Acetylethanolamine

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  • Identifiers

    CAS number
    142-26-7

    Molecular formula
    C4H9NO2

    SMILES
    CC(=O)NCCO

    Safety labels

    Corrosive
    Corrosive

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 40.9%
    Sweet 40.45%
    Fishy 35.28%
    Meaty 33.67%
    Savory 32.91%
    Cheesy 20.93%
    Nutty 19.03%
    Pungent 18.98%
    Milky 17.93%
    Cooked 17.82%

     

    Flavor
    Odorless 58.97%
    Sour 28.61%
    Acidic 27.52%
    Pungent 24.5%
    Sweet-like 22.6%
    Milky 21.79%
    Very slight 21.73%
    Soy 21.34%
    Mousy 21.11%
    Acetoin 21.01%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.1

    pKa est.
    8.32 (weak base)

    Molecular weight
    103.12 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Melting point expt.

    • 63-65 °C

    Boiling point

    • 166-167 °C @ 8 MM HG

    Flash point

    • 137.48 ˚C est.
    • 176.6 °C
    • 350 °F OC

    Solubility expt.

    • SOL IN ALL PROP IN WATER; SOL IN HOT ACETONE; SLIGHTLY SOL IN BENZENE, PETROLEUM ETHER

  • Synonyms

    • N-(2-Hydroxyethyl)acetamide
    • N-Acetylethanolamine
    • 142-26-7
    • 2-Acetamidoethanol
    • Acetylcolamine
    • Acetamide, N-(2-hydroxyethyl)-
    • Acetamide MEA
    • 2-Acetylaminoethanol
    • N-Ethanolacetamide
    • N-Acetyl-2-aminoethanol
    • Hydroxyethyl acetamide
    • N-Acetyl ethanolamine
    • ACETYLETHANOLAMINE
    • N-2-Hydroxyethylacetamide
    • Acetic monoethanolamide
    • beta-Hydroxyethylacetamide
    • N-beta-Hydroxyethylacetamide
    • NSC 5999
    • HSDB 2713
    • EINECS 205-530-8
    • BRN 1811708
    • A9O0818TWD
    • Acetic acid amide, N-(2-hydroxyethyl)-
    • DTXSID6044804
    • AI3-02836
    • NSC-5999
    • ACETAMIDE MEA [VANDF]
    • acetamide, N-(2-hydroxyethyl)
    • DTXCID4024804
    • ACETYLETHANOLAMINE [HSDB]
    • CHEBI:74687
    • 4-04-00-01535 (Beilstein Handbook Reference)
    • NEthanolacetamide
    • 2Acetamidoethanol
    • NAcetylethanolamine
    • 2Acetylaminoethanol
    • NAcetyl ethanolamine
    • NAcetyl2aminoethanol
    • betaHydroxyethylacetamide
    • NbetaHydroxyethylacetamide
    • RefChem:552499
    • N(2Hydroxyethyl)acetamide
    • ACETAMIDE MEA [INCI]
    • N-(beta-Hydroxyethyl)acetamide
    • Acetic acid amide, N(2hydroxyethyl)
    • ACETIC ACID, AMIDE, N(2-HYDROXYETHYL)-
    • InChI=1/C4H9NO2/c1-4(7)5-2-3-6/h6H,2-3H2,1H3,(H,5,7
    • MFCD00002836
    • .beta.-Hydroxyethylacetamide
    • N-(.beta.-Hydroxyethyl)acetamide
    • N-Acetylethanolamine (~90%)
    • UNII-A9O0818TWD
    • Hetamide MA
    • Carsamide AMEA
    • Lipamide MEAA
    • Amidex AME
    • Upamide ACMEA
    • N-acetyl-ethanolamine
    • Schercomid AME 70
    • Foamid AME-70
    • Foamid AME-75
    • Mackamide AME-100
    • Foamid AME-100
    • Incromectant AMEA-70
    • Incromectant AMEA-100
    • n-2-hydroxyethyl-acetamide
    • WLN: Q2MV1
    • SCHEMBL48502
    • N-(2-hydroxyethyl)-acetamide
    • SCHEMBL149184
    • SCHEMBL209977
    • N-(2-hydroxy-ethyl)-acetamide
    • SCHEMBL1563041
    • SCHEMBL5753972
    • SCHEMBL5754056
    • CHEMBL3188272
    • NSC5999
    • Tox21_301724
    • N-Acetylethanolamine, technical grade
    • SBB007954
    • STL283925
    • AKOS005206796
    • CS-W013689
    • FD10637
    • FS-4296
    • NCGC00256051-01
    • CAS-142-26-7
    • FA183124
    • SY007881
    • DB-000300
    • A0075
    • A1935
    • NS00001024
    • EN300-15590
    • F094790
    • Q27144824
    • 142-26-7

  • Applications

    Acetylethanolamine, CAS 142-26-7, is mainly used as an intermediate in organic synthesis, serving as a precursor to amino alcohol derivatives, carbamates, and related specialty chemicals. In industry, it is commonly used to prepare polymers and polyurethane materials by providing an acetylated amino alcohol building block; it can function as a reactive intermediate for coatings and inks, enabling urethane linkages and surface modification. In cosmetics and personal care, it may be employed as a formulation component to influence solubility, pH, or as a conditioning/functional additive. In pharmaceutical manufacture, it is evaluated as a starting material for synthesis of acetylated amino alcohols and related intermediates. It also serves as a precursor in surfactant chemistry for making amphiphilic derivatives. Use is subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 206.75
    methanol 527.92
    isopropanol 90.41
    water 1495.54
    ethyl acetate 17.29
    n-propanol 108.08
    acetone 52.76
    n-butanol 68.81
    acetonitrile 56.45
    DMF 635.68
    toluene 2.64
    isobutanol 59.42
    1,4-dioxane 39.4
    methyl acetate 25.57
    THF 68.2
    2-butanone 27.06
    n-pentanol 34.75
    sec-butanol 55.69
    n-hexane 1.13
    ethylene glycol 306.67
    NMP 280.22
    cyclohexane 0.75
    DMSO 399.71
    n-butyl acetate 9.96
    n-octanol 13.24
    chloroform 14.79
    n-propyl acetate 9.35
    acetic acid 268.6
    dichloromethane 20.77
    cyclohexanone 38.47
    propylene glycol 228.74
    isopropyl acetate 8.64
    DMAc 360.73
    2-ethoxyethanol 117.68
    isopentanol 42.24
    n-heptane 1.1
    ethyl formate 81.56
    1,2-dichloroethane 12.49
    n-hexanol 22.29
    2-methoxyethanol 310.17
    isobutyl acetate 5.66
    tetrachloromethane 5.16
    n-pentyl acetate 8.75
    transcutol 91.81
    n-heptanol 12.64
    ethylbenzene 2.11
    MIBK 10.94
    2-propoxyethanol 74.62
    tert-butanol 68.37
    MTBE 15.07
    2-butoxyethanol 39.88
    propionic acid 109.74
    o-xylene 4.19
    formic acid 729.26
    diethyl ether 9.14
    m-xylene 3.55
    p-xylene 3.09
    chlorobenzene 5.64
    dimethyl carbonate 14.34
    n-octane 0.55
    formamide 372.8
    cyclopentanone 66.08
    2-pentanone 19.01
    anisole 10.53
    cyclopentyl methyl ether 16.87
    gamma-butyrolactone 96.56
    1-methoxy-2-propanol 134.62
    pyridine 25.69
    3-pentanone 11.13
    furfural 147.69
    n-dodecane 0.58
    diethylene glycol 130.54
    diisopropyl ether 2.28
    tert-amyl alcohol 52.61
    acetylacetone 22.86
    n-hexadecane 0.61
    acetophenone 14.63
    methyl propionate 22.13
    isopentyl acetate 9.29
    trichloroethylene 20.79
    n-nonanol 10.77
    cyclohexanol 28.03
    benzyl alcohol 25.51
    2-ethylhexanol 10.39
    isooctanol 9.69
    dipropyl ether 6.16
    1,2-dichlorobenzene 7.37
    ethyl lactate 22.04
    propylene carbonate 46.52
    n-methylformamide 336.18
    2-pentanol 21.98
    n-pentane 1.2
    1-propoxy-2-propanol 39.31
    1-methoxy-2-propyl acetate 15.79
    2-(2-methoxypropoxy) propanol 38.48
    mesitylene 2.69
    ε-caprolactone 39.97
    p-cymene 3.37
    epichlorohydrin 58.21
    1,1,1-trichloroethane 6.88
    2-aminoethanol 311.52
    morpholine-4-carbaldehyde 214.72
    sulfolane 141.06
    2,2,4-trimethylpentane 1.06
    2-methyltetrahydrofuran 31.13
    n-hexyl acetate 12.43
    isooctane 0.65
    2-(2-butoxyethoxy)ethanol 44.16
    sec-butyl acetate 5.33
    tert-butyl acetate 8.44
    decalin 0.78
    glycerin 373.38
    diglyme 76.98
    acrylic acid 135.93
    isopropyl myristate 4.87
    n-butyric acid 90.11
    acetyl acetate 12.55
    di(2-ethylhexyl) phthalate 12.59
    ethyl propionate 9.41
    nitromethane 233.05
    1,2-diethoxyethane 12.22
    benzonitrile 21.68
    trioctyl phosphate 8.61
    1-bromopropane 6.44
    gamma-valerolactone 127.87
    n-decanol 7.7
    triethyl phosphate 8.59
    4-methyl-2-pentanol 11.69
    propionitrile 33.78
    vinylene carbonate 53.05
    1,1,2-trichlorotrifluoroethane 114.51
    DMS 11.55
    cumene 2.54
    2-octanol 7.6
    2-hexanone 10.97
    octyl acetate 7.6
    limonene 4.81
    1,2-dimethoxyethane 114.4
    ethyl orthosilicate 7.84
    tributyl phosphate 9.64
    diacetone alcohol 30.29
    N,N-dimethylaniline 12.3
    acrylonitrile 61.51
    aniline 18.51
    1,3-propanediol 220.58
    bromobenzene 3.43
    dibromomethane 10.02
    1,1,2,2-tetrachloroethane 17.84
    2-methyl-cyclohexyl acetate 8.85
    tetrabutyl urea 16.19
    diisobutyl methanol 6.02
    2-phenylethanol 15.81
    styrene 2.53
    dioctyl adipate 10.33
    dimethyl sulfate 42.47
    ethyl butyrate 8.93
    methyl lactate 55.06
    butyl lactate 18.83
    diethyl carbonate 7.13
    propanediol butyl ether 51.09
    triethyl orthoformate 8.6
    p-tert-butyltoluene 3.28
    methyl 4-tert-butylbenzoate 19.41
    morpholine 71.4
    tert-butylamine 28.34
    n-dodecanol 5.69
    dimethoxymethane 79.07
    ethylene carbonate 36.24
    cyrene 49.77
    2-ethoxyethyl acetate 13.42
    2-ethylhexyl acetate 6.78
    1,2,4-trichlorobenzene 9.02
    4-methylpyridine 30.66
    dibutyl ether 5.41
    2,6-dimethyl-4-heptanol 6.02
    DEF 62.2
    dimethyl isosorbide 45.08
    tetrachloroethylene 14.54
    eugenol 30.16
    triacetin 16.52
    span 80 31.4
    1,4-butanediol 104.18
    1,1-dichloroethane 9.09
    2-methyl-1-pentanol 26.79
    methyl formate 193.11
    2-methyl-1-butanol 46.22
    n-decane 0.86
    butyronitrile 39.12
    3,7-dimethyl-1-octanol 11.76
    1-chlorooctane 3.24
    1-chlorotetradecane 1.49
    n-nonane 0.8
    undecane 0.67
    tert-butylcyclohexane 0.98
    cyclooctane 0.37
    cyclopentanol 53.68
    tetrahydropyran 17.09
    tert-amyl methyl ether 13.58
    2,5,8-trioxanonane 60.15
    1-hexene 3.34
    2-isopropoxyethanol 45.51
    2,2,2-trifluoroethanol 135.08
    methyl butyrate 18.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction