4-Ethoxyphenol

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  • Identifiers

    CAS number
    622-62-8

    Molecular formula
    C8H10O2

    SMILES
    CCOC1=CC=C(C=C1)O

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Sweet 87.46%
    Phenolic 83.09%
    Vanilla 60.24%
    Medicinal 54.32%
    Smoky 53.39%
    Nutty 49.62%
    Anisic 45.36%
    Spicy 41.32%
    Aromatic 39.85%
    Woody 36.89%

     

    Flavor
    Bitter 62.91%
    Phenolic 60.45%
    Sweet 55.0%
    Vanilla 47.51%
    Powdery 37.86%
    Smoky 37.32%
    Spicy 36.2%
    Medicinal 35.85%
    Spice 32.89%
    Woody 32.33%

     

    Odor impact est.
    Medium

  • Properties

    XLogP3-AA
    1.8

    pKa est.
    9.24 (weak base)

    Molecular weight
    138.16 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Slow

    Melting point expt.

    • 66 - 67 °C

    Boiling point

    • 246.00 to 247.00 °C. @ 760.00 mm Hg

    Flash point

    • 106.28 ˚C est.

    Solubility expt.

    • slightly soluble to soluble in water; soluble in oils
    • moderately soluble (in ethanol)

  • Synonyms

    • 4-Ethoxyphenol
    • 622-62-8
    • Phenol, 4-ethoxy-
    • P-ETHOXYPHENOL
    • Hydroquinone monoethyl ether
    • p-Hydroxyphenetole
    • 4-Ethyloxyphenol
    • Phenol, p-ethoxy-
    • 4-ethoxy-phenol
    • 1-Ethoxy-4-hydroxybenzene
    • Ethoxyphenol, p-
    • FEMA No. 3695
    • NSC 9885
    • Ether monoethylique de l'hydroquinone
    • MFCD00002334
    • p-ethoxy-phenol
    • 4-Ethoxyphenole
    • EINECS 210-748-1
    • BRN 1907114
    • DTXSID3044251
    • UNII-605352N8AQ
    • NSC-9885
    • Ether monoethylique de l'hydroquinone [French]
    • HYDROQUINONE MONO ETHYL ETHER
    • 605352N8AQ
    • DTXCID1024251
    • FEMA 3695
    • 4-06-00-05719 (Beilstein Handbook Reference)
    • 4-Ethoxyphenol, 99%
    • HYDROQUINONE MONOETHYL ETHER [FHFI]
    • 4-Hydroxyphenetole
    • hydroquinone monoethylether
    • p-ethoxylphenol
    • para-ethoxyphenol
    • 4-ethoxy phenol
    • 4-(ethyloxy)phenol
    • hydroquinone ethyl ether
    • SCHEMBL28520
    • CHEMBL225153
    • NSC9885
    • CHEBI:179262
    • 4-Ethoxyphenol, analytical standard
    • Tox21_302684
    • STK078066
    • AKOS000120913
    • CS-W016502
    • DS-8026
    • FE61834
    • HY-W015786
    • NCGC00256790-01
    • CAS-622-62-8
    • PD158327
    • SY015677
    • DB-028862
    • A3598
    • E0216
    • NS00021260
    • EN300-17907
    • Q27263168
    • Z57073756
    • F0001-1662
    • Hydroquinone monoethylether 100 microg/mL in Acetonitrile
    • 210-748-1
    • 29692-57-7

  • Applications

    4-Ethoxyphenol, CAS 622-62-8, is primarily used as an intermediate in the synthesis of specialty chemicals, including aromatic derivatives and pharmaceutical intermediates; it also serves as a precursor for the production of dyes and pigments; due to its phenolic structure, it is considered as a fragrance intermediate for perfumery applications; it remains a feedstock for coatings, paints, and inks; and it may function as a building block for pharmaceutical or agrochemical intermediates, subject to local regulations and formulation limits.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 582.72
    methanol 700.28
    isopropanol 412.06
    water 2.53
    ethyl acetate 468.29
    n-propanol 398.22
    acetone 872.79
    n-butanol 345.98
    acetonitrile 711.07
    DMF 819.56
    toluene 107.87
    isobutanol 251.97
    1,4-dioxane 784.63
    methyl acetate 629.02
    THF 1004.09
    2-butanone 659.79
    n-pentanol 260.74
    sec-butanol 345.01
    n-hexane 46.43
    ethylene glycol 211.29
    NMP 664.33
    cyclohexane 37.14
    DMSO 2371.76
    n-butyl acetate 379.96
    n-octanol 122.35
    chloroform 643.71
    n-propyl acetate 323.45
    acetic acid 486.51
    dichloromethane 843.06
    cyclohexanone 493.25
    propylene glycol 212.64
    isopropyl acetate 208.76
    DMAc 820.04
    2-ethoxyethanol 555.97
    isopentanol 290.22
    n-heptane 24.24
    ethyl formate 295.41
    1,2-dichloroethane 633.93
    n-hexanol 216.46
    2-methoxyethanol 777.32
    isobutyl acetate 164.14
    tetrachloromethane 131.42
    n-pentyl acetate 166.02
    transcutol 2059.47
    n-heptanol 85.71
    ethylbenzene 88.69
    MIBK 194.13
    2-propoxyethanol 413.06
    tert-butanol 564.7
    MTBE 522.34
    2-butoxyethanol 197.98
    propionic acid 386.37
    o-xylene 96.04
    formic acid 261.27
    diethyl ether 496.22
    m-xylene 80.37
    p-xylene 106.81
    chlorobenzene 222.87
    dimethyl carbonate 199.2
    n-octane 9.62
    formamide 557.45
    cyclopentanone 707.86
    2-pentanone 396.54
    anisole 318.91
    cyclopentyl methyl ether 343.14
    gamma-butyrolactone 858.8
    1-methoxy-2-propanol 468.2
    pyridine 451.44
    3-pentanone 325.14
    furfural 694.43
    n-dodecane 8.9
    diethylene glycol 413.81
    diisopropyl ether 114.14
    tert-amyl alcohol 492.48
    acetylacetone 480.19
    n-hexadecane 10.17
    acetophenone 262.66
    methyl propionate 365.74
    isopentyl acetate 286.26
    trichloroethylene 978.82
    n-nonanol 101.03
    cyclohexanol 228.1
    benzyl alcohol 198.41
    2-ethylhexanol 136.23
    isooctanol 74.59
    dipropyl ether 183.62
    1,2-dichlorobenzene 225.69
    ethyl lactate 143.2
    propylene carbonate 389.17
    n-methylformamide 494.22
    2-pentanol 225.06
    n-pentane 34.92
    1-propoxy-2-propanol 284.03
    1-methoxy-2-propyl acetate 308.13
    2-(2-methoxypropoxy) propanol 321.68
    mesitylene 58.99
    ε-caprolactone 438.42
    p-cymene 65.36
    epichlorohydrin 994.28
    1,1,1-trichloroethane 450.9
    2-aminoethanol 305.38
    morpholine-4-carbaldehyde 765.85
    sulfolane 1165.87
    2,2,4-trimethylpentane 27.25
    2-methyltetrahydrofuran 691.74
    n-hexyl acetate 260.46
    isooctane 18.08
    2-(2-butoxyethoxy)ethanol 430.05
    sec-butyl acetate 185.56
    tert-butyl acetate 272.18
    decalin 33.64
    glycerin 294.67
    diglyme 821.0
    acrylic acid 343.51
    isopropyl myristate 100.59
    n-butyric acid 365.58
    acetyl acetate 286.17
    di(2-ethylhexyl) phthalate 100.41
    ethyl propionate 250.15
    nitromethane 1142.85
    1,2-diethoxyethane 522.38
    benzonitrile 269.08
    trioctyl phosphate 72.79
    1-bromopropane 324.8
    gamma-valerolactone 724.33
    n-decanol 75.02
    triethyl phosphate 128.27
    4-methyl-2-pentanol 120.83
    propionitrile 390.94
    vinylene carbonate 325.23
    1,1,2-trichlorotrifluoroethane 568.35
    DMS 306.0
    cumene 68.63
    2-octanol 67.89
    2-hexanone 332.47
    octyl acetate 126.75
    limonene 94.11
    1,2-dimethoxyethane 830.09
    ethyl orthosilicate 119.87
    tributyl phosphate 118.93
    diacetone alcohol 325.08
    N,N-dimethylaniline 183.11
    acrylonitrile 463.44
    aniline 214.09
    1,3-propanediol 365.35
    bromobenzene 233.28
    dibromomethane 511.45
    1,1,2,2-tetrachloroethane 706.91
    2-methyl-cyclohexyl acetate 178.49
    tetrabutyl urea 145.03
    diisobutyl methanol 85.85
    2-phenylethanol 171.11
    styrene 121.93
    dioctyl adipate 170.83
    dimethyl sulfate 413.06
    ethyl butyrate 230.71
    methyl lactate 186.69
    butyl lactate 152.34
    diethyl carbonate 186.56
    propanediol butyl ether 265.51
    triethyl orthoformate 161.98
    p-tert-butyltoluene 65.25
    methyl 4-tert-butylbenzoate 186.6
    morpholine 833.84
    tert-butylamine 322.62
    n-dodecanol 56.74
    dimethoxymethane 543.01
    ethylene carbonate 274.25
    cyrene 246.71
    2-ethoxyethyl acetate 313.09
    2-ethylhexyl acetate 228.35
    1,2,4-trichlorobenzene 282.63
    4-methylpyridine 380.75
    dibutyl ether 176.69
    2,6-dimethyl-4-heptanol 85.85
    DEF 445.3
    dimethyl isosorbide 445.58
    tetrachloroethylene 433.44
    eugenol 197.82
    triacetin 307.33
    span 80 211.7
    1,4-butanediol 181.13
    1,1-dichloroethane 497.69
    2-methyl-1-pentanol 248.32
    methyl formate 397.34
    2-methyl-1-butanol 278.9
    n-decane 14.94
    butyronitrile 340.5
    3,7-dimethyl-1-octanol 139.3
    1-chlorooctane 75.23
    1-chlorotetradecane 29.35
    n-nonane 14.85
    undecane 11.12
    tert-butylcyclohexane 34.74
    cyclooctane 14.87
    cyclopentanol 268.35
    tetrahydropyran 552.29
    tert-amyl methyl ether 344.57
    2,5,8-trioxanonane 526.01
    1-hexene 145.5
    2-isopropoxyethanol 348.75
    2,2,2-trifluoroethanol 192.6
    methyl butyrate 329.65

    Scent© AI

1 4

IFRA standard 51

Recommendation
Prohibition
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 0 % Category 7A
Rinse-off products applied to the hair with some hand contact
 0 %
Category 2
Products applied to the axillae
 0 % Category 7B
Leave-on products applied to the hair with some hand contact
 0 %
Category 3
Products applied to the face/body using fingertips
 0 % Category 8
Products with significant anogenital exposure
 0 %
Category 4
Products related to fine fragrance
 0 % Category 9
Products with body and hand exposure, primarily rinse off
 0 %
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 0 % Category 10A
Household care products with mostly hand contact
 0 %
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 0 % Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 0 %
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 0 % Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 0 %
Category 5D
Baby Creams, baby Oils and baby talc
 0 % Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 0 %
Category 6
Products with oral and lip exposure
 0 % Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 0 %

Prohibition
Hydroquinone monoethyl ether should not be used as a fragrance ingredient.