Aminopeptidase

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  • Identifiers

    CAS number
    9031-94-1

    Molecular formula
    C74H42F4N2O12S2

    SMILES
    C1=CC=C(C=C1)COC(=O)C2(C3=CC4=C(C=C3C5=C2N=C(S5)C=C6C(C7=C(C6=O)C=C8C=C(C(=CC8=C7)F)F)O)C(C9=C4SC(=N9)C=C1C(=O)C2=C(C1=O)C=C1C=C(C(=CC1=C2)F)F)(C(=O)OCC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1)C(=O)OCC1=CC=CC=C1

    Safety labels

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Fruity 46.89%
    Odorless 42.6%
    Grape 34.91%
    Floral 28.24%
    Neroli 25.61%
    Fatty 23.93%
    Balsamic 22.66%
    Cooked 20.17%
    Bitter 20.04%
    Fresh 19.8%

     

    Flavor
    Bitter 96.87%
    Odorless 30.21%
    Bland 23.79%
    Sweet-like 18.55%
    Nitrile 17.93%
    Cedarleaf 17.85%
    Very strong 17.34%
    Lovage 17.2%
    Indole 17.2%
    Heather 16.9%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    13.6

    pKa est.
    2.26 (strong acid)

    Molecular weight
    1291.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2102°C

    Flash point

    • 333.37 ˚C est.

  • Synonyms

    • Aminopeptidase
    • 9031-94-1
    • Aminopolypeptidase
    • Peptidase, amino-
    • RefChem:557564
    • DTXSID301042818
    • EINECS 232-874-6
    • 232-874-6
    • XSAWDVWPTLJVKL-UHFFFAOYSA-N
    • DA-65943
    • Native Streptomyces griseus Aminopeptidase I
    • tetrabenzyl 6-[(6,7-difluoro-1,3-dioxocyclopenta[b]naphthalen-2-ylidene)methyl]-15-[(6,7-difluoro-1-hydroxy-3-oxo-1H-cyclopenta[b]naphthalen-2-ylidene)methyl]-5,14-dithia-7,16-diazapentacyclo[10.6.0.03,10.04,8.013,17]octadeca-1,3(10),4(8),6,11,13(17),15-heptaene-9,9,18,18-tetracarboxylate
    • tetrabenzyl 6-[(6,7-difluoro-1,3-dioxocyclopenta[b]naphthalen-2-ylidene)methyl]-15-[(Z)-(6,7-difluoro-1-hydroxy-3-oxo-1H-cyclopenta[b]naphthalen-2-ylidene)methyl]-5,14-dithia-7,16-diazapentacyclo[10.6.0.03,10.04,8.013,17]octadeca-1,3(10),4(8),6,11,13(17),15-heptaene-9,9,18,18-tetracarboxylate
    • 9031-94-1

  • Applications

    Aminopeptidase, CAS 9031-94-1, is an exopeptidase that removes N-terminal amino acids from peptides. In food processing, it is used to debitter protein hydrolysates and generate free amino acids for flavor enhancement. In pharmaceutical and biotechnological manufacturing, it serves as a selective biocatalyst for peptide modification and N-terminal trimming, supporting peptide synthesis and sample preparation for proteomics. In industrial enzyme formulations, it is included in proteolytic enzyme blends to improve protein hydrolysis and to produce specialty amino acids or short peptides. In animal nutrition, it can be used as an enzyme additive to improve protein digestibility. In proteomics and peptide analysis, it is used for sample preparation and to facilitate N-terminal sequencing workflows.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 4.72
    methanol 5.24
    isopropanol 4.78
    water 0.02
    ethyl acetate 25.55
    n-propanol 6.75
    acetone 44.01
    n-butanol 5.8
    acetonitrile 12.64
    DMF 67.77
    toluene 14.02
    isobutanol 4.82
    1,4-dioxane 28.09
    methyl acetate 30.33
    THF 107.23
    2-butanone 49.01
    n-pentanol 5.59
    sec-butanol 6.89
    n-hexane 0.56
    ethylene glycol 2.31
    NMP 140.73
    cyclohexane 1.1
    DMSO 74.68
    n-butyl acetate 15.54
    n-octanol 4.44
    chloroform 44.14
    n-propyl acetate 18.04
    acetic acid 30.39
    dichloromethane 39.64
    cyclohexanone 86.45
    propylene glycol 4.38
    isopropyl acetate 18.21
    DMAc 104.82
    2-ethoxyethanol 14.46
    isopentanol 4.86
    n-heptane 0.68
    ethyl formate 17.42
    1,2-dichloroethane 23.11
    n-hexanol 4.39
    2-methoxyethanol 19.33
    isobutyl acetate 9.49
    tetrachloromethane 5.62
    n-pentyl acetate 16.95
    transcutol 20.94
    n-heptanol 4.24
    ethylbenzene 5.64
    MIBK 16.38
    2-propoxyethanol 17.53
    tert-butanol 5.04
    MTBE 7.98
    2-butoxyethanol 13.38
    propionic acid 18.72
    o-xylene 8.18
    formic acid 8.9
    diethyl ether 9.72
    m-xylene 6.68
    p-xylene 7.4
    chlorobenzene 15.8
    dimethyl carbonate 24.93
    n-octane 0.46
    formamide 14.28
    cyclopentanone 124.52
    2-pentanone 31.84
    anisole 13.14
    cyclopentyl methyl ether 26.01
    gamma-butyrolactone 106.85
    1-methoxy-2-propanol 18.9
    pyridine 50.31
    3-pentanone 30.77
    furfural 77.59
    n-dodecane 0.46
    diethylene glycol 9.32
    diisopropyl ether 3.08
    tert-amyl alcohol 6.67
    acetylacetone 53.63
    n-hexadecane 0.56
    acetophenone 25.35
    methyl propionate 30.57
    isopentyl acetate 11.81
    trichloroethylene 66.24
    n-nonanol 4.98
    cyclohexanol 9.84
    benzyl alcohol 13.51
    2-ethylhexanol 3.7
    isooctanol 3.38
    dipropyl ether 8.11
    1,2-dichlorobenzene 13.03
    ethyl lactate 12.37
    propylene carbonate 42.59
    n-methylformamide 25.35
    2-pentanol 4.67
    n-pentane 0.58
    1-propoxy-2-propanol 14.52
    1-methoxy-2-propyl acetate 21.71
    2-(2-methoxypropoxy) propanol 15.64
    mesitylene 3.3
    ε-caprolactone 63.53
    p-cymene 3.53
    epichlorohydrin 80.88
    1,1,1-trichloroethane 22.98
    2-aminoethanol 4.24
    morpholine-4-carbaldehyde 76.47
    sulfolane 161.57
    2,2,4-trimethylpentane 0.39
    2-methyltetrahydrofuran 40.38
    n-hexyl acetate 16.5
    isooctane 0.22
    2-(2-butoxyethoxy)ethanol 16.81
    sec-butyl acetate 13.25
    tert-butyl acetate 16.46
    decalin 0.68
    glycerin 8.51
    diglyme 28.52
    acrylic acid 22.08
    isopropyl myristate 7.5
    n-butyric acid 21.09
    acetyl acetate 23.62
    di(2-ethylhexyl) phthalate 7.72
    ethyl propionate 17.7
    nitromethane 68.45
    1,2-diethoxyethane 12.9
    benzonitrile 17.39
    trioctyl phosphate 6.37
    1-bromopropane 12.18
    gamma-valerolactone 146.81
    n-decanol 3.71
    triethyl phosphate 7.9
    4-methyl-2-pentanol 2.8
    propionitrile 13.46
    vinylene carbonate 42.81
    1,1,2-trichlorotrifluoroethane 61.79
    DMS 17.85
    cumene 3.09
    2-octanol 3.81
    2-hexanone 25.13
    octyl acetate 10.47
    limonene 5.54
    1,2-dimethoxyethane 27.79
    ethyl orthosilicate 6.76
    tributyl phosphate 7.07
    diacetone alcohol 22.09
    N,N-dimethylaniline 9.93
    acrylonitrile 21.44
    aniline 14.0
    1,3-propanediol 7.4
    bromobenzene 15.32
    dibromomethane 22.84
    1,1,2,2-tetrachloroethane 46.5
    2-methyl-cyclohexyl acetate 12.68
    tetrabutyl urea 13.59
    diisobutyl methanol 2.54
    2-phenylethanol 11.48
    styrene 6.82
    dioctyl adipate 12.82
    dimethyl sulfate 45.72
    ethyl butyrate 14.63
    methyl lactate 22.79
    butyl lactate 14.38
    diethyl carbonate 8.98
    propanediol butyl ether 11.4
    triethyl orthoformate 10.93
    p-tert-butyltoluene 3.22
    methyl 4-tert-butylbenzoate 16.82
    morpholine 33.78
    tert-butylamine 2.06
    n-dodecanol 2.85
    dimethoxymethane 34.35
    ethylene carbonate 31.87
    cyrene 32.56
    2-ethoxyethyl acetate 22.72
    2-ethylhexyl acetate 10.45
    1,2,4-trichlorobenzene 21.1
    4-methylpyridine 40.05
    dibutyl ether 6.85
    2,6-dimethyl-4-heptanol 2.54
    DEF 37.44
    dimethyl isosorbide 30.7
    tetrachloroethylene 25.61
    eugenol 15.12
    triacetin 20.75
    span 80 15.9
    1,4-butanediol 3.84
    1,1-dichloroethane 20.86
    2-methyl-1-pentanol 4.94
    methyl formate 25.42
    2-methyl-1-butanol 5.69
    n-decane 0.76
    butyronitrile 11.11
    3,7-dimethyl-1-octanol 3.89
    1-chlorooctane 3.62
    1-chlorotetradecane 1.69
    n-nonane 0.62
    undecane 0.57
    tert-butylcyclohexane 0.47
    cyclooctane 0.51
    cyclopentanol 15.52
    tetrahydropyran 26.85
    tert-amyl methyl ether 9.52
    2,5,8-trioxanonane 22.39
    1-hexene 2.65
    2-isopropoxyethanol 11.02
    2,2,2-trifluoroethanol 13.71
    methyl butyrate 23.88

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction