Acetamidopropyl trimonium chloride

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  • Identifiers

    CAS number
    123776-56-7

    Molecular formula
    C8H19ClN2O

    SMILES
    CC(=O)NCCC[N+](C)(C)C.[Cl-]

    Safety labels

  • Odor profile

    Fragrance
    Mint 39.53%
    Cooling 36.91%
    Fishy 35.49%
    Cheesy 35.29%
    Grapefruit 27.22%
    Savory 25.74%
    Meaty 25.27%
    Ripe 24.45%
    Animal 23.04%
    Herbal 22.87%

     

    Flavor
    Sulfurous 28.2%
    Sulfury 26.16%
    Mild 25.47%
    Bland 23.64%
    Green 23.48%
    Yeasty 20.37%
    Acrid 20.37%
    Bloody 20.33%
    Glue 20.24%
    Black currant 19.93%

     

    Odor impact est.
    Low

  • Properties

    pKa est.
    7.43 (neutral)

    Molecular weight
    194.7 g/mol

    Flash point

    • 6.98 ˚C est.

  • Synonyms

    • Acetamidopropyl trimonium chloride
    • Incromectant AO
    • Incromectant AQ
    • Quamide ame-50
    • UNII-2SQT0WU9CO
    • 2SQT0WU9CO
    • 123776-56-7
    • AEC acetamidopropyl trimonium chloride
    • Acetamidopropyl trimonium chloride [INCI]
    • 1-Propanaminium, 3-(acetylamino)-N,N,N-trimethyl-, chloride (1:1)
    • ACETAMIDOPROPYL TRIMONIUM
    • DTXSID70154089
    • acetamidopropyl trimethylammonium chloride
    • RefChem:108867
    • DTXCID6076580
    • SCHEMBL4058823
    • 3-Acetamido-N,N,N-trimethylpropan-1-aminium chloride
    • Q27255545
    • 123776-56-7

  • Applications

    Acetamidopropyl trimonium chloride (CAS 123776-56-7) is a cationic surfactant used as a conditioning/softening component in personal care products (e.g., hair care), and as a surface-active additive in household and industrial cleaners. It can function as an emulsifier and wetting agent to stabilize formulations and improve substrate wetting. In industrial manufacturing, it serves as a cationic surfactant and functional additive in coatings, inks and adhesives, aiding compatibility and deposition. It is also employed as a building block or intermediate for polymers and polyquaternary ammonium resins, providing conditioning, antistatic and viscosity-modifying properties in textiles, paper and related products. In specialty applications, it may be evaluated for use in polymer formulations and as a functional modifier to improve gloss and feel. Subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 2901.76
    methanol 5604.01
    isopropanol 1274.57
    water 2242.49
    ethyl acetate 370.09
    n-propanol 1820.67
    acetone 641.64
    n-butanol 1177.01
    acetonitrile 404.95
    DMF 2053.81
    toluene 107.62
    isobutanol 888.4
    1,4-dioxane 450.78
    methyl acetate 637.86
    THF 553.93
    2-butanone 533.53
    n-pentanol 378.52
    sec-butanol 943.44
    n-hexane 34.88
    ethylene glycol 2339.31
    NMP 1598.83
    cyclohexane 46.1
    DMSO 689.5
    n-butyl acetate 200.37
    n-octanol 117.33
    chloroform 1080.27
    n-propyl acetate 163.96
    acetic acid 5610.33
    dichloromethane 653.79
    cyclohexanone 541.36
    propylene glycol 2343.26
    isopropyl acetate 160.36
    DMAc 1781.58
    2-ethoxyethanol 826.08
    isopentanol 482.26
    n-heptane 17.78
    ethyl formate 734.99
    1,2-dichloroethane 371.58
    n-hexanol 364.08
    2-methoxyethanol 2450.0
    isobutyl acetate 102.07
    tetrachloromethane 403.72
    n-pentyl acetate 110.44
    transcutol 843.88
    n-heptanol 142.25
    ethylbenzene 36.65
    MIBK 100.91
    2-propoxyethanol 715.65
    tert-butanol 763.13
    MTBE 282.42
    2-butoxyethanol 362.65
    propionic acid 2237.17
    o-xylene 83.11
    formic acid 7881.23
    diethyl ether 264.47
    m-xylene 66.79
    p-xylene 59.29
    chlorobenzene 166.97
    dimethyl carbonate 212.58
    n-octane 5.69
    formamide 4232.35
    cyclopentanone 540.23
    2-pentanone 261.16
    anisole 101.79
    cyclopentyl methyl ether 270.79
    gamma-butyrolactone 815.12
    1-methoxy-2-propanol 975.19
    pyridine 531.93
    3-pentanone 242.1
    furfural 992.08
    n-dodecane 3.48
    diethylene glycol 875.47
    diisopropyl ether 40.23
    tert-amyl alcohol 707.39
    acetylacetone 209.28
    n-hexadecane 3.68
    acetophenone 138.27
    methyl propionate 420.93
    isopentyl acetate 155.73
    trichloroethylene 890.07
    n-nonanol 93.73
    cyclohexanol 636.6
    benzyl alcohol 229.69
    2-ethylhexanol 139.97
    isooctanol 90.32
    dipropyl ether 77.96
    1,2-dichlorobenzene 140.74
    ethyl lactate 205.26
    propylene carbonate 484.12
    n-methylformamide 2396.46
    2-pentanol 399.31
    n-pentane 48.74
    1-propoxy-2-propanol 364.39
    1-methoxy-2-propyl acetate 207.29
    2-(2-methoxypropoxy) propanol 221.0
    mesitylene 36.87
    ε-caprolactone 611.68
    p-cymene 39.62
    epichlorohydrin 592.97
    1,1,1-trichloroethane 425.11
    2-aminoethanol 3239.18
    morpholine-4-carbaldehyde 1054.96
    sulfolane 769.86
    2,2,4-trimethylpentane 27.67
    2-methyltetrahydrofuran 477.42
    n-hexyl acetate 162.54
    isooctane 9.76
    2-(2-butoxyethoxy)ethanol 314.96
    sec-butyl acetate 95.42
    tert-butyl acetate 136.4
    decalin 14.41
    glycerin 2832.4
    diglyme 470.34
    acrylic acid 2440.91
    isopropyl myristate 35.06
    n-butyric acid 1618.48
    acetyl acetate 249.09
    di(2-ethylhexyl) phthalate 80.16
    ethyl propionate 140.43
    nitromethane 2662.51
    1,2-diethoxyethane 113.07
    benzonitrile 168.39
    trioctyl phosphate 54.01
    1-bromopropane 198.18
    gamma-valerolactone 998.1
    n-decanol 57.74
    triethyl phosphate 78.82
    4-methyl-2-pentanol 122.91
    propionitrile 385.89
    vinylene carbonate 541.43
    1,1,2-trichlorotrifluoroethane 1803.3
    DMS 164.19
    cumene 31.77
    2-octanol 65.31
    2-hexanone 136.89
    octyl acetate 61.9
    limonene 65.72
    1,2-dimethoxyethane 499.54
    ethyl orthosilicate 82.47
    tributyl phosphate 69.99
    diacetone alcohol 274.67
    N,N-dimethylaniline 86.13
    acrylonitrile 535.84
    aniline 407.61
    1,3-propanediol 2361.69
    bromobenzene 104.0
    dibromomethane 421.19
    1,1,2,2-tetrachloroethane 751.06
    2-methyl-cyclohexyl acetate 100.96
    tetrabutyl urea 82.17
    diisobutyl methanol 48.33
    2-phenylethanol 197.44
    styrene 49.13
    dioctyl adipate 66.93
    dimethyl sulfate 373.12
    ethyl butyrate 115.2
    methyl lactate 517.83
    butyl lactate 192.23
    diethyl carbonate 86.1
    propanediol butyl ether 397.13
    triethyl orthoformate 103.18
    p-tert-butyltoluene 39.72
    methyl 4-tert-butylbenzoate 140.98
    morpholine 920.62
    tert-butylamine 381.46
    n-dodecanol 37.2
    dimethoxymethane 436.59
    ethylene carbonate 403.62
    cyrene 252.94
    2-ethoxyethyl acetate 172.94
    2-ethylhexyl acetate 126.42
    1,2,4-trichlorobenzene 213.6
    4-methylpyridine 424.07
    dibutyl ether 48.89
    2,6-dimethyl-4-heptanol 48.33
    DEF 542.48
    dimethyl isosorbide 237.25
    tetrachloroethylene 830.0
    eugenol 180.88
    triacetin 186.86
    span 80 228.92
    1,4-butanediol 708.31
    1,1-dichloroethane 426.47
    2-methyl-1-pentanol 234.8
    methyl formate 1466.26
    2-methyl-1-butanol 674.25
    n-decane 7.37
    butyronitrile 324.3
    3,7-dimethyl-1-octanol 88.19
    1-chlorooctane 35.97
    1-chlorotetradecane 10.12
    n-nonane 7.4
    undecane 4.77
    tert-butylcyclohexane 16.29
    cyclooctane 12.13
    cyclopentanol 720.0
    tetrahydropyran 427.17
    tert-amyl methyl ether 259.64
    2,5,8-trioxanonane 276.54
    1-hexene 84.75
    2-isopropoxyethanol 359.81
    2,2,2-trifluoroethanol 2857.18
    methyl butyrate 224.31

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction