Alpha-Arbutin

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  • Identifiers

    CAS number
    84380-01-8

    Molecular formula
    C12H16O7

    SMILES
    C1=CC(=CC=C1O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 62.78%
    Sweet 45.58%
    Vanilla 41.94%
    Phenolic 34.89%
    Smoky 23.68%
    Creamy 23.04%
    Balsamic 22.74%
    Bitter 22.42%
    Milky 21.66%
    Caramellic 20.46%

     

    Flavor
    Bitter 68.63%
    Sweet 38.36%
    Odorless 38.08%
    Sweet-like 30.04%
    Bland 27.03%
    Very slight 21.48%
    Very mild 21.03%
    Vanilla 21.01%
    Eugenol 20.88%
    Cauliflower 20.79%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -0.7

    pKa est.
    7.34 (neutral)

    Molecular weight
    272.25 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1047°C

    Flash point

    • 245.98 ˚C est.

  • Synonyms

    • alpha-Arbutin
    • 84380-01-8
    • alpha arbutin
    • UNII-72VUP07IT5
    • 72VUP07IT5
    • ORISTAR AAT
    • DTXSID20233358
    • RefChem:58967
    • Derma Pella Intimate Brightening
    • DTXCID20155849
    • P-HYDROXYPHENYL-alpha-D-GLUCOPYRANOSIDE
    • 4-Hydroxyphenyl a-D-glucopyranoside
    • a-Arbutin
    • 4-hydroxyphenyl alpha-D-glucopyranoside
    • MFCD09838262
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol
    • a-D-Glucopyranoside, 4-hydroxyphenyl
    • alpha-D-Glucopyranoside, 4-hydroxyphenyl
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol
    • CHEMBL226495
    • (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydropyran-3,4,5-triol
    • AC1L4KBI
    • Alpha Arbutine
    • Alfa Arbutina
    • I+/--Arbutin
    • 4-Hydroxyphenyl-alpha-D-glucopyranoside
    • PubChem16460
    • .ALPHA.-ARBUTIN
    • |A-Arbutin (Standard)
    • SCHEMBL435261
    • orb1302457
    • orb3024931
    • ALPHA-ARBUTIN [WHO-DD]
    • f inverted question mark-Arbutin
    • CHEBI:29710
    • HY-N3002R
    • BJRNKVDFDLYUGJ-ZIQFBCGOSA-N
    • alpha-Arbutin, analytical standard
    • HY-N3002
    • MSK40211
    • BDBM50636367
    • EBC-26391
    • s5112
    • AKOS015905235
    • CCG-267174
    • DB14109
    • EA10634
    • AC-34884
    • AS-15466
    • SY056800
    • A3284
    • CS-0022901
    • NS00120412
    • EN300-7406351
    • P-HYDROXYPHENYL-.ALPHA.-D-GLUCOPYRANOSIDE
    • 4-HYDROXYPHENYL-.ALPHA.-D-GLUCOPYRANOSIDE
    • F215658
    • Q27110235
    • 84380-01-8

  • Applications

    Alpha-Arbutin (CAS 84380-01-8) is widely used in cosmetics and personal care as a skin-brightening agent due to its tyrosinase-inhibiting activity, commonly formulated in serums and creams for depigmenting effects. It is also evaluated in pharmaceutical/dermatology research as a depigmenting agent candidate in topical formulations. In industrial manufacturing, it serves as an intermediate for the synthesis of hydroquinone and related phenolic derivatives, and it can be hydrolyzed to hydroquinone, providing a potential controlled-release source in cosmetic products. In laboratory settings, it is used in research and development for method development and as a chemical precursor in related synthetic routes.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 15.54
    methanol 81.69
    isopropanol 4.78
    water 92.02
    ethyl acetate 0.57
    n-propanol 5.02
    acetone 4.49
    n-butanol 3.58
    acetonitrile 1.11
    DMF 126.24
    toluene 0.81
    isobutanol 1.46
    1,4-dioxane 18.72
    methyl acetate 0.87
    THF 22.25
    2-butanone 1.36
    n-pentanol 1.51
    sec-butanol 2.78
    n-hexane 0.1
    ethylene glycol 217.56
    NMP 49.15
    cyclohexane 0.95
    DMSO 540.36
    n-butyl acetate 0.56
    n-octanol 2.2
    chloroform 0.08
    n-propyl acetate 0.54
    acetic acid 59.55
    dichloromethane 0.07
    cyclohexanone 4.4
    propylene glycol 63.29
    isopropyl acetate 0.74
    DMAc 97.59
    2-ethoxyethanol 54.76
    isopentanol 2.98
    n-heptane 0.65
    ethyl formate 1.76
    1,2-dichloroethane 0.22
    n-hexanol 2.33
    2-methoxyethanol 167.03
    isobutyl acetate 0.25
    tetrachloromethane 0.12
    n-pentyl acetate 0.91
    transcutol 59.46
    n-heptanol 2.78
    ethylbenzene 0.37
    MIBK 1.58
    2-propoxyethanol 20.43
    tert-butanol 9.53
    MTBE 1.4
    2-butoxyethanol 13.01
    propionic acid 6.41
    o-xylene 1.16
    formic acid 413.74
    diethyl ether 1.21
    m-xylene 0.88
    p-xylene 0.36
    chlorobenzene 0.15
    dimethyl carbonate 5.24
    n-octane 0.34
    formamide 394.95
    cyclopentanone 8.08
    2-pentanone 1.51
    anisole 1.55
    cyclopentyl methyl ether 5.23
    gamma-butyrolactone 10.72
    1-methoxy-2-propanol 62.28
    pyridine 3.77
    3-pentanone 1.11
    furfural 14.76
    n-dodecane 0.22
    diethylene glycol 76.77
    diisopropyl ether 0.57
    tert-amyl alcohol 5.53
    acetylacetone 5.93
    n-hexadecane 0.24
    acetophenone 2.36
    methyl propionate 1.64
    isopentyl acetate 0.68
    trichloroethylene 0.32
    n-nonanol 2.42
    cyclohexanol 7.51
    benzyl alcohol 3.9
    2-ethylhexanol 1.32
    isooctanol 2.16
    dipropyl ether 2.15
    1,2-dichlorobenzene 0.2
    ethyl lactate 5.31
    propylene carbonate 3.53
    n-methylformamide 50.26
    2-pentanol 2.04
    n-pentane 0.19
    1-propoxy-2-propanol 11.02
    1-methoxy-2-propyl acetate 4.04
    2-(2-methoxypropoxy) propanol 16.99
    mesitylene 0.7
    ε-caprolactone 4.52
    p-cymene 0.65
    epichlorohydrin 4.81
    1,1,1-trichloroethane 0.1
    2-aminoethanol 113.38
    morpholine-4-carbaldehyde 69.37
    sulfolane 46.17
    2,2,4-trimethylpentane 0.11
    2-methyltetrahydrofuran 4.86
    n-hexyl acetate 1.53
    isooctane 0.07
    2-(2-butoxyethoxy)ethanol 24.47
    sec-butyl acetate 0.39
    tert-butyl acetate 2.11
    decalin 0.17
    glycerin 213.49
    diglyme 40.15
    acrylic acid 13.7
    isopropyl myristate 1.03
    n-butyric acid 4.68
    acetyl acetate 1.28
    di(2-ethylhexyl) phthalate 1.9
    ethyl propionate 0.69
    nitromethane 40.06
    1,2-diethoxyethane 3.83
    benzonitrile 0.9
    trioctyl phosphate 1.67
    1-bromopropane 0.12
    gamma-valerolactone 25.98
    n-decanol 2.1
    triethyl phosphate 1.6
    4-methyl-2-pentanol 1.56
    propionitrile 0.69
    vinylene carbonate 2.99
    1,1,2-trichlorotrifluoroethane 28.33
    DMS 2.0
    cumene 0.32
    2-octanol 1.48
    2-hexanone 0.68
    octyl acetate 1.55
    limonene 1.05
    1,2-dimethoxyethane 30.79
    ethyl orthosilicate 1.57
    tributyl phosphate 1.37
    diacetone alcohol 13.9
    N,N-dimethylaniline 2.23
    acrylonitrile 1.74
    aniline 3.01
    1,3-propanediol 90.2
    bromobenzene 0.09
    dibromomethane 0.06
    1,1,2,2-tetrachloroethane 0.6
    2-methyl-cyclohexyl acetate 1.36
    tetrabutyl urea 3.41
    diisobutyl methanol 1.44
    2-phenylethanol 3.1
    styrene 0.33
    dioctyl adipate 2.26
    dimethyl sulfate 16.37
    ethyl butyrate 0.93
    methyl lactate 20.28
    butyl lactate 3.38
    diethyl carbonate 0.88
    propanediol butyl ether 16.49
    triethyl orthoformate 1.82
    p-tert-butyltoluene 0.72
    methyl 4-tert-butylbenzoate 6.49
    morpholine 29.48
    tert-butylamine 2.49
    n-dodecanol 1.77
    dimethoxymethane 33.04
    ethylene carbonate 2.37
    cyrene 21.64
    2-ethoxyethyl acetate 2.21
    2-ethylhexyl acetate 0.47
    1,2,4-trichlorobenzene 0.37
    4-methylpyridine 1.94
    dibutyl ether 1.26
    2,6-dimethyl-4-heptanol 1.44
    DEF 8.95
    dimethyl isosorbide 20.73
    tetrachloroethylene 0.71
    eugenol 7.91
    triacetin 4.67
    span 80 12.32
    1,4-butanediol 26.27
    1,1-dichloroethane 0.06
    2-methyl-1-pentanol 1.31
    methyl formate 23.98
    2-methyl-1-butanol 2.2
    n-decane 0.36
    butyronitrile 0.67
    3,7-dimethyl-1-octanol 1.87
    1-chlorooctane 0.53
    1-chlorotetradecane 0.34
    n-nonane 0.33
    undecane 0.27
    tert-butylcyclohexane 0.09
    cyclooctane 0.5
    cyclopentanol 7.21
    tetrahydropyran 5.24
    tert-amyl methyl ether 1.83
    2,5,8-trioxanonane 37.84
    1-hexene 0.16
    2-isopropoxyethanol 14.22
    2,2,2-trifluoroethanol 29.65
    methyl butyrate 1.03

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction