8-Hydroxypinoresinol

Overview IFRA Request a quote

  • Identifiers

    CAS number
    81426-17-7

    Molecular formula
    C20H22O7

    SMILES
    COC1=C(C=CC(=C1)[C@@H]2[C@H]3CO[C@@H]([C@]3(CO2)O)C4=CC(=C(C=C4)O)OC)O

    Safety labels

  • Odor profile

    Fragrance
    Vanilla 76.54%
    Sweet 60.52%
    Phenolic 46.68%
    Creamy 45.26%
    Balsamic 41.43%
    Spicy 40.76%
    Smoky 36.25%
    Powdery 36.13%
    Odorless 33.89%
    Milky 29.71%

     

    Flavor
    Bitter 83.68%
    Bland 25.31%
    Sweet-like 23.83%
    Eugenol 21.46%
    Parsley 20.98%
    Naphthalic 20.66%
    Cedarleaf 20.65%
    Lovage 19.74%
    Allspice 19.61%
    Patchouli 19.61%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    1.2

    pKa est.
    7.53 (neutral)

    Molecular weight
    374.4 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    832°C

    Melting point expt.

    • 183 - 185 °C

    Flash point

    • 251.96 ˚C est.

  • Synonyms

    • 8-hydroxypinoresinol
    • 81426-17-7
    • DTXSID001315412
    • RefChem:914591
    • DTXCID801745322
    • (3R,3aS,6S,6aR)-3,6-bis(4-hydroxy-3-methoxyphenyl)-3,4,6,6a-tetrahydro-1H-furo(3,4-c)furan-3a-ol
    • (+)-1-Hydroxylpinoresinol
    • 1-Hydroxypinoresinol
    • 8'-hydroxypinoresinol
    • (+)-8(1)-Hydroxypinoresinol
    • CHEMBL471274
    • orb1683284
    • SCHEMBL31315047
    • SCHEMBL31441207
    • CHEBI:175806
    • AKOS040761269
    • FS-7748
    • DA-50020
    • HY-122379
    • CS-0084933
    • 4,4',8-Trihydroxy-3,3'-dimethoxy-7,9':7',9-diepoxylignan
    • 2,6-Bis(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo[3.3.0]octan-1-ol
    • (1S,3aS,4R,6aR)-1,4-Bis(4-hydroxy-3-methoxyphenyl)dihydro-1H,3H-furo[3,4-c]furan-3a(4H)-ol
    • (3R,3aS,6S,6aR)-3,6-bis(4-hydroxy-3-methoxy-phenyl)-3,4,6,6a-tetrahydro-1H-furo[3,4-c]furan-3a-ol
    • (3R,3aS,6S,6aR)-3,6-bis(4-hydroxy-3-methoxyphenyl)-3,4,6,6a-tetrahydro-1H-uro[3,4-c]uran-3a-ol
    • 1H,3H-Furo[3,4-c]furan-3a(4H)-ol, dihydro-1,4-bis(4-hydroxy-3-methoxyphenyl)-, (1S,3aS,4R,6aR)-
    • 81426-17-7

  • Applications

    8-Hydroxypinoresinol, CAS 81426-17-7, is often treated as an intermediate in the synthesis of lignan-based compounds and related organics; in cosmetics and personal care, it is evaluated as an antioxidant and stabilizer to improve formulation durability. In the plastics and polymer sector, it may serve as an antioxidant stabilizer to extend the lifetime of polymer systems; in coatings and inks, it can be used as a bio-based additive to enhance oxidative stability and surface performance. Additionally, it is studied as a building block for pharmaceutical-related compounds and as a reference standard for the analytical determination of lignans in samples.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 7.36
    methanol 16.72
    isopropanol 5.59
    water 0.86
    ethyl acetate 14.83
    n-propanol 6.45
    acetone 24.86
    n-butanol 5.71
    acetonitrile 14.83
    DMF 109.62
    toluene 1.54
    isobutanol 3.59
    1,4-dioxane 27.76
    methyl acetate 12.4
    THF 90.68
    2-butanone 11.24
    n-pentanol 3.18
    sec-butanol 3.54
    n-hexane 0.1
    ethylene glycol 15.77
    NMP 41.5
    cyclohexane 0.28
    DMSO 153.21
    n-butyl acetate 4.77
    n-octanol 5.4
    chloroform 26.27
    n-propyl acetate 6.05
    acetic acid 78.43
    dichloromethane 24.14
    cyclohexanone 17.56
    propylene glycol 8.27
    isopropyl acetate 11.9
    DMAc 88.66
    2-ethoxyethanol 40.59
    isopentanol 5.4
    n-heptane 0.39
    ethyl formate 12.6
    1,2-dichloroethane 11.84
    n-hexanol 3.81
    2-methoxyethanol 83.57
    isobutyl acetate 4.12
    tetrachloromethane 2.71
    n-pentyl acetate 8.16
    transcutol 74.63
    n-heptanol 6.1
    ethylbenzene 1.03
    MIBK 10.89
    2-propoxyethanol 35.8
    tert-butanol 8.19
    MTBE 5.85
    2-butoxyethanol 24.48
    propionic acid 13.82
    o-xylene 1.59
    formic acid 78.47
    diethyl ether 7.6
    m-xylene 1.51
    p-xylene 1.22
    chlorobenzene 2.55
    dimethyl carbonate 35.6
    n-octane 0.32
    formamide 116.12
    cyclopentanone 38.86
    2-pentanone 13.1
    anisole 6.18
    cyclopentyl methyl ether 13.29
    gamma-butyrolactone 54.22
    1-methoxy-2-propanol 56.35
    pyridine 12.4
    3-pentanone 9.24
    furfural 42.82
    n-dodecane 0.32
    diethylene glycol 46.12
    diisopropyl ether 2.6
    tert-amyl alcohol 5.61
    acetylacetone 39.29
    n-hexadecane 0.36
    acetophenone 8.48
    methyl propionate 18.31
    isopentyl acetate 6.27
    trichloroethylene 36.2
    n-nonanol 6.21
    cyclohexanol 4.67
    benzyl alcohol 6.39
    2-ethylhexanol 3.0
    isooctanol 5.45
    dipropyl ether 6.38
    1,2-dichlorobenzene 4.43
    ethyl lactate 12.2
    propylene carbonate 20.41
    n-methylformamide 46.26
    2-pentanol 3.53
    n-pentane 0.16
    1-propoxy-2-propanol 19.96
    1-methoxy-2-propyl acetate 20.72
    2-(2-methoxypropoxy) propanol 24.59
    mesitylene 1.2
    ε-caprolactone 17.74
    p-cymene 1.83
    epichlorohydrin 58.93
    1,1,1-trichloroethane 8.54
    2-aminoethanol 16.37
    morpholine-4-carbaldehyde 70.37
    sulfolane 70.57
    2,2,4-trimethylpentane 0.2
    2-methyltetrahydrofuran 13.55
    n-hexyl acetate 9.68
    isooctane 0.16
    2-(2-butoxyethoxy)ethanol 32.56
    sec-butyl acetate 4.58
    tert-butyl acetate 15.83
    decalin 0.23
    glycerin 42.01
    diglyme 70.54
    acrylic acid 24.13
    isopropyl myristate 4.96
    n-butyric acid 18.42
    acetyl acetate 23.23
    di(2-ethylhexyl) phthalate 6.17
    ethyl propionate 8.45
    nitromethane 158.56
    1,2-diethoxyethane 14.54
    benzonitrile 5.84
    trioctyl phosphate 5.35
    1-bromopropane 2.77
    gamma-valerolactone 67.79
    n-decanol 4.32
    triethyl phosphate 7.38
    4-methyl-2-pentanol 3.68
    propionitrile 8.31
    vinylene carbonate 23.64
    1,1,2-trichlorotrifluoroethane 71.56
    DMS 14.4
    cumene 0.92
    2-octanol 3.79
    2-hexanone 5.28
    octyl acetate 6.31
    limonene 2.35
    1,2-dimethoxyethane 48.56
    ethyl orthosilicate 7.01
    tributyl phosphate 5.46
    diacetone alcohol 26.66
    N,N-dimethylaniline 5.36
    acrylonitrile 17.95
    aniline 4.61
    1,3-propanediol 24.7
    bromobenzene 2.38
    dibromomethane 9.39
    1,1,2,2-tetrachloroethane 23.04
    2-methyl-cyclohexyl acetate 7.07
    tetrabutyl urea 8.45
    diisobutyl methanol 3.23
    2-phenylethanol 7.15
    styrene 1.13
    dioctyl adipate 9.11
    dimethyl sulfate 59.94
    ethyl butyrate 6.96
    methyl lactate 26.71
    butyl lactate 11.48
    diethyl carbonate 6.84
    propanediol butyl ether 18.6
    triethyl orthoformate 8.63
    p-tert-butyltoluene 1.84
    methyl 4-tert-butylbenzoate 18.19
    morpholine 31.76
    tert-butylamine 2.89
    n-dodecanol 3.09
    dimethoxymethane 92.63
    ethylene carbonate 19.12
    cyrene 29.43
    2-ethoxyethyl acetate 17.55
    2-ethylhexyl acetate 4.1
    1,2,4-trichlorobenzene 6.05
    4-methylpyridine 7.53
    dibutyl ether 4.96
    2,6-dimethyl-4-heptanol 3.23
    DEF 25.65
    dimethyl isosorbide 41.6
    tetrachloroethylene 16.17
    eugenol 19.03
    triacetin 22.24
    span 80 16.56
    1,4-butanediol 7.45
    1,1-dichloroethane 6.78
    2-methyl-1-pentanol 3.2
    methyl formate 41.94
    2-methyl-1-butanol 4.14
    n-decane 0.61
    butyronitrile 6.25
    3,7-dimethyl-1-octanol 4.89
    1-chlorooctane 2.18
    1-chlorotetradecane 0.99
    n-nonane 0.48
    undecane 0.41
    tert-butylcyclohexane 0.19
    cyclooctane 0.2
    cyclopentanol 6.54
    tetrahydropyran 10.91
    tert-amyl methyl ether 5.54
    2,5,8-trioxanonane 51.43
    1-hexene 0.41
    2-isopropoxyethanol 20.85
    2,2,2-trifluoroethanol 45.76
    methyl butyrate 9.07

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction