Alpha-Lactose

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  • Identifiers

    CAS number
    14641-93-1

    Molecular formula
    C12H22O11

    SMILES
    C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@@H]([C@@H]([C@H]2O)O)O)CO)O)O)O)O

  • Odor profile

    Fragrance
    Odorless 72.77%
    Sweet 47.26%
    Alcoholic 22.37%
    Caramellic 22.34%
    Woody 21.23%
    Clean 16.45%
    Vanilla 16.36%
    Milky 15.93%
    Bitter 15.57%
    Cooling 15.48%

     

    Flavor
    Sweet 83.15%
    Odorless 57.11%
    Bitter 45.56%
    Sweet-like 32.23%
    Cauliflower 22.26%
    Very slight 22.14%
    Soup 20.6%
    Alkaline 20.44%
    Fatty 20.4%
    Mentholic 20.03%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -4.7

    pKa est.
    4.04 (weak acid)

    Molecular weight
    342.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    2988°C

    Melting point expt.

    • 201 - 202 °C

    Flash point

    • 275.27 ˚C est.

    Solubility expt.

    • 195 mg/mL at 20 °C

  • Synonyms

    • alpha-lactose
    • 14641-93-1
    • Anhydrous lactose
    • alpha-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-
    • alpha lactose
    • alpha-D-lactose
    • MJF4JAT10B
    • 4-O-beta-D-Galactopyranosyl-alpha-D-glucopyranose
    • .ALPHA.-LACTOSE
    • EINECS 238-691-8
    • (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol
    • (2S,3R,4R,5S,6R)-6-(Hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2,3,4-triol
    • Aletobiose
    • Lactobiose
    • CHEBI:36219
    • DTXSID50873004
    • alpha-D-Lactose monohydrate
    • 1-beta-D-Galactopyranosyl-4-alpha-D-glucopyranose
    • beta-D-Gal-(1->4)-alpha-D-Glc
    • beta-D-Galp-(1->4)-alpha-D-Glcp
    • beta-D-galactopyranosyl-(1->4)-alpha-D-glucopyranose
    • .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-
    • Galactinum
    • Osmolactan
    • Tablettose
    • (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-{[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy}oxane-3,4,5-triol
    • Lactin
    • Saccharum lactin
    • Super-Tab
    • Zeparox EP
    • Fast-flo Lactose
    • Lactose Fast-flo
    • Pharmatose 21
    • Tablettose 70
    • Tablettose 80
    • Dilactose
    • Pharmatose 325M
    • a-Lactose
    • Sorbalac 400
    • O-.BETA.-D-GALACTOPYRANOSYL-(1->4)-.ALPHA.-D-GLUCOPYRANOSE
    • Flowlac 100
    • Pharmatosa DCL 21
    • Lactin (carbohydrate)
    • (2S,3R,4R,5S,6R)-6-(hydroxymethyl)-5-{[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxane-2,3,4-triol
    • NSC-760401
    • UNII-MJF4JAT10B
    • Prismalac
    • Sachelac
    • Spherolac
    • GLC-(4-1)GAL
    • Lactose anhydride
    • a-D-lactose
    • 4ouj
    • WURCS=2.0/2,2,1/(a2122h-1a_1-5)(a2112h-1b_1-5)/1-2/a4-b1
    • WURCS=2.0/2,2,1/[a2122h-1a_1-5][a2112h-1b_1-5]/1-2/a4-b1
    • (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(((2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl)oxy)oxane-3,4,5-triol
    • (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-((2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl)oxyoxane-3,4,5-triol
    • (2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydropyran-3-yl]oxy-tetrahydropyran-3,4,5-triol
    • Lactohale 300
    • Lactose, -
    • 6-Deoxy-D-lactose
    • Granulac 140M
    • Sorbolac 400
    • 4-O-beta-D-galactopyranosyl-D-glucopyranose
    • Pharmatose DCL 15
    • Respitose ML 003
    • Respitose SV 003
    • alpha-4-(beta-D-Galactosido)-D-glucose
    • 2y9g
    • 3ap4
    • 3i8t
    • 4-O-Hexopyranosylhexose
    • hygroscopic alpha-lactose
    • bmse000065
    • bmse000813
    • bmse000938
    • DTXCID30820516
    • Pharmakon1600-01301020
    • HY-N2514
    • MFCD00191455
    • NSC760401
    • AKOS015900418
    • MD76590
    • AS-66473
    • CS-0022785
    • L0008
    • NS00085890
    • EN300-1655902
    • Q27104342
    • 1-beta-delta-Galactopyranosyl-4-alpha-delta-glucopyranose
    • O-BETA-D-GALACTOPYRANOSYL-(1->4)-ALPHA-D-GLUCOPYRANOSE
    • 4-O--D-Galactopyranosyl--D-glucopyranose; -D-Lactose; -Lactose
    • 4-O-beta-D-Galactopyranosyl-alpha-D-glucopyranose, 98%, Dnase free and Rnase free
    • 52689-62-0

  • Applications

    Alpha-Lactose (CAS 14641-93-1) is a disaccharide widely used as an inert pharmaceutical excipient, serving as a filler/diluent and, in many solid-dose formulations, a stabilizing carrier for active ingredients, and it can also function as a mild binder in some formulations. In the food industry, lactose acts as a carbohydrate source and bulking agent in processed foods, commonly found in dairy ingredients, bakery and confectionery formulations. In cosmetics and personal care, lactose is used as an inert carrier for fragrance and colorants in loose and pressed powders, and can serve as a texture-enhancing filler in certain formulations. In biotechnological and industrial processing, lactose may serve as a carbon source in fermentation media and as a carrier for enzymes or biocatalysts in processing applications. All uses are subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.86
    methanol 4.65
    isopropanol 0.24
    water 407.99
    ethyl acetate 0.11
    n-propanol 0.35
    acetone 0.22
    n-butanol 0.25
    acetonitrile 0.15
    DMF 36.01
    toluene 0.11
    isobutanol 0.15
    1,4-dioxane 1.12
    methyl acetate 0.11
    THF 0.71
    2-butanone 0.14
    n-pentanol 0.13
    sec-butanol 0.21
    n-hexane 0.03
    ethylene glycol 37.47
    NMP 33.32
    cyclohexane 0.21
    DMSO 156.22
    n-butyl acetate 0.13
    n-octanol 0.31
    chloroform 0.04
    n-propyl acetate 0.06
    acetic acid 7.13
    dichloromethane 0.05
    cyclohexanone 0.65
    propylene glycol 9.66
    isopropyl acetate 0.09
    DMAc 18.0
    2-ethoxyethanol 3.3
    isopentanol 0.15
    n-heptane 0.17
    ethyl formate 0.2
    1,2-dichloroethane 0.08
    n-hexanol 0.31
    2-methoxyethanol 12.38
    isobutyl acetate 0.03
    tetrachloromethane 0.04
    n-pentyl acetate 0.17
    transcutol 7.62
    n-heptanol 0.46
    ethylbenzene 0.05
    MIBK 0.12
    2-propoxyethanol 3.02
    tert-butanol 0.28
    MTBE 0.07
    2-butoxyethanol 2.22
    propionic acid 0.99
    o-xylene 0.21
    formic acid 162.08
    diethyl ether 0.13
    m-xylene 0.13
    p-xylene 0.05
    chlorobenzene 0.03
    dimethyl carbonate 1.16
    n-octane 0.08
    formamide 90.9
    cyclopentanone 0.8
    2-pentanone 0.16
    anisole 0.12
    cyclopentyl methyl ether 0.59
    gamma-butyrolactone 1.47
    1-methoxy-2-propanol 5.73
    pyridine 0.53
    3-pentanone 0.21
    furfural 2.87
    n-dodecane 0.04
    diethylene glycol 15.38
    diisopropyl ether 0.06
    tert-amyl alcohol 0.27
    acetylacetone 0.56
    n-hexadecane 0.04
    acetophenone 0.27
    methyl propionate 0.39
    isopentyl acetate 0.1
    trichloroethylene 0.1
    n-nonanol 0.32
    cyclohexanol 0.76
    benzyl alcohol 0.37
    2-ethylhexanol 0.18
    isooctanol 0.27
    dipropyl ether 0.35
    1,2-dichlorobenzene 0.04
    ethyl lactate 0.81
    propylene carbonate 0.55
    n-methylformamide 8.49
    2-pentanol 0.18
    n-pentane 0.06
    1-propoxy-2-propanol 1.86
    1-methoxy-2-propyl acetate 0.82
    2-(2-methoxypropoxy) propanol 2.41
    mesitylene 0.12
    ε-caprolactone 0.81
    p-cymene 0.13
    epichlorohydrin 0.47
    1,1,1-trichloroethane 0.02
    2-aminoethanol 13.08
    morpholine-4-carbaldehyde 21.62
    sulfolane 14.8
    2,2,4-trimethylpentane 0.02
    2-methyltetrahydrofuran 0.31
    n-hexyl acetate 0.2
    isooctane 0.01
    2-(2-butoxyethoxy)ethanol 3.63
    sec-butyl acetate 0.05
    tert-butyl acetate 0.15
    decalin 0.04
    glycerin 69.9
    diglyme 5.45
    acrylic acid 3.14
    isopropyl myristate 0.1
    n-butyric acid 0.56
    acetyl acetate 0.18
    di(2-ethylhexyl) phthalate 0.22
    ethyl propionate 0.11
    nitromethane 4.36
    1,2-diethoxyethane 0.46
    benzonitrile 0.11
    trioctyl phosphate 0.23
    1-bromopropane 0.03
    gamma-valerolactone 4.03
    n-decanol 0.25
    triethyl phosphate 0.3
    4-methyl-2-pentanol 0.11
    propionitrile 0.09
    vinylene carbonate 0.63
    1,1,2-trichlorotrifluoroethane 6.77
    DMS 0.41
    cumene 0.05
    2-octanol 0.23
    2-hexanone 0.07
    octyl acetate 0.17
    limonene 0.21
    1,2-dimethoxyethane 1.47
    ethyl orthosilicate 0.26
    tributyl phosphate 0.17
    diacetone alcohol 1.17
    N,N-dimethylaniline 0.28
    acrylonitrile 0.26
    aniline 0.38
    1,3-propanediol 6.34
    bromobenzene 0.02
    dibromomethane 0.03
    1,1,2,2-tetrachloroethane 0.15
    2-methyl-cyclohexyl acetate 0.17
    tetrabutyl urea 0.47
    diisobutyl methanol 0.17
    2-phenylethanol 0.42
    styrene 0.04
    dioctyl adipate 0.21
    dimethyl sulfate 5.65
    ethyl butyrate 0.17
    methyl lactate 4.66
    butyl lactate 0.69
    diethyl carbonate 0.14
    propanediol butyl ether 3.54
    triethyl orthoformate 0.31
    p-tert-butyltoluene 0.15
    methyl 4-tert-butylbenzoate 0.99
    morpholine 2.06
    tert-butylamine 0.13
    n-dodecanol 0.19
    dimethoxymethane 3.98
    ethylene carbonate 0.43
    cyrene 5.12
    2-ethoxyethyl acetate 0.39
    2-ethylhexyl acetate 0.09
    1,2,4-trichlorobenzene 0.07
    4-methylpyridine 0.24
    dibutyl ether 0.14
    2,6-dimethyl-4-heptanol 0.17
    DEF 1.73
    dimethyl isosorbide 3.1
    tetrachloroethylene 0.21
    eugenol 1.18
    triacetin 0.69
    span 80 2.47
    1,4-butanediol 2.17
    1,1-dichloroethane 0.02
    2-methyl-1-pentanol 0.09
    methyl formate 3.14
    2-methyl-1-butanol 0.17
    n-decane 0.07
    butyronitrile 0.07
    3,7-dimethyl-1-octanol 0.16
    1-chlorooctane 0.08
    1-chlorotetradecane 0.04
    n-nonane 0.07
    undecane 0.05
    tert-butylcyclohexane 0.02
    cyclooctane 0.15
    cyclopentanol 0.7
    tetrahydropyran 0.34
    tert-amyl methyl ether 0.16
    2,5,8-trioxanonane 5.51
    1-hexene 0.03
    2-isopropoxyethanol 1.07
    2,2,2-trifluoroethanol 8.35
    methyl butyrate 0.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction