Acriflavine

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  • Identifiers

    CAS number
    65589-70-0

    Molecular formula
    C27H25ClN6

    SMILES
    C[N+]1=C2C=C(C=CC2=CC3=C1C=C(C=C3)N)N.C1=CC(=CC2=NC3=C(C=CC(=C3)N)C=C21)N.[Cl-]

    Safety labels

  • Odor profile

    Fragrance
    Animal 42.91%
    Floral 40.45%
    Sweet 36.83%
    Fruity 34.06%
    Grape 30.63%
    Phenolic 29.33%
    Burnt 26.49%
    Meaty 25.89%
    Musty 25.18%
    Musk 24.82%

     

    Flavor
    Bitter 55.6%
    Very strong 23.4%
    Indole 22.64%
    Animal 22.18%
    Mild 20.56%
    Nitrile 20.31%
    Moth ball 20.26%
    Orange flower 20.24%
    Naphthelene 20.04%
    Flat 19.96%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.44 (neutral)

    Molecular weight
    469.0 g/mol

    Flash point

    • 265.55 ˚C est.

  • Synonyms

    • Acriflavine
    • Acriflavin
    • 65589-70-0
    • Flavacridine
    • Triphaflavine
    • Xanthacridinum
    • 1T3A50395T
    • Choliflavin
    • Diacrid
    • Vetaflavin
    • Zoriflavin
    • Flavacridinum hydrochloricum
    • API Fungus Cure
    • RefChem:53981
    • DTXSID60110078
    • 8048-52-0
    • MFCD00064307
    • Trypaflavine Neutral
    • 3,6-Diamino-10-methylacridinium chloride-3,6-acridinediamine mixt
    • acridine-3,6-diamine;10-methylacridin-10-ium-3,6-diamine;chloride
    • 68518-47-8
    • DSSTox_CID_25848
    • DSSTox_RID_81170
    • DSSTox_GSID_45848
    • Acriflavine [NF]
    • Flavacridinum
    • Acriflavine Hydrochloride (>90%)
    • Fungus Cure
    • CAS-69235-50-3
    • Neutroflavin
    • CCRIS 5428
    • UNII-1T3A50395T
    • Acriflavine Dihydrochloride; Acriflavinium Chloride; Flavacridine Hydrochloride; NSC 689003
    • Acriflavine(Neutral)
    • Acriflavini Chloridium
    • Flavacridine hydrochloirde
    • Acriflavine, hydrochloride
    • Acriflavine dihydrochloride
    • SCHEMBL77745
    • Acriflavinium chloride [INN]
    • UNII-1S73VW819C
    • Acriflavine hydrochloride [NF]
    • orb1706392
    • SCHEMBL29385079
    • DTXSID30988185
    • PEJLNXHANOHNSU-UHFFFAOYSA-N
    • 1S73VW819C
    • RKL10102
    • Tox21_111337
    • MSK405015
    • AKOS015902524
    • Tox21_111337_1
    • CS-6959
    • FA01502
    • NSC 689003
    • NSC 757387
    • NCGC00178831-03
    • MS-28669
    • HY-100575
    • A0134
    • Cl,13.3-15.8%
    • Acriflavinium chloride 3,6-Acridinediamine mix
    • D88218
    • 3,6-Diamino-10-methylacridiniumchloride-3,6-acridinediaminemixt
    • 3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-diaminoacridine
    • 3,6-Diamino-10-methylacridin-10-ium chloride--acridine-3,6-diamine (1/1/1)
    • mixture of 3,6-Diamino-10-methylacridinium Chloride and 3,6-Diaminoacridine
    • 65589-70-0

  • Applications

    Acriflavine (CAS 65589-70-0) is a triarylmethane dye used as a laboratory stain and fluorescent probe in microbiology and histology to visualize cells and bacteria; it is employed as a colorant in inks, coatings, and plastics to impart a bright yellow-green hue; in research and manufacturing it can serve as a fluorescent marker or indicator in microscopy and analytical assays; historically it was used as a topical antiseptic in some formulations and has appeared in older pharmaceutical or cosmetic preparations; it may also function as an intermediate or additive in dye formulations and polymer systems, subject to formulation limits and local regulations.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 3.07
    methanol 4.7
    isopropanol 1.26
    water 0.95
    ethyl acetate 4.66
    n-propanol 2.14
    acetone 4.01
    n-butanol 2.06
    acetonitrile 2.67
    DMF 17.9
    toluene 0.7
    isobutanol 1.66
    1,4-dioxane 5.67
    methyl acetate 3.59
    THF 31.4
    2-butanone 3.88
    n-pentanol 2.53
    sec-butanol 0.99
    n-hexane 0.08
    ethylene glycol 3.36
    NMP 27.59
    cyclohexane 0.07
    DMSO 43.09
    n-butyl acetate 7.76
    n-octanol 1.49
    chloroform 4.82
    n-propyl acetate 4.38
    acetic acid 17.03
    dichloromethane 4.8
    cyclohexanone 9.07
    propylene glycol 1.71
    isopropyl acetate 2.64
    DMAc 32.19
    2-ethoxyethanol 16.64
    isopentanol 2.65
    n-heptane 0.26
    ethyl formate 7.03
    1,2-dichloroethane 4.13
    n-hexanol 6.18
    2-methoxyethanol 24.92
    isobutyl acetate 3.66
    tetrachloromethane 1.95
    n-pentyl acetate 4.43
    transcutol 13.62
    n-heptanol 4.33
    ethylbenzene 0.67
    MIBK 3.26
    2-propoxyethanol 29.7
    tert-butanol 2.46
    MTBE 0.99
    2-butoxyethanol 15.83
    propionic acid 5.18
    o-xylene 0.78
    formic acid 21.14
    diethyl ether 1.0
    m-xylene 0.99
    p-xylene 1.11
    chlorobenzene 2.21
    dimethyl carbonate 7.3
    n-octane 0.14
    formamide 25.38
    cyclopentanone 26.39
    2-pentanone 3.44
    anisole 2.78
    cyclopentyl methyl ether 5.63
    gamma-butyrolactone 39.49
    1-methoxy-2-propanol 12.19
    pyridine 7.13
    3-pentanone 2.72
    furfural 42.13
    n-dodecane 0.1
    diethylene glycol 37.07
    diisopropyl ether 0.48
    tert-amyl alcohol 1.92
    acetylacetone 8.0
    n-hexadecane 0.11
    acetophenone 6.05
    methyl propionate 5.8
    isopentyl acetate 7.82
    trichloroethylene 10.78
    n-nonanol 1.72
    cyclohexanol 1.51
    benzyl alcohol 5.17
    2-ethylhexanol 4.02
    isooctanol 3.68
    dipropyl ether 3.14
    1,2-dichlorobenzene 3.76
    ethyl lactate 6.23
    propylene carbonate 18.62
    n-methylformamide 13.86
    2-pentanol 0.92
    n-pentane 0.05
    1-propoxy-2-propanol 14.32
    1-methoxy-2-propyl acetate 13.24
    2-(2-methoxypropoxy) propanol 9.31
    mesitylene 0.73
    ε-caprolactone 10.93
    p-cymene 1.73
    epichlorohydrin 32.44
    1,1,1-trichloroethane 3.3
    2-aminoethanol 4.92
    morpholine-4-carbaldehyde 26.88
    sulfolane 54.47
    2,2,4-trimethylpentane 0.09
    2-methyltetrahydrofuran 7.97
    n-hexyl acetate 3.54
    isooctane 0.08
    2-(2-butoxyethoxy)ethanol 12.02
    sec-butyl acetate 2.42
    tert-butyl acetate 3.62
    decalin 0.13
    glycerin 10.39
    diglyme 24.07
    acrylic acid 7.74
    isopropyl myristate 1.59
    n-butyric acid 9.54
    acetyl acetate 4.67
    di(2-ethylhexyl) phthalate 4.18
    ethyl propionate 3.93
    nitromethane 32.63
    1,2-diethoxyethane 4.09
    benzonitrile 5.06
    trioctyl phosphate 3.23
    1-bromopropane 1.0
    gamma-valerolactone 37.5
    n-decanol 1.38
    triethyl phosphate 5.58
    4-methyl-2-pentanol 1.36
    propionitrile 2.3
    vinylene carbonate 15.88
    1,1,2-trichlorotrifluoroethane 39.7
    DMS 4.85
    cumene 0.97
    2-octanol 1.69
    2-hexanone 3.97
    octyl acetate 2.49
    limonene 1.67
    1,2-dimethoxyethane 17.4
    ethyl orthosilicate 4.89
    tributyl phosphate 3.26
    diacetone alcohol 9.27
    N,N-dimethylaniline 2.97
    acrylonitrile 5.14
    aniline 2.87
    1,3-propanediol 8.39
    bromobenzene 1.72
    dibromomethane 2.43
    1,1,2,2-tetrachloroethane 8.3
    2-methyl-cyclohexyl acetate 6.45
    tetrabutyl urea 4.5
    diisobutyl methanol 2.06
    2-phenylethanol 9.23
    styrene 0.62
    dioctyl adipate 2.8
    dimethyl sulfate 20.04
    ethyl butyrate 5.32
    methyl lactate 8.76
    butyl lactate 6.38
    diethyl carbonate 4.62
    propanediol butyl ether 5.87
    triethyl orthoformate 5.13
    p-tert-butyltoluene 1.56
    methyl 4-tert-butylbenzoate 9.0
    morpholine 7.96
    tert-butylamine 0.88
    n-dodecanol 1.07
    dimethoxymethane 14.75
    ethylene carbonate 12.04
    cyrene 16.95
    2-ethoxyethyl acetate 8.03
    2-ethylhexyl acetate 5.99
    1,2,4-trichlorobenzene 5.41
    4-methylpyridine 4.74
    dibutyl ether 1.14
    2,6-dimethyl-4-heptanol 2.06
    DEF 6.22
    dimethyl isosorbide 22.58
    tetrachloroethylene 9.33
    eugenol 12.07
    triacetin 5.56
    span 80 7.26
    1,4-butanediol 3.83
    1,1-dichloroethane 1.59
    2-methyl-1-pentanol 3.03
    methyl formate 13.94
    2-methyl-1-butanol 2.06
    n-decane 0.14
    butyronitrile 2.41
    3,7-dimethyl-1-octanol 1.75
    1-chlorooctane 0.69
    1-chlorotetradecane 0.33
    n-nonane 0.12
    undecane 0.11
    tert-butylcyclohexane 0.15
    cyclooctane 0.05
    cyclopentanol 3.35
    tetrahydropyran 2.88
    tert-amyl methyl ether 1.24
    2,5,8-trioxanonane 16.71
    1-hexene 0.33
    2-isopropoxyethanol 9.35
    2,2,2-trifluoroethanol 16.97
    methyl butyrate 5.89

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction