4-Aminoantipyrine

Overview IFRA Request a quote

  • Identifiers

    CAS number
    83-07-8

    Molecular formula
    C11H13N3O

    SMILES
    CC1=C(C(=O)N(N1C)C2=CC=CC=C2)N

    Safety labels

    Irritant
    Irritant

  • Odor profile

    Fragrance
    Odorless 45.42%
    Burnt 31.6%
    Bitter 27.94%
    Fruity 22.76%
    Musty 22.0%
    Animal 21.85%
    Roasted 21.63%
    Grape 20.11%
    Cooked 19.15%
    Phenolic 18.88%

     

    Flavor
    Bitter 84.0%
    Odorless 30.09%
    Very strong 22.06%
    Indole 21.6%
    Nitrile 21.58%
    Bread crust 20.97%
    Soybean 20.67%
    Cedarleaf 20.41%
    Orange flower 20.23%
    Mild 20.21%

     

    Odor impact est.
    Low

  • Properties

    XLogP3-AA
    0.1

    pKa est.
    4.51 (weak acid)

    Molecular weight
    203.24 g/mol

    Vapor pressure est.

    • hPa @ 20°C
    • hPa @ 25°C

    Evaporation rate
    Ultra slow

    Boiling point est.
    502°C

    Flash point

    • 174.83 ˚C est.

  • Synonyms

    • 4-Aminoantipyrine
    • AMPYRONE
    • 83-07-8
    • 4-Aminophenazone
    • Aminoantipyrine
    • Metapirazone
    • 4-Aminoantipyrene
    • Aminoantipyrin
    • Solvapyrin-A
    • Aminoazophene
    • Solnapyrin-A
    • Aminoazophenazone
    • 4-AAP
    • 4-Amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
    • 3H-Pyrazol-3-one, 4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-
    • 4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one
    • DTXSID8048860
    • CHEBI:59026
    • 0M0B7474RA
    • NSC-60242
    • DTXCID1028786
    • 4 Aminophenazone
    • 4 aminoantipyrine
    • RefChem:517541
    • 4 Amino 1,5 Dimethyl 2 Phenyl 3H Pyrazolone
    • 4-Amino-1,5-Dimethyl-2-Phenyl-3H-Pyrazolone
    • 201-452-3
    • Antipyrine, 4-amino-
    • MFCD00003145
    • 4-Amminoantipirina
    • 4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one
    • 4-Amminoantipirina [Italian]
    • NSC 60242
    • 4-amino-1,5-dimethyl-2-phenyl-2,3-dihydro-1H-pyrazol-3-one
    • 1,5-Dimethyl-2-phenyl-4-aminopyrazoline
    • BRN 0181635
    • 4-AA
    • 3-Pyrazolin-5-one, 4-amino-2,3-dimethyl-1-phenyl-
    • AI3-14639
    • 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one
    • 4-amino-1,5-dimethyl-2-phenyl-pyrazol-3-one
    • NSC60242
    • s4509
    • CAS-83-07-8
    • NCGC00016328-01
    • solvapyrin A
    • 4-Amino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one (Ampyrone)
    • NSC1740
    • CCRIS 2906
    • SR-01000399288
    • EINECS 201-452-3
    • Aminoantipyrene
    • Minoazophene
    • Aminoanti
    • UNII-0M0B7474RA
    • 4-aminoantipyrin
    • 4-Aminopyrine
    • Prestwick_16
    • Spectrum_000758
    • Prestwick0_000181
    • Prestwick1_000181
    • Prestwick2_000181
    • Prestwick3_000181
    • Spectrum2_000934
    • Spectrum3_000604
    • Spectrum4_000386
    • Spectrum5_001583
    • 4-Amino-1-phenyl-2,3-dimethyl-5-pyrazolone
    • bmse000147
    • Epitope ID:124938
    • Ampyrone, NSC 60242
    • 4-Aminoantipyrine ACS grade
    • Oprea1_651348
    • BSPBio_000101
    • BSPBio_002108
    • KBioGR_000911
    • KBioSS_001238
    • 5-25-14-00096 (Beilstein Handbook Reference)
    • MLS002154229
    • DivK1c_000454
    • SCHEMBL128544
    • SPECTRUM1500621
    • SPBio_000868
    • SPBio_002022
    • Antipyrine, 4-amino- (8CI)
    • BPBio1_000113
    • 4-AMINOANTIPYRINE [MI]
    • CHEMBL1165011
    • 4-Aminoantipyrine, reagent grade
    • BDBM85515
    • HMS501G16
    • KBio1_000454
    • KBio2_001238
    • KBio2_003806
    • KBio2_006374
    • KBio3_001608
    • Metamizole Sodium EP Impurity B
    • MSK7117
    • NINDS_000454
    • AA METABOLITE OF METAMIZOLE
    • HMS1568F03
    • HMS1921K17
    • HMS2095F03
    • HMS2235D04
    • HMS3373A14
    • HMS3712F03
    • HMS5083H03
    • ALBB-037248
    • BB_SC-00011
    • HY-B1398
    • NSC_2151
    • STR05569
    • Tox21_113352
    • 4-Aminoantipyrine, p.a., 99.0%
    • CCG-39099
    • EBC-03665
    • Metamizole EP Impurity B (Ampyrone)
    • MSK7117-100M
    • NSC782758
    • SBB003514
    • STK171821
    • AKOS000119290
    • MSK7117-1000M
    • Tox21_113352_1
    • CS-4903
    • FA10254
    • ND-1774
    • 83-07-8

  • Applications

    4-Aminoantipyrine is widely used as a chromogenic reagent in peroxidase-catalyzed colorimetric assays, enabling detection of oxidizable substrates via hydrogen peroxide in analytical and clinical chemistry; in particular it is employed in Trinder-type reactions with phenol to form a colored quinoneimine dye for enzyme assays such as glucose, lactate, uric acid, and related analytes; it is also used as a diagnostic kit component and as a research reagent for colorimetric sensing of hydrogen peroxide; and as an intermediate in the synthesis of dyes and pigments used in research and industry.

    gpt-5-nano

  • Solubility @25˚C

    Solvent Solubility (g/L)
    ethanol 971.42
    methanol 1352.95
    isopropanol 595.81
    water 1128.08
    ethyl acetate 195.43
    n-propanol 674.45
    acetone 1253.08
    n-butanol 376.06
    acetonitrile 591.83
    DMF 822.36
    toluene 38.4
    isobutanol 350.25
    1,4-dioxane 551.76
    methyl acetate 234.77
    THF 514.87
    2-butanone 337.98
    n-pentanol 222.14
    sec-butanol 309.11
    n-hexane 1.72
    ethylene glycol 452.12
    NMP 206.99
    cyclohexane 5.51
    DMSO 789.44
    n-butyl acetate 54.29
    n-octanol 36.11
    chloroform 547.85
    n-propyl acetate 74.47
    acetic acid 706.1
    dichloromethane 828.24
    cyclohexanone 290.39
    propylene glycol 253.62
    isopropyl acetate 66.67
    DMAc 373.51
    2-ethoxyethanol 528.4
    isopentanol 208.48
    n-heptane 1.88
    ethyl formate 481.53
    1,2-dichloroethane 405.34
    n-hexanol 91.59
    2-methoxyethanol 1247.92
    isobutyl acetate 37.08
    tetrachloromethane 64.72
    n-pentyl acetate 50.41
    transcutol 239.56
    n-heptanol 58.32
    ethylbenzene 23.26
    MIBK 71.96
    2-propoxyethanol 209.72
    tert-butanol 299.83
    MTBE 77.83
    2-butoxyethanol 142.58
    propionic acid 263.09
    o-xylene 28.7
    formic acid 1263.29
    diethyl ether 117.07
    m-xylene 23.24
    p-xylene 37.44
    chlorobenzene 117.39
    dimethyl carbonate 90.45
    n-octane 1.59
    formamide 2385.57
    cyclopentanone 387.25
    2-pentanone 196.28
    anisole 70.29
    cyclopentyl methyl ether 85.21
    gamma-butyrolactone 463.4
    1-methoxy-2-propanol 440.84
    pyridine 399.95
    3-pentanone 112.09
    furfural 561.99
    n-dodecane 1.5
    diethylene glycol 293.45
    diisopropyl ether 11.96
    tert-amyl alcohol 174.82
    acetylacetone 196.67
    n-hexadecane 1.73
    acetophenone 87.44
    methyl propionate 160.68
    isopentyl acetate 47.62
    trichloroethylene 646.22
    n-nonanol 31.98
    cyclohexanol 144.6
    benzyl alcohol 149.09
    2-ethylhexanol 34.85
    isooctanol 40.43
    dipropyl ether 18.63
    1,2-dichlorobenzene 96.06
    ethyl lactate 55.99
    propylene carbonate 202.45
    n-methylformamide 1049.07
    2-pentanol 133.13
    n-pentane 2.83
    1-propoxy-2-propanol 85.06
    1-methoxy-2-propyl acetate 51.42
    2-(2-methoxypropoxy) propanol 52.78
    mesitylene 12.55
    ε-caprolactone 202.59
    p-cymene 13.44
    epichlorohydrin 645.59
    1,1,1-trichloroethane 177.88
    2-aminoethanol 676.25
    morpholine-4-carbaldehyde 319.77
    sulfolane 324.57
    2,2,4-trimethylpentane 1.9
    2-methyltetrahydrofuran 241.42
    n-hexyl acetate 50.35
    isooctane 1.17
    2-(2-butoxyethoxy)ethanol 97.38
    sec-butyl acetate 33.03
    tert-butyl acetate 52.3
    decalin 2.47
    glycerin 400.01
    diglyme 216.16
    acrylic acid 270.42
    isopropyl myristate 16.13
    n-butyric acid 368.67
    acetyl acetate 90.82
    di(2-ethylhexyl) phthalate 26.9
    ethyl propionate 57.83
    nitromethane 1233.75
    1,2-diethoxyethane 72.19
    benzonitrile 151.91
    trioctyl phosphate 19.95
    1-bromopropane 95.71
    gamma-valerolactone 571.63
    n-decanol 23.12
    triethyl phosphate 23.86
    4-methyl-2-pentanol 49.66
    propionitrile 247.78
    vinylene carbonate 254.25
    1,1,2-trichlorotrifluoroethane 352.51
    DMS 53.55
    cumene 16.97
    2-octanol 33.9
    2-hexanone 84.43
    octyl acetate 25.0
    limonene 16.02
    1,2-dimethoxyethane 485.01
    ethyl orthosilicate 22.08
    tributyl phosphate 21.58
    diacetone alcohol 106.64
    N,N-dimethylaniline 41.36
    acrylonitrile 404.23
    aniline 130.68
    1,3-propanediol 840.0
    bromobenzene 85.65
    dibromomethane 328.32
    1,1,2,2-tetrachloroethane 387.62
    2-methyl-cyclohexyl acetate 31.96
    tetrabutyl urea 30.53
    diisobutyl methanol 16.47
    2-phenylethanol 80.22
    styrene 28.89
    dioctyl adipate 25.84
    dimethyl sulfate 127.86
    ethyl butyrate 34.51
    methyl lactate 102.99
    butyl lactate 50.82
    diethyl carbonate 31.22
    propanediol butyl ether 91.92
    triethyl orthoformate 27.95
    p-tert-butyltoluene 11.35
    methyl 4-tert-butylbenzoate 50.39
    morpholine 569.08
    tert-butylamine 101.24
    n-dodecanol 16.45
    dimethoxymethane 421.86
    ethylene carbonate 205.76
    cyrene 88.26
    2-ethoxyethyl acetate 79.08
    2-ethylhexyl acetate 32.33
    1,2,4-trichlorobenzene 102.96
    4-methylpyridine 240.17
    dibutyl ether 21.69
    2,6-dimethyl-4-heptanol 16.47
    DEF 175.49
    dimethyl isosorbide 88.91
    tetrachloroethylene 318.72
    eugenol 71.12
    triacetin 48.84
    span 80 46.97
    1,4-butanediol 319.14
    1,1-dichloroethane 274.49
    2-methyl-1-pentanol 124.02
    methyl formate 810.75
    2-methyl-1-butanol 208.2
    n-decane 2.28
    butyronitrile 253.25
    3,7-dimethyl-1-octanol 26.79
    1-chlorooctane 13.48
    1-chlorotetradecane 5.26
    n-nonane 1.88
    undecane 1.82
    tert-butylcyclohexane 1.94
    cyclooctane 1.34
    cyclopentanol 241.78
    tetrahydropyran 240.42
    tert-amyl methyl ether 45.41
    2,5,8-trioxanonane 110.15
    1-hexene 12.31
    2-isopropoxyethanol 197.15
    2,2,2-trifluoroethanol 379.99
    methyl butyrate 114.42

    Scent© AI

1 4

IFRA standard 51

Recommendation
No restriction
Maximum acceptable concentrations in the finished product (%)
Category 1
Products applied to the lips
 No restriction Category 7A
Rinse-off products applied to the hair with some hand contact
 No restriction
Category 2
Products applied to the axillae
 No restriction Category 7B
Leave-on products applied to the hair with some hand contact
 No restriction
Category 3
Products applied to the face/body using fingertips
 No restriction Category 8
Products with significant anogenital exposure
 No restriction
Category 4
Products related to fine fragrance
 No restriction Category 9
Products with body and hand exposure, primarily rinse off
 No restriction
Category 5A
Body lotion products applied to the body using the hands (palms), primarily leave on
 No restriction Category 10A
Household care products with mostly hand contact
 No restriction
Category 5B
Face moisturizer products applied to the face using the hands (palms), primarily leave on
 No restriction Category 10B
Household care products with mostly hand contact, including aerosol/spray products (with potential leave-on skin contact)
 No restriction
Category 5C
Hand cream products applied to the hands using the hands (palms), primarily leave on
 No restriction Category 11A
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
 No restriction
Category 5D
Baby Creams, baby Oils and baby talc
 No restriction Category 11B
Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
 No restriction
Category 6
Products with oral and lip exposure
 No restriction Category 12
Products not intended for direct skin contact, minimal or insignificant transfer to skin
 No restriction