Acetyl-11-Keto-Beta-Boswellic Acid

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  • Identifiers

    CAS number
    67416-61-9

    Molecular formula
    C32H48O5

    SMILES
    C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC(=O)[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@H]([C@]5(C)C(=O)O)OC(=O)C)C)C)[C@@H]2[C@H]1C)C)C

    Safety labels

  • Odor profile

    Fragrance
    Woody 80.98%
    Cedar 51.82%
    Amber 50.25%
    Dry 45.8%
    Balsamic 37.07%
    Spicy 36.65%
    Vetiver 34.24%
    Musk 31.27%
    Pine 27.87%
    Camphoreous 27.81%

     

    Flavor
    Woody 45.65%
    Bitter 44.58%
    Camphor 37.0%
    Pine 33.46%
    Herbal 28.38%
    Balsam 28.2%
    Minty 26.49%
    Fir 23.23%
    Ripe apricot 22.74%
    Cedarleaf 22.56%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    7.2

    pKa est.
    4.87 (weak acid)

    Molecular weight
    512.7 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    545°C

    Flash point

    • 258.51 ˚C est.

  • Synonyms

    • 67416-61-9
    • 3-acetyl-11-keto-beta-boswellic acid
    • AKBA cpd
    • Acetyl-11-keto-beta-boswellic acid
    • acetyl-11-ketoboswellic acid
    • acetyl-11-keto-boswellic acid
    • BS16QT99Q1
    • (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-acetyloxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4a,5,6,7,8,9,10,11,12,12a,14a-tetradecahydropicene-4-carboxylic acid
    • DTXSID601303401
    • 3-O-acetyl-11-keto-boswellic acid
    • AcKBA
    • RefChem:25878
    • DTXCID001733438
    • AKBA
    • 3-O-Acetyl-11-keto-beta-Boswellic Acid
    • MFCD03788777
    • Acetyl-11-keto--boswellic acid
    • (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-acetoxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid
    • CHEMBL237111
    • Acetyl-11-keto-|A-boswellic acid
    • Acetyl-11-keto-beta-Boswellic Acid, Boswellia serrata
    • 3-Acetyl-11-keto-?-boswellic Acid
    • UNII-BS16QT99Q1
    • AKBA (Standard)
    • 3alpha-acetoxy-11-keto-beta-boswellic acid
    • Curator_000001
    • SCHEMBL23610472
    • HY-N0892R
    • CHEBI:166842
    • HMS6019P06
    • HY-N0892
    • 3-Acetyl-11-keto-ss-boswellic acid
    • BDBM50241262
    • s9024
    • AKOS026670207
    • CCG-269792
    • CS-3736
    • EBC-521836
    • FA42758
    • NCGC00482913-02
    • (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-(acetyloxy)-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydropicene-4-carboxylic acid
    • AC-34814
    • DA-69987
    • SY076792
    • ACETYL-11-OXO-.BETA.-BOSWELLIC ACID
    • ACETYL-11-KETO-.BETA.-BOSWELLIC ACID
    • 11-KETO-.BETA.-BOSWELLIC ACID ACETATE
    • 3-O-ACETYL-11-KETO-.BETA.-BOSWELLIC ACID
    • 3alpha-(Acetyloxy)-11-oxours-12-en-24-oic acid
    • 416A619
    • BRD-K54907283-001-01-2
    • Q27274850
    • 3-ACETYL-11-KETO-BETA-BOSWELLIC ACID [USP-RS]
    • 3.ALPHA.-ACETOXY-11-OXO-12-URSEN-24-OIC ACID
    • 3.ALPHA.-ACETYL-11-KETO-.BETA.-BOSWELLIC ACID
    • Acetyl-11-keto- beta -Boswellic Acid, Boswellia serrata
    • 3-O-Acetyl-11-keto-beta-boswellic acid, analytical standard
    • (3.ALPHA.,4.BETA.)-3-(ACETYLOXY)-11-OXOURS-12-EN-23-OIC ACID
    • 3-O-Acetyl-11-keto-|A-boswellic acid; Acetyl-11-keto-|A-boswellic acid
    • 3-ACETYL-11-KETO-.BETA.-BOSWELLIC ACID (CONSTITUENT OF BOSWELLIA SERRATA) [DSC]
    • 3-Acetyl-11-keto-beta-boswellic acid, United States Pharmacopeia (USP) Reference Standard
    • URS-12-EN-23-OIC ACID, 3-(ACETYLOXY)-11-OXO-, (3.ALPHA.,4.BETA.)-
    • (3R,4R,4aR,6aR,6bS,8aR,11R,12S,12aR,14aR,14bS)-3-acetoxy-4,6a,6b,8a,11,12,14b-heptamethyl-14-oxo-1,2,3,4a,5,6,7,8,9,10,11,12,12a,14a-tetradecahydropicene-4-carboxylic acid
    • 67416-61-9

  • Applications

    Acetyl-11-Keto-Beta-Boswellic Acid (AKBA, CAS 67416-61-9) is a pentacyclic triterpenoid derived from Boswellia serrata resin. It is primarily pursued as an active constituent in pharmaceuticals and nutraceuticals due to its anti-inflammatory activity, typically via inhibition of 5-lipoxygenase and related inflammatory pathways; it is commonly used as a marker compound for standardized boswellia extracts and for quality control of these materials. It is evaluated for inclusion in topical cosmetic and skincare formulations where anti-inflammatory or soothing properties are desirable. It is also used in research and development as a reference compound in in vitro enzyme inhibition assays and bioactivity profiling. Collectively, applications center on pharmaceutical and nutraceutical products, cosmetic formulations, and analytical/quality-control uses for frankincense-based materials.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 24.03
    methanol 18.25
    isopropanol 25.35
    water 0.01
    ethyl acetate 8.67
    n-propanol 36.93
    acetone 17.14
    n-butanol 26.18
    acetonitrile 5.84
    DMF 87.99
    toluene 11.23
    isobutanol 20.89
    1,4-dioxane 44.55
    methyl acetate 10.56
    THF 87.93
    2-butanone 23.38
    n-pentanol 17.23
    sec-butanol 17.7
    n-hexane 0.49
    ethylene glycol 2.52
    NMP 63.24
    cyclohexane 0.68
    DMSO 33.15
    n-butyl acetate 8.36
    n-octanol 3.83
    chloroform 38.29
    n-propyl acetate 6.68
    acetic acid 12.35
    dichloromethane 20.97
    cyclohexanone 32.95
    propylene glycol 8.3
    isopropyl acetate 7.1
    DMAc 64.93
    2-ethoxyethanol 26.1
    isopentanol 13.59
    n-heptane 0.25
    ethyl formate 6.77
    1,2-dichloroethane 13.87
    n-hexanol 14.47
    2-methoxyethanol 42.65
    isobutyl acetate 5.44
    tetrachloromethane 4.74
    n-pentyl acetate 9.97
    transcutol 22.86
    n-heptanol 7.55
    ethylbenzene 4.36
    MIBK 9.09
    2-propoxyethanol 48.95
    tert-butanol 12.91
    MTBE 7.79
    2-butoxyethanol 22.45
    propionic acid 11.68
    o-xylene 5.41
    formic acid 5.0
    diethyl ether 13.8
    m-xylene 5.71
    p-xylene 4.87
    chlorobenzene 10.14
    dimethyl carbonate 9.44
    n-octane 0.11
    formamide 7.5
    cyclopentanone 46.76
    2-pentanone 16.3
    anisole 9.22
    cyclopentyl methyl ether 19.36
    gamma-butyrolactone 35.48
    1-methoxy-2-propanol 45.28
    pyridine 36.46
    3-pentanone 13.65
    furfural 25.15
    n-dodecane 0.05
    diethylene glycol 22.73
    diisopropyl ether 2.15
    tert-amyl alcohol 9.67
    acetylacetone 13.59
    n-hexadecane 0.07
    acetophenone 10.11
    methyl propionate 13.7
    isopentyl acetate 8.29
    trichloroethylene 29.49
    n-nonanol 4.34
    cyclohexanol 14.31
    benzyl alcohol 14.02
    2-ethylhexanol 4.68
    isooctanol 5.22
    dipropyl ether 5.39
    1,2-dichlorobenzene 8.07
    ethyl lactate 6.43
    propylene carbonate 12.22
    n-methylformamide 26.13
    2-pentanol 10.76
    n-pentane 0.61
    1-propoxy-2-propanol 26.57
    1-methoxy-2-propyl acetate 15.84
    2-(2-methoxypropoxy) propanol 13.18
    mesitylene 2.81
    ε-caprolactone 24.44
    p-cymene 2.14
    epichlorohydrin 43.85
    1,1,1-trichloroethane 10.59
    2-aminoethanol 12.41
    morpholine-4-carbaldehyde 63.5
    sulfolane 41.14
    2,2,4-trimethylpentane 0.29
    2-methyltetrahydrofuran 28.07
    n-hexyl acetate 10.01
    isooctane 0.21
    2-(2-butoxyethoxy)ethanol 16.91
    sec-butyl acetate 4.78
    tert-butyl acetate 7.2
    decalin 0.43
    glycerin 10.88
    diglyme 29.63
    acrylic acid 10.39
    isopropyl myristate 2.63
    n-butyric acid 15.86
    acetyl acetate 5.56
    di(2-ethylhexyl) phthalate 6.07
    ethyl propionate 6.2
    nitromethane 17.03
    1,2-diethoxyethane 8.56
    benzonitrile 9.64
    trioctyl phosphate 3.77
    1-bromopropane 9.86
    gamma-valerolactone 65.58
    n-decanol 2.32
    triethyl phosphate 3.89
    4-methyl-2-pentanol 4.97
    propionitrile 11.52
    vinylene carbonate 13.78
    1,1,2-trichlorotrifluoroethane 30.82
    DMS 8.8
    cumene 2.59
    2-octanol 3.29
    2-hexanone 11.47
    octyl acetate 4.25
    limonene 2.67
    1,2-dimethoxyethane 31.52
    ethyl orthosilicate 3.99
    tributyl phosphate 3.35
    diacetone alcohol 13.07
    N,N-dimethylaniline 7.43
    acrylonitrile 12.61
    aniline 15.67
    1,3-propanediol 22.45
    bromobenzene 9.19
    dibromomethane 14.52
    1,1,2,2-tetrachloroethane 26.45
    2-methyl-cyclohexyl acetate 7.2
    tetrabutyl urea 5.96
    diisobutyl methanol 2.15
    2-phenylethanol 15.41
    styrene 4.76
    dioctyl adipate 5.45
    dimethyl sulfate 14.83
    ethyl butyrate 5.75
    methyl lactate 12.5
    butyl lactate 10.56
    diethyl carbonate 3.57
    propanediol butyl ether 15.79
    triethyl orthoformate 5.76
    p-tert-butyltoluene 1.99
    methyl 4-tert-butylbenzoate 12.06
    morpholine 72.41
    tert-butylamine 5.13
    n-dodecanol 1.21
    dimethoxymethane 48.87
    ethylene carbonate 11.16
    cyrene 19.89
    2-ethoxyethyl acetate 15.3
    2-ethylhexyl acetate 6.6
    1,2,4-trichlorobenzene 12.57
    4-methylpyridine 26.39
    dibutyl ether 2.3
    2,6-dimethyl-4-heptanol 2.15
    DEF 20.16
    dimethyl isosorbide 20.69
    tetrachloroethylene 16.68
    eugenol 13.86
    triacetin 9.73
    span 80 12.33
    1,4-butanediol 9.06
    1,1-dichloroethane 12.93
    2-methyl-1-pentanol 9.64
    methyl formate 13.1
    2-methyl-1-butanol 14.69
    n-decane 0.15
    butyronitrile 10.72
    3,7-dimethyl-1-octanol 3.0
    1-chlorooctane 1.29
    1-chlorotetradecane 0.3
    n-nonane 0.13
    undecane 0.09
    tert-butylcyclohexane 0.36
    cyclooctane 0.24
    cyclopentanol 22.16
    tetrahydropyran 35.72
    tert-amyl methyl ether 6.11
    2,5,8-trioxanonane 16.93
    1-hexene 2.74
    2-isopropoxyethanol 15.37
    2,2,2-trifluoroethanol 5.08
    methyl butyrate 8.14

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction