Aminacrine Hydrochloride

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  • Identifiers

    CAS number
    134-50-9

    Molecular formula
    C13H11ClN2

    SMILES
    C1=CC=C2C(=C1)C(=C3C=CC=CC3=N2)N.Cl

    Safety labels

    Acute Toxic
    Acute Toxic

    Irritant
    Irritant

    Health Hazard
    Health

  • Odor profile

    Fragrance
    Floral 56.34%
    Animal 47.71%
    Fruity 46.33%
    Grape 38.66%
    Neroli 34.38%
    Sweet 33.67%
    Orange 29.36%
    Musty 28.79%
    Phenolic 27.64%
    Burnt 27.42%

     

    Flavor
    Bitter 76.97%
    Animal 28.28%
    Very strong 25.68%
    Fecal 25.64%
    Indole 25.18%
    Moth ball 23.43%
    Naphthelene 22.92%
    Mothball 21.7%
    Nitrile 21.69%
    Cereal 21.39%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    5.77 (weak acid)

    Molecular weight
    230.69 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    409°C

    Flash point

    • 231.73 ˚C est.

    Solubility expt.

    • less than 1 mg/mL at 72 °F (NTP, 1992)
    • 1 G SOL IN 300 ML WATER & 150 ML ALCOHOL; SOL IN GLYCERIN

  • Synonyms

    • acridin-9-amine hydrochloride
    • 134-50-9
    • 9-AMINOACRIDINE HYDROCHLORIDE
    • Aminacrine hydrochloride
    • Acramine Yellow
    • Monacrin
    • Aminacrine HCl
    • Aminoacridine hydrochloride
    • Mycosert
    • Aminoakridin
    • Quench
    • 9-Aminoacridinium chloride
    • 9-Acridinamine, monohydrochloride
    • 9-Acridinamine monohydrochloride
    • Monacrin hydrochloride
    • Caswell No. 033A
    • NSC-7571
    • Aminoacridine hcl
    • Aminacrine hydrochloride [USAN]
    • 9-Aminoacridine monohydrochloride
    • CCRIS 3802
    • HSDB 4505
    • UNII-OR5RM3Q5QL
    • Acridine, 9-amino-, hydrochloride
    • 9-AMINOACRIDINE HCl
    • EINECS 205-145-5
    • Monacrin (TN)
    • 9-acridinamine HCl
    • EPA Pesticide Chemical Code 055503
    • CHEBI:74837
    • AI3-16947
    • OR5RM3Q5QL
    • acridin-9-amine;hydrochloride
    • Acridine-9-amine Hydrochloride
    • Aminacrine hydrochloride (USAN)
    • DTXSID8030473
    • NSC7571
    • AMINACRINE HYDROCHLORIDE [MI]
    • AMINACRINE HYDROCHLORIDE [HSDB]
    • AMINACRINE HYDROCHLORIDE [VANDF]
    • AMINOACRIDINE HYDROCHLORIDE [MART.]
    • AMINOACRIDINE HYDROCHLORIDE [WHO-DD]
    • Hydrochloride, Aminoacridine
    • AMINOACRIDINE HYDROCHLORIDE (MART.)
    • 9-Acridinamine hydrochloride hydrate
    • Acridine, 9-amino-, monohydrochloride
    • Acridin-9-ylamine hydrochloride monohydrate
    • Hydrochloride, Aminacrine
    • acridin-9-aminehydrochloride
    • SCHEMBL635597
    • CHEMBL1330022
    • DTXCID6010473
    • MFCD00012663
    • 9-Acridinamine, hydrochloride (1:1)
    • AKOS015903444
    • WLN: T C666 BNJ IZ & GH
    • ACRIDINE, 9-AMINO, HYDROCHLORIDE
    • DB-042240
    • A0619
    • EN300-74224
    • D02905
    • Q27144949
    • Z57039678
    • 205-145-5

  • Applications

    Aminacrine hydrochloride is an acridine derivative used primarily as an intermediate in the synthesis of dyes, pigments, and certain pharmaceutical compounds, leveraging the intercalation-like interactions of its acridine ring. In industry it is commonly employed as a chemical intermediate for colorant and pharmaceutical formulations, subject to local regulations. Acridine-class agents have historically served as antiseptics and disinfectants, so aminacrine may be considered for similar uses only where permissible. It is also evaluated as a fluorescent dye or staining agent in biological research and microscopy, and can be used in coatings/inks as a colorant or color additive. In research and development, aminacrine hydrochloride may function as a reagent or binding component in nucleic-acid related assays, again under appropriate formulation limits and regulatory compliance.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 13.84
    methanol 10.11
    isopropanol 10.06
    water 0.09
    ethyl acetate 37.74
    n-propanol 13.13
    acetone 50.11
    n-butanol 14.79
    acetonitrile 24.0
    DMF 114.47
    toluene 20.7
    isobutanol 10.7
    1,4-dioxane 99.55
    methyl acetate 29.64
    THF 187.62
    2-butanone 34.8
    n-pentanol 17.06
    sec-butanol 8.35
    n-hexane 2.59
    ethylene glycol 3.93
    NMP 98.2
    cyclohexane 3.4
    DMSO 142.3
    n-butyl acetate 45.74
    n-octanol 15.42
    chloroform 105.49
    n-propyl acetate 36.61
    acetic acid 35.32
    dichloromethane 122.61
    cyclohexanone 80.72
    propylene glycol 3.18
    isopropyl acetate 24.66
    DMAc 78.57
    2-ethoxyethanol 28.95
    isopentanol 17.05
    n-heptane 5.47
    ethyl formate 39.61
    1,2-dichloroethane 107.47
    n-hexanol 29.59
    2-methoxyethanol 45.79
    isobutyl acetate 29.98
    tetrachloromethane 14.95
    n-pentyl acetate 35.39
    transcutol 90.78
    n-heptanol 22.82
    ethylbenzene 16.19
    MIBK 27.18
    2-propoxyethanol 51.62
    tert-butanol 15.52
    MTBE 12.43
    2-butoxyethanol 42.41
    propionic acid 19.28
    o-xylene 14.04
    formic acid 10.43
    diethyl ether 27.02
    m-xylene 15.6
    p-xylene 20.98
    chlorobenzene 39.81
    dimethyl carbonate 35.82
    n-octane 3.16
    formamide 25.66
    cyclopentanone 130.52
    2-pentanone 37.3
    anisole 30.82
    cyclopentyl methyl ether 48.68
    gamma-butyrolactone 152.83
    1-methoxy-2-propanol 30.41
    pyridine 98.47
    3-pentanone 29.74
    furfural 124.03
    n-dodecane 2.58
    diethylene glycol 38.49
    diisopropyl ether 8.48
    tert-amyl alcohol 10.8
    acetylacetone 52.87
    n-hexadecane 2.92
    acetophenone 38.19
    methyl propionate 32.84
    isopentyl acetate 38.09
    trichloroethylene 164.77
    n-nonanol 15.86
    cyclohexanol 15.48
    benzyl alcohol 26.12
    2-ethylhexanol 22.8
    isooctanol 19.39
    dipropyl ether 31.22
    1,2-dichlorobenzene 40.75
    ethyl lactate 19.52
    propylene carbonate 80.49
    n-methylformamide 39.91
    2-pentanol 9.51
    n-pentane 2.19
    1-propoxy-2-propanol 33.53
    1-methoxy-2-propyl acetate 42.21
    2-(2-methoxypropoxy) propanol 27.4
    mesitylene 11.07
    ε-caprolactone 67.94
    p-cymene 15.76
    epichlorohydrin 170.16
    1,1,1-trichloroethane 49.58
    2-aminoethanol 7.74
    morpholine-4-carbaldehyde 91.77
    sulfolane 142.51
    2,2,4-trimethylpentane 1.53
    2-methyltetrahydrofuran 66.87
    n-hexyl acetate 35.43
    isooctane 1.59
    2-(2-butoxyethoxy)ethanol 44.68
    sec-butyl acetate 22.75
    tert-butyl acetate 25.29
    decalin 3.38
    glycerin 10.89
    diglyme 97.66
    acrylic acid 23.58
    isopropyl myristate 15.81
    n-butyric acid 38.01
    acetyl acetate 31.08
    di(2-ethylhexyl) phthalate 18.65
    ethyl propionate 31.18
    nitromethane 80.22
    1,2-diethoxyethane 46.74
    benzonitrile 40.5
    trioctyl phosphate 15.36
    1-bromopropane 33.6
    gamma-valerolactone 124.2
    n-decanol 12.84
    triethyl phosphate 22.79
    4-methyl-2-pentanol 10.16
    propionitrile 25.01
    vinylene carbonate 77.24
    1,1,2-trichlorotrifluoroethane 77.64
    DMS 32.03
    cumene 13.88
    2-octanol 14.63
    2-hexanone 36.53
    octyl acetate 20.71
    limonene 17.75
    1,2-dimethoxyethane 85.63
    ethyl orthosilicate 21.81
    tributyl phosphate 16.63
    diacetone alcohol 29.07
    N,N-dimethylaniline 25.65
    acrylonitrile 37.66
    aniline 25.04
    1,3-propanediol 15.72
    bromobenzene 39.5
    dibromomethane 70.08
    1,1,2,2-tetrachloroethane 116.65
    2-methyl-cyclohexyl acetate 30.07
    tetrabutyl urea 23.44
    diisobutyl methanol 14.12
    2-phenylethanol 35.01
    styrene 17.83
    dioctyl adipate 22.69
    dimethyl sulfate 57.46
    ethyl butyrate 34.35
    methyl lactate 19.69
    butyl lactate 25.41
    diethyl carbonate 26.42
    propanediol butyl ether 22.1
    triethyl orthoformate 26.59
    p-tert-butyltoluene 13.6
    methyl 4-tert-butylbenzoate 34.32
    morpholine 75.16
    tert-butylamine 10.04
    n-dodecanol 10.51
    dimethoxymethane 80.3
    ethylene carbonate 64.13
    cyrene 37.5
    2-ethoxyethyl acetate 44.49
    2-ethylhexyl acetate 32.11
    1,2,4-trichlorobenzene 45.49
    4-methylpyridine 61.61
    dibutyl ether 22.44
    2,6-dimethyl-4-heptanol 14.12
    DEF 50.48
    dimethyl isosorbide 58.3
    tetrachloroethylene 88.41
    eugenol 37.03
    triacetin 33.49
    span 80 27.46
    1,4-butanediol 7.79
    1,1-dichloroethane 46.66
    2-methyl-1-pentanol 18.37
    methyl formate 41.77
    2-methyl-1-butanol 13.32
    n-decane 3.95
    butyronitrile 27.47
    3,7-dimethyl-1-octanol 13.94
    1-chlorooctane 14.79
    1-chlorotetradecane 6.6
    n-nonane 3.49
    undecane 3.13
    tert-butylcyclohexane 3.01
    cyclooctane 1.78
    cyclopentanol 20.45
    tetrahydropyran 66.76
    tert-amyl methyl ether 12.23
    2,5,8-trioxanonane 58.98
    1-hexene 11.39
    2-isopropoxyethanol 23.66
    2,2,2-trifluoroethanol 19.46
    methyl butyrate 43.08

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction