8-Methyl-8-azabicyclo(3.2.1)octan-3-ol

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  • Identifiers

    CAS number
    7432-10-2

    Molecular formula
    C8H15NO

    SMILES
    CN1C2CCC1CC(C2)O

    Safety labels

  • Odor profile

    Fragrance
    Odorless 43.88%
    Fishy 40.24%
    Nutty 32.16%
    Sweet 26.82%
    Animal 25.51%
    Roasted 24.86%
    Popcorn 24.52%
    Musty 20.84%
    Cooling 20.55%
    Burnt 19.05%

     

    Flavor
    Bitter 47.13%
    Sweet 32.66%
    Odorless 24.35%
    Fatty 24.26%
    Alkaline 24.24%
    Sweet-like 23.75%
    Cauliflower 21.29%
    Cedarleaf 21.24%
    Shrimp 21.17%
    Cereal 20.8%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    0.8

    pKa est.
    9.11 (weak base)

    Molecular weight
    141.21 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Moderately slow

    Boiling point est.
    230°C

    Flash point

    • 100.32 ˚C est.

  • Synonyms

    • 8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
    • 7432-10-2
    • DTXSID70859224
    • 8-Methyl-8-azabicyclo(3.2.1)octan-3-ol
    • RefChem:1074746
    • DTXCID20210381
    • Tropine
    • 120-29-6
    • 3-Tropanol
    • Tropanol
    • 3alpha-Tropanol
    • 3.alpha.-Tropanol
    • NSC43870
    • NSC43871
    • 8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, endo-
    • 8-Azabicyclo(3.2.1)octanol, 8-methyl-
    • 1-Methyl-2,5-(2-hydroxytrimethylene)pyrrolidine
    • MFCD00180667
    • 2,3-Dihydro-3.alpha.-hydroxytropidine
    • 1.alpha.H,5.alpha.H-Tropan-3.alpha.-ol
    • 2,3-Dihydro-3alpha-hydroxytropidine
    • NSC 43870
    • 3.beta.-Tropanol
    • tropan-3-ol
    • 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol
    • 8-Azabicyclo[3.2.1]octanol, 8-methyl-
    • N-Tropine (trans)
    • b-Tropine
    • NSC-43870
    • NSC-43871
    • 8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, exo-
    • Prestwick0_001077
    • Prestwick1_001077
    • Prestwick2_001077
    • Prestwick3_001077
    • bmse000974
    • Oprea1_099397
    • SCHEMBL38978
    • BSPBio_001094
    • rel-(1R,3s,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-ol
    • SPBio_002997
    • BPBio1_001204
    • CHEMBL113555
    • orb1311042
    • SCHEMBL1916173
    • SCHEMBL9387173
    • HMS1571G16
    • HMS1661L14
    • HMS2098G16
    • HMS5084C05
    • BB_NC-00109
    • HY-N7061
    • EBC-47282
    • NSC241183
    • STL377773
    • AKOS005267127
    • AKOS015955557
    • AC-1979
    • AC-1980
    • CCG-208541
    • CS-W016435
    • NSC-241183
    • Tropine(Discontinued,See C4X-25571)
    • NCGC00179307-01
    • AS-13524
    • AS-13829
    • 1alphaH,5alphaH-Tropan-3alpha-ol (8CI)
    • DB-220048
    • N-Methyl-8-azabicyclo[3.2.1]octan-3-ol
    • 8-Methyl-8-aza-bicyclo[3.2.1]octan-3-ol
    • AB00514033
    • CS-0369298
    • C00729
    • C02066
    • EN300-223936
    • 2,3-Dihydro-3alpha-hydroxy-8-methylnortropidine
    • 8-Methyl-8-azabicyclo[3.2.1]octan-3-ol, endo-
    • endo-8-Azabicyclo[3.2.1]-3-octanol, 8-methyl-
    • F317851
    • SR-05000002205
    • SR-05000002205-2
    • F0001-2567
    • 0AC9FE9A-C292-490C-A504-EA261C257333
    • InChI=1/C8H15NO/c1-9-6-2-3-7(9)5-8(10)4-6/h6-8,10H,2-5H2,1H
    • 120-29-6

  • Applications

    8-Methyl-8-azabicyclo(3.2.1)octan-3-ol (CAS 7432-10-2) is a substituted quinuclidine derivative with an amine and an alcohol group and has practical applications including a synthetic intermediate in pharmaceutical research, serving as a chiral building block for CNS-active and related alkaloid-like compounds; it is also evaluated for agrochemical synthesis as a versatile amine-containing intermediate; in industrial manufacturing, it may function as a base or catalyst in organic synthesis and as a curing accelerator or reactive additive in epoxy and other polymer systems, supporting coatings, inks, and adhesive formulations; it can also be used as a functional building block for specialty polymers and materials, subject to formulation constraints and local regulatory requirements.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 175.04
    methanol 278.53
    isopropanol 115.04
    water 92.08
    ethyl acetate 112.63
    n-propanol 144.04
    acetone 100.98
    n-butanol 104.46
    acetonitrile 130.73
    DMF 181.56
    toluene 22.59
    isobutanol 89.51
    1,4-dioxane 188.97
    methyl acetate 115.91
    THF 158.16
    2-butanone 84.56
    n-pentanol 47.39
    sec-butanol 74.14
    n-hexane 1.26
    ethylene glycol 177.69
    NMP 133.8
    cyclohexane 3.38
    DMSO 227.73
    n-butyl acetate 60.04
    n-octanol 37.21
    chloroform 420.32
    n-propyl acetate 36.71
    acetic acid 303.21
    dichloromethane 279.12
    cyclohexanone 109.39
    propylene glycol 141.76
    isopropyl acetate 50.36
    DMAc 124.85
    2-ethoxyethanol 138.56
    isopentanol 69.06
    n-heptane 2.93
    ethyl formate 119.72
    1,2-dichloroethane 105.77
    n-hexanol 77.43
    2-methoxyethanol 316.53
    isobutyl acetate 23.31
    tetrachloromethane 72.63
    n-pentyl acetate 42.77
    transcutol 294.58
    n-heptanol 48.38
    ethylbenzene 9.01
    MIBK 37.03
    2-propoxyethanol 206.06
    tert-butanol 93.76
    MTBE 27.71
    2-butoxyethanol 122.14
    propionic acid 219.3
    o-xylene 19.82
    formic acid 383.83
    diethyl ether 36.15
    m-xylene 22.89
    p-xylene 15.51
    chlorobenzene 56.92
    dimethyl carbonate 44.08
    n-octane 1.79
    formamide 335.67
    cyclopentanone 144.6
    2-pentanone 58.8
    anisole 29.32
    cyclopentyl methyl ether 56.96
    gamma-butyrolactone 237.44
    1-methoxy-2-propanol 202.89
    pyridine 117.44
    3-pentanone 44.06
    furfural 266.04
    n-dodecane 1.81
    diethylene glycol 257.88
    diisopropyl ether 10.14
    tert-amyl alcohol 57.95
    acetylacetone 96.13
    n-hexadecane 2.02
    acetophenone 38.92
    methyl propionate 85.36
    isopentyl acetate 47.15
    trichloroethylene 271.25
    n-nonanol 32.78
    cyclohexanol 60.78
    benzyl alcohol 51.12
    2-ethylhexanol 33.09
    isooctanol 31.98
    dipropyl ether 24.76
    1,2-dichlorobenzene 63.16
    ethyl lactate 42.65
    propylene carbonate 124.76
    n-methylformamide 273.67
    2-pentanol 48.46
    n-pentane 2.23
    1-propoxy-2-propanol 117.41
    1-methoxy-2-propyl acetate 88.9
    2-(2-methoxypropoxy) propanol 75.79
    mesitylene 14.37
    ε-caprolactone 121.21
    p-cymene 16.3
    epichlorohydrin 217.63
    1,1,1-trichloroethane 124.08
    2-aminoethanol 242.73
    morpholine-4-carbaldehyde 202.3
    sulfolane 204.32
    2,2,4-trimethylpentane 1.91
    2-methyltetrahydrofuran 92.12
    n-hexyl acetate 53.17
    isooctane 1.81
    2-(2-butoxyethoxy)ethanol 116.02
    sec-butyl acetate 22.15
    tert-butyl acetate 40.35
    decalin 2.06
    glycerin 287.56
    diglyme 200.45
    acrylic acid 219.03
    isopropyl myristate 18.73
    n-butyric acid 209.71
    acetyl acetate 86.11
    di(2-ethylhexyl) phthalate 28.25
    ethyl propionate 35.68
    nitromethane 428.97
    1,2-diethoxyethane 55.53
    benzonitrile 72.58
    trioctyl phosphate 21.73
    1-bromopropane 36.83
    gamma-valerolactone 265.72
    n-decanol 23.33
    triethyl phosphate 25.2
    4-methyl-2-pentanol 30.52
    propionitrile 87.63
    vinylene carbonate 143.2
    1,1,2-trichlorotrifluoroethane 261.63
    DMS 49.32
    cumene 9.89
    2-octanol 25.85
    2-hexanone 27.65
    octyl acetate 27.23
    limonene 16.76
    1,2-dimethoxyethane 105.78
    ethyl orthosilicate 23.37
    tributyl phosphate 24.53
    diacetone alcohol 81.61
    N,N-dimethylaniline 20.07
    acrylonitrile 151.75
    aniline 68.45
    1,3-propanediol 248.44
    bromobenzene 49.04
    dibromomethane 133.91
    1,1,2,2-tetrachloroethane 200.37
    2-methyl-cyclohexyl acetate 30.3
    tetrabutyl urea 28.12
    diisobutyl methanol 21.06
    2-phenylethanol 66.47
    styrene 10.09
    dioctyl adipate 27.43
    dimethyl sulfate 74.56
    ethyl butyrate 38.51
    methyl lactate 87.59
    butyl lactate 54.41
    diethyl carbonate 30.29
    propanediol butyl ether 95.63
    triethyl orthoformate 31.83
    p-tert-butyltoluene 16.0
    methyl 4-tert-butylbenzoate 54.05
    morpholine 199.8
    tert-butylamine 39.24
    n-dodecanol 16.79
    dimethoxymethane 93.68
    ethylene carbonate 115.65
    cyrene 61.31
    2-ethoxyethyl acetate 74.98
    2-ethylhexyl acetate 34.97
    1,2,4-trichlorobenzene 78.5
    4-methylpyridine 84.2
    dibutyl ether 20.23
    2,6-dimethyl-4-heptanol 21.06
    DEF 68.85
    dimethyl isosorbide 102.97
    tetrachloroethylene 156.1
    eugenol 65.79
    triacetin 59.78
    span 80 70.11
    1,4-butanediol 83.72
    1,1-dichloroethane 116.57
    2-methyl-1-pentanol 32.2
    methyl formate 175.51
    2-methyl-1-butanol 62.65
    n-decane 2.97
    butyronitrile 75.12
    3,7-dimethyl-1-octanol 30.47
    1-chlorooctane 14.33
    1-chlorotetradecane 5.76
    n-nonane 2.69
    undecane 2.22
    tert-butylcyclohexane 2.27
    cyclooctane 1.67
    cyclopentanol 98.65
    tetrahydropyran 84.1
    tert-amyl methyl ether 20.7
    2,5,8-trioxanonane 136.03
    1-hexene 5.12
    2-isopropoxyethanol 69.0
    2,2,2-trifluoroethanol 210.33
    methyl butyrate 42.46

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction