Acetamide, 2,2'-thiobis-

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  • Identifiers

    CAS number
    14618-65-6

    Molecular formula
    C4H8N2O2S

    SMILES
    C(C(=O)N)SCC(=O)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Meaty 48.64%
    Sweet 42.23%
    Savory 39.42%
    Roasted 32.79%
    Sulfurous 32.74%
    Cooked 32.35%
    Onion 27.12%
    Cheesy 24.34%
    Fishy 23.73%
    Odorless 23.46%

     

    Flavor
    Roasted 42.06%
    Cooked 37.9%
    Sulfury 32.96%
    Odorless 28.16%
    Nutty 28.13%
    Sulfurous 27.12%
    Meaty 26.64%
    Onion 25.62%
    Cabbage 24.72%
    Sulfur 24.11%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    -1.2

    pKa est.
    5.7 (weak acid)

    Molecular weight
    148.19 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    412°C

    Flash point

    • 181.73 ˚C est.

  • Synonyms

    • 14618-65-6
    • 2,2'-Thiobisacetamide
    • Thiodiglycolamide
    • Thiodiacetamide
    • Thiobisacetamide
    • ACETAMIDE, 2,2'-THIOBIS-
    • 2,2'-Thio-bis-acetamide
    • EINECS 238-657-2
    • G4Y5Q1UXX2
    • NSC 82327
    • BRN 1764428
    • MEXORYL SA
    • NSC-82327
    • DTXSID30163293
    • 4-03-00-00625 (Beilstein Handbook Reference)
    • RefChem:551534
    • THIODIGLYCOLAMIDE [INCI]
    • DTXCID1085784
    • 2,2'-Thiodiacetamide
    • 2-(2-amino-2-oxoethyl)sulfanylacetamide
    • CHEMBL171496
    • 2,2/'-THIODIACETAMIDE
    • 2-(carbamoylmethylthio)acetamide
    • UNII-G4Y5Q1UXX2
    • monothiodiacetamide
    • NSC82327
    • Acetamide,2'-thiobis-
    • 2,2'-Thiobis(acetamide)
    • WLN: ZV1S1VZ
    • 2,2'-Sulfanediyldiacetamide
    • SCHEMBL3069757
    • SCHEMBL5841715
    • 2-Carbamoylmethylsulfanyl-acetamide
    • BDBM50224826
    • SBB058334
    • AKOS003325212
    • 2-(2-amino-2-oxo-ethyl)sulfanylacetamide
    • DB-042829
    • CS-0337195
    • NS00014154
    • ST45023917
    • Q27278754
    • 14618-65-6

  • Applications

    Acetamide, 2,2'-thiobis- (CAS number: 14618-65-6) is used as an organic synthesis intermediate and as a crosslinking/curing agent in polymer formulations and coatings; it can function as a processing aid or solvent in chemical manufacturing; it serves as a building block for specialty chemicals used in coatings and adhesives; and it may be evaluated as an intermediate for pharmaceutical or agrochemical synthesis, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 42.4
    methanol 128.23
    isopropanol 14.84
    water 443.14
    ethyl acetate 8.14
    n-propanol 18.19
    acetone 48.27
    n-butanol 9.44
    acetonitrile 22.72
    DMF 208.45
    toluene 0.75
    isobutanol 7.81
    1,4-dioxane 47.6
    methyl acetate 16.02
    THF 53.01
    2-butanone 15.33
    n-pentanol 4.99
    sec-butanol 7.0
    n-hexane 0.37
    ethylene glycol 87.69
    NMP 200.37
    cyclohexane 0.6
    DMSO 160.94
    n-butyl acetate 5.79
    n-octanol 3.74
    chloroform 0.83
    n-propyl acetate 6.37
    acetic acid 112.91
    dichloromethane 1.75
    cyclohexanone 21.91
    propylene glycol 47.49
    isopropyl acetate 4.44
    DMAc 166.21
    2-ethoxyethanol 42.01
    isopentanol 4.67
    n-heptane 0.56
    ethyl formate 19.12
    1,2-dichloroethane 2.12
    n-hexanol 5.19
    2-methoxyethanol 110.33
    isobutyl acetate 3.34
    tetrachloromethane 0.34
    n-pentyl acetate 4.51
    transcutol 49.77
    n-heptanol 4.02
    ethylbenzene 0.49
    MIBK 4.09
    2-propoxyethanol 38.32
    tert-butanol 8.63
    MTBE 3.15
    2-butoxyethanol 20.64
    propionic acid 40.93
    o-xylene 1.14
    formic acid 214.12
    diethyl ether 5.5
    m-xylene 0.72
    p-xylene 0.85
    chlorobenzene 0.78
    dimethyl carbonate 14.56
    n-octane 0.25
    formamide 207.33
    cyclopentanone 43.76
    2-pentanone 9.31
    anisole 3.05
    cyclopentyl methyl ether 10.04
    gamma-butyrolactone 77.01
    1-methoxy-2-propanol 49.78
    pyridine 12.14
    3-pentanone 8.06
    furfural 62.58
    n-dodecane 0.2
    diethylene glycol 66.27
    diisopropyl ether 1.06
    tert-amyl alcohol 5.31
    acetylacetone 17.46
    n-hexadecane 0.21
    acetophenone 6.68
    methyl propionate 15.33
    isopentyl acetate 3.69
    trichloroethylene 2.09
    n-nonanol 3.51
    cyclohexanol 6.69
    benzyl alcohol 5.71
    2-ethylhexanol 2.3
    isooctanol 2.41
    dipropyl ether 4.52
    1,2-dichlorobenzene 0.87
    ethyl lactate 12.53
    propylene carbonate 26.55
    n-methylformamide 115.58
    2-pentanol 3.7
    n-pentane 0.43
    1-propoxy-2-propanol 18.36
    1-methoxy-2-propyl acetate 12.15
    2-(2-methoxypropoxy) propanol 18.58
    mesitylene 0.67
    ε-caprolactone 25.17
    p-cymene 0.94
    epichlorohydrin 24.92
    1,1,1-trichloroethane 0.65
    2-aminoethanol 71.2
    morpholine-4-carbaldehyde 165.16
    sulfolane 90.7
    2,2,4-trimethylpentane 0.16
    2-methyltetrahydrofuran 14.29
    n-hexyl acetate 5.85
    isooctane 0.1
    2-(2-butoxyethoxy)ethanol 25.38
    sec-butyl acetate 2.77
    tert-butyl acetate 4.39
    decalin 0.24
    glycerin 107.64
    diglyme 46.77
    acrylic acid 62.39
    isopropyl myristate 2.12
    n-butyric acid 21.07
    acetyl acetate 6.5
    di(2-ethylhexyl) phthalate 5.02
    ethyl propionate 6.5
    nitromethane 132.95
    1,2-diethoxyethane 8.24
    benzonitrile 4.27
    trioctyl phosphate 3.58
    1-bromopropane 0.8
    gamma-valerolactone 100.7
    n-decanol 2.54
    triethyl phosphate 4.59
    4-methyl-2-pentanol 1.73
    propionitrile 8.4
    vinylene carbonate 24.45
    1,1,2-trichlorotrifluoroethane 37.71
    DMS 9.96
    cumene 0.57
    2-octanol 1.97
    2-hexanone 5.27
    octyl acetate 3.7
    limonene 1.43
    1,2-dimethoxyethane 42.92
    ethyl orthosilicate 3.8
    tributyl phosphate 4.02
    diacetone alcohol 11.8
    N,N-dimethylaniline 3.76
    acrylonitrile 17.35
    aniline 4.35
    1,3-propanediol 49.53
    bromobenzene 0.36
    dibromomethane 0.83
    1,1,2,2-tetrachloroethane 2.01
    2-methyl-cyclohexyl acetate 4.98
    tetrabutyl urea 7.54
    diisobutyl methanol 1.42
    2-phenylethanol 5.5
    styrene 0.54
    dioctyl adipate 5.32
    dimethyl sulfate 31.53
    ethyl butyrate 5.71
    methyl lactate 33.2
    butyl lactate 9.57
    diethyl carbonate 4.58
    propanediol butyl ether 20.69
    triethyl orthoformate 5.35
    p-tert-butyltoluene 0.88
    methyl 4-tert-butylbenzoate 10.37
    morpholine 56.03
    tert-butylamine 3.27
    n-dodecanol 1.91
    dimethoxymethane 55.23
    ethylene carbonate 19.84
    cyrene 32.33
    2-ethoxyethyl acetate 10.3
    2-ethylhexyl acetate 2.96
    1,2,4-trichlorobenzene 1.39
    4-methylpyridine 8.26
    dibutyl ether 2.31
    2,6-dimethyl-4-heptanol 1.42
    DEF 27.14
    dimethyl isosorbide 29.77
    tetrachloroethylene 1.79
    eugenol 14.17
    triacetin 13.76
    span 80 16.96
    1,4-butanediol 19.24
    1,1-dichloroethane 0.83
    2-methyl-1-pentanol 2.67
    methyl formate 78.3
    2-methyl-1-butanol 4.87
    n-decane 0.31
    butyronitrile 6.34
    3,7-dimethyl-1-octanol 2.12
    1-chlorooctane 0.83
    1-chlorotetradecane 0.43
    n-nonane 0.3
    undecane 0.24
    tert-butylcyclohexane 0.19
    cyclooctane 0.27
    cyclopentanol 14.05
    tetrahydropyran 12.31
    tert-amyl methyl ether 2.94
    2,5,8-trioxanonane 35.96
    1-hexene 0.77
    2-isopropoxyethanol 16.41
    2,2,2-trifluoroethanol 59.78
    methyl butyrate 9.55

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction