Alkaline Phosphatase

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  • Identifiers

    CAS number
    9001-78-9

    Molecular formula
    C21H36N8O6

    SMILES
    CC(C(=O)N1CCCC1C(=O)NCC(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C(=O)O)N

    Safety labels

  • Odor profile

    Fragrance
    Odorless 70.43%
    Savory 36.49%
    Fishy 30.56%
    Cooling 28.06%
    Meaty 25.41%
    Cooked 18.67%
    Popcorn 17.1%
    Roasted 15.99%
    Alcoholic 15.23%
    Sweet 14.89%

     

    Flavor
    Bitter 74.42%
    Odorless 47.26%
    Bland 30.3%
    Sweet-like 21.5%
    Nitrile 19.52%
    Very mild 18.92%
    Yeast 18.9%
    Mild 18.8%
    Taco 18.55%
    Cedarleaf 18.51%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -5.0

    pKa est.
    7.89 (neutral)

    Molecular weight
    496.6 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    949°C

    Flash point

    • 323.5 ˚C est.

  • Synonyms

    • Alkaline phosphatase
    • Phosphatase, alkaline
    • RefChem:388781
    • DTXSID4093801
    • EINECS 232-631-4
    • Phosphatase, Alkaline, from Escherichia coli
    • Orthophosphoric-monoester phosphohydrolase (alkaline optimum)
    • Orthophosphoricmonoester phosphohydrolase (alkaline optimum)
    • 232-631-4
    • 9001-78-9
    • 2-[[1-[2-[[1-(2-aminopropanoyl)pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid
    • ENTEROSTATIN,HUMAN
    • Alkaline Phosphatase (ALP)
    • ITZMJCSORYKOSI-UHFFFAOYSA-N
    • Phosphatase, Alkaline from Escherichia coli
    • Phosphatase, Alkaline from calf intestine(Purified)
    • (S)-2-((S)-1-(2-((S)-1-((S)-2-aminopropanoyl)pyrrolidine-2-carboxamido)acetyl)pyrrolidine-2-carboxamido)-5-((diaminomethylene)amino)pentanoic acid
    • 9001-78-9

  • Applications

    Alkaline Phosphatase (CAS 9001-78-9) is used across multiple industries as both a biocatalyst and a reporter enzyme: in diagnostics and life sciences it provides robust colorimetric or chemiluminescent readouts in ELISA, Western blotting and immunohistochemistry assays; in biotechnology and pharmaceutical manufacturing it is employed to dephosphorylate substrates and support processing steps, including the removal of phosphate groups from intermediates; in molecular biology and basic research laboratories it enables dephosphorylation of DNA termini and other substrates for cloning and labeling workflows; in histology it underpins tissue staining to map enzyme activity; and in process development and analytical work it serves as a standard enzyme activity reagent for quality control and formulation development, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 1.92
    methanol 9.05
    isopropanol 0.53
    water 18.19
    ethyl acetate 0.36
    n-propanol 0.85
    acetone 0.85
    n-butanol 0.54
    acetonitrile 0.65
    DMF 10.56
    toluene 0.12
    isobutanol 0.35
    1,4-dioxane 0.85
    methyl acetate 0.52
    THF 1.53
    2-butanone 0.72
    n-pentanol 0.37
    sec-butanol 0.38
    n-hexane 0.03
    ethylene glycol 5.51
    NMP 20.28
    cyclohexane 0.02
    DMSO 26.24
    n-butyl acetate 0.17
    n-octanol 0.15
    chloroform 0.83
    n-propyl acetate 0.26
    acetic acid 14.11
    dichloromethane 1.22
    cyclohexanone 1.35
    propylene glycol 3.89
    isopropyl acetate 0.17
    DMAc 13.73
    2-ethoxyethanol 3.68
    isopentanol 0.25
    n-heptane 0.02
    ethyl formate 1.3
    1,2-dichloroethane 0.62
    n-hexanol 0.16
    2-methoxyethanol 10.37
    isobutyl acetate 0.11
    tetrachloromethane 0.19
    n-pentyl acetate 0.23
    transcutol 4.56
    n-heptanol 0.21
    ethylbenzene 0.07
    MIBK 0.18
    2-propoxyethanol 2.02
    tert-butanol 0.22
    MTBE 0.08
    2-butoxyethanol 1.91
    propionic acid 2.19
    o-xylene 0.09
    formic acid 73.74
    diethyl ether 0.19
    m-xylene 0.06
    p-xylene 0.1
    chlorobenzene 0.15
    dimethyl carbonate 0.92
    n-octane 0.01
    formamide 48.02
    cyclopentanone 2.34
    2-pentanone 0.48
    anisole 0.18
    cyclopentyl methyl ether 0.38
    gamma-butyrolactone 3.97
    1-methoxy-2-propanol 3.58
    pyridine 1.42
    3-pentanone 0.42
    furfural 8.13
    n-dodecane 0.01
    diethylene glycol 4.35
    diisopropyl ether 0.03
    tert-amyl alcohol 0.25
    acetylacetone 0.76
    n-hexadecane 0.01
    acetophenone 0.45
    methyl propionate 0.68
    isopentyl acetate 0.12
    trichloroethylene 1.46
    n-nonanol 0.15
    cyclohexanol 0.35
    benzyl alcohol 0.58
    2-ethylhexanol 0.08
    isooctanol 0.12
    dipropyl ether 0.12
    1,2-dichlorobenzene 0.19
    ethyl lactate 0.73
    propylene carbonate 1.68
    n-methylformamide 9.39
    2-pentanol 0.19
    n-pentane 0.02
    1-propoxy-2-propanol 0.86
    1-methoxy-2-propyl acetate 0.43
    2-(2-methoxypropoxy) propanol 1.13
    mesitylene 0.03
    ε-caprolactone 1.46
    p-cymene 0.03
    epichlorohydrin 2.55
    1,1,1-trichloroethane 0.2
    2-aminoethanol 5.45
    morpholine-4-carbaldehyde 10.09
    sulfolane 11.46
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.55
    n-hexyl acetate 0.24
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 1.97
    sec-butyl acetate 0.12
    tert-butyl acetate 0.12
    decalin 0.01
    glycerin 16.48
    diglyme 3.56
    acrylic acid 4.71
    isopropyl myristate 0.05
    n-butyric acid 1.67
    acetyl acetate 0.32
    di(2-ethylhexyl) phthalate 0.18
    ethyl propionate 0.27
    nitromethane 10.41
    1,2-diethoxyethane 0.35
    benzonitrile 0.39
    trioctyl phosphate 0.13
    1-bromopropane 0.19
    gamma-valerolactone 8.28
    n-decanol 0.1
    triethyl phosphate 0.19
    4-methyl-2-pentanol 0.07
    propionitrile 0.38
    vinylene carbonate 1.98
    1,1,2-trichlorotrifluoroethane 10.16
    DMS 0.38
    cumene 0.05
    2-octanol 0.11
    2-hexanone 0.32
    octyl acetate 0.11
    limonene 0.03
    1,2-dimethoxyethane 2.4
    ethyl orthosilicate 0.16
    tributyl phosphate 0.15
    diacetone alcohol 0.67
    N,N-dimethylaniline 0.19
    acrylonitrile 0.93
    aniline 0.44
    1,3-propanediol 4.79
    bromobenzene 0.11
    dibromomethane 0.49
    1,1,2,2-tetrachloroethane 1.09
    2-methyl-cyclohexyl acetate 0.13
    tetrabutyl urea 0.29
    diisobutyl methanol 0.03
    2-phenylethanol 0.31
    styrene 0.08
    dioctyl adipate 0.12
    dimethyl sulfate 3.72
    ethyl butyrate 0.18
    methyl lactate 2.56
    butyl lactate 0.65
    diethyl carbonate 0.15
    propanediol butyl ether 2.17
    triethyl orthoformate 0.21
    p-tert-butyltoluene 0.03
    methyl 4-tert-butylbenzoate 0.51
    morpholine 1.86
    tert-butylamine 0.08
    n-dodecanol 0.06
    dimethoxymethane 2.47
    ethylene carbonate 1.11
    cyrene 2.55
    2-ethoxyethyl acetate 0.56
    2-ethylhexyl acetate 0.1
    1,2,4-trichlorobenzene 0.28
    4-methylpyridine 0.83
    dibutyl ether 0.1
    2,6-dimethyl-4-heptanol 0.03
    DEF 1.41
    dimethyl isosorbide 1.4
    tetrachloroethylene 1.01
    eugenol 0.89
    triacetin 0.48
    span 80 0.9
    1,4-butanediol 1.66
    1,1-dichloroethane 0.26
    2-methyl-1-pentanol 0.21
    methyl formate 5.94
    2-methyl-1-butanol 0.31
    n-decane 0.01
    butyronitrile 0.35
    3,7-dimethyl-1-octanol 0.06
    1-chlorooctane 0.05
    1-chlorotetradecane 0.01
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.01
    cyclopentanol 0.61
    tetrahydropyran 0.35
    tert-amyl methyl ether 0.12
    2,5,8-trioxanonane 2.19
    1-hexene 0.08
    2-isopropoxyethanol 1.16
    2,2,2-trifluoroethanol 10.0
    methyl butyrate 0.44

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction