSOL IN ETHER & CHLOROFORM /ANILERIDINE DIHYDROCHLORIDE/
    • SOL IN ALCOHOL, CHLOROFORM; VERY SLIGHTLY SOL IN WATER
    • SOL IN ETHER
    • Sol in 1 in 2 parts of alcohol and 1 in 1 of chloroform.
    • 1.24e-02 g/L

  • Synonyms

    • ANILERIDINE
    • Alidine
    • Leritin
    • Nipecotan
    • Adopol
    • Apidol
    • Anileridina
    • Leritine
    • Anileridinum
    • 144-14-9
    • Apodol
    • Anileridinum [INN-Latin]
    • Anileridina [INN-Spanish]
    • Ethyl 1-(p-aminophenethyl)-4-phenylisonipecotate
    • ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate
    • N-beta-(p-Aminophenyl)ethylnormeperidine
    • Ethyl 1-(4-aminophenethyl)-4-phenylisonipecotate
    • N-(beta-(p-Aminophenyl)ethyl)-4-phenyl-4-carbethoxypiperidine
    • Ethyl 1-(2-(4-aminophenyl)ethyl)-4-phenyl-4-piperidinecarboxylate
    • IDS-NA-012
    • DTXSID8022610
    • CHEBI:61203
    • 4-Piperidinecarboxylic acid, 1-(2-(4-aminophenyl)ethyl)-4-phenyl-, ethyl ester
    • ANILERIDINE [MI]
    • ANILERIDINE [INN]
    • ANILERIDINE [HSDB]
    • Isonipecotic acid, 1-(p-aminophenethyl)-4-phenyl-, ethyl ester
    • 71Q1A3O279
    • 1-(p-Aminophenethyl)-4-phenylpiperidine-4-carboxylic acid ethyl ester
    • ANILERIDINE [MART.]
    • 1-[2-(4-Aminophenyl)ethyl]-4-phenyl-4-piperidinecarboxlic acid ethyl ester
    • ANILERIDINE [WHO-DD]
    • 4-Piperidinecarboxylic acid, 1-[2-(4-aminophenyl)ethyl]-4-phenyl-, ethyl ester
    • DTXCID702610
    • ANILERIDINE [USP IMPURITY]
    • ANILERIDINE (MART.)
    • ANILERIDINE (USP IMPURITY)
    • 1-P-AMINOPHENETHYL-4-PHENYLPIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER
    • Anileridine (1.0 mg/mL in ethyl acetate)
    • HSDB 3288
    • Anileridine (USP/INN)
    • Anileridine [USP:INN:BAN]
    • ethyl 1-(2-(4-aminophenyl)ethyl)-4-phenylpiperidine-4-carboxylate
    • 1-(p-Aminophenethyl)-4-phenylisonipecotic acid ethyl ester
    • DEA No. 9020
    • 1-(2-(4-Aminophenyl)ethyl)-4-phenyl-4-piperidinecarboxlic acid ethyl ester
    • UNII-71Q1A3O279
    • Leritine (Canada)
    • 1-(2-(4-Aminophenyl)ethyl)-4-phenyl-4-piperidinecarboxylic acid ethyl ester
    • SCHEMBL26333
    • GTPL7115
    • CHEMBL1201347
    • N01AH05
    • LKYQLAWMNBFNJT-UHFFFAOYSA-N
    • Tox21_113744
    • AKOS027446331
    • DB00913
    • NCGC00253613-01
    • CAS-144-14-9
    • NS00067931
    • D02941
    • L000700
    • Q742266
    • Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenyl-4-piperidinecarboxylate #

  • Applications

    Anileridine (CAS 144-14-9) is a synthetic piperidine opioid analgesic used primarily as an active pharmaceutical ingredient (API) for pain relief under strict regulatory controls. In industry, its main application is as an API in pharmaceutical manufacturing, with potential use as an intermediate in the synthesis of related piperidine opioids. It is also employed in research and development for pharmacological studies and structure–activity relationship investigations, and may appear as an analytical reference standard or impurity marker in regulated toxicology or pharmaceutical laboratories. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 32.57
    methanol 76.8
    isopropanol 10.39
    water 0.2
    ethyl acetate 25.23
    n-propanol 28.59
    acetone 33.85
    n-butanol 23.86
    acetonitrile 12.54
    DMF 60.89
    toluene 24.39
    isobutanol 14.95
    1,4-dioxane 58.1
    methyl acetate 22.45
    THF 72.2
    2-butanone 41.31
    n-pentanol 18.42
    sec-butanol 10.05
    n-hexane 0.13
    ethylene glycol 5.37
    NMP 43.91
    cyclohexane 0.58
    DMSO 107.75
    n-butyl acetate 16.27
    n-octanol 4.44
    chloroform 301.04
    n-propyl acetate 18.2
    acetic acid 56.04
    dichloromethane 316.32
    cyclohexanone 79.22
    propylene glycol 8.21
    isopropyl acetate 13.84
    DMAc 111.48
    2-ethoxyethanol 61.37
    isopentanol 17.29
    n-heptane 0.18
    ethyl formate 39.54
    1,2-dichloroethane 129.64
    n-hexanol 11.16
    2-methoxyethanol 77.44
    isobutyl acetate 11.65
    tetrachloromethane 11.11
    n-pentyl acetate 13.63
    transcutol 99.14
    n-heptanol 9.1
    ethylbenzene 7.02
    MIBK 16.01
    2-propoxyethanol 46.83
    tert-butanol 8.42
    MTBE 4.12
    2-butoxyethanol 33.27
    propionic acid 23.79
    o-xylene 10.68
    formic acid 42.41
    diethyl ether 7.54
    m-xylene 10.19
    p-xylene 8.64
    chlorobenzene 47.29
    dimethyl carbonate 19.99
    n-octane 0.15
    formamide 69.38
    cyclopentanone 76.47
    2-pentanone 28.16
    anisole 19.23
    cyclopentyl methyl ether 18.33
    gamma-butyrolactone 78.54
    1-methoxy-2-propanol 40.61
    pyridine 92.08
    3-pentanone 22.71
    furfural 106.77
    n-dodecane 0.17
    diethylene glycol 38.71
    diisopropyl ether 1.53
    tert-amyl alcohol 7.41
    acetylacetone 37.76
    n-hexadecane 0.2
    acetophenone 29.62
    methyl propionate 24.99
    isopentyl acetate 15.39
    trichloroethylene 292.37
    n-nonanol 5.43
    cyclohexanol 15.4
    benzyl alcohol 35.19
    2-ethylhexanol 6.43
    isooctanol 7.72
    dipropyl ether 4.38
    1,2-dichlorobenzene 41.9
    ethyl lactate 16.06
    propylene carbonate 43.84
    n-methylformamide 47.64
    2-pentanol 6.68
    n-pentane 0.15
    1-propoxy-2-propanol 22.34
    1-methoxy-2-propyl acetate 27.13
    2-(2-methoxypropoxy) propanol 23.92
    mesitylene 4.43
    ε-caprolactone 56.03
    p-cymene 4.24
    epichlorohydrin 153.56
    1,1,1-trichloroethane 45.21
    2-aminoethanol 18.18
    morpholine-4-carbaldehyde 69.24
    sulfolane 85.34
    2,2,4-trimethylpentane 0.22
    2-methyltetrahydrofuran 23.75
    n-hexyl acetate 12.09
    isooctane 0.15
    2-(2-butoxyethoxy)ethanol 35.65
    sec-butyl acetate 10.04
    tert-butyl acetate 12.19
    decalin 0.49
    glycerin 18.64
    diglyme 79.06
    acrylic acid 27.57
    isopropyl myristate 4.86
    n-butyric acid 44.58
    acetyl acetate 22.39
    di(2-ethylhexyl) phthalate 11.5
    ethyl propionate 14.03
    nitromethane 87.78
    1,2-diethoxyethane 22.18
    benzonitrile 30.45
    trioctyl phosphate 6.31
    1-bromopropane 24.11
    gamma-valerolactone 125.71
    n-decanol 3.88
    triethyl phosphate 11.09
    4-methyl-2-pentanol 5.19
    propionitrile 17.68
    vinylene carbonate 59.07
    1,1,2-trichlorotrifluoroethane 105.96
    DMS 17.41
    cumene 4.39
    2-octanol 3.77
    2-hexanone 19.82
    octyl acetate 6.83
    limonene 4.41
    1,2-dimethoxyethane 65.94
    ethyl orthosilicate 10.2
    tributyl phosphate 7.71
    diacetone alcohol 21.65
    N,N-dimethylaniline 12.2
    acrylonitrile 29.34
    aniline 40.51
    1,3-propanediol 31.77
    bromobenzene 42.98
    dibromomethane 124.22
    1,1,2,2-tetrachloroethane 188.11
    2-methyl-cyclohexyl acetate 15.58
    tetrabutyl urea 11.13
    diisobutyl methanol 3.21
    2-phenylethanol 25.38
    styrene 9.84
    dioctyl adipate 11.86
    dimethyl sulfate 32.06
    ethyl butyrate 13.87
    methyl lactate 22.11
    butyl lactate 16.38
    diethyl carbonate 12.49
    propanediol butyl ether 18.7
    triethyl orthoformate 12.95
    p-tert-butyltoluene 3.43
    methyl 4-tert-butylbenzoate 24.13
    morpholine 64.79
    tert-butylamine 2.99
    n-dodecanol 2.73
    dimethoxymethane 59.39
    ethylene carbonate 46.98
    cyrene 36.16
    2-ethoxyethyl acetate 29.68
    2-ethylhexyl acetate 12.18
    1,2,4-trichlorobenzene 51.7
    4-methylpyridine 61.51
    dibutyl ether 4.07
    2,6-dimethyl-4-heptanol 3.21
    DEF 34.38
    dimethyl isosorbide 46.18
    tetrachloroethylene 113.48
    eugenol 29.27
    triacetin 21.64
    span 80 17.84
    1,4-butanediol 14.61
    1,1-dichloroethane 63.16
    2-methyl-1-pentanol 15.7
    methyl formate 41.13
    2-methyl-1-butanol 16.01
    n-decane 0.29
    butyronitrile 18.5
    3,7-dimethyl-1-octanol 4.81
    1-chlorooctane 2.13
    1-chlorotetradecane 0.92
    n-nonane 0.21
    undecane 0.21
    tert-butylcyclohexane 0.35
    cyclooctane 0.18
    cyclopentanol 13.88
    tetrahydropyran 34.62
    tert-amyl methyl ether 4.67
    2,5,8-trioxanonane 50.67
    1-hexene 1.3
    2-isopropoxyethanol 31.05
    2,2,2-trifluoroethanol 26.63
    methyl butyrate 23.41

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction