5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,8-dimethoxy-4H-1-benzopyran-4-one

Overview IFRA Request a quote

  • Identifiers

    CAS number
    15835-74-2

    Molecular formula
    C18H16O8

    SMILES
    COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C(=C(C(=C3O2)OC)O)OC)O)O

    Safety labels

  • Odor profile

    Fragrance
    Phenolic 61.83%
    Spicy 44.11%
    Burnt 42.61%
    Smoky 42.32%
    Vanilla 41.98%
    Balsamic 34.31%
    Odorless 33.69%
    Woody 33.5%
    Sweet 28.26%
    Medicinal 27.75%

     

    Flavor
    Bitter 73.52%
    Bland 25.22%
    Eugenol 23.22%
    Odorless 22.29%
    Parsley 22.26%
    Ham 20.93%
    Sweet-like 20.9%
    Vanilla 20.68%
    Allspice 20.46%
    Cedarleaf 19.85%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    2.6

    pKa est.
    8.92 (weak base)

    Molecular weight
    360.3 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    1120°C

    Melting point expt.

    • 239 - 241 °C

    Flash point

    • 227.6 ˚C est.

  • Synonyms

    • Acerosin
    • 15835-74-2
    • CHEBI:2382
    • 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,8-dimethoxychromen-4-one
    • 3',5,7-Trihydroxy-4',6,8-trimethoxyflavone
    • DTXSID30166406
    • 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,8-dimethoxy-4H-1-benzopyran-4-one
    • RefChem:1072243
    • DTXCID9088897
    • CHEMBL3314497
    • 5,7,3'-trihydroxy-6,8,4'-trimethoxyflavone
    • 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,8-dimethoxy-4H-chromen-4-one
    • C09982
    • SCHEMBL12469965
    • BDBM50046951
    • LMPK12111473
    • XA177971
    • Q27105652
    • 5,7-dihydroxy-2-(3-hydroxy-4-methoxy-phenyl)-6,8-dimethoxy-chromen-4-one
    • 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,8-dimethoxy-4H-1-benzopyran-4-one, 9CI
    • 15835-74-2

  • Applications

    5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,8-dimethoxy-4H-1-benzopyran-4-one (CAS 15835-74-2) may be used as an intermediate or scaffold in the synthesis of flavonoid-like bioactive compounds for pharmaceutical and natural product research; in cosmetics and personal care, it is studied as an antioxidant and potential UV stabilizer in formulations; as a stabilizer/antioxidant, it is evaluated for polymer, coating, and ink formulations to improve oxidative and photochemical durability; in agricultural chemistry, it is explored as a scaffold for developing bioactive agents with potential plant-protective properties; and generally it serves as a building block for structure-activity relationship studies in flavonoid chemistry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 0.04
    methanol 0.04
    isopropanol 0.05
    water 0.0
    ethyl acetate 0.11
    n-propanol 0.09
    acetone 0.05
    n-butanol 0.07
    acetonitrile 0.05
    DMF 1.04
    toluene 0.02
    isobutanol 0.07
    1,4-dioxane 0.38
    methyl acetate 0.16
    THF 1.31
    2-butanone 0.2
    n-pentanol 0.09
    sec-butanol 0.1
    n-hexane 0.01
    ethylene glycol 0.11
    NMP 4.95
    cyclohexane 0.01
    DMSO 2.9
    n-butyl acetate 0.21
    n-octanol 0.12
    chloroform 0.06
    n-propyl acetate 0.16
    acetic acid 0.24
    dichloromethane 0.12
    cyclohexanone 0.49
    propylene glycol 0.1
    isopropyl acetate 0.1
    DMAc 3.26
    2-ethoxyethanol 0.7
    isopentanol 0.1
    n-heptane 0.02
    ethyl formate 0.08
    1,2-dichloroethane 0.12
    n-hexanol 0.11
    2-methoxyethanol 0.99
    isobutyl acetate 0.11
    tetrachloromethane 0.01
    n-pentyl acetate 0.27
    transcutol 2.46
    n-heptanol 0.17
    ethylbenzene 0.03
    MIBK 0.1
    2-propoxyethanol 1.18
    tert-butanol 0.11
    MTBE 0.09
    2-butoxyethanol 0.9
    propionic acid 0.23
    o-xylene 0.04
    formic acid 0.26
    diethyl ether 0.07
    m-xylene 0.02
    p-xylene 0.04
    chlorobenzene 0.03
    dimethyl carbonate 0.27
    n-octane 0.01
    formamide 0.53
    cyclopentanone 0.86
    2-pentanone 0.1
    anisole 0.13
    cyclopentyl methyl ether 0.33
    gamma-butyrolactone 1.52
    1-methoxy-2-propanol 0.69
    pyridine 0.41
    3-pentanone 0.14
    furfural 1.44
    n-dodecane 0.01
    diethylene glycol 1.27
    diisopropyl ether 0.03
    tert-amyl alcohol 0.18
    acetylacetone 0.22
    n-hexadecane 0.01
    acetophenone 0.27
    methyl propionate 0.24
    isopentyl acetate 0.28
    trichloroethylene 0.27
    n-nonanol 0.17
    cyclohexanol 0.15
    benzyl alcohol 0.16
    2-ethylhexanol 0.16
    isooctanol 0.18
    dipropyl ether 0.24
    1,2-dichlorobenzene 0.06
    ethyl lactate 0.32
    propylene carbonate 0.4
    n-methylformamide 0.3
    2-pentanol 0.06
    n-pentane 0.0
    1-propoxy-2-propanol 0.81
    1-methoxy-2-propyl acetate 0.63
    2-(2-methoxypropoxy) propanol 1.32
    mesitylene 0.02
    ε-caprolactone 0.7
    p-cymene 0.08
    epichlorohydrin 1.32
    1,1,1-trichloroethane 0.03
    2-aminoethanol 0.17
    morpholine-4-carbaldehyde 2.99
    sulfolane 5.56
    2,2,4-trimethylpentane 0.01
    2-methyltetrahydrofuran 0.55
    n-hexyl acetate 0.28
    isooctane 0.0
    2-(2-butoxyethoxy)ethanol 1.36
    sec-butyl acetate 0.13
    tert-butyl acetate 0.19
    decalin 0.01
    glycerin 0.63
    diglyme 3.12
    acrylic acid 0.38
    isopropyl myristate 0.15
    n-butyric acid 0.18
    acetyl acetate 0.1
    di(2-ethylhexyl) phthalate 0.28
    ethyl propionate 0.23
    nitromethane 0.67
    1,2-diethoxyethane 0.48
    benzonitrile 0.12
    trioctyl phosphate 0.21
    1-bromopropane 0.05
    gamma-valerolactone 2.12
    n-decanol 0.13
    triethyl phosphate 0.44
    4-methyl-2-pentanol 0.06
    propionitrile 0.1
    vinylene carbonate 0.32
    1,1,2-trichlorotrifluoroethane 2.53
    DMS 0.47
    cumene 0.03
    2-octanol 0.11
    2-hexanone 0.19
    octyl acetate 0.2
    limonene 0.11
    1,2-dimethoxyethane 1.31
    ethyl orthosilicate 0.42
    tributyl phosphate 0.23
    diacetone alcohol 0.56
    N,N-dimethylaniline 0.2
    acrylonitrile 0.21
    aniline 0.1
    1,3-propanediol 0.24
    bromobenzene 0.02
    dibromomethane 0.05
    1,1,2,2-tetrachloroethane 0.29
    2-methyl-cyclohexyl acetate 0.41
    tetrabutyl urea 0.48
    diisobutyl methanol 0.11
    2-phenylethanol 0.24
    styrene 0.02
    dioctyl adipate 0.36
    dimethyl sulfate 1.28
    ethyl butyrate 0.3
    methyl lactate 0.49
    butyl lactate 0.42
    diethyl carbonate 0.26
    propanediol butyl ether 0.68
    triethyl orthoformate 0.5
    p-tert-butyltoluene 0.08
    methyl 4-tert-butylbenzoate 0.79
    morpholine 0.8
    tert-butylamine 0.05
    n-dodecanol 0.09
    dimethoxymethane 0.61
    ethylene carbonate 0.23
    cyrene 1.84
    2-ethoxyethyl acetate 0.58
    2-ethylhexyl acetate 0.24
    1,2,4-trichlorobenzene 0.14
    4-methylpyridine 0.19
    dibutyl ether 0.18
    2,6-dimethyl-4-heptanol 0.11
    DEF 0.47
    dimethyl isosorbide 2.81
    tetrachloroethylene 0.18
    eugenol 0.87
    triacetin 0.65
    span 80 0.82
    1,4-butanediol 0.11
    1,1-dichloroethane 0.03
    2-methyl-1-pentanol 0.14
    methyl formate 0.2
    2-methyl-1-butanol 0.12
    n-decane 0.01
    butyronitrile 0.06
    3,7-dimethyl-1-octanol 0.14
    1-chlorooctane 0.06
    1-chlorotetradecane 0.03
    n-nonane 0.01
    undecane 0.01
    tert-butylcyclohexane 0.01
    cyclooctane 0.0
    cyclopentanol 0.24
    tetrahydropyran 0.21
    tert-amyl methyl ether 0.16
    2,5,8-trioxanonane 2.41
    1-hexene 0.02
    2-isopropoxyethanol 0.54
    2,2,2-trifluoroethanol 0.21
    methyl butyrate 0.27

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction