Adamantanyl dihydroxybenzamide

Overview IFRA Request a quote

  • Identifiers

    CAS number
    1145869-22-2

    Molecular formula
    C17H21NO3

    SMILES
    C1C2CC3CC1CC(C2)(C3)NC(=O)C4=CC(=C(C=C4)O)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 67.02%
    Savory 26.55%
    Cooling 24.75%
    Animal 20.7%
    Spicy 17.88%
    Meaty 17.86%
    Burnt 17.79%
    Bitter 15.66%
    Phenolic 15.33%
    Smoky 15.24%

     

    Flavor
    Bitter 77.46%
    Odorless 27.89%
    Sweet-like 20.96%
    Cedarleaf 20.59%
    Bland 20.23%
    Fruity 19.77%
    Alkaline 19.66%
    Very strong 19.39%
    Nitrile 19.34%
    Cereal 19.09%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    3.6

    pKa est.
    9.55 (weak base)

    Molecular weight
    287.35 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderate

    Boiling point est.
    408°C

    Flash point

    • 197.64 ˚C est.

  • Synonyms

    • Snowin
    • Adamantanyl dihydroxybenzamide
    • UNII-8LCG38V652
    • 8LCG38V652
    • Benzamide, 3,4-dihydroxy-N-tricyclo(3.3.1.13,7)dec-1-yl-
    • 1145869-22-2
    • RefChem:199371
    • ADAMANTANYL DIHYDROXYBENZAMIDE [INCI]
    • CHEMBL474954
    • SCHEMBL29475160
    • N-adamantyl-3,4-dihydroxybenzamide
    • BDBM50248205
    • N-Adamantan-1-yl-3,4-dihydroxy-benzamide
    • Q27270715
    • 1145869-22-2

  • Applications

    Adamantanyl dihydroxybenzamide (CAS 1145869-22-2) may be used as an intermediate in organic synthesis and as a building block for specialty chemicals in pharmaceutical, polymer, and materials research. Its adamantyl-dihydroxybenzamide structure can be evaluated as a fragrance component or fixative in perfumery, and as a basis for cosmetic and personal care formulations where a hydrophobic aryl-amide fragment is desirable. In coatings and inks, it may serve as a reactive intermediate or additive to influence adhesion, texture, or compatibility in formulated systems. It can also be explored as a niche polymer modifier or processing aid in plastics and advanced materials. In laboratory settings, it is typically used as a synthetic intermediate during method development or compound library generation, subject to relevant regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 33.09
    methanol 47.37
    isopropanol 26.98
    water 0.21
    ethyl acetate 45.46
    n-propanol 29.98
    acetone 54.03
    n-butanol 27.73
    acetonitrile 18.52
    DMF 91.25
    toluene 9.6
    isobutanol 16.19
    1,4-dioxane 54.53
    methyl acetate 36.89
    THF 272.13
    2-butanone 47.82
    n-pentanol 14.26
    sec-butanol 14.21
    n-hexane 0.34
    ethylene glycol 12.38
    NMP 39.22
    cyclohexane 0.55
    DMSO 119.83
    n-butyl acetate 29.18
    n-octanol 10.71
    chloroform 31.38
    n-propyl acetate 23.13
    acetic acid 54.17
    dichloromethane 14.43
    cyclohexanone 54.74
    propylene glycol 22.08
    isopropyl acetate 39.47
    DMAc 122.67
    2-ethoxyethanol 57.68
    isopentanol 23.9
    n-heptane 0.84
    ethyl formate 22.67
    1,2-dichloroethane 16.84
    n-hexanol 20.41
    2-methoxyethanol 133.91
    isobutyl acetate 16.28
    tetrachloromethane 2.81
    n-pentyl acetate 21.49
    transcutol 228.56
    n-heptanol 15.94
    ethylbenzene 4.2
    MIBK 37.24
    2-propoxyethanol 82.15
    tert-butanol 30.14
    MTBE 20.03
    2-butoxyethanol 49.4
    propionic acid 28.39
    o-xylene 6.62
    formic acid 37.33
    diethyl ether 19.68
    m-xylene 10.45
    p-xylene 5.6
    chlorobenzene 10.46
    dimethyl carbonate 31.21
    n-octane 0.62
    formamide 78.93
    cyclopentanone 105.78
    2-pentanone 51.58
    anisole 14.12
    cyclopentyl methyl ether 46.32
    gamma-butyrolactone 114.42
    1-methoxy-2-propanol 119.31
    pyridine 36.63
    3-pentanone 29.97
    furfural 67.24
    n-dodecane 0.52
    diethylene glycol 75.25
    diisopropyl ether 7.49
    tert-amyl alcohol 17.58
    acetylacetone 73.98
    n-hexadecane 0.61
    acetophenone 21.18
    methyl propionate 46.93
    isopentyl acetate 29.89
    trichloroethylene 45.97
    n-nonanol 11.6
    cyclohexanol 17.39
    benzyl alcohol 19.19
    2-ethylhexanol 11.05
    isooctanol 13.73
    dipropyl ether 12.48
    1,2-dichlorobenzene 10.49
    ethyl lactate 25.25
    propylene carbonate 45.49
    n-methylformamide 62.43
    2-pentanol 16.92
    n-pentane 0.49
    1-propoxy-2-propanol 56.49
    1-methoxy-2-propyl acetate 60.03
    2-(2-methoxypropoxy) propanol 47.49
    mesitylene 5.96
    ε-caprolactone 48.26
    p-cymene 5.52
    epichlorohydrin 107.28
    1,1,1-trichloroethane 13.85
    2-aminoethanol 30.72
    morpholine-4-carbaldehyde 82.15
    sulfolane 103.15
    2,2,4-trimethylpentane 0.64
    2-methyltetrahydrofuran 52.62
    n-hexyl acetate 24.1
    isooctane 0.71
    2-(2-butoxyethoxy)ethanol 73.15
    sec-butyl acetate 18.33
    tert-butyl acetate 43.18
    decalin 0.61
    glycerin 52.84
    diglyme 118.39
    acrylic acid 29.1
    isopropyl myristate 11.19
    n-butyric acid 51.16
    acetyl acetate 30.33
    di(2-ethylhexyl) phthalate 13.04
    ethyl propionate 22.26
    nitromethane 96.05
    1,2-diethoxyethane 43.08
    benzonitrile 16.67
    trioctyl phosphate 10.83
    1-bromopropane 7.14
    gamma-valerolactone 125.19
    n-decanol 8.97
    triethyl phosphate 12.5
    4-methyl-2-pentanol 15.5
    propionitrile 18.26
    vinylene carbonate 39.79
    1,1,2-trichlorotrifluoroethane 83.17
    DMS 30.17
    cumene 3.78
    2-octanol 9.44
    2-hexanone 20.04
    octyl acetate 14.67
    limonene 6.42
    1,2-dimethoxyethane 68.9
    ethyl orthosilicate 12.58
    tributyl phosphate 12.08
    diacetone alcohol 61.72
    N,N-dimethylaniline 10.87
    acrylonitrile 28.63
    aniline 21.46
    1,3-propanediol 56.85
    bromobenzene 8.12
    dibromomethane 8.33
    1,1,2,2-tetrachloroethane 45.19
    2-methyl-cyclohexyl acetate 17.39
    tetrabutyl urea 15.21
    diisobutyl methanol 9.57
    2-phenylethanol 25.24
    styrene 4.06
    dioctyl adipate 15.99
    dimethyl sulfate 46.84
    ethyl butyrate 19.96
    methyl lactate 47.8
    butyl lactate 27.97
    diethyl carbonate 13.69
    propanediol butyl ether 41.47
    triethyl orthoformate 17.57
    p-tert-butyltoluene 5.79
    methyl 4-tert-butylbenzoate 29.76
    morpholine 81.35
    tert-butylamine 11.13
    n-dodecanol 6.47
    dimethoxymethane 115.87
    ethylene carbonate 35.0
    cyrene 38.1
    2-ethoxyethyl acetate 43.18
    2-ethylhexyl acetate 19.61
    1,2,4-trichlorobenzene 14.61
    4-methylpyridine 28.2
    dibutyl ether 10.77
    2,6-dimethyl-4-heptanol 9.57
    DEF 40.45
    dimethyl isosorbide 71.12
    tetrachloroethylene 24.96
    eugenol 31.45
    triacetin 35.52
    span 80 34.29
    1,4-butanediol 14.84
    1,1-dichloroethane 14.05
    2-methyl-1-pentanol 12.45
    methyl formate 42.64
    2-methyl-1-butanol 16.05
    n-decane 0.9
    butyronitrile 19.14
    3,7-dimethyl-1-octanol 12.33
    1-chlorooctane 4.23
    1-chlorotetradecane 1.78
    n-nonane 0.75
    undecane 0.66
    tert-butylcyclohexane 0.65
    cyclooctane 0.42
    cyclopentanol 24.24
    tetrahydropyran 39.32
    tert-amyl methyl ether 15.57
    2,5,8-trioxanonane 75.96
    1-hexene 1.87
    2-isopropoxyethanol 37.52
    2,2,2-trifluoroethanol 25.33
    methyl butyrate 27.28

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction