Adipic Acid

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  • Identifiers

    CAS number
    124-04-9

    Molecular formula
    C6H10O4

    SMILES
    C(CCC(=O)O)CC(=O)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sour 56.61%
    Odorless 51.46%
    Cheesy 35.36%
    Sharp 24.77%
    Buttery 24.65%
    Milky 23.3%
    Savory 23.07%
    Fatty 23.04%
    Creamy 22.28%
    Dairy 21.94%

     

    Flavor
    Odorless 70.12%
    Sour 54.95%
    Acidic 40.61%
    Rancid 34.46%
    Sweat 33.99%
    Cheese 33.16%
    Very mild 25.11%
    Mild 25.05%
    Vinegar 24.71%
    Yeast 24.56%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    6.31 (neutral)

    Molecular weight
    146.14 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 304 °F (USCG, 1999)
    • 151,5-154,0 °C
    • 151.5 °C
    • 151 - 154 °C
    • 152 °C
    • 304 °F

    Boiling point

    • 337.5 °C at 760 mm Hg: 265 °C at 100 mm Hg: 240.5 °C at 40 mm Hg: 222 °Cat 20 mm Hg: 205.5 °C at 10 mm Hg; 191 °C at 5 mm Hg; 159.5 °C at 1.0 mm Hg
    • 265.00 °C. @ 100.00 mm Hg
    • 338 °C

    Flash point

    • 186.65 ˚C est.
    • 376 °F Combustible solid (USCG, 1999)
    • 385 °F, 196 °C (closed cup)
    • 196 °C c.c.
    • 376 °F

    Solubility expt.

    • Slightly soluble in water. Freely soluble in ethanol
    • In water, 3.00X10+4 mg/L at 30 °C
    • In water, 0.633/100 parts (wt/wt) ether at 19 °C
    • In water, 160 g/100 mL boiling water
    • 1.4 g/100 mL water at 10 °C
    • For more Solubility (Complete) data for ADIPIC ACID (7 total), please visit the HSDB record page.
    • 30.8 mg/mL at 34 °C
    • Solubility in water, g/100ml at 15 °C: 1.4 (moderate)
    • slightly soluble in water; soluble in alcohol and acetone

  • Synonyms

    • adipic acid
    • hexanedioic acid
    • 124-04-9
    • Adipinic acid
    • 1,4-Butanedicarboxylic acid
    • Acifloctin
    • Acinetten
    • Adilactetten
    • 1,6-Hexanedioic acid
    • Molten adipic acid
    • Kyselina adipova
    • FEMA No. 2011
    • Adipinsaeure
    • Adipinsaure
    • adipic-acid
    • Adipinsaure [German]
    • Acide adipique
    • Adipidic acid
    • Acide adipique [French]
    • FEMA Number 2011
    • Kyselina adipova [Czech]
    • Hexanedioate
    • NSC 7622
    • CCRIS 812
    • ADIPIC-DB ACID
    • HSDB 188
    • Hexanedioc acid
    • Adi-pure
    • UNII-76A0JE0FKJ
    • NSC-7622
    • EINECS 204-673-3
    • 76A0JE0FKJ
    • MFCD00004420
    • Adipic acid [NF]
    • BRN 1209788
    • INS NO.355
    • CHEBI:30832
    • AI3-03700
    • INS-355
    • E-355
    • Hexan-1,6-dicarboxylate
    • E355
    • INS No. 355
    • 1,6-HEXANE-DIOIC ACID
    • DTXSID7021605
    • NSC7622
    • EC 204-673-3
    • ADIPIC-1,6-13C2 ACID
    • 4-02-00-01956 (Beilstein Handbook Reference)
    • Adipic acid (NF)
    • Hexanedioic-2,2,5,5-d4 acid
    • NCGC00091345-01
    • hexane-1,6-dioic acid
    • E 355
    • ADIPIC ACID (II)
    • ADIPIC ACID [II]
    • ADIPIC ACID (MART.)
    • ADIPIC ACID [MART.]
    • Adipic acid; Hexanedioic acid
    • DTXCID301605
    • adipicacid
    • ADIPIC ACID (EP MONOGRAPH)
    • ADIPIC ACID [EP MONOGRAPH]
    • CAS-124-04-9
    • Adipinate
    • Adilac-tetten
    • Molten adipate
    • hexane dioic acid
    • 1,6-Hexanedioate
    • 0L1
    • ASAPIC
    • Adipic acid, 99%
    • INIPOL DS
    • Adipic acid (Standard)
    • Adipic acid, >=99%
    • ADIPIC ACID [MI]
    • WLN: QV4VQ
    • ADIPIC ACID [FCC]
    • bmse000424
    • ADIPIC ACID [FHFI]
    • ADIPIC ACID [HSDB]
    • SCHEMBL4930
    • CHEMBL1157
    • NCIOpen2_001004
    • NCIOpen2_001222
    • HOOC-(CH2)4-COOH
    • Adipic acid, >=99.5%
    • ADIPIC ACID [USP-RS]
    • ADIPIC ACID [WHO-DD]
    • BIDD:ER0342
    • Adipic acid, puriss., 99.8%
    • Pharmakon1600-01301012
    • HY-W017522R
    • Tox21_111118
    • Tox21_202161
    • Tox21_300344
    • BBL011615
    • LMFA01170048
    • NSC760121
    • s3594
    • STL163338
    • AKOS000119031
    • Tox21_111118_1
    • CCG-230896
    • CS-W018238
    • FH37732
    • HY-W017522
    • NSC-760121
    • NCGC00091345-02
    • NCGC00091345-03
    • NCGC00091345-04
    • NCGC00091345-05
    • NCGC00254389-01
    • NCGC00259710-01
    • AC-10343
    • BP-21150
    • BP-30248
    • A0161
    • Adipic acid, BioXtra, >=99.5% (HPLC)
    • Adipic acid, SAJ special grade, >=99.5%
    • NS00005309
    • EN300-18041
    • Adipic acid, Vetec(TM) reagent grade, >=99%
    • C06104
    • D08839
    • D70505
    • EC 432-790-1
    • SBI-0653842.0001

  • Applications

    Adipic Acid (CAS 124-04-9) is a di-carboxylic acid that serves mainly as a key monomer for nylon 6,6 production by reacting with hexamethylenediamine; it also serves as a precursor for aliphatic polyesters such as polyethylene adipate and related resins used in coatings, adhesives, and other polyester applications. Adipic acid esters (adipate esters) are widely used as plasticizers for PVC and other polymers to impart flexibility. It also acts as a feedstock for polyurethane materials via polyester polyols and for alkyd coating resins, among other applications.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 98.58
    methanol 175.63
    isopropanol 44.45
    water 25.58
    ethyl acetate 7.04
    n-propanol 50.93
    acetone 40.46
    n-butanol 28.86
    acetonitrile 7.41
    DMF 331.01
    toluene 0.4
    isobutanol 23.29
    1,4-dioxane 16.77
    methyl acetate 16.52
    THF 34.53
    2-butanone 25.98
    n-pentanol 14.96
    sec-butanol 31.79
    n-hexane 1.59
    ethylene glycol 92.01
    NMP 200.64
    cyclohexane 0.7
    DMSO 487.09
    n-butyl acetate 7.0
    n-octanol 7.66
    chloroform 5.4
    n-propyl acetate 4.16
    acetic acid 53.68
    dichloromethane 6.73
    cyclohexanone 18.68
    propylene glycol 82.86
    isopropyl acetate 3.81
    DMAc 231.92
    2-ethoxyethanol 45.59
    isopentanol 15.84
    n-heptane 0.94
    ethyl formate 19.63
    1,2-dichloroethane 8.1
    n-hexanol 12.93
    2-methoxyethanol 123.29
    isobutyl acetate 1.22
    tetrachloromethane 2.57
    n-pentyl acetate 5.32
    transcutol 53.81
    n-heptanol 6.97
    ethylbenzene 0.95
    MIBK 5.92
    2-propoxyethanol 32.93
    tert-butanol 42.61
    MTBE 11.22
    2-butoxyethanol 18.97
    propionic acid 63.96
    o-xylene 1.52
    formic acid 115.73
    diethyl ether 7.38
    m-xylene 0.67
    p-xylene 1.29
    chlorobenzene 1.35
    dimethyl carbonate 9.77
    n-octane 0.44
    formamide 135.64
    cyclopentanone 33.66
    2-pentanone 12.46
    anisole 4.36
    cyclopentyl methyl ether 7.51
    gamma-butyrolactone 44.75
    1-methoxy-2-propanol 61.33
    pyridine 8.68
    3-pentanone 10.75
    furfural 45.67
    n-dodecane 0.3
    diethylene glycol 53.13
    diisopropyl ether 1.78
    tert-amyl alcohol 37.74
    acetylacetone 12.56
    n-hexadecane 0.32
    acetophenone 7.97
    methyl propionate 13.79
    isopentyl acetate 5.57
    trichloroethylene 10.23
    n-nonanol 6.68
    cyclohexanol 11.56
    benzyl alcohol 7.9
    2-ethylhexanol 5.73
    isooctanol 4.58
    dipropyl ether 3.71
    1,2-dichlorobenzene 2.73
    ethyl lactate 10.68
    propylene carbonate 16.84
    n-methylformamide 149.59
    2-pentanol 12.07
    n-pentane 1.17
    1-propoxy-2-propanol 20.44
    1-methoxy-2-propyl acetate 10.12
    2-(2-methoxypropoxy) propanol 27.15
    mesitylene 0.88
    ε-caprolactone 19.91
    p-cymene 1.84
    epichlorohydrin 27.37
    1,1,1-trichloroethane 3.71
    2-aminoethanol 100.96
    morpholine-4-carbaldehyde 90.66
    sulfolane 126.47
    2,2,4-trimethylpentane 0.89
    2-methyltetrahydrofuran 16.86
    n-hexyl acetate 8.38
    isooctane 0.42
    2-(2-butoxyethoxy)ethanol 28.81
    sec-butyl acetate 2.08
    tert-butyl acetate 5.75
    decalin 0.61
    glycerin 122.28
    diglyme 41.09
    acrylic acid 66.67
    isopropyl myristate 2.85
    n-butyric acid 26.48
    acetyl acetate 4.06
    di(2-ethylhexyl) phthalate 7.55
    ethyl propionate 4.98
    nitromethane 71.64
    1,2-diethoxyethane 6.69
    benzonitrile 4.11
    trioctyl phosphate 5.39
    1-bromopropane 3.75
    gamma-valerolactone 52.58
    n-decanol 4.51
    triethyl phosphate 5.67
    4-methyl-2-pentanol 5.4
    propionitrile 7.68
    vinylene carbonate 14.69
    1,1,2-trichlorotrifluoroethane 62.72
    DMS 8.42
    cumene 1.3
    2-octanol 4.37
    2-hexanone 6.58
    octyl acetate 4.7
    limonene 2.87
    1,2-dimethoxyethane 44.92
    ethyl orthosilicate 4.77
    tributyl phosphate 6.17
    diacetone alcohol 20.93
    N,N-dimethylaniline 6.76
    acrylonitrile 13.42
    aniline 3.78
    1,3-propanediol 74.99
    bromobenzene 0.89
    dibromomethane 4.64
    1,1,2,2-tetrachloroethane 12.32
    2-methyl-cyclohexyl acetate 5.22
    tetrabutyl urea 11.18
    diisobutyl methanol 3.49
    2-phenylethanol 7.38
    styrene 0.92
    dioctyl adipate 6.02
    dimethyl sulfate 38.31
    ethyl butyrate 4.93
    methyl lactate 29.73
    butyl lactate 13.04
    diethyl carbonate 4.0
    propanediol butyl ether 31.54
    triethyl orthoformate 4.87
    p-tert-butyltoluene 1.94
    methyl 4-tert-butylbenzoate 15.34
    morpholine 33.92
    tert-butylamine 18.39
    n-dodecanol 3.0
    dimethoxymethane 46.63
    ethylene carbonate 9.69
    cyrene 29.26
    2-ethoxyethyl acetate 8.55
    2-ethylhexyl acetate 4.14
    1,2,4-trichlorobenzene 3.92
    4-methylpyridine 7.08
    dibutyl ether 3.29
    2,6-dimethyl-4-heptanol 3.49
    DEF 32.67
    dimethyl isosorbide 29.59
    tetrachloroethylene 11.06
    eugenol 17.38
    triacetin 10.34
    span 80 20.38
    1,4-butanediol 29.93
    1,1-dichloroethane 3.95
    2-methyl-1-pentanol 10.01
    methyl formate 74.86
    2-methyl-1-butanol 19.36
    n-decane 0.55
    butyronitrile 6.17
    3,7-dimethyl-1-octanol 5.99
    1-chlorooctane 1.88
    1-chlorotetradecane 0.72
    n-nonane 0.55
    undecane 0.39
    tert-butylcyclohexane 0.67
    cyclooctane 0.32
    cyclopentanol 23.54
    tetrahydropyran 8.34
    tert-amyl methyl ether 10.48
    2,5,8-trioxanonane 32.23
    1-hexene 2.75
    2-isopropoxyethanol 17.34
    2,2,2-trifluoroethanol 33.35
    methyl butyrate 8.43

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction